Determining the Actual Local Density of Dark Matter Particles

Even if dark matter particles are unambiguously discovered in experiments, there is no clear reason to expect that the dark matter problem has been solved. It is very easy to provide examples of dark matter scenarios (e.g. in supersymmetric models) where nearly identical detector signals correspond to extremely different relic densities. Therefore, the density of the particles discovered must be determined before their cosmological relevance is established. In this talk, I will present a general method to estimate the local density of dark matter particles using both dark matter and hadron collider experimental data when it becomes available. These results were obtained in collaboration with Gordon Kane at the University of Michigan.Comment: 9 pages, 4 figures. Talk given at the 42nd International School of Subnuclear Physics at Erice, Sicily, 30 August 200

Copy-cat Bot for Narendra Modi which generates plausible new speeches in Modhi’s style using machine learning approaches

Many consequences in the human past can be traced back to that one well-written, well-presentedspeech. Speeches grasp the power to move nations or touch hearts as long as they are well-thought-out.This is why gaining the expertise of speech giving and speech writing is something we should all intent togain. A copy-cat bot is a model that can learn the writing and talking style of a certain person and replicateit. The main objective of this research study is to apply simple Recurrent Neural Network (RNN), LongShort-Term Memory (LSTM) Recurrent Neural Networks and Gated Recurrent Unit (GRU) in developinga speech generation system that deep learns one text and then generates new text. This research looks intothe generation of English transcripts of Narendra Modi’s speeches. The generated text using LSTM andGRU models has great potential. The output resulted by RNN is less realistic and pragmatic, but itsvariants LSTM and GRU performed better. Though the grammatical correctness and the sentencetransitions were absent in generated text of LSTM and GRU, but their output is somewhat logical ascompared to RNN. LSTM and GRU performed better as it generated more realistic text and training lossis small, perplexity is small and mean probability is high compared to RNN

Study od a Slice at +9 to +15 degrees of Declination: I. The Neutral Hydrogen Content of Galaxies in Loose Groups

We examine the H1 content of spiral galaxies in groups by using a catalog of loose groups of galaxies identified in a magnitude limited sample m < 15.7 spanning the range 8 h to 18 h in right ascension and +9 to +15 in declination. The redshift completeness of the galaxy sample is ~95%. No significant effect of H1 depletion is found, although there may be a hint that the earliest type spirals are slightly deficient.Comment: 10 pages, Latex, 3 tables, 5 figures, to appear in the Astronomical Journa

Assessing methods to improve benthic fish sampling in a stony headwater stream

Electrofishing is a well-established and widely used method for surveying fish populations. Nonetheless, its effectiveness is impacted by numerous factors, including water chemistry, habitat type and fish species. Both physiological and behavioural responses make bottom-dwelling ‘benthic’ fish which lack swim bladders (e.g. European bullhead Cottus gobio) particularly difficult to survey by electrofishing. We compare the performance and practicalities of electrofishing for benthic fish at a rocky northern English headwater stream with two sampling methods originally designed for crayfish surveys; the triple drawdown method which involves repeated dewatering of a site, and the Pritchard Trap method which involves sunken traps filled with natural substrate that samples a small, fixed (0.25 m2) area of river bed. Both the Pritchard trapping and triple drawdown methods provided similar high-density population density estimates for bullhead which were at least 2.5–5 times higher than predicted from electrofishing derived sweep depletion curves. Electrofishing and the triple drawdown method are both resource-intensive, requiring expensive equipment and a team of trained operatives. These approaches also pose a risk to fish and non-target organisms. In contrast, Pritchard Traps provide a cost-effective passive, low risk survey method requiring minimal training and only one operative. Pritchard traps, therefore, show particular promise for benthic fish surveying and monitoring

Pre-treatment cerebrospinal fluid bacterial load correlates with inflammatory response and predicts neurological events during tuberculous meningitis treatment.

Background Mycobacterium tuberculosis (Mtb) bacillary load in the brain of those with tuberculous meningitis (TBM) may reflect the host ability to control the pathogen and determine disease severity and treatment outcomes. Methods We measured pre-treatment cerebrospinal fluid (CSF) Mtb bacterial load by GeneXpert in 692 adults with TBM. We sought to understand the relationship between CSF bacterial load and inflammation, and their respective impact on disease severity and treatment outcomes. Results Ten-fold higher Mtb load was associated with increased disease severity (Odds Ratio=1.59, p=0.001 for grade 1 versus grade 3), and increased CSF neutrophils (r=0.364, p<0.0001) and cytokine concentrations (r=0.438, p<0.0001). High Mtb load predicted new neurological events after starting treatment (Multinomial logistic regression, p=0.005), but not death. Death was previously associated with attenuated inflammatory response at the start of treatment, with reduced cytokine concentrations compared to survivors. In contrast, patients with high pre-treatment CSF bacterial loads, cytokines, and neutrophils were more likely to subsequently suffer neurological events. Conclusions Pre-treatment GeneXpert-derived Mtb load may be a useful predictor of neurological complications occurring during TBM treatment. Therapeutic strategies aimed at reducing neurological complications and deaths from TBM may need reassessment, given the evidence for their divergent pathogenesis

Explanation of colon cancer pathophysiology through analyzing the disrupted homeostasis of bile acids

Background: The colon plays a key role in regulating the homeostasis of bile acids.Aim: The present study aims to evaluate the influence of colon cancer towards the homeostasis of bile acids.Methods: The free and conjugated bile acids were determined using ultraperformance LC (UPLC) coupled with ABI 4000 QTRAP triple quadrupole instruments.Results: The results showed that the free bile acids in serum of patients with colon cancers tend to increase, and the conjugated bile acids tended to decrease, especially for taurolithocholate (TLCA) (p&lt;0.001).Conclusion: The alteration of bile acids balance in colon cancers indicated the possibility of complicated diseases due to the disrupted balance of bile acids.Keywords: Colon cancer, free bile acids, conjugated bile acid

Aid conditionalities, international Good Manufacturing Practice standards and local production rights: a case study of local production in Nepal

© 2015 Brhlikova et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http:// creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.This work was supported by the Economic and Social Research Council and the Department for International Development [RES-167-25-0110] through the collaborative research project Tracing Pharmaceuticals in South Asia (2006 – 2009). In addition to the authors of this paper, the project team included: Soumita Basu, Gitanjali Priti Bhatia, Erin Court, Abhijit Das, Stefan Ecks, Patricia Jeffery, Roger Jeffery, Rachel Manners, and Liz Richardson. Martin Chautari (Kathmandu) and the Centre for Health and Social Justice (New Delhi) provided resources drawn upon in writing this paper but are not responsible for the views expressed, nor are ESRC or DFID. Ethical review was provided by the School of Social and Political Science at the University of Edinburgh, and ethical approval in Nepal for the study granted by the Nepal Health Research Council (NHRC)

AVANÇOS E DESAFIOS DO SISTEMA ÚNICO DE SAUDE: UMA REVISÃO DE LITERATURA

O Sistema Único de Saúde (SUS) foi pensado e construído através das ideias da declaração de Alma-ATA, da 8° Conferência de Saúde e a Reforma Sanitária, as quais respaldaram que o Estado deveria ser o responsável a promover políticas de saúde que visassem o bem-estar físico, social e psíquico da população