A component-level methodology to evaluate the seismic repair costs of infills and services for Italian RC buildings

The reliable estimation of seismic losses due to damage to buildings is paramount for the post-emergency management and the planning of recovery activities. For residential reinforced concrete (RC) infilled buildings, a significant role in the computation of seismic loss is played by non-structural components, above all infills, partitions and services, as shown in past earthquakes. In this work, a component-based methodology is proposed to assess seismic losses for residential RC buildings in Mediterranean region. The attention is focused on the repairing activities for masonry infills (typical enclosure or partitions elements in Italian and Mediterranean RC buildings), and for services (plumbing systems, electric equipment, floor/wall tiles…), commonly enclosed within the infill panels for the considered building typology. The described methodology can be used starting from the expected damage level to infills and partitions. It adopts given repair unit costs at different damage states of infills. The loss estimation methodology has been, first, validated by comparing predicted and actual repair costs for specific case-study buildings damaged by L’Aquila (Italy) 2009 earthquake. Then, the methodology has been applied to a wide dataset of RC buildings (about 2500 residential buildings) damaged by L’Aquila earthquake available from the literature, to show its possible application at a large-scale level. A good agreement between observed and predicted costs is obtained both for specific case-study buildings and for the wider building stock, especially when damage to structural components is very limited

A component-level methodology to evaluate the seismic repair costs of infills and services for Italian RC buildings

AbstractThe reliable estimation of seismic losses due to damage to buildings is paramount for the post-emergency management and the planning of recovery activities. For residential reinforced concrete (RC) infilled buildings, a significant role in the computation of seismic loss is played by non-structural components, above all infills, partitions and services, as shown in past earthquakes. In this work, a component-based methodology is proposed to assess seismic losses for residential RC buildings in Mediterranean region. The attention is focused on the repairing activities for masonry infills (typical enclosure or partitions elements in Italian and Mediterranean RC buildings), and for services (plumbing systems, electric equipment, floor/wall tiles…), commonly enclosed within the infill panels for the considered building typology. The described methodology can be used starting from the expected damage level to infills and partitions. It adopts given repair unit costs at different damage states of infills. The loss estimation methodology has been, first, validated by comparing predicted and actual repair costs for specific case-study buildings damaged by L'Aquila (Italy) 2009 earthquake. Then, the methodology has been applied to a wide dataset of RC buildings (about 2500 residential buildings) damaged by L'Aquila earthquake available from the literature, to show its possible application at a large-scale level. A good agreement between observed and predicted costs is obtained both for specific case-study buildings and for the wider building stock, especially when damage to structural components is very limited

Seismic Loss Estimation in Pre-1970 Residential RC Buildings: The Role of Infills and Services in Low–Mid-Rise Case Studies

The lessons learned after recent earthquakes have highlighted the key role played by infills and services in damage and loss of Reinforced Concrete (RC) buildings. Their influence in seismic performance and loss estimation of selected RC building case studies is thoroughly analyzed here. The case study selection aims to be representative of existing buildings built in Italy before 1970, and covers a different number of stories and design typologies. The seismic responses of the case-study buildings are numerically analyzed by means of non-linear static pushover analysis (PO) considering a lumped plasticity approach with a quadri-linear flexural response for beam/column elements (properly calibrated for RC elements reinforced with plain bars) and a tri-linear compressive-only axial response with diagonal concentric struts for infill panels (empirically derived from experimental data on hollow clay masonry walls). Economic loss estimation is carried out via a component-based methodology that relies on the main repairing activities and resultant costs required for the refurbishment of infills and services for different damage levels. Accordingly, a damage analysis is performed herein, given the intensity measure, based on a comparison between Interstory drift demand from PO analysis and drift-based fragility functions specific for masonry infills. Loss curves, relating the total building repair cost to peak ground acceleration (PGA), are presented and compared for the analyzed case study buildings to show their trends and quantify the incidence of infills and services with respect to the reconstruction cost. A comparison between these outcomes and those recently found in the literature emphasizes the robustness of the considered approach and the reliability of the hypotheses about damage and loss assessment

Detection of pollutant sources in the atmosphere with Lidar/Dial techniques: Results of an experimental campaign in the south of Italy

In the last years, surveying large regions of the atmosphere in an automatic way, for early detection of pollutant sources in urban and industrial areas, has become a strategic objective of various public health organizations. The Lidar/Dial technique has become a well-established laser remote sensing method for atmosphere monitoring. It is often used to probe almost any level of the atmosphere and to acquire information necessary to validate theoretical models about different topics of atmospheric physics. It can also be deployed for environment surveying by monitoring particles, aerosols and molecules. For these reasons, an experimental campaign for evaluating the performances of a Lidar/Dial system in detecting pollutants (particulate and/or chemical compounds) has been carried out in an industrial area in the south of Italy. In this work, a homemade Lidar/Dial system (developed and built by the authors) and the results of the experimental campaign will be presented and discussed. © 2014 AEIT

E-Defense 2015 ten-story building: beam–column joint assessment according to different code-based design

Recent devastating earthquakes worldwide pointed out the importance of seismic detailing and their influence on the observed damage and subsequent repairability of reinforced concrete buildings. Several studies and post-earthquake observations remarked the role of beam–column joints (BCJs) on the global building response and the effectiveness of transverse reinforcement in increasing the joint shear strength and the ultimate deformation. Although number of experimental and theoretical studies focused on the seismic response of BCJs, their mechanical behaviour is still a discussed topic. This resulted in number of design approaches available in worldwide code or standards that lead to different quantity of joint stirrups. This study focuses on the response of BCJs of a 10-story prototype building designed according to Japanese standards and tested in 2015 on the E-Defense shaking table. First the damage assessment at global (building) and local (joint) level is performed at increasing intensities and considering the building in the base slip and base fixed configurations. A refined numerical model is then developed and validated against global and local experimental results. Then, the joint stirrups are re-designed according to different international standards (ACI, EC8, NZS) and different numerical models are developed. The numerical results are then compared in terms of interstorey drift demand and joint shear strain. Finally, a comparison in terms of expected damage varying the design approach of joint stirrups is proposed

Adult human biliary tree stem cells differentiate to β-pancreatic islet cells by treatment with a recombinant human Pdx1 peptide

Generation of β-pancreatic cells represents a major goal in research. The aim of this study was to explore a protein-based strategy to induce differentiation of human biliary tree stem cells (hBTSCs) towards β-pancreatic cells. A plasmid containing the sequence of the human pancreatic and duodenal homeobox 1 (PDX1) has been expressed in E. coli. Epithelial-Cell-Adhesion-Molecule positive hBTSCs or mature human hepatocyte cell line, HepG2, were grown in medium to which Pdx1 peptide was added. Differentiation toward pancreatic islet cells were evaluated by the expression of the β-cell transcription factors, Pdx1 and musculoapo-neurotic fibrosarcoma oncogene homolog A, and of the pancreatic hormones, insulin, glucagon, and somatostatin, investigated by real time polymerase chain reaction, western blot, light microscopy and immunofluorescence. C-peptide secretion in response to high glucose was also measured. Results indicated how purified Pdx1 protein corresponding to the primary structure of the human Pdx1 by mass spectroscopy was efficiently produced in bacteria, and transduced into hBTSCs. Pdx1 exposure triggered the expression of both intermediate and mature stage β-cell differentiation markers only in hBTSCs but not in HepG2 cell line. Furthermore, hBTSCs exposed to Pdx1 showed up-regulation of insulin, glucagon and somatostatin genes and formation of 3-dimensional islet-like structures intensely positive for insulin and glucagon. Finally, Pdx1-induced islet-like structures exhibited glucose-regulated C-peptide secretion. In conclusion, the human Pdx1 is highly effective in triggering hBTSC differentiation toward functional β-pancreatic cells

Cytogenetic bio-dosimetry techniques in the detection of dicentric chromosomes induced by ionizing radiation: A review

Ionizing radiation is ubiquitous in the environment. Its source can be natural, such as radioactive materials present in soil and cosmic rays, or artificial, such as the fuel for nuclear power plants. Overexposure to ionizing radiation may damage living tissue and could cause severe health problems (i.e., mutations, radiation sickness, cancer, and death). Cytogenetic bio-dosimetry has the great advantage to take into account the inter-individual variation, and it is informative even when physical dosimetry is not applicable; moreover, it is the definitive method to assess exposure to ionizing radiation recommended by the World Health Organization (WHO). Such a procedure involves counting the frequency of dicentric chromosomes (DCs), which are the most studied chromosomal aberrations used as absorbed radiation biomarkers, during the metaphase of cells. A set of algorithms, tested on different programming languages to automatically identify DCs, is analyzed by the authors together with an Automated Dicentric Chromosome Identifying software (ADCI) mostly based on OpenCV programming libraries. The purpose of this work is to review the main results regarding the correlation between ionizing radiation and dicentric chromosomes in cytogenetic bio-dosimetry

Dual-readout Calorimetry

The RD52 Project at CERN is a pure instrumentation experiment whose goal is to understand the fundamental limitations to hadronic energy resolution, and other aspects of energy measurement, in high energy calorimeters. We have found that dual-readout calorimetry provides heretofore unprecedented information event-by-event for energy resolution, linearity of response, ease and robustness of calibration, fidelity of data, and particle identification, including energy lost to binding energy in nuclear break-up. We believe that hadronic energy resolutions of {\sigma}/E $\approx$ 1 - 2% are within reach for dual-readout calorimeters, enabling for the first time comparable measurement preci- sions on electrons, photons, muons, and quarks (jets). We briefly describe our current progress and near-term future plans. Complete information on all aspects of our work is available at the RD52 website http://highenergy.phys.ttu.edu/dream/.Comment: 10 pages, 10 figures, Snowmass White pape