The glycaemic effects of single doses of Panax ginseng in young healthy volunteers

The results of two acute placebo-controlled, double-blind cross-over studies assessing the effect of Panax ginseng (G115) on blood glucose levels are reported. In study 1, thirty participants received three treatments: placebo; 200 mg G115; 400 mg G115. In study 2, twenty-seven participants received four treatments: placebo (0 mg ginseng and 30 mg saccharin); ginseng (200 mg ginseng and 30 mg saccharin); placebo–glucose (0 mg ginseng and 25 g oral glucose); ginseng–glucose (200 mg ginseng and 25 g oral glucose). Blood glucose levels were measured at baseline (at 09.00 hours after an overnight fast) and then 60, 90 (study 1 only) and 120 min post-dose. Both studies demonstrated that G115 alone significantly lowers fasting blood glucose levels. Conversely, in study 2 there was a significant drink × ginseng interaction suggesting opposing glycaemic effects of ginseng under fasting and raised blood glucose conditions. These data have implications for the use of ginseng in individuals with poor gluco-regulation

DHA-rich oil modulates the cerebral haemodynamic response to cognitive tasks in healthy young adults: a near IR spectroscopy pilot study

The impact of dietary n-3 PUFA on behavioural outcomes has been widely researched; however, very little attention has been given to their impact on brain functioning in physiological terms. A total of twenty-two healthy adults took part in this double-blind, placebo-controlled study, wherein the cerebral haemodynamic effects of 12 weeks of daily dietary supplementation with either 1 g DHA-rich or 1 g EPA-rich fish oil (FO) or placebo (1 g olive oil) were assessed. Relative changes in the concentration of oxygenated Hb (oxy-Hb) and deoxygenated Hb were assessed in the prefrontal cortex using near IR spectroscopy (NIRS) during the performance of four computerised cognitive tasks. Supplementation with DHA-rich FO, in comparison with placebo, resulted in a significant increase in the concentrations of oxy-Hb and total levels of Hb, indicative of increased cerebral blood flow (CBF), during the cognitive tasks. In comparison, no effect on CBF was observed following supplementation with EPA-rich FO, where concentration changes in the chromophores followed the same pattern as placebo. These encouraging pilot data warrant further application of NIRS in this area

Kinetic Monte Carlo simulations of oscillatory shape evolution for electromigration-driven islands

The shape evolution of two-dimensional islands under electromigration-driven periphery diffusion is studied by kinetic Monte Carlo (KMC) simulations and continuum theory. The energetics of the KMC model is adapted to the Cu(100) surface, and the continuum model is matched to the KMC model by a suitably parametrized choice of the orientation-dependent step stiffness and step atom mobility. At 700 K shape oscillations predicted by continuum theory are quantitatively verified by the KMC simulations, while at 500 K qualitative differences between the two modeling approaches are found.Comment: 7 pages, 6 figure

Panax ginseng has no effect on indices of glucose regulation following acute or chronic ingestion in healthy volunteers

In the absence of effective pharmacotherapy for diabetes there has been an increase in the use of, and research into, alternative treatment strategies. These include exercise, dietary interventions and the use of supplements including extracts of ginseng. Two separate, placebo-controlled, double-blind, cross-over studies investigating the effects of chronic ingestion of Panax ginseng (study 1 used G115, study 2 used Cheong Kwan Jang) on glycated Hb (HbA1c; study 1, n 18; study 2, n 11), fasting plasma insulin (study 1, n 17; study 2, n 12), fasting plasma glucose and postprandial response (following breakfast) (study 1, n 23; study 2, n 14) in healthy volunteers are reported. In both studies it was found that Panax ginseng had no effect on any gluco-regulatory parameter investigated. These results are not consistent with those reported for a diabetic sample (albeit using slightly different outcomes). These results would suggest that chronic use of Panax ginseng by non-diabetic individuals will have little long-term effect on glucose regulation. The benefits to glucose regulation associated with long-term ginseng use may only be present in populations with compromised glucose control; however, further research is needed to confirm such a speculation

Agricultural methane emissions and the potential formitigation

Funding Information: The input of P.S. contributes to projects DEVIL (grant no. NE/M021327/1) and Soils-R-GRREAT (grant no. NE/P019455/1).Peer reviewedPostprin

Quantifying, Projecting, and Addressing India's Hidden Hunger

<p>It is estimated that more than two billion people suffer from ‘hidden hunger’ (micronutrient malnutrition) globally, with nearly half living in India. Despite being highlighted as one the most cost-effective investments for human development, progress on addressing micronutrient deficiencies (MiND) has been slowing. The severe social, health, and economic costs of MiND in India should make it a top priority for domestic governance and international donors alike. This study, for the first time, maps food system pathways from crop production through to household-level food availability, for a range of key vitamins, minerals, and amino acids. Results suggest widespread (>80% total Indian population) risk of deficiencies in calcium, vitamin A, B₁₂, folate, in addition to lysine limitation, with more localized deficiencies (<25% population) in iron, zinc, and vitamin B₆. These deficiencies are the result of a combination of a monotonous cereal-dominated diet lacking in diversity, and overall insufficient food intake. This approach also allowed for “MiND by micronutrient” scenario analysis to 2030, to identify potential intervention points in the food system and the capacity of these interventions to address deficiency. Scenario analysis to 2030 and 2050 indicates that, although increased availability of animal-based products, reduction of supply chain losses, and close to maximum (90%) attainable yields could make some contribution to addressing Indian MiND, additional intervention strategies will be essential. Recommendations for intervention in the short (urgent), near-term (2030), and long-term (2050) have been formulated based on this analysis.</p

Recent research developments in polymer heat exchangers: a review

Due to their low cost, light weight and corrosive resistant features, polymer heat exchangers have been intensively studied by researchers with the aim to replace metallic heat exchangers in a wide range of applications. This paper reviews the development of polymer heat exchangers in the last decade, including cutting edge materials characteristics, heat transfer enhancement methods of polymer materials and a wide range of polymer heat exchanger applications. Theoretical modelling and experimental testing results have been reviewed and compared with literature. A recent development, the polymer micro-hollow fibre heat exchanger, is introduced and described. It is shown that polymer materials do hold promise for use in the construction of heat exchangers in many applications, but that a considerable amount of research is still required into material properties, thermal performance and life-time behaviour

A review on graphene based nanofluids: preparation, characterization and applications

A wide range of heat transfer systems require efficient heat transfer management from source to sink and vice versa. Over the last decade, graphene nanoparticles, matrix nanofluids have been one of the most investigated nanoparticles for a wide range of engineering applications. Graphene–based nanoparticles have several advantages over other nanoparticles: high stability, high thermal conductivity, low erosion and corrosion, and higher carrier mobility. Graphene–based nanofluids have found applications such as heat transfer, defect sensor, anti–infection therapy, energy harvesting systems, biomedical and cosmetics. With advancement of technology, more compact and efficient cooling media are needed to ensure efficiency and reliability of engineering systems and devices. This research study reports an overview of experimental and numerical investigations of graphene nanometer–sized particles with different base host fluids for major engineering applications of energy transfer systems and further thermophysical properties of graphene nanofluids