A randomized comparison of branded sodium stibogluconate and generic sodium stibogluconate for the treatment of visceral leishmaniasis under field conditions in Sudan.

OBJECTIVE: To compare the outcome of treatment of Sudanese kala-azar patients treated under field conditions with either branded sodium stibogluconate (SSG) (Pentostam GlaxoWellcome) or generic SSG (Albert David Ltd, Calcutta, supplied by International Dispensary Association, Amsterdam). METHOD: Randomised comparison. 271 patients were treated with Pentostam and 245 with generic SSG. RESULTS: No statistically significant differences in cure rate or mortality were detected between Pentostam and generic SSG. No differences in side-effects between the two drugs were noted. The initial cure rate at the time of discharge was 93.7 and 97.6%, respectively; the death rate during treatment 5.9 and 2.4%. Six months follow up was achieved in 88.5% of the discharged patients. Two patients had died in the Pentostam group and two had died in the generic SSG group, giving a final death rate of 7.5 and 3.7%. The number of relapses in the Pentostam and generic SSG groups were 3 and 1, respectively. The final cure rates, calculated at 6 months after discharge, were 91.3% and 95.9%. CONCLUSION: No difference was observed in the performance of generic SSG compared to Pentostam for the treatment of visceral leishmaniasis in Sudan. Generic SSG can be routinely and safely used for the treatment of kala-azar. Generic SSG costs only 1/14 of the price of Pentostam. The use of generic SSG may make treatment of kala-azar affordable for national governments in Africa

Clash of symmetries on the brane

If our 3+1-dimensional universe is a brane or domain wall embedded in a higher dimensional space, then a phenomenon we term the ``clash of symmetries'' provides a new method of breaking some continuous symmetries. A global $G_{\text{cts}} \otimes G_{\text{discrete}}$ symmetry is spontaneously broken to $H_{\text{cts}} \otimes H_{\text{discrete}}$, where the continuous subgroup $H_{\text{cts}}$ can be embedded in several different ways in the parent group $G_{\text{cts}}$, and $H_{\text{discrete}} < G_{\text{discrete}}$. A certain class of topological domain wall solutions connect two vacua that are invariant under {\it differently embedded} $H_{\text{cts}}$ subgroups. There is then enhanced symmetry breakdown to the intersection of these two subgroups on the domain wall. This is the ``clash''. In the brane limit, we obtain a configuration with $H_{\text{cts}}$ symmetries in the bulk but the smaller intersection symmetry on the brane itself. We illustrate this idea using a permutation symmetric three-Higgs-triplet toy model exploiting the distinct $I-$, $U-$ and $V-$spin U(2) subgroups of U(3). The three disconnected portions of the vacuum manifold can be treated symmetrically through the construction of a three-fold planar domain wall junction configuration, with our universe at the nexus. A possible connection with $E_6$ is discussed.Comment: 30 pages, 9 embedded figure

Cultural Impacts On Occupant Behaviour And Energy Efficiency

Canadian cultural and consumer trends have established high household energy consumption rates, as compared to other first world nations. This study examines the correlation between cultural influence, occupant behaviour, and the resulting effectiveness of optional or mandatory energy efficiency strategies in Canadian homes. Energy efficiency has historically been approached from a design and construction perspective; however, monitoring and verification during a post-occupancy period has gone largely undocumented. Given the lack of data, the effectiveness of any policy or standard towards sustainability is difficult to quantify. In two case studies, located in Calgary, AB (Canada), the impacts of housing typology, construction methodology and occupant behaviour were researched to collect post-occupancy energy use data. The results of the first case study demonstrate a +300% variation in consumption rates when comparing same unit type, location, construction and solar photovoltaic array. A second case study examines a home designed to be Net-Zero Energy (NZE), which is coupled with renewable technology and subsequently monitored post-occupancy, then compared to modelled/predicted loads. A third case, which strives to reduce both operational and embodied energy pre- and post-occupancy, is examined to illustrate the pre-occupancy energy required by various standard and alternative construction materials. This paper aims to provide context and validation of energy efficient design, construction, standards/codes, and in conjunction with occupant behaviour or cultural patterns of consumption. The results strive to identify which strategies may ultimately have more impact on national goals of energy efficiency and carbon reduction, and whether or not top down policy can be an effective way of managing energy use in households

Reflexivity of the translation-dilation algebras on L^2(R)

The hyperbolic algebra A_h, studied recently by Katavolos and Power, is the weak star closed operator algebra on L^2(R) generated by H^\infty(R), as multiplication operators, and by the dilation operators V_t, t \geq 0, given by V_t f(x) = e^{t/2} f(e^t x). We show that A_h is a reflexive operator algebra and that the four dimensional manifold Lat A_h (with the natural topology) is the reflexive hull of a natural two dimensional subspace.Comment: 10 pages, no figures To appear in the International Journal of Mathematic

A simulation study of the flight dynamics of elastic aircraft. Volume 1: Experiment, results and analysis

The simulation experiment described addresses the effects of structural flexibility on the dynamic characteristics of a generic family of aircraft. The simulation was performed using the NASA Langley VMS simulation facility. The vehicle models were obtained as part of this research. The simulation results include complete response data and subjective pilot ratings and comments and so allow a variety of analyses. The subjective ratings and analysis of the time histories indicate that increased flexibility can lead to increased tracking errors, degraded handling qualities, and changes in the frequency content of the pilot inputs. These results, furthermore, are significantly affected by the visual cues available to the pilot

A simulation study of the flight dynamics of elastic aircraft. Volume 2: Data

The simulation experiment described addresses the effects of structural flexibility on the dynamic characteristics of a generic family of aircraft. The simulation was performed using the NASA Langley VMS simulation facility. The vehicle models were obtained as part of this research project. The simulation results include complete response data and subjective pilot ratings and comments and so allow a variety of analyses. The subjective ratings and analysis of the time histories indicate that increased flexibility can lead to increased tracking errors, degraded handling qualities, and changes in the frequency content of the pilot inputs. These results, furthermore, are significantly affected by the visual cues available to the pilot