25,808 research outputs found
Sexual networks and the transmission of HIV in London
Copyright @ 1998 Cambridge University Press.This paper discusses ways in which empirical research investigating sexual networks can further understanding of the transmission of HIV in London, using information from a 24-month period of participant observation and 53 open-ended, in-depth interviews with eighteen men and one woman who have direct and indirect sexual links with each other. These interviews enabled the identification of a wider sexual network between 154 participants and contacts during the year August 1994-July 1995. The linked network data help to identify pathways of transmission between individuals who are HIV + and those who are HIV -, as well as sexual links between 'older' and 'younger' men, and with male prostitutes. There appears to be considerable on-going transmission of HIV in London. The majority of participants reported having had unprotected anal and/or vaginal sex within a variety of relationships. The implications of these findings for policies designed to prevent the transmission of HIV are discussed.The Wellcome Trust and The Health Education Authority
Towards the Distributed Burning Regime in Turbulent Premixed Flames
Three-dimensional numerical simulations of canonical statistically-steady
statistically-planar turbulent flames have been used in an attempt to produce
distributed burning in lean methane and hydrogen flames. Dilatation across the
flame means that extremely large Karlovitz numbers are required; even at the
extreme levels of turbulence studied (up to a Karlovitz number of 8767)
distributed burning was only achieved in the hydrogen case. In this case,
turbulence was found to broaden the reaction zone visually by around an order
of magnitude, and thermodiffusive effects (typically present for lean hydrogen
flames) were not observed. In the preheat zone, the species compositions differ
considerably from those of one-dimensional flames based a number of different
transport models (mixture-averaged, unity Lewis number, and a turbulent eddy
viscosity model). The behaviour is a characteristic of turbulence dominating
non-unity Lewis number species transport, and the distinct limit is again
attributed to dilatation and its effect on the turbulence. Peak local reaction
rates are found to be lower in the distributed case than in the lower Karlovitz
cases but higher than in the laminar flame, which is attributed to effects that
arise from the modified fuel-temperature distribution that results from
turbulent mixing dominating low Lewis number thermodiffusive effects. Finally,
approaches to achieve distributed burning at realisable conditions are
discussed; factors that increase the likelihood of realising distributed
burning are higher pressure, lower equivalence ratio, higher Lewis number, and
lower reactant temperature
AAA gunnermodel based on observer theory
The Luenberger observer theory is used to develop a predictive model of a gunner's tracking response in antiaircraft artillery systems. This model is composed of an observer, a feedback controller and a remnant element. An important feature of the model is that the structure is simple, hence a computer simulation requires only a short execution time. A parameter identification program based on the least squares curve fitting method and the Gauss Newton gradient algorithm is developed to determine the parameter values of the gunner model. Thus, a systematic procedure exists for identifying model parameters for a given antiaircraft tracking task. Model predictions of tracking errors are compared with human tracking data obtained from manned simulation experiments. Model predictions are in excellent agreement with the empirical data for several flyby and maneuvering target trajectories
Asymptotic Exit Location Distributions in the Stochastic Exit Problem
Consider a two-dimensional continuous-time dynamical system, with an
attracting fixed point . If the deterministic dynamics are perturbed by
white noise (random perturbations) of strength , the system state
will eventually leave the domain of attraction of . We analyse the
case when, as , the exit location on the boundary
is increasingly concentrated near a saddle point of the
deterministic dynamics. We show that the asymptotic form of the exit location
distribution on is generically non-Gaussian and asymmetric,
and classify the possible limiting distributions. A key role is played by a
parameter , equal to the ratio of the stable
and unstable eigenvalues of the linearized deterministic flow at . If
then the exit location distribution is generically asymptotic as
to a Weibull distribution with shape parameter , on the
length scale near . If it is generically
asymptotic to a distribution on the length scale, whose
moments we compute. The asymmetry of the asymptotic exit location distribution
is attributable to the generic presence of a `classically forbidden' region: a
wedge-shaped subset of with as vertex, which is reached from ,
in the limit, only via `bent' (non-smooth) fluctuational paths
that first pass through the vicinity of . We deduce from the presence of
this forbidden region that the classical Eyring formula for the
small- exponential asymptotics of the mean first exit time is
generically inapplicable.Comment: This is a 72-page Postscript file, about 600K in length. Hardcopy
requests to [email protected] or [email protected]
Intrinsic Spin Hall Effect in the presence of Extrinsic Spin-Orbit Scattering
Intrinsic and extrinsic spin Hall effects are considered together on an equal
theoretical footing for the Rashba spin-orbit coupling in two-dimensional (2D)
electron and hole systems, using the diagrammatic method for calculating the
spin Hall conductivity. Our analytic theory for the 2D holes shows the expected
lowest-order additive result for the spin Hall conductivity. But, the 2D
electrons manifest a very surprising result, exhibiting a non-analyticity in
the Rashba coupling strength where the strictly extrinsic spin Hall
conductivity (for ) cannot be recovered from the
limit of the combined theory. The theoretical results are discussed in the
context of existing experimental results.Comment: 5 pages, 2 figure
Association between MAPT polymorphism but not APOE promoter and elite rugby athlete status
INTRODUCTION: Incidence and outcomes of concussions have been hypothesised to be genetically influenced. The APOE Promoter G219T (rs405509) polymorphism has been associated with differential promoter activity and unfavourable outcomes after traumatic brain injury. The TT genotype is associated with a 3-fold greater risk of multiple concussions. The TT genotype of MAPT (rs10445337) has also been associated with poorer outcomes after concussion. Rugby has one of the highest incidences of concussion in sport, so it was hypothesised that APOE Promoter TT and MAPT TT genotypes would be less prevalent in elite rugby athletes because those genotypes, previously associated with increased risk, would be less compatible with achieving elite athlete status. METHODS: Participants were from the RugbyGene project, comprising elite Caucasian male rugby athletes (n = 528; mean (standard deviation) height 1.85 (0.07) m, mass 101 (14) kg, age 29 (7) yr), including 420 rugby union (RU) athletes that for some analyses were divided into forwards and backs and 108 rugby league (RL) athletes. Non-athletes were 592 Caucasian men and women (57% male, height 1.72 (0.10) m, mass 74 (14) kg, age 31 (7) yr). PCR of genomic DNA was used to determine genotypes using TaqMan probes, then groups were compared using Ļ2 and odds ratio (OR) statistics. RESULTS: All genotype data were in Hardy-Weinberg equilibrium. For MAPT (rs10445337), the risk genotype (TT) was underrepresented in rugby athletes (60%) compared to non-athletes (66%), CT more common in rugby athletes (34%) than non-athletes (29%) and little difference in CC genotype frequencies (Ļ2 = 7.092, P = 0.029; TT genotype frequency OR = 0.80, 95% confidence intervals (CI) = 0.62-1.02). There were no differences in MAPT (rs10445337) genotype frequencies between RU forwards and backs. For APOE Promoter G219T (rs405509), there were no differences in genotype frequencies between all athletes (RU and RL) and non-athletes (27% TT genotype in players and non-athletes), nor between RU forwards and backs. CONCLUSION: The MAPT (rs10445337) TT genotype is 6% less common in elite rugby athletes than non-athletes. Therefore, carrying at least one rs10445337 C allele appears to increase the probability of sustained career success in the high-risk concussion environment of elite rugby, perhaps via a greater ability to recover from concussions.Peer reviewe
Association of MMP3 but not TIMP2 gene variants with elite rugby player status and rugby code
Introduction: Achilles tendon pathology and anterior cruciate ligament rupture are multifactorial conditions for which genetic risk factors have been identified. Single nucleotide polymorphisms (SNPs) within the MMP3 (rs591058, rs679620, rs650108) and TIMP2 (rs4789932) genes have previously been associated with tendon and ligament pathologies. Although not entirely clear, prior literature indicates the risk alleles for Achilles tendon pathology as T (rs591058), G (rs679620) and A (rs650108) for MMP3. However, prior evidence regarding TIMP2 is equivocal. MMP3 is considered an essential regulator of matrix degradation and remodelling within diseased and normal musculoskeletal soft tissues. TIMP2 maintains homeostasis in the extracellular matrix in part by inhibiting MMP function. Given the high incidence and severity of tendon and ligament injuries in elite rugby athletes, we hypothesised that the aforementioned SNPs would be associated with career success. Methods: Participants from the RugbyGene project were elite Caucasian male rugby athletes (n = 566; mean (standard deviation) height 1.85 (0.07) m, mass 101 (14) kg, age 29 (7) yr), including 420 rugby union (RU) athletes that for some analyses were divided into forwards and backs and 120 rugby league (RL) athletes. Non-athletes were 589 Caucasian men and women (n = 589, 57% male, height 1.72 (0.10) m, mass 74 (14) kg, age 31 (7) yr). PCR of genomic DNA was used to determine genotypes using TaqMan probes, then groups were compared using Ī§2 and odds ratio (OR) statistics. Results: As hypothesized, the MMP3 rs591058 risk genotype (TT) was less frequent in rugby athletes (28%) compared to non-athletes (33%) (Ī§2 = 7.265, P = 0.026; OR = 1.18, 95% confidence intervals (CI) = 0.86-1.63). No differences were found for MMP3 rs679620, rs650108 or TIMP2 rs4789932 between rugby athletes and non-athletes. When RL athletes were compared to non-athletes, the risk genotype (TT) of MMP3 rs591058 was underrepresented in RL athletes (19%) compared to non-athletes (33%). The MMP3 rs679620 āprotectiveā allele (C) was more frequent in RL athletes (55%) compared to non-athletes (48%) (OR = 1.3, 95% CI = 0.98-1.74). However, for MMP3 rs650108 the āriskā allele (A) was overrepresented in RL athletes (32%) compared to non-athletes (26%). There were no genotype differences for any gene variant between RU athletes and non-athletes. The āriskā allele (T) of the MMP3 rs679629 polymorphism and the āprotectiveā allele (G) of the MMP3 rs650108 polymorphism were less common in RL (45%, 68%, respectively) than RU athletes (54%, 76%, respectively). Conclusion: We provide evidence for elite rugby athletes possessing a protective genetic profile regarding tendon and ligament injury risk. Notably, a less frequent rs591058 TT genotype in athletes suggests a lower risk of injury could therefore enhance career success in rugby. Furthermore, RL players appear to have differing genetic characteristics compared to their RU counterparts, which might reflect some differences in physiological demands between codes.Peer reviewedFinal Published versio
Spin Hall Effect in Doped Semiconductor Structures
In this Letter we present a microscopic theory of the extrinsic spin Hall
effect based on the diagrammatic perturbation theory. Side-jump (SJ) and
skew-scattering (SS) contributions are explicitly taken into account to
calculate the spin Hall conductivity, and we show their effects scale as
, with
being the transport relaxation time. Motivated by recent experimental work we
apply our theory to n- and p-doped 3D and 2D GaAs structures, obtaining
where is the spin Hall
(charge) conductivity, which is in reasonable agreement with the recent
experimental results of Kato \textit{et al}. [Science \textbf{306}, 1910
(2004)] in n-doped 3D GaAs system.Comment: 5 pages, 2 figure
Stability of pulse-like earthquake ruptures
Pulse-like ruptures arise spontaneously in many elastodynamic rupture
simulations and seem to be the dominant rupture mode along crustal faults.
Pulse-like ruptures propagating under steady-state conditions can be
efficiently analysed theoretically, but it remains unclear how they can arise
and how they evolve if perturbed. Using thermal pressurisation as a
representative constitutive law, we conduct elastodynamic simulations of
pulse-like ruptures and determine the spatio-temporal evolution of slip, slip
rate and pulse width perturbations induced by infinitesimal perturbations in
background stress. These simulations indicate that steady-state pulses driven
by thermal pressurisation are unstable. If the initial stress perturbation is
negative, ruptures stop; conversely, if the perturbation is positive, ruptures
grow and transition to either self-similar pulses (at low background stress) or
expanding cracks (at elevated background stress). Based on a dynamic
dislocation model, we develop an elastodynamic equation of motion for slip
pulses, and demonstrate that steady-state slip pulses are unstable if their
accrued slip is a decreasing function of the uniform background stress
. This condition is satisfied by slip pulses driven by thermal
pressurisation. The equation of motion also predicts quantitatively the growth
rate of perturbations, and provides a generic tool to analyse the propagation
of slip pulses. The unstable character of steady-state slip pulses implies that
this rupture mode is a key one determining the minimum stress conditions for
sustainable ruptures along faults, i.e., their ``strength''. Furthermore, slip
pulse instabilities can produce a remarkable complexity of rupture dynamics,
even under uniform background stress conditions and material properties
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