Intragenerational Mobility in Italy: a Non-parametric Estimates

The paper proposes a novel methodology based on a non-parametric method to estimate intragenerational income mobility. We apply it to the analysis of mobility of a sample of Italian individuals (between 16 and 65 years old) from the Survey on Household Income and Wealth (SHIW) by the Bank of Italy in the period 1987-2010. First, the linear specification of the Markovian model is estimated removing the assumption of no serial correlation in the error term suggesting a low level of income mobility. Second, a non-linear specification of Markovian model is estimated providing both “local” and global measures of income mobility. Income mobility appears to be low; in particular it reaches a minimum in the middle of income distribution and maximum values at the extreme bounds, with an income elasticity ranging from 0.4 to 0.8 in the relevant range of income (0.5-2). Moreover, from 1987-1998 to 2000-2010 income mobility has increased over time, in particular in the middle of distribution

Occupational Mobility across Generations: a Theoretical Model with an Application to Italy

This paper proposes a simple theoretical model to identify the main determinants of intergenerational occupational mobility with an ap- plication to Italian data. We assume that occupational mobility is described by a Markov matrix and that three factor affect the occu- pational choice of an individual: the income incentives of each occu- pation, the family background and the occupational structure. The empirical application of the proposed model to a sample of Italian families describes Italy as a less mobile country, and in partic- ular we show that occupational mobility decreases for children born between 1966 and 1976. This result is due to the worsening of oppor- tunities. The estimate of three synthetic indexes confirms the decease of mobility

Occupational Mobility: Theory and Estimation for Italy

This paper presents a model where intergenerational occupational mobility is the joint outcome of three main determinants: income incentives, equality of opportunity and changes in the composition of occupations. The model rationalizes the use of transition matrices to measure mobility, which allows for the identification of asymmetric mobility patterns and for the formulation of a specific mobility index for each determinant. Italian children born in 1940-1951 had a lower mobility with respect to those born after 1965. The steady mobility for children born after 1965, however, covers a lower structural mobility in favour of upper-middle classes and a higher downward mobility from upper-middle classes. Equality of opportunity was far from the perfection but steady for those born after 1965. Changes in income incentives instead played a major role, leading to a higher downward mobility from upper-middle classes and lower upward mobility from the lower class.Comment: 31 pages, 2 figure

Molecular characterisation of breast cancer patients at high and low recurrence risk

The ability to predict the recurrence risk in breast cancer patients is not available for the individual. It is commonly accepted that the different clinical course of tumours with identical histology and stage are the result of differences at the molecular level. This case study of 80 patients affected by breast cancer looked at the messenger ribonucleic acid expression level of 22 genes, by using quantitative reverse transcriptase-polymerase chain reaction. Our results showed that a panel of seven genes is associated to patients' survival. Moreover, the combination of two couples of genes is able to define short- and long-living cohorts of patients. In particular, our findings strongly demonstrate that retinoblastoma (RB) and cyclin-dependent kinase 2 (CDK2) on one side and cytokeratin 8 (CK8) and epidermal growth factor receptor 2 (HER2) on the other may affect the clinical course of the disease in 56% of patients. Groups characterised by low RB and high CDK2 as with low CK8 and high HER2 have a higher risk of recurrences and death in 5 years. The identification of these sub-groups of patients with higher risk of early relapse could have further involvement in the selection of the cases to submit to therapy against HER2 or CDK2 as a possible therapy target

The dry grasslands of Abruzzo National Park, the oldest protected area in the Apennines (Central Italy): overview of vegetation composition, syntaxonomy, ecology and diversity

The Abruzzo, Lazio and Molise National Park was established in 1923 and is considered a flagship conservation area in Italy. It includes large extensions of semi-natural grasslands, maintained by traditional transhumant grazing for centuries. The patterns and drivers of grassland composition within the Park are still poorly investigated, and the scattered phytosociological data available were often based on relevés with varied and not precisely defined sizes. In order to provide for the first time a general overview of the Park’s dry grasslands, we analysed a dataset of 87 relevés with a fixed size of 2 × 2 m, precisely delimited in the field and GPS-located. Specific research aims were: (1) to classify the vegetation plots into floristic-ecological types, supported by an analysis of mean (Italy-specific) Ellenberg Indicator Values (EIVs); (2) to assign the types to up-to-date phytosociological syntaxa; (3) to identify the main environmental drivers for both composition and richness patterns; (4) to test the degree of correlation between (Italy-specific) EIVs and the measured environmental variables. Environmental predictors included high-resolution climatologies and remote-sensed standing biomass. Main vegetation types were identified using Hierarchical Cluster Analysis (HCA). Distancebased RDA was performed as a constrained ordination method to reveal correlations between floristic composition and environmental variables. Drivers of species richness were explored through partial correlation and Regression Trees. HCA and NMDS revealed four floristically and ecologically well-interpretable groups, in turn well corresponding to the level of phytosociological class (namely Molinio-Arrhenatheretea, Nardetea strictae, Festuco hystricis-Ononidetea striatae and Festuco-Brometea). Constrained ordination showed that most of the floristic variation was explained by biomass, annual precipitation (Pann) and mean annual temperature (Tm). Strong and significant positive correlations were found between biomass and EIV for Nitrogen (EIV-N), and between Tm and EIV for Temperature (EIV-T). Strong and significant negative correlations were found between Pann and EIV-T, EIV for Continentality (EIV-C) and EIV for soil Reaction (EIV-R). Species richness was positively correlated with slope inclination and negatively with elevation; richness was higher in sites with a high rock cover, and on limestone or clayey substrata than on siliceous ones. We conclude that in the study area: a) dry semi-natural grasslands are arranged at least into four distinguishable, high rank floristic-ecological groups; b) a mixture of climatic (especially precipitation) and edaphic (especially bedrock and soil reaction) gradients are the main drivers of such composition patterns; c) species richness is higher in sites more stressed by summer drought and/or nutrient scarcity; d) community-means of Italy’s specific EIVs are well correlated with environmental variables in grasslands, including a good correspondence between EIV-T and mean annual temperature

Rare histotypes of epithelial biliary tract tumors: A literature review

Adenocarcinoma represents the most frequent biliary tract cancer. However, other rare histotypes can be found in the biliary tract, such as cholangiolocellular carcinoma, cholangiocarcinoma with ductal plate malformation pattern, adenosquamous carcinoma, mucinous carcinoma, signet ring cell carcinoma, clear cell carcinoma, mucoepidermoid carcinoma, lymphoepithelioma-like carcinoma, and sarcomatous cholangiocarcinoma. These cancer types account for less than 10 % of all the already rare biliary tract tumors. Yet, they represent a relevant issue in everyday clinical practice, given the lack of therapeutic recommendations and the overall scarcity of data, mainly deriving from isolated small center-specific cohorts of patients.The shifts of such histotypes from the most common ones reflect genetic and molecular differences, determine changes in clinical aggressiveness, and suggest a possible variability in sensitivity to the standard treatments of biliary adenocarcinomas. The consistency and degree of these variables are still to be solidly demonstrated and investigated. Therefore, this paper aims to review the current literature concerning very infrequent and rare epithelial biliary tract cancers, focusing our attention on the clinical, molecular, and immunohistochemical features of these tumors

Metronomic capecitabine versus best supportive care as second-line treatment in hepatocellular carcinoma: A retrospective study

Preliminary studies suggest that capecitabine may be safe and effective in HCC patients. The aim of this study was to retrospectively evaluate the safety and efficacy of metronomic capecitabine as second-line treatment. This multicentric study retrospectively analyzed data of HCC patients unresponsive or intolerant to sorafenib treatment with metronomic capecitabine or best supportive care (BSC).Median progression free survival was 3.1 months in patients treated with capecitabine (95%CI: 2.7-3.5). Median overall survival was 12.0 months (95% CI: 10.7-15.8) in patients receiving capecitabine, while 9.0 months (95% CI: 6.5-13.9) in patients receiving BSC. The result of univariate unweighted Cox regression model shows a 46% reduction in death risk for patients on capecitabine (95%CI: 0.357-0.829; p=0.005) compared to patients receiving BSC alone. After weighting for potential confounders, death risk remained essentially unaltered (45%; 95%CI: 0.354-0.883; p = 0.013). Metronomic capecitabine seems a safe second-line treatment for HCC patients in terms of management of adverse events, showing a potential anti-tumour activity which needs further evaluation in phase III studies

"A Gianni Rodari, via Lattea quaraquarinci". Report della seconda edizione del Concorso INAF di scrittura per bambini (anno 2021-2022)

Il 23 ottobre 2021, l’Istituto Nazionale di Astrofisica (INAF) ha lanciato la seconda edizione del Concorso di scrittura a tema astronomico ispirato a Gianni Rodari, “A Gianni Rodari, via Lattea quaraquarinci”. Il Concorso, a cura del Gruppo Storie dell’INAF e in collaborazione con EduINAF, è rivolto agli studenti della scuola primaria e secondaria di primo grado (6-13 anni). In questa seconda edizione, il Concorso ha aperto le porte alla partecipazione di classe oltre a quella individuale, ricevendo 168 opere individuali e 44 di classe. Come nella prima edizione, l’accoglienza è stata estremamente calorosa, i giovani partecipanti – e in generale il loro contesto scolastico e famigliare – hanno risposto positivamente e con entusiasmo alla sfida. La collaborazione del Concorso con i progetti dell’INAF PRISMA e Sorvegliati Spaziali ha portato alla scelta del tema dell’edizione che quest’anno ha riguardato gli “Asteroidi e altri sorvegliati spaziali”. La seconda edizione ha goduto di un aumento di personale INAF nel gruppo di lavoro del Concorso, permettendo un più efficace divisione dei ruoli e del carico di lavoro: persone di diversi profili e sedi dell’INAF hanno collaborato fra loro e con professionalità esterne quali Emanuela Bussolati (autrice e illustratrice per l’infanzia), Cesare Sottocorno (docente) e Francesca Poppi (illustratrice, graphic e web designer). In questo Report sono discussi i punti salienti della seconda edizione del Concorso, un confronto con la prima edizione e le criticità rilevate