Woodland clearance in the Mesolithic: the social aspects.

Did Mesolithic people regard the woodland as a wilderness or park? Previous models have portrayed the hunter-gatherers of the Mesolithic as in tune with nature and making use of clearings to attract game. Using equally valid analogies, the authors propose a more hostile landscape that was conceived and managed with clearings and paths to help allay its menacing character

Coordinated RNA-Seq and peptidomics identify neuropeptides and G-protein coupled receptors (GPCRs) in the large pine weevil Hylobius abietis, a major forestry pest

Hylobius abietis (Linnaeus), or large pine weevil (Coleoptera, Curculionidae), is a pest of European coniferous forests. In order to gain understanding of the functional physiology of this species, we have assembled a de novo transcriptome of H. abietis, from sequence data obtained by Next Generation Sequencing. In particular, we have identified genes encoding neuropeptides, peptide hormones and their putative G-protein coupled receptors (GPCRs) to gain insights into neuropeptide-modulated processes. The transcriptome was assembled de novo from pooled paired-end, sequence reads obtained from RNA from whole adults, gut and central nervous system tissue samples. Data analysis was performed on the transcripts obtained from the assembly including, annotation, gene ontology and functional assignment as well as transcriptome completeness assessment and KEGG pathway analysis. Pipelines were created using Bioinformatics tools and techniques for prediction and identification of neuropeptides and neuropeptide receptors. Peptidomic analysis was also carried out using a combination of MALDI-TOF as well as Q-Exactive Orbitrap mass spectrometry to confirm the identified neuropeptide. 41 putative neuropeptide families were identified in H. abietis, including Adipokinetic hormone (AKH), CAPA and DH31. Neuropeptide F, which has not been yet identified in the model beetle T. castaneum, was identified. Additionally, 24 putative neuropeptide and 9 leucine-rich repeat containing G protein coupled receptor-encoding transcripts were determined using both alignment as well as non-alignment methods. This information, submitted to the NCBI sequence read archive repository (SRA accession: SRP133355), can now be used to inform understanding of neuropeptide-modulated physiology and behaviour in H. abietis; and to develop specific neuropeptide-based tools for H. abietis control

The Possibilist Transactional Interpretation and Relativity

A recent ontological variant of Cramer's Transactional Interpretation, called "Possibilist Transactional Interpretation" or PTI, is extended to the relativistic domain. The present interpretation clarifies the concept of 'absorption,' which plays a crucial role in TI (and in PTI). In particular, in the relativistic domain, coupling amplitudes between fields are interpreted as amplitudes for the generation of confirmation waves (CW) by a potential absorber in response to offer waves (OW), whereas in the nonrelativistic context CW are taken as generated with certainty. It is pointed out that solving the measurement problem requires venturing into the relativistic domain in which emissions and absorptions take place; nonrelativistic quantum mechanics only applies to quanta considered as 'already in existence' (i.e., 'free quanta'), and therefore cannot fully account for the phenomenon of measurement, in which quanta are tied to sources and sinks.Comment: Final version with some minor corrections as published in Foundations of Physics. This paper has significant overlap with Chapter 6 of my book on the Transactional Interpretation, forthcoming from Cambridge University Press: http://www.cambridge.org/us/knowledge/isbn/item6860644/?site_locale=en_US (Additional preview material is available at rekastner.wordpress.com) Comments welcom

HiQuake: The Human-Induced Earthquake Database

HiQuake—The Human‐Induced Earthquake Database is the most complete database of anthropogenic projects proposed, on scientific grounds, to have induced earthquake sequences. It is freely available to download from the website given in Data and Resources. At the time this article was written, HiQuake contained ∼730∼730 anthropogenic projects proposed to have induced earthquakes, as well as associated project‐related and seismic data. The most commonly reported anthropogenic activities proposed to have induced earthquakes are mining and water reservoir impoundment. In recent years, the number of earthquake sequences proposed to have been induced by fluid‐injection activities has grown. The most commonly reported maximum observed magnitude in an induced earthquake sequence is 3≤MMAX<43≤MMAX<4 . The largest earthquake in HiQuake proposed to have been induced had a magnitude of MwMw 7.9 and occurred in China. Such large earthquakes release mostly stress of natural tectonic origin, but are conceivably triggered by small anthropogenic stress changes. The data in HiQuake are of variable quality because they are drawn from publications that span almost a century. We estimate underreporting to be ∼30%∼30% for M∼4M∼4 events, ∼60%∼60% for M∼3M∼3 events, and ∼90%∼90% for M∼2M∼2 events. The degree of certitude that the given earthquake sequences were anthropogenically induced is variable. HiQuake includes all earthquake sequences proposed on scientific grounds to have been human induced without regard to the strength of the case made. HiQuake is offered freely as a resource to interested parties, and judging the reliability of any particular case is the responsibility of the database user. HiQuake will be routinely updated to correct errors, update existing entries, and add new entries. It has the potential to help improve our understanding of induced earthquakes and to manage their impact on society

Revisiting the 26.5°C Sea Surface Temperature Threshold for Tropical Cyclone Development

Abstract A high sea surface temperature is generally accepted to be one of the necessary ingredients for tropical cyclone development, indicative of the potential for surface heat and moisture fluxes capable of fueling a self-sustaining circulation. Although the minimum 26.5°C threshold for tropical cyclogenesis has become a mainstay in research and education, the fact that a nonnegligible fraction of storm formation events (about 5%) occur over cooler waters casts some doubt on the robustness of this estimate. Tropical cyclogenesis over subthreshold sea surface temperatures is associated with low tropopause heights, indicative of the presence of a cold trough aloft. To focus on this type of development environment, the applicability of the 26.5°C threshold is investigated for tropical transitions from baroclinic precursor disturbances in all basins between 1989 and 2013. Although the threshold performs well in the majority of cases without appreciable environmental baroclinicity, the potential for development is underestimated by up to 27% for systems undergoing tropical transition. An alternative criterion of a maximum 22.5°C difference between the tropopause-level and 850-hPa equivalent potential temperatures (defined as the coupling index) is proposed for this class of development. When combined with the standard 26.5°C sea surface temperature threshold for precursor-free environments, error rates are reduced to 3%–6% for all development types. The addition of this physically relevant representation of the deep-tropospheric state to the ingredients-based conceptual model for tropical cyclogenesis improves the representation of the important tropical transition-based subset of development events.</jats:p

Towards a novel carbon device for the treatment of sepsis

Sepsis is a systemic inflammatory response to infection in which the balance of pro- andanti-inflammatory mediators, which normally isolate and eliminate infection, is disrupted[1]. Gram negative sepsis is initiated by bacterial endotoxin release which activatesmacrophages and circulating monocytes to release TNF and IL-1β followed by IL-6 andother inflammatory cytokines [2]. As the disease progresses, an unregulatedinflammatory response results in, tissue injury, haematological dysfunction and organdysfunction. Severe sepsis, involving organ hypoperfusion may be further complicatedby hypotension that is unresponsive to adequate fluid replacement, resulting in septicshock and finally death [3].Despite improvements in anti-microbial and supportive therapies, sepsis remains asignificant cause of morbidity and mortality in ICUs worldwide [4]. The complexity ofprocesses mediating the progression of sepsis suggests that an extracorporeal devicecombining blood filtration with adsorption of a wide range of toxins, and inflammatorymediators offers the most comprehensive treatment strategy. However, no such deviceexists at present. A novel, uncoated, polymer pyrolysed synthetic carbon device isproposed which combines the superior adsorption properties of uncoated activatedcarbons with the capacity to manipulate porous structure for controlled adsorption oftarget plasma proteins and polypeptides [5]. Preliminary haemocompatibility andadsorptive capacity was assessed using a carbon matrix prototype

The problem with Kappa

It is becoming clear that traditional evaluation measures used in Computational Linguistics (including Error Rates, Accuracy, Recall, Precision and F-measure) are of limited value for unbiased evaluation of systems, and are not meaningful for comparison of algorithms unless both the dataset and algorithm parameters are strictly controlled for skew (Prevalence and Bias). The use of techniques originally designed for other purposes, in particular Receiver Operating Characteristics Area Under Curve, plus variants of Kappa, have been proposed to fill the void. This paper aims to clear up some of the confusion relating to evaluation, by demonstrating that the usefulness of each evaluation method is highly dependent on the assumptions made about the distributions of the dataset and the underlying populations. The behaviour of a number of evaluation measures is compared under common assumptions. Deploying a system in a context which has the opposite skew from its validation set can be expected to approximately negate Fleiss Kappa and halve Cohen Kappa but leave Powers Kappa unchanged. For most performance evaluation purposes, the latter is thus most appropriate, whilst for comparison of behaviour, Matthews Correlation is recommended

Time-of-arrival distributions from position-momentum and energy-time joint measurements

The position-momentum quasi-distribution obtained from an Arthurs and Kelly joint measurement model is used to obtain indirectly an ``operational'' time-of-arrival (TOA) distribution following a quantization procedure proposed by Kocha\'nski and W\'odkiewicz [Phys. Rev. A 60, 2689 (1999)]. This TOA distribution is not time covariant. The procedure is generalized by using other phase-space quasi-distributions, and sufficient conditions are provided for time covariance that limit the possible phase-space quasi-distributions essentially to the Wigner function, which, however, provides a non-positive TOA quasi-distribution. These problems are remedied with a different quantization procedure which, on the other hand, does not guarantee normalization. Finally an Arthurs and Kelly measurement model for TOA and energy (valid also for arbitrary conjugate variables when one of the variables is bounded from below) is worked out. The marginal TOA distribution so obtained, a distorted version of Kijowski's distribution, is time covariant, positive, and normalized

Effective Theoretical Approach to Back Reaction of the Dynamical Casimir Effect in 1+1 Dimensions

We present an approach to studying the Casimir effects by means of the effective theory. An essential point of our approach is replacing the mirror separation into the size of space S^1 in the adiabatic approximation. It is natural to identify the size of space S^1 with the scale factor of the Robertson-Walker-type metric. This replacement simplifies the construction of a class of effective models to study the Casimir effects. To check the validity of this replacement we construct a model for a scalar field coupling to the two-dimensional gravity and calculate the Casimir effects by the effective action for the variable scale factor. Our effective action consists of the classical kinetic term of the mirror separation and the quantum correction derived by the path-integral method. The quantum correction naturally contains both the Casimir energy term and the back-reaction term of the dynamical Casimir effect, the latter of which is expressed by the conformal anomaly. The resultant effective action describes the dynamical vacuum pressure, i.e., the dynamical Casimir force. We confirm that the force depends on the relative velocity of the mirrors, and that it is always attractive and stronger than the static Casimir force within the adiabatic approximation.Comment: Published Version, 16 pages, LaTeX2e with graphics package, 1 figur