9,539 research outputs found
Optical off-nuclear spectra of quasar hosts and radio galaxies
We present optical (~3200A to ~9000A) off-nuclear spectra of 26 powerful
active galaxies in the redshift range 0.1 < z < 0.3, obtained with the Mayall
and William Herschel 4-meter class telescopes. The sample consists of
radio-quiet quasars, radio-loud quasars (all with -23 > M_V > -26) and radio
galaxies of Fanaroff & Riley Type II (with extended radio luminosities and
spectral indices comparable to those of the radio-loud quasars). The spectra
were all taken approximately 5 arcseconds off-nucleus, with offsets carefully
selected so as to maximise the amount of galaxy light falling into the slit,
whilst simultaneously minimising the amount of scattered nuclear light. The
majority of the resulting spectra appear to be dominated by the integrated
stellar continuum of the underlying galaxies rather than by light from the
non-stellar processes occurring in the active nuclei, and in many cases a 4000A
break feature can be identified. The individual spectra are described in
detail, and the importance of the various spectral components is discussed.
Stellar population synthesis modelling of the spectra will follow in a
subsequent paper (Nolan et al. 2000).Comment: 23 pages, LaTeX, uses MNRAS style file, incorporates 71 postscript
figures, to be published in MNRAS. Contact author: [email protected]
Structure-based discovery of fiber-binding compounds that reduce the cytotoxicity of amyloid beta.
Amyloid protein aggregates are associated with dozens of devastating diseases including Alzheimer's, Parkinson's, ALS, and diabetes type 2. While structure-based discovery of compounds has been effective in combating numerous infectious and metabolic diseases, ignorance of amyloid structure has hindered similar approaches to amyloid disease. Here we show that knowledge of the atomic structure of one of the adhesive, steric-zipper segments of the amyloid-beta (Aβ) protein of Alzheimer's disease, when coupled with computational methods, identifies eight diverse but mainly flat compounds and three compound derivatives that reduce Aβ cytotoxicity against mammalian cells by up to 90%. Although these compounds bind to Aβ fibers, they do not reduce fiber formation of Aβ. Structure-activity relationship studies of the fiber-binding compounds and their derivatives suggest that compound binding increases fiber stability and decreases fiber toxicity, perhaps by shifting the equilibrium of Aβ from oligomers to fibers. DOI:http://dx.doi.org/10.7554/eLife.00857.001
The Nonlinear Evolution of Instabilities Driven by Magnetic Buoyancy: A New Mechanism for the Formation of Coherent Magnetic Structures
Motivated by the problem of the formation of active regions from a
deep-seated solar magnetic field, we consider the nonlinear three-dimensional
evolution of magnetic buoyancy instabilities resulting from a smoothly
stratified horizontal magnetic field. By exploring the case for which the
instability is continuously driven we have identified a new mechanism for the
formation of concentrations of magnetic flux.Comment: Published in ApJL. Version with colour figure
The ages of quasar host galaxies
We present the results of fitting deep off-nuclear optical spectroscopy of
radio-quiet quasars, radio-loud quasars and radio galaxies at z ~ 0.2 with
evolutionary synthesis models of galaxy evolution. Our aim was to determine the
age of the dynamically dominant stellar populations in the hos t galaxies of
these three classes of powerful AGN. Some of our spectra display residual
nuclear contamination at the shortest wavelengths, but the detailed quality of
the fits longward of the 4000A break provide unequivocal proof, if further
proof were needed, that quasars lie in massive galaxies with (at least at z ~
0.2) evolved stellar populations. By fitting a two-component model we have
separated the very blue (starburst and/or AGN contamination) from the redder
underlying spectral energy distribution, and find that the hosts of all three
classes of AGN are dominated by old stars of age 8 - 14 Gyr. If the blue
component is attributed to young stars, we find that, at most, 1% of the
baryonic mass of these galaxies is involved in star-formation activity at the
epoch of observation. These results strongly support the conclusion reached by
McLure et al. (1999) that the host galaxies of luminous quasars are massive
ellipticals which formed prior to the peak epoch of quasar activity at z ~ 2.5.Comment: 24 pages, LaTeX, uses MNRAS style file, incorporates 19 postscript
figures, final version, to be published in MNRA
Double-impulse magnetic focusing of launched cold atoms.
We have theoretically investigated three-dimensional focusing of a launched cloud of cold atoms using a pair of magnetic lens pulses (the alternate-gradient method). Individual lenses focus radially and defocus axially or vice versa. The performance of the two possible pulse sequences are compared and found to be ideal for loading both 'pancake' and 'sausage' shaped magnetic/optical microtraps. It is shown that focusing aberrations are considerably smaller for double-impulse magnetic lenses compared to single-impulse magnetic lenses. An analysis of clouds focused by the double-impulse technique is presented
Salt fingering staircases and the three-component Phillips effect
Understanding the dynamics of staircases in salt fingering convection
presents a long-standing theoretical challenge to fluid dynamicists. Although
there has been significant progress, particularly through numerical
simulations, there are a number of conflicting theoretical explanations as to
the driving mechanism underlying staircase formation. The Phillips effect
proposes that layering in stirred stratified flow is due to an antidiffusive
process, and it has been suggested that this mechanism may also be responsible
for salt fingering staircases. However, the details of this process, as well as
mathematical models to predict the evolution and merger dynamics of staircases,
have yet to be developed. We generalise the theory of the Phillips effect to a
three-component system (e.g. temperature, salinity, energy) and demonstrate the
first regularised nonlinear model of layering based on mixing-length
parameterisations. The model predicts both the inception of layering and its
long-term evolution through mergers , whilst generalising, and remaining
consistent with, previous results for double-diffusive layering based on flux
ratios. Our model of salt fingering is formulated using spatial averaging
processes and closed by a mixing length parameterised in terms of the kinetic
energy and the salt and temperature gradients. The model predicts a layering
instability for a bounded range of parameter values in the salt fingering
regime. Nonlinear solutions show that an initially unstable linear buoyancy
gradient develops into layers, which merge through a process of stronger
interfaces growing at the expense of weaker interfaces. Mergers increase the
buoyancy gradient across interfaces, and increase the buoyancy flux through the
staircase.Comment: 24 pages, 8 figure
Structural studies of crystalline forms of triamterene with carboxylic acid, GRAS and API molecules.
Pharmaceutical salt solvates (dimethyl sulfoxide, DMSO) of the drug triamterene with the coformers acetic, succinic, adipic, pimelic, azelaic and nicotinic acid and ibuprofen are prepared by liquid-assisted grinding and solvent-evaporative crystallization. The modified ΔpKa rule as proposed by Cruz-Cabeza [(2012 ▸). CrystEngComm, 14, 6362-6365] is in close agreement with the results of this study. All adducts were characterized by X-ray diffraction and thermal analytical techniques, including single-crystal X-ray diffraction, powder X-ray diffraction, differential scanning calorimetry and thermal gravimetric analysis. Hydrogen-bonded motifs combined to form a variety of extended tapes and sheets. Analysis of the crystal structures showed that all adducts existed as salt solvates and contained the amino-pyridinium-carboxyl-ate heterodimer, except for the solvate containing triamterene, ibuprofen and DMSO, as a result of the presence of a strong and stable hemitriamterenium duplex. A search of the Cambridge Structural Database (CSD 5.36, Version 1.18) to determine the frequency of occurrence of the putative supramolecular synthons found in this study showed good agreement with previous work
Using crystallography, topology and graph set analysis for the description of the hydrogen bond network of triamterene: a rational approach to solid form selection.
This study has demonstrated the use of crystallography, topology and graph set analysis in the description and classification of the complex hydrogen bonded network of triamterene. The aim is to give a brief overview of the methodology used to discuss the crystal structure of triamterene with a view to extending the study to include the solvates, cocrystals and salts of this compound. Graphical abstract One of the structurally significant dimers (supramolecular synthons) of triamterene identified by this study
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