348 research outputs found

    A Study of Isaiah\u27s Use of Kabod

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    The purpose of this study is to discover the theological significance of the word פָבוֹ ד as used in the Book of Isaiah. פָבוֹ ד , most often translated into English as glory, is a term which encompasses such meanings as honor, fame, wealth, reputation, brightness, brilliance or splendor, and, when used in reference to God, heavenly brilliance, sublimity or magnificence.) Throughout Isaiah, the term פָבוֹ ד is utilized frequently, with reference to God, as well as to men and nations. It is the thesis of this study that, as the term is used throughout Isaiah, the term- פָבוֹ דbecomes a theologically important word which expresses both God\u27s immanence and His transcendence: His immanence revealed in His declaration of His presence and protection for His people; His transcendence disclosed in the midst of theophanic encounter, revealing His holiness, character and essence. The purpose of this study is to make an exegetical study of Isaiah\u27s use of פָבוֹ ד, to determine its theological significance within the book of Isaiah and to bring the study of this subject up to date

    Structure and hydration of membranes embedded with voltage-sensing domains.

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    Despite the growing number of atomic-resolution membrane protein structures, direct structural information about proteins in their native membrane environment is scarce. This problem is particularly relevant in the case of the highly charged S1-S4 voltage-sensing domains responsible for nerve impulses, where interactions with the lipid bilayer are critical for the function of voltage-activated ion channels. Here we use neutron diffraction, solid-state nuclear magnetic resonance (NMR) spectroscopy and molecular dynamics simulations to investigate the structure and hydration of bilayer membranes containing S1-S4 voltage-sensing domains. Our results show that voltage sensors adopt transmembrane orientations and cause a modest reshaping of the surrounding lipid bilayer, and that water molecules intimately interact with the protein within the membrane. These structural findings indicate that voltage sensors have evolved to interact with the lipid membrane while keeping energetic and structural perturbations to a minimum, and that water penetrates the membrane, to hydrate charged residues and shape the transmembrane electric field

    Crossing Cultures: Guides and Models for Development, Selection, and Application

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    Despite many calls for it, there has been little action toward an all-inclusive manuscript that is practical, empirically verified, and provides guidelines for becoming and remaining strategically culturally adaptive. Further, a tremendous number of current articles and books emphasize managing or leading in an era of globalization. To meet these calls to work, learn, and innovate across cultures, the goal must be to move from the mass of unrelated assertions to the weaving of co-created, manageable models that are useful in learning, teaching, and practice

    Polls and the political process: the use of opinion polls by political parties and mass media organizations in European post‐communist societies (1990–95)

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    Opinion polling occupies a significant role within the political process of most liberal-capitalist societies, where it is used by governments, parties and the mass media alike. This paper examines the extent to which polls are used for the same purposes in the post-communist countries of Central and Eastern Europe, and in particular, for bringing political elites and citizens together. It argues that these political elites are more concerned with using opinion polls for gaining competitive advantage over their rivals and for reaffirming their political power, than for devolving political power to citizens and improving the general processes of democratization

    Enteric bacterial pathogen detection in southern sea otters (Enhydra lutris nereis) is associated with coastal urbanization and freshwater runoff

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    Although protected for nearly a century, California’s sea otters have been slow to recover, in part due to exposure to fecally-associated protozoal pathogens like Toxoplasma gondii and Sarcocystis neurona. However, potential impacts from exposure to fecal bacteria have not been systematically explored. Using selective media, we examined feces from live and dead sea otters from California for specific enteric bacterial pathogens (Campylobacter, Salmonella, Clostridium perfringens, C. difficile and Escherichia coli O157:H7), and pathogens endemic to the marine environment (Vibrio cholerae, V. parahaemolyticus and Plesiomonas shigelloides). We evaluated statistical associations between detection of these pathogens in otter feces and demographic or environmental risk factors for otter exposure, and found that dead otters were more likely to test positive for C. perfringens, Campylobacter and V. parahaemolyticus than were live otters. Otters from more urbanized coastlines and areas with high freshwater runoff (near outflows of rivers or streams) were more likely to test positive for one or more of these bacterial pathogens. Other risk factors for bacterial detection in otters included male gender and fecal samples collected during the rainy season when surface runoff is maximal. Similar risk factors were reported in prior studies of pathogen exposure for California otters and their invertebrate prey, suggesting that land-sea transfer and/or facilitation of pathogen survival in degraded coastal marine habitat may be impacting sea otter recovery. Because otters and humans share many of the same foods, our findings may also have implications for human health

    AND/R: Advanced neutron diffractometer/reflectometer for investigation of thin films and multilayers for the life sciences

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    An elastic neutron scattering instrument, the advanced neutron diffractometer/reflectometer (AND/R), has recently been commissioned at the National Institute of Standards and Technology Center for Neutron Research. The AND/R is the centerpiece of the Cold Neutrons for Biology and Technology partnership, which is dedicated to the structural characterization of thin films and multilayers of biological interest. The instrument is capable of measuring both specular and nonspecular reflectivity, as well as crystalline or semicrystalline diffraction at wave-vector transfers up to approximately 2.20 Å(-1). A detailed description of this flexible instrument and its performance characteristics in various operating modes are given.D. J. M. is supported through a NSF NIRT grant Contract No. 0304062
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