Optimal Technological Portfolios for Climate-Change Policy under Uncertainty: A Computable General Equilibrium Approach

When exploring solutions to long-term environmental problems such as climate change, it is crucial to understand how the rates and directions of technological change may interact with environmental policies in the presence of uncertainty. This paper analyzes optimal technological portfolios for global carbon emissions reductions in an integrated assessment model of the coupled social-natural system. The model used here is a probabilistic, two-technology extension of Nordhaus" earlier model (Nordhaus and Boyer, 2000) by incorporating endogenous technological choice between conventional and carbon-free technologies. Taking into account the possible competitions among the technological options, we address the issues of optimal timing, costs and burden-sharing of optimal carbon mitigation strategies in the inherently uncertain world. We perform various analyses related to the major uncertainties about natural, socioeconomic and technological parameters, and investigate the effects of uncertainties resolution, risks and alternative political preferences. The results show that analyses ignoring uncertainty could lead to inefficient and biased technology-policy recommendations for the future.Integrated assessment modeling; Global Warming; Uncertainty; Endogenous technological portfolios

Perceived Discrimination and Self-Rated Health in South Korea: A Nationally Representative Survey

Background: There is mounting evidence that discriminatory experiences can harm health. However, previous research has mainly focused on the health effects of racial discrimination in U.S. or European countries although there is pervasive discrimination by gender, age, education and other factors in Asian countries. Methods: We analyzed the data from the 7th wave of Korean Labor and Income Panel Study to investigate the association between perceived discriminatory experience and poor self-rated health in South Korea. Perceived discriminatory experiences were measured in eight situations through a modified Experience of Discrimination questionnaire. In each of eight situations, the lifetime prevalence of perceived discriminatory experience was compared between men and women and the main causes of those experiences were identified separately by gender. After adjusting for potential confounders, we examined the association between perceived discriminatory experience and poor self-rated health in each of eight social situations and also checked the association using the number of situations of perceived discriminatory experiences. Results: For both men and women, education level and age were the main sources of work-related perceived discriminatory experiences. Gender was one of the main causes among women across eight situations and more than 90% of women reported their gender as a main cause of discriminatory experience in getting higher education and at home. Discriminatory experiences in four situations were positively associated with poor self-rated health. The odds ratio for poor self-rated health for those exposed to one, two, three or four or more social situations of perceived discrimination were respectively 1.06 (95% CI : 0.87–1.29), 1.15 (95% CI : 0.96–1.55), 1.59 (95% CI : 1.19–2.14), and 1.78 (95% CI :1.26–2.51). Conclusion: There is consistent association between perceived discriminatory experience and poor self-rated health across eight social situations in South Korea

AAVR-Displaying Interfaces: Serotype-Independent Adeno-Associated Virus Capture and Local Delivery Systems.

Interfacing gene delivery vehicles with biomaterials has the potential to play a key role in diversifying gene transfer capabilities, including localized, patterned, and controlled delivery. However, strategies for modifying biomaterials to interact with delivery vectors must be redesigned whenever new delivery vehicles and applications are explored. We have developed a vector-independent biomaterial platform capable of interacting with various adeno-associated viral (AAV) serotypes. A water-soluble, cysteine-tagged, recombinant protein version of the recently discovered multi-AAV serotype receptor (AAVR), referred to as cys-AAVR, was conjugated to maleimide-displaying polycaprolactone (PCL) materials using click chemistry. The resulting cys-AAVR-PCL system bound to a broad range of therapeutically relevant AAV serotypes, thereby providing a platform capable of modulating the delivery of all AAV serotypes. Intramuscular injection of cys-AAVR-PCL microspheres with bound AAV vectors resulted in localized and sustained gene delivery as well as reduced spread to off-target organs compared to a vector solution. This cys-AAVR-PCL system is thus an effective approach for biomaterial-based AAV gene delivery for a broad range of therapeutic applications

Multi-kilowatt single-mode ytterbium-doped large-core fiber laser

We have demonstrated a highly efficient cladding-pumped ytterbium-doped fiber laser, generating >2.1 kW of continuous-wave output power at 1.1 µm with 74% slope efficiency with respect to launched pump power. The beam quality factor (M2) was better than 1.2. The maximum output power was only limited by available pump power, showing no evidence of roll-over even at the highest output power. We present data on how the beam quality depends on the fiber parameter, based on our current and past fiber laser developments. We also discuss the ultimate power-capability of our fiber in terms of thermal management, Raman nonlinear scattering, and material damage, and estimate it to 10 k

SHARPP Games for the Education Prevention and Reversion of Chronic Diseases

Prevalence of chronic diseases has become a serious problem in our society. These illnesses are commonly caused by dietary and lifestyle risk factors and are hard to cure completely. However, behavioral changes such as adopting a healthy diet and lifestyle are effective in reducing chronic conditions. In this research, we propose to build games that could support the Sustainable transformation of chronic patients in a Holistic and Adaptable manner using Real-time, Precise, and Persuasive (SHARPP) principles, processes, systems, and technologies. This research leverages wearable information technologies and chronic disease studies to design games that interweave virtual worlds with the real world. It not only supports patients to form healthy habits that prevent and revert chronic diseases but also helps individuals to balance various life dimensions

Estimating probabilities from experimental frequencies

Estimating the probability distribution 'q' governing the behaviour of a certain variable by sampling its value a finite number of times most typically involves an error. Successive measurements allow the construction of a histogram, or frequency count 'f', of each of the possible outcomes. In this work, the probability that the true distribution be 'q', given that the frequency count 'f' was sampled, is studied. Such a probability may be written as a Gibbs distribution. A thermodynamic potential, which allows an easy evaluation of the mean Kullback-Leibler divergence between the true and measured distribution, is defined. For a large number of samples, the expectation value of any function of 'q' is expanded in powers of the inverse number of samples. As an example, the moments, the entropy and the mutual information are analyzed.Comment: 10 pages, 3 figures, to be published in Physical Review

Efficient Bayesian Inference for Learning in the Ising Linear Perceptron and Signal Detection in CDMA

Efficient new Bayesian inference technique is employed for studying critical properties of the Ising linear perceptron and for signal detection in Code Division Multiple Access (CDMA). The approach is based on a recently introduced message passing technique for densely connected systems. Here we study both critical and non-critical regimes. Results obtained in the non-critical regime give rise to a highly efficient signal detection algorithm in the context of CDMA; while in the critical regime one observes a first order transition line that ends in a continuous phase transition point. Finite size effects are also studied.Comment: 11 pages, 3 figure