Bacterial Cholangitis, Cholecystitis, or both in Dogs

BACKGROUND: Bacterial cholangitis and cholecystitis are rarely reported, poorly characterized diseases in the dog. OBJECTIVES: To characterize the clinical features of these conditions. ANIMALS: Twenty‐seven client‐owned dogs with bacterial cholangitis, cholecystitis, or both. METHODS: Multicenter, retrospective cases series of dogs with bacterial cholangitis, cholecystitis, or both, presenting January 2000 to June 2011 to 4 Veterinary Schools in Ireland/United Kingdom. Interrogation of hospital databases identified all cases with the inclusion criteria; histopathologically confirmed cholangitis or cholecystitis and bile culture/cytology results supporting a bacterial etiology. RESULTS: Twenty‐seven dogs met the inclusion criteria with approximately 460 hepatitis cases documented over the same study period. Typical clinical pathology findings were increases in liver enzyme activities (25/26), hyperbilirubinemia (20/26), and an inflammatory leukogram (21/24). Ultrasound findings, although nonspecific, aided decision‐making in 25/26 cases. The most frequent hepatobiliary bacterial isolates were Escherichia coli (n = 17; 16 cases), Enterococcus spp. (n = 8; 6 cases), and Clostridium spp. (n = 5; 5 cases). Antimicrobial resistance was an important feature of aerobic isolates; 10/16 E. coli isolates resistant to 3 or more antimicrobial classes. Biliary tract rupture complicated nearly one third of cases, associated with significant mortality (4/8). Discharged dogs had a guarded to fair prognosis; 17/18 alive at 2 months, although 5/10 re‐evaluated had persistent liver enzyme elevation 2–12 months later. CONCLUSION AND CLINICAL SIGNIFICANCE: Bacterial cholangitis and cholecystitis occur more frequently than suggested by current literature and should be considered in dogs presenting with jaundice and fever, abdominal pain, or an inflammatory leukogram or with ultrasonographic evidence of gallbladder abnormalities

IT-technology in the budgeting

Budgeting plays an important role in modern organization, it is the tool that is necessary for the survival of the company in a competitive environment. Budgeting has become necessary business management process, and like any management activities, it requires automation

Modeling Exposure-Lag-Response Associations with Penalized Piece-wise Exponential Models

We present a novel approach for the flexible modeling of exposure-lag-response associations, i.e., time-to-event data where multiple past exposures are cumulatively associated with the hazard after a certain temporal delay. Our method is based on piece-wise exponential models and allows estimation of a wide variety of effects, including potentially smooth and time-varying effects as well as cumulative effects with leads and lags, taking advantage of the advanced inference methods that have recently been developed for generalized additive mixed models

Two new ultracool benchmark systems from WISE+2MASS

We have used the Two-Micron All-Sky Survey and the Wide-field Infrared Survey Explorer to look for ultracool dwarfs that are part of multiple systems containing main-sequence stars. We cross-matched L dwarf candidates from the surveys with Hipparcos and Gliese stars, finding two new systems. The first system, G255-34AB, is an L2 dwarf companion to a K8 star, at a distance of 36 pc. We estimate its bolometric luminosity as log L/L-circle dot = -3.78 +/- 0.045 and T-eff = 2080 +/- 260 K. The second system, GJ499ABC, is a triple, with an L5 dwarf as a companion to a binary with an M4 and K5 star. These two new systems bring the number of L dwarf plus main-sequence star multiple systems to 24, which we discuss. We consider the binary fraction for L dwarfs and main-sequence stars, and further assess possible unresolved multiplicity within the full companion sample. This analysis shows that some of the L dwarfs in this sample might actually be unresolved binaries themselves, since their M-J appears to be brighter than the expected for their spectral types.Peer reviewe

Synthesis of new chiral organosulfur donors with hydrogen bonding functionality and their first charge transfer salts

The syntheses of a range of enantiopure organosulfur donors with hydrogen bonding groups are described including TTF related materials with two, four, six and eight hydroxyl groups and multiple stereogenic centres and a pair of chiral N-substituted BEDT-TTF acetamides. Three charge transfer salts of enantiopure poly-hydroxy-substituted donors are reported, including a 4:1 salt with the meso stereoisomer of the dinuclear [Fe2(oxalate)5 ]4- anion in which both cation and anion have chiral components linked together by hydrogen bonding, and a semiconducting salt with triiodide

Modeling Exposure-Lag-Response Associations with Penalized Piece-wise Exponential Models

We present a novel approach for the flexible modeling of exposure-lag-response associations, i.e., time-to-event data where multiple past exposures are cumulatively associated with the hazard after a certain temporal delay. Our method is based on piece-wise exponential models and allows estimation of a wide variety of effects, including potentially smooth and time-varying effects as well as cumulative effects with leads and lags, taking advantage of the advanced inference methods that have recently been developed for generalized additive mixed models

Modifications to the University of Michigan 83‐Inch Cyclotron to Improve Beam Quality

Recent studies of the internal and extracted beams at the higher energies (up to 40‐MeV deuterons and 80‐MeV α‐particles) led us to convert the dee system of the 83‐inch cyclotron from two 150° dees to one 180° dee. The primary purpose was to remove from the deflector channel the rf dee voltage, which because of its phase opposes the dc deflector voltage and in addition introduces an energy spread in the extracted beam. The one‐dee system offers further advantages. The equivalent first harmonic due to a gap‐crossing driving force which is a function of the dee geometry and dee voltage balance in the two‐dee system, is essentially eliminated, and control of the central orbits, in particular the selection of phase width, is facilitated. The measured values of the beam quality and energy spread are in good agreement with calculations. These results, together with the diagnostic instrumentation used in obtaining them, are described.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/87291/2/366_1.pd

The extremely red L dwarf ULAS J222711-004547-dominated by dust

We report the discovery of a peculiar L dwarf from the United Kingdom Infrared Deep Sky Survey Large Area Survey, ULAS J222711-004547. The very red infrared photometry (MKO J-K = 2.79 +/- 0.06, WISEW1-W2 = 0.65 +/- 0.05) of ULAS J222711-004547 makes it one of the reddest brown dwarfs discovered so far. We obtained a moderate resolution spectrum of this target using the XSHOOTER spectrograph on the Very Large Telescope, and we classify it as L7pec, confirming its very red nature. Comparison to theoretical models suggests that the object could be a low-gravity L dwarf with a solar or higher than solar metallicity. Nonetheless, the match of such fits to the spectral energy distribution is rather poor, and this and other less red peculiar L dwarfs pose new challenges for the modelling of ultracool atmospheres, especially to the understanding of the effects of condensates and their sensitivity to gravity and metallicity. We determined the proper motion of ULAS J222711-004547 using the data available in the literature, and we find that its kinematics do not suggest membership of any of the known young associations. We show that applying a simple de-reddening curve to its spectrum allows it to resemble the spectra of the L7 spectroscopic standards without any spectral features that distinguish it as a low-metallicity or low-gravity dwarf. Given the negligible interstellar reddening of the field containing our target, we conclude that the reddening of the spectrum is mostly due to an excess of dust in the photosphere of the target. De-reddening the spectrum using extinction curves for different dust species gives surprisingly good results and suggests a characteristic grain size of similar to 0.5 mu m. We show that by increasing the optical depth, the same extinction curves allow the spectrum of ULAS J222711-004547 to resemble the spectra of unusually blue L dwarfs and even slightly metal-poor L dwarfs. Grains of similar size also yield very good fits when de-reddening other unusually red L dwarfs in the L5-L7.5 range. These results suggest that the diversity in near-infrared colours and spectra seen in late L dwarfs could be due to differences in the optical thickness of the dust cloud deck.Peer reviewe

The brightest pure-H ultracool white dwarf

We report the identification of LSR J0745+2627 in the United Kingdom InfraRed Telescope Infrared Deep Sky Survey (UKIDSS) Large Area Survey (LAS) as a cool white dwarf with kinematics and age compatible with the thick-disk/halo population. LSR J0745+2627 has a high proper motion (890 mas/yr) and a high reduced proper motion value in the J band (H_J=21.87). We show how the infrared-reduced proper motion diagram is useful for selecting a sample of cool white dwarfs with low contamination. LSR J0745+2627 is also detected in the Sloan Digital Sky Survey (SDSS) and the Wide-field Infrared Survey Explorer (WISE). We have spectroscopically confirmed this object as a cool white dwarf using X-Shooter on the Very Large Telescope. A detailed analysis of its spectral energy distribution reveals that its atmosphere is compatible with a pure-H composition model with an effective temperature of 3880+-90 K. This object is the brightest pure-H ultracool white dwarf (Teff<4000 K) ever identified. We have constrained the distance (24-45 pc), space velocities and age considering different surface gravities. The results obtained suggest that LSR J0745+2627 belongs to the thick-disk/halo population and is also one of the closest ultracool white dwarfs.Comment: 5 pages, 7 figures, accepted for publication in A&A Letter

Identifying Ultra-Cool Dwarfs at Low Galactic Latitudes: A Southern Candidate Catalogue

We present an Ultra-Cool Dwarf (UCD) catalogue compiled from low southern Galactic latitudes and mid-plane, from a cross-correlation of the 2MASS and SuperCOSMOS surveys. The catalogue contains 246 members identified from 5042 sq. deg. within 220 deg. <= l <= 360 deg. and 0 deg. < l <= 30 deg., for |b| <= 15 deg. Sixteen candidates are spectroscopically confirmed in the near-IR as UCDs with spectral types from M7.5V to L9. Our catalogue selection method is presented enabling UCDs from ~M8V to the L-T transition to be selected down to a 2MASS limiting magnitude of Ks ~= 14.5 mag. This method does not require candidates to have optical detections for catalogue inclusion. An optimal set of optical/near-IR and reduced proper-motion selection criteria have been defined that includes: an Rf and Ivn photometric surface gravity test, a dual Rf-band variability check, and an additional photometric classification scheme to selectively limit contaminants. We identify four candidates as possible companions to nearby Hipparcos stars -- observations are needed to identify these as potential benchmark UCD companions. We also identify twelve UCDs within a possible distance 20 pc, three are previously unknown of which two are estimated within 10 pc, complimenting the nearby volume-limited census of UCDs. An analysis of the catalogue spatial completeness provides estimates for distance completeness over three UCD MJ ranges, while Monte-Carlo simulations provide an estimate of catalogue areal completeness at the 75 per cent level. We estimate a UCD space density of Rho (total) = (6.41+-3.01)x10^3/pc^3 over the range of 10.5 <= MJ ~< 14.9, similar to values measured at higher Galactic latitudes (|b| ~> 10 deg.) in the field population and obtained from more robust spectroscopically confirmed UCD samples.Comment: MNRAS accepted April 2012. Contains 30 figures and 11 tables. Tables 2 and 6 to be published in full and on-line only. The on-line tables can also be obtained by contacting the author