'Satan's bludy clawses':How religious persecution, exile and radicalization moulded British Protestant identities

This paper explores the social effects of pornography as they are portrayed in the tv series Damages. The key words that are analyzed – pleasure, guilt, screen, society, habit, masturbation – create an indirect but strong relationship between the lonely practice and the everyday forms of life. This conceptual constellation – that arises from the interpretation of the first season of the series, “The Frobisher case” – composes an organic pattern and provide a problematic image of the pornographic matter.

The early career op Christopher Goodman and his place in the development of English protestant thought

The career and thought of Christopher Goodman provides the backbone of this thesis. They are used to demonstrate the interaction between men and ideas in England during the middle years of the sixteenth century and so give a clearer picture of the development of English protestant thought. The study has set out to discover three things about Goodman and his book 'How Superior Powers Oght to be Obeyd(^1). The first is to explain his intention in writing the book; the second to describe its content] and the third to understand its impact in 1558.As a study of Goodman's book cannot be divorced from the study of its author, the biographical details of Goodman's life to I558 are investigated. They help to give the fullest possible picture of his intentions in writing the book. Detailed consideration Is given to his experiences in Edwardian Oxford at Brasenose College and Christ church and to his exile in Germany and Switzerland during the reign of Mary. To give an accurate description of the content and impact of Goodman's book it is necessary to establish its ideological context. This involves documenting the personnel, activities and ideas of the Christ Church Circle and of the Marian exiles, particularly those who comprised the English exile community in Geneva. Only if such a picture is pieced together is it possible to distinguish between the unusual and the commonplace in Goodman's thinking, and appreciate the revolutionary nature of his concept of a covenanted society, the people of God

Scotland and the example of Geneva

Jane Dawson examines the extent to which the new Reformed church in Scotland owed a debt to the Genevan model and looks at how, as the Reformation in Europe progressed, the 'example of Geneva' became the 'example of Scotland'

The Campbells: lordship, literature and liminality

The Campbells have the potential to offer much to the theme of literature and borders, given that the kindred’s astonishing political success in the late medieval and early modern period depended heavily upon the ability to negotiate multiple frontiers: between Highlands and Lowlands; between Gaelic Scotland and Ireland, and, especially after the Reformation, with England and the matter of Britain. This paper will explore the literary dimension to Campbell expansionism, from the Book of the Dean of Lismore in the earlier sixteenth century, to poetry addressed to dukes of Argyll in the earlier eighteenth century. Particular attention will be paid to the literary proclivities of the household of the Campbells of Glenorchy on either side of what appears to be a major watershed in 1550; and to the agenda of the Campbell protégé John Carswell, first post-Reformation bishop of the Isles, and author of the first printed book in Gaelic in either Scotland or Ireland, Foirm na n-Urrnuidheadh (‘The Form of Prayers’), published at Edinburgh in 1567

An Evolutionarily Conserved Function of Polycomb Silences the MHC Class I Antigen Presentation Pathway and Enables Immune Evasion in Cancer.

Loss of MHC class I (MHC-I) antigen presentation in cancer cells can elicit immunotherapy resistance. A genome-wide CRISPR/Cas9 screen identified an evolutionarily conserved function of polycomb repressive complex 2 (PRC2) that mediates coordinated transcriptional silencing of the MHC-I antigen processing pathway (MHC-I APP), promoting evasion of T cell-mediated immunity. MHC-I APP gene promoters in MHC-I low cancers harbor bivalent activating H3K4me3 and repressive H3K27me3 histone modifications, silencing basal MHC-I expression and restricting cytokine-induced upregulation. Bivalent chromatin at MHC-I APP genes is a normal developmental process active in embryonic stem cells and maintained during neural progenitor differentiation. This physiological MHC-I silencing highlights a conserved mechanism by which cancers arising from these primitive tissues exploit PRC2 activity to enable immune evasion.Cancer Research UK Clinician Scientist Fellowship C53779/A20097 (M.L.B), Leukaemia Foundation Australia Senior Fellowship and Howard Hughes Medical Institute International Research Scholarship 55008729 (M.A.D), Peter and Julie Alston Centenary fellowship (K.D.S.), Wellcome Trust Principal Research Fellowship 101835/Z/13/Z (P.J.L), Peter MacCallum Postgraduate Scholarship (C.E.S), NHMRC Postgraduate Scholarship (K.L.C.), Maddie Riewoldt's Vision 064728 (Y-C.C), Victorian Cancer Agency (E.Y.N.L), CSL Centenary fellowship (S-J.D), National Breast Cancer Foundation Fellowship ECF-17-005 (P.A.B.), Addenbrooke’s Charitable Trust and NIHR Cambridge BRC (M.L.B., P.J.L), NHMRC grant 1085015, 1106444 (M.A.D) and 1128984 (M.A.D, S-J.D)

Targeting enhancer switching overcomes non-genetic drug resistance in acute myeloid leukaemia.

Non-genetic drug resistance is increasingly recognised in various cancers. Molecular insights into this process are lacking and it is unknown whether stable non-genetic resistance can be overcome. Using single cell RNA-sequencing of paired drug naïve and resistant AML patient samples and cellular barcoding in a unique mouse model of non-genetic resistance, here we demonstrate that transcriptional plasticity drives stable epigenetic resistance. With a CRISPR-Cas9 screen we identify regulators of enhancer function as important modulators of the resistant cell state. We show that inhibition of Lsd1 (Kdm1a) is able to overcome stable epigenetic resistance by facilitating the binding of the pioneer factor, Pu.1 and cofactor, Irf8, to nucleate new enhancers that regulate the expression of key survival genes. This enhancer switching results in the re-distribution of transcriptional co-activators, including Brd4, and provides the opportunity to disable their activity and overcome epigenetic resistance. Together these findings highlight key principles to help counteract non-genetic drug resistance