The biogeochemical cycling of ammonium and methylamines in intertidal sediments

The methylamines (MAs) are chemical analogues of ammonia and contain one, two or three methyl groups. This study looked at their occurrence in inter-tidal sediments and at changes in their abundance during tidal cycling, including forced and naturally occurring sediment resuspension. Two sites in the UK, Burnham Overy Staithe (BOS) and the Thames Estuary (TE), and the Ria Formosa (RF), Portugal, were chosen for the study. The MAs were abundant in all samples collected. MA concentrations were compared to NH ₄⁺ at BOS and TE. A consistent trend emerged, with NH ₄⁺ more abundant in the pore-waters and the MAs dominating the solid phase. Most NH ₄⁺ and MAs were found on the solid-phase, and the general magnitude of adsorption was: TMA > DMA > MMA > NH ₄⁺. This was inconsistent with their pKb values but could be explained by the ability of each cation to form hydrogen bonds with water. Pore-water MA concentrations at BOS were compared with salinity but no correlation was observed. However, the clam Ruditapes decussatus (L.) released TMA during tidal inundation. The mechanism of release is unclear as these organisms do not osmoregulate, but the calculated TMA loss from these sediments (169 mmol m⁻² per tide) could be increasing dissolved organic nitrogen concentrations in the Ria Formosa. TE sediments were used in desorption experiments. Desorption of NH ₄⁺ was more rapid than the MAs and their mean chemical response times were 15 and 25 minutes, respectively. Increases in concentrations of dissolved NH ₄⁺ and MAs over a tidal cycle were coincident with remobilisation of seabed sediments. Desorption of NH ₄⁺ and MAs from the remobilised sediments accounted for approximately 50% and > 90% of the increase, respectively. The results are proposed as a predictor for the sorption behaviour of other ON compounds and emphasise the importance of sediment resuspension as a mechanism of ON release to the water column

Analysis of Grain Traders’ Performance in Ethiopia: The Case of Contribution of Social Capital

This article examines the performance of 206 grain traders in 20 markets found in Amhara, Tigray, Oromiya and SNNPR of Ethiopia. The study adopts Fafchamps and Minten (1999) approach and used multiple regression model. The study identified that financial capital (working capital), social capital (using intermediary at the time of sale and customer relationship), human capital (farming experience) and transaction cost (having mobile, Oromiya and SNNPR) affected traders’ performance. The findings suggested adding working capital through different means (like access to credit through micro finance institutes, banks, etc.) with planned and market assessment, establishing licensed and well organized brokerage strengthen traders business relationship with regular customers in a formal or informal way, farmer-trader linkages are recommended through the dissemination of information (e.g. workshops) and training on quality and production management, establish and strengthen, a reliable, permanent,  public domain market information and other infrastructure are important to enhance traders performance, in turn encourage farmers to produce more and maximize benefit from grain market. Keywords: Ethiopia, social-capital, performance, customer-relationship, marketing-margi

Massive megarectum secondary to constipation in institutionalized patient

Chronic constipation is a common cause of morbidity in the elderly and institutionalized population. It can be associated with significant morbidity and socioeconomical burden. Chronic resistance constipation can rarely be associated with megarectum. Herein, we present the case of a patient with physical and mental disability that presented with refractory constipation associated with extreme stool burden and a massive megarectum. We discuss chronic constipation in the elderly population, its etiologies and diagnostic work-up including surgical options. The management of chronic constipation with megarectum should be on a case-by-case basis

Knowledge, attitudes, and practices regarding cervical cancer and screening among Ethiopian health care workers

Background: Though cervical cancer incidence has dramatically decreased in resource rich regions due to the implementation of universal screening programs, it remains one of the most common cancers affecting women worldwide and has one of the highest mortality rates. The vast majority of cervical cancer-related deaths are among women that have never been screened. Prior to implementation of a screening program in Addis Ababa University-affiliated hospitals in Ethiopia, a survey was conducted to assess knowledge of cervical cancer etiology, risk factors, and screening, as well as attitudes and practices regarding cervical cancer screening among women’s health care providers.Methods: Between February and March 2012 an anonymous, self-administered survey to assess knowledge, attitudes, and practices related to cervical cancer and its prevention was distributed to 334 health care providers at three government hospitals in Addis Ababa, Ethiopia and three Family Guidance Association clinics in Awassa, Adama, and Bahir Dar. Data were analyzed using SPSS software and chi-square test was used to test differences in knowledge, attitudes, and practices across provider type.Results: Overall knowledge surrounding cervical cancer was high, although awareness of etiology and risk factors was low among nurses and midwives. Providers had no experience performing cervical cancer screening on a routine basis with \u3c40% having performed any type of cervical cancer screening. Reported barriers to performing screening were lack of training (52%) and resources (53%); however the majority (97%) of providers indicated cervical cancer screening is an essential part of women’s health care.Conclusion: There is a clear need among women’s health care providers for education regarding cervical cancer etiology, risk factors and for training in low-tech, low-cost screening methods. Meeting these needs and improving the infrastructure necessary to implement appropriate screening programs is essential to reduce the burden of cervical cancer in Ethiopia

Malaria, Oromia Regional State, Ethiopia, 2001–2006

[Extract] In Ethiopia, malaria is unstable and commonly occurs as intraannual and interannual epidemics. Transmission is associated with altitude, temperature, and rainfall, generally peaking twice a year, after the 2 rainy seasons (March-May and July-September). Cases are caused by Plasmodium falciparum and P. vivax. Anopheles arabiensis mosquitoes are the main vector for both species. Although malaria is the most common communicable disease in Ethiopia, few longitudinal case data has been published

Printable microscale interfaces for long-term peripheral nerve mapping and precision control

The nascent field of bioelectronic medicine seeks to decode and modulate peripheral nervous system signals to obtain therapeutic control of targeted end organs and effectors. Current approaches rely heavily on electrode-based devices, but size scalability, material and microfabrication challenges, limited surgical accessibility, and the biomechanically dynamic implantation environment are significant impediments to developing and deploying advanced peripheral interfacing technologies. Here, we present a microscale implantable device – the nanoclip – for chronic interfacing with fine peripheral nerves in small animal models that begins to meet these constraints. We demonstrate the capability to make stable, high-resolution recordings of behaviorally-linked nerve activity over multi-week timescales. In addition, we show that multi-channel, current-steering-based stimulation can achieve a high degree of functionally-relevant modulatory specificity within the small scale of the device. These results highlight the potential of new microscale design and fabrication techniques for the realization of viable implantable devices for long-term peripheral interfacing.https://www.biorxiv.org/node/801468.fullFirst author draf

Infectivity of an Infectious Clone of Banana Streak CA Virus in A-Genome Bananas (Musa acuminata ssp.)

We have characterized the complete genome sequence of an Australian isolate of banana streak CA virus (BSCAV). A greater-than-full-length, cloned copy of the virus genome was assembled and agroinoculated into five tissue-cultured plants of nine different Musa acuminata banana accessions. BSCAV was highly infectious in all nine accessions. All five inoculated plants from eight accessions developed symptoms by 28 weeks post-inoculation, while all five plants of M. acuminata AA subsp. zebrina remained symptomless. Symptoms were mild in six accessions but were severe in Khae Phrae (M. acuminata subsp. siamea) and the East African Highland banana accession Igisahira Gisanzwe. This is the first full-length BSCAV genome sequence reported from Australia and the first report of the infectivity of an infectious clone of banana streak virus

Developmental Trajectories of Postpartum Weight 3 Years After Birth: Norwegian Mother and Child Cohort Study

This study explored the developmental trajectories of postpartum weight from 0.5 to 3 years after childbirth, and aimed to determine the associations between postpartum weight trajectories and prepregnancy body mass index and adequacy of gestational weight gain (GWG). Data from the Norwegian Mother and Child Cohort study were used, following 49,528 mothers 0.5, 1.5, and 3 years after childbirth. Analyses were performed using latent growth mixture modeling. Three groups of developmental trajectories of postpartum weight were found, with most women (85.9 %) having a low level of weight retention initially and slight gain over 3 years, whereas 5.6 % of women started at a high postpartum weight retention (on average 7.56 kg) at 0.5 years but followed by a marked weight loss over time (2.63 kg per year on average), and the third trajectory represented women (8.5 %) who had high weight retention high initially (on average 4.67 kg at 0.5 years) and increasing weight over time (1.43 kg per year on average). Prepregnancy overweight and obesity and excessive GWG significantly predicted a high postpartum weight trend. Women had substantial variability in postpartum weight development—both initially after birth and in their weight trajectories over time. Early preventive interventions may be designed to assist women with prepregnancy overweight and obesity and excessive GWG, which helps to reduce the increasing trend for postpartum weight

Comorbidity phenotypes and risk of mortality in patients with osteoarthritis in the UK:a latent class analysis

BACKGROUND: Osteoarthritis (OA) is a common chronic condition but its association with other chronic conditions and mortality is largely unknown. This study aimed to use latent class analysis (LCA) of 30 comorbidities in patients with OA and matched controls without OA to identify clusters of comorbidities and examine the associations between the clusters, opioid use, and mortality. METHODS: A matched cohort analysis of patients derived from the IQVIA Medical Research Data (IMRD-UK) database between 2000 and 2019. 418,329 patients with newly diagnosed OA were matched to 243,170 patients without OA to identify comorbidity phenotypes. Further analysis investigated the effect of opioid use on mortality in individuals with OA and their matched controls. RESULTS: The median (interquartile range (IQR)) number of comorbidities was 2 (1–4) and 1 (0–3) in the OA and control groups respectively. LCA identified six comorbidity phenotypes in individuals with and without OA. Clusters with a high prevalence of comorbidities were characterised by hypertension, circulatory, and metabolic diseases. We identified a comorbidity cluster with the aforementioned comorbidities plus a high prevalence of chronic kidney disease, which was associated with twice the hazard of mortality in hand OA with a hazard ratio (HR) (95% CI) of 2.53 (2.05–3.13) compared to the hazard observed in hip/knee OA subtype 1.33 (1.24–1.42). The impact of opioid use in the first 12 months on hazards of mortality was significantly greater for weak opioids and strong opioids across all groups HR (95% CI) ranging from 1.11 (1.07–11.6) to 1.80 (1.69–1.92)). There was however no evidence of association between NSAID use and altered risk of mortality. CONCLUSION: This study identified six comorbidity clusters in individuals with OA and matched controls within this cohort. Opioid use and comorbidity clusters were differentially associated with the risk of mortality. The analyses may help shape the development of future interventions or health services that take into account the impact of these comorbidity clusters. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13075-022-02909-4