SAFETY MONITORING BY MEANS OF SENSOR NETWORKS DISTRIBUTED WITHIN THE FOSSA SITE PLAN

Abstract. The seismic event of 6 April 2009 has inevitably left its mark on the history of the entire territory of L'Aquila (Italy), completely devastating the town and much of the province. Within such frantic and extensive reconstruction activity, the resulting construction works could not but draw attention to some issues of fundamental importance such as coordinated planning, safety, respect for the rules and above all the rebirth of the territory. This research is aimed at drawing up the site plan for Fossa, a municipality in the Province of L'Aquila and not far from the region capital of Abruzzo, Italy. The main objective is to create a monitoring standard by means of a dedicated sensors network and detailed strategies in order to coordinate, guide and support the single actions of intervention through design behaviours and highly technological tools. The Plan is configured as a tool for participatory planning, with the active involvement of planners, companies and citizens, whose common goal is the preservation of the identity of locations, the mitigation of seismic risk and the enhancement of the cultural heritage of the Municipality of Fossa. Implementation of this work is the application of technological systems for construction site monitoring: a concrete response to the growing demand for organized management of the construction process on site and safety in the workplace can be achieved through the use of systems and rational control and management procedures that include the use of innovative technologies

Effect of metabolic and antioxidant supplementation on sperm parameters in oligo-astheno-teratozoospermia, with and without varicocele: a double-blind placebo-controlled study

Since sperm require high energy levels to perform their specialised function, it is vital that essential nutrients are available for spermatozoa when they develop, capacitate and acquire motility. However, they are vulnerable to a lack of energy and excess amounts of reactive oxygen species, which can impair sperm function, lead to immotility, acrosomal reaction impairment, DNA fragmentation and cell death. This monocentric, randomised, double-blind, placebo-controlled trial investigated the effect of 6 months of supplementation with l-carnitine, acetyl-l-carnitine and other micronutrients on sperm quality in 104 subjects with oligo- and/or astheno- and/or teratozoospermia with or without varicocele. In 94 patients who completed the study, sperm concentration was significantly increased in supplemented patients compared to the placebo (p =.0186). Total sperm count also increased significantly (p =.0117) in the supplemented group as compared to the placebo group. Both, progressive and total motility were higher in supplemented patients (p =.0088 and p =.0120, respectively). Although pregnancy rate was not an endpoint of the study, of the 12 pregnancies that occurred during the follow-up, 10 were reported in the supplementation group. In general, all these changes were more evident in varicocele patients. In conclusion, supplementation with metabolic and antioxidant compounds could be efficacious when included in strategies to improve fertility

Chronic bacterial prostatitis: efficacy of short-lasting antibiotic therapy with prulifloxacin (Unidrox®) in association with saw palmetto extract, lactobacillus sporogens and arbutin (Lactorepens®)

Bacterial prostatitis (BP) is a common condition accounting responsible for about 5-10% of all prostatitis cases; chronic bacterial prostatitis (CBP) classified as type II, are less common but is a condition that significantly hampers the quality of life, (QoL) because not only is it a physical condition but also a psychological distress. Commonly patients are treated with antibiotics alone, and in particular fluoroquinolones are suggested by the European Urology guidelines. This approach, although recommended, may not be enough. Thus, a multimodal approach to the prolonged antibiotic therapy may be helpful.210 patients affected by chronic bacterial prostatitis were enrolled in the study. All patients were positive to Meares-Stamey test and symptoms duration was > 3 months. The purpose of the study was to evaluate the efficacy of a long lasting therapy with a fluoroquinolone in association with a nutraceutical supplement (prulifloxacin 600 mg for 21 days and an association of Serenoa repens 320 mg, Lactobacillus Sporogens 200 mg, Arbutin 100 mg for 30 days). Patients were randomized in two groups (A and B) receiving respectively antibiotic alone and an association of antibiotic plus supplement.Biological recurrence at 2 months in Group A was observed in 21 patients (27.6%) and in Group B in 6 patients (7.8%). Uropathogens found at the first follow-up were for the majority Gram - (E. coli and Enterobacter spp.). A statistically significant difference was found at the time of the follow-up between Group A and B in the NIH-CPSI questionnaire score, symptoms evidence and serum PSA.Broad band, short-lasting antibiotic therapy in association with a nutritional supplement (serenoa repens, lactobacillus sporogens and arbutin) show better control and recurrence rate on patients affected by chronic bacterial prostatitits in comparison with antibiotic treatment alone.NCT02130713Date of trial Registration: 30/04/2014

3D AND 4D MODELLING IN BUILDING SITE WORKING CONTROL

The purpose of this contribution is to describe the use of the HBIM method for the management of the restoration building site applied to a historic building in the heart of the historic center of L'Aquila. The construction is located in a densely constructed area and it is characterized by a high spatial complexity with various types of limitations including: small external and internal spaces and interferences due to neighboring construction sites. The proposed method involves a particularly detailed organization of the construction site, simultaneously planning both the development of the working and the safety in order to have more transparency and more control of the information shared among stakeholders. This method consists in planning the Gantt diagram from general to detailed level, according to certain parameters that will be cross-examined and checked regurarly. A screening step has been carried out regarding the current situation, the proceedings to be undertaken and the stakeholders to be included. Thank to this, it has been possible to have automated processes to control not only geometrical interferences but also the ones related to the completion of the work in the interest of enhancing the risk management. Due to a 3D and 4D BIM modelling, there are been found advanced layouts and some timeliners that have allowed a rigourus control of the building process, particularly in the case of precise working and potencial changes that are common in building sites of this type

BEP & MAPPING PROCESS FOR THE RESTORATION BUILDING SITE

The BEP, acronym for BIM Execution Plan, consists of the information management plan created by the design team to illustrate how to meet the requirements defined in the Employer's Information Requirement (EIR).The big amount of data will have to be organized a priori both for the professionals who will use that piece of information and for the stakeholders who will have to receive only the right information and use specific worksets. Just at this stage, the heart of the BIM method, there are different advantages compared to the traditional process, in which these informational steps were omitted, causing errors, delays and therefore an increase in active and passive costs. This paper explores the methodology applied to the mapping process of the management of a recovery site. For a better understanding of the result achieved, the stages of the process have been explained, from the acquisition of data, through the scan to BIM process up to the construction phases. In addition, the phases (Identify BIM goal and uses, Design BIM Project Execution Process, Develop information exchange) and the steps (Investigation, Identification and Strategy) necessary to achieve the objective have been analyzed. This is the Lean construction and Integrated Project Delivery (IPD), methodologies and systems that allow the improvement of the building process thanks to data sharing and communication between stakeholders before work begins so as to eliminate any possible delay.</p

Penile prosthesis implant for erectile dysfunction: A new minimally invasive infrapubic surgical technique

Erectile dysfunction, the most common male sexual disorder after premature ejaculation, with its important impact on man and partner’s sexuality and quality of life is a persistent inability to obtain and maintain an erection sufficient to permit satisfactory sexual performance. Non-surgical treatments with controversial results are usually applyed before surgical treatment that has reached high levels of satisfaction. We describe a new surgical technique to implant three-pieces penile prosthesis in patients suffering from erectile dysfunction (ED) not responding to conventional medical therapy or reporting side effects with such a therapy. Implantation of an inflatable prosthesis, for treatment of ED, is a safe and efficacious approach with high satisfaction reported by patients and partners. Surgical technique should be minimally invasive and latest technology equipment should be implanted in order to decrease common complications and to obtain a better aesthetic result

Clinical correlation among male infertility and overall male health: a systematic review of the literature

Purpose: Ongoing evidence has suggested the role of male factor infertility as a potential predictor of mortality and general health status. The aim of the present review is to update the current knowledge base regarding the association between male factor infertility and general health through a critical review of the literature. Materials and Methods: A systematic review of the literature was carried out from inception to November 2019 in order to evaluate significant associations between male infertility and adverse health outcomes such as cardiovascular, oncologic, metabolic and autoimmune diseases as well as overall mortality. Results: In all, 27 studies met inclusion criteria and were critically examined. Five studies examined male infertility and cardiovascular disease risk, 11 examined oncologic risk (e.g., overall cancer risk, testis and prostate cancer), 8 examined aggregate chronic medical diseases and 5 infertility related to incidence of mortality, for a total of 599,807 men diagnosed with any male factor infertility covering a period from 1916 to 2016. Conclusions: A man’s fertility and overall health appear to be interconnected. Therefore, a diagnosis of male infertility may allow a window into future comorbidity and/or mortality which may help guide clinical decisions and counseling. Several possible etiologies such as genetic, epigenetic, developmental, and lifestyle-based factors need to be further evaluated in order to establish the underlying mechanisms between male infertility and health

COFLEX: FLEXIBLE BRACELET ANTI COVID-19 TO PROTECT CONSTRUCTION WORKERS

Abstract. To implement the protocol contrasting the diffusion of Covid-19, the employer is required, to ensure the safety and health of the worker at work, to adopt measures related to the control of body temperature (with respect for privacy), the minimum distance during work and all other activities such as breaks, canteen breaks, access to toilets, in addition to the adoption of specifically developed safety procedures, such as e.g. the use of man-down detection devices. In this context, the project aims to illustrate a system able of providing support in the safeguarding of workers' health on construction sites. This system, based on information received from sensors capable of identifying workers' positions (e.g., if less than 1m away) and their vital parameters (e.g., body temperature, gasped breathing), as well as moving objects inside the construction site area (e.g., to check if a worker is passing under a moving crane), will raise early alerts directly to the workers and/or to the central software, with respect for privacy, to immediately activate all the necessary measures to mitigate the risk. The system, based on the data communicated by the various sensors, will store and process them for the purpose of extracting useful information for risk management. The proposed system configured itself as a new product taking advantage from a high Technology Readiness Level maturated from the Smart Safety Belt already developed by some of the authors

Androgen-deprivation therapy and SARS-Cov-2 infection: the potential double-face role of testosterone

To analyze possible effect of androgen deprivation therapy in preventing SARS-Cov-2 infection and respiratory complication

Effect of metabolic and antioxidant supplementation on sperm parameters in oligo-astheno-teratozoospermia, with and without varicocele: a double-blind placebo-controlled study

Since sperm require high energy levels to perform their specialised function, it is vital that essential nutrients are available for spermatozoa when they develop, capacitate and acquire motility. However, they are vulnerable to a lack of energy and excess amounts of reactive oxygen species, which can impair sperm function, lead to immotility, acrosomal reaction impairment, DNA fragmentation and cell death. This monocentric, randomised, double-blind, placebo-controlled trial investigated the effect of 6 months of supplementation with l-carnitine, acetyl-l- carnitine and other micronutrients on sperm quality in 104 subjects with oligo-and/ or astheno-and/ or teratozoospermia with or without varicocele. In 94 patients who completed the study, sperm concentration was significantly increased in supplemented patients compared to the placebo (p = .0186). Total sperm count also increased significantly (p = .0117) in the supplemented group as compared to the placebo group. Both, progressive and total motility were higher in supplemented patients (p = .0088 and p = .0120, respectively). Although pregnancy rate was not an endpoint of the study, of the 12 pregnancies that occurred during the follow-up, 10 were reported in the supplementation group. In general, all these changes were more evident in varicocele patients. In conclusion, supplementation with metabolic and antioxidant compounds could be efficacious when included in strategies to improve fertility