What do English speakers know about gera-gera and yota-yota?: A cross-linguistic investigation of mimetic words for laughing and walking

The relation between word form and meaning is considered arbitrary; however, Japanese mimetic words, giseigo and gitaigo , are exceptions. For giseigo (words mimicking voices), there is a direct resemblance(‘iconicity’) between the sound of the word and the sound it refers to; for gitaigo (words that mimic manners/states) there is a symbolic relationship (‘sound symbolism’) between the sound and the manner/state to which the word refers. While native speakers intuitively recognize these relationships, it is questionable whether speakers of other languages are able to access the meaning of Japanese mimetic words from their sounds. In the current study, we asked native English speakers with no prior experience with the Japanese language to listen to Japanese mimetic words for laughing (giseigo) and for walking (gitaigo), and rate each word’s meaning on semantic differential scales (e.g.,“GRACEFUL-VULGAR”(laughing,“GRACEFUL-CLUMSY”(walking). We compared English and Japanese speakers’ ratings and found that English speakers construed many of the features of laughing in a similar manner as Japanese native speakers (e.g., words containing /a/ were rated as more amused, cheerful, nice and pleasant laughs). They differed only with regard to a few sound-meaning relationships of an evaluative nature (e.g., words for laughing containing /u/ were rated as more feminine and graceful, and those containing /e/ were rated as less graceful and unpleasant). In contrast, for the words referring to walking, English speakers’ ratings differed greatly from native Japanese speakers’. Native Japanese speakers rated words beginning with voiced consonants as referring to a big person walking with big strides, and words beginning with voiceless consonants as more even-paced, feminine and formal walking; English speakers were sensitive only to the relation between voiced consonants and a big person walking. Hence, some sound-meaning associations were language-specific. This study also confirmed the more conventional and lexicalized nature of the mimetic words of manner

Presyncope Is Associated with Intensive Care Unit Admission in Emergency Department Patients with Acute Pulmonary Embolism

Introduction: Syncope is common among emergency department (ED) patients with acute pulmonary embolism (PE) and indicates a higher acuity and worse prognosis than in patients without syncope. Whether presyncope carries the same prognostic implications has not been established. We compared incidence of intensive care unit (ICU) admission in three groups of ED PE patients: those with presyncope; syncope; and neither.Methods: This retrospective cohort study included all adults with acute, objectively confirmed PE in 21 community EDs from January 2013–April 2015. We combined electronic health record extraction with manual chart abstraction. We used chi-square test for univariate comparisons and performed multivariate analysis to evaluate associations between presyncope or syncope and ICU admission from the ED, reported as adjusted odds ratios (aOR) with 95% confidence intervals (CI).Results: Among 2996 PE patients, 82 (2.7%) had presyncope and 109 (3.6%) had syncope. ICU admission was similar between groups (presyncope 18.3% vs syncope 25.7%) and different than their non-syncope counterparts (either 22.5% vs neither 4.7%; p<0.0001). On multivariate analysis, both presyncope and syncope were independently associated with ICU admission, controlling for demographics, higher-risk PE Severity Index (PESI) class, ventilatory support, proximal clot location, and submassive and massive PE classification: presyncope, aOR 2.79 (95% CI, 1.40, 5.56); syncope, aOR 4.44 (95% CI 2.52, 7.80). These associations were only minimally affected when excluding massive PE from the model. There was no significant interaction between either syncope or presyncope and PESI, submassive or massive classification in predicting ICU admission.Conclusion: Presyncope appears to carry similar strength of association with ICU admission as syncope in ED patients with acute PE. If this is confirmed, clinicians evaluating patients with acute PE may benefit from including presyncope in their calculus of risk assessment and site-of-care decision-making

ギセイゴ ・ ギタイゴ ノ オト トクチョウ : エイゴ ワシャ ハ ドンナ ワライ カタ ・ アルキ カタ ト トラエル ノカ

The relation between word form and meaning is considered arbitrary; however, Japanese mimetic words, giseigo and gitaigo, are exceptions. For giseigo (words mimicking voices), there is a direct resemblance (‘ico-nicity’) between the sound of the word and the sound it refers to; for gitaigo (words that mimic manners/states) there is a symbolic relationship (‘sound symbolism’) between the sound and the manner/state to which the word refers. While native speakers intuitively recognize these relationships, it is questionable whether speakers of other languages are able to access the meaning of Japanese mimetic words from their sounds. In the current study, we asked native English speakers with no prior experience with the Japanese language to listen to Japanese mimetic words for laughing (giseigo) and for walking (gitaigo), and rate each word’meaning on semantic differential scales (e.g. s “GRACEFUL-VULGAR” (laughing), “GRACEFUL-CLUMSY” (walking)). We compared English and Japanese speakers’ ratings and found that English speakers construed many of the features of laughing in a similar manner as native Japanese speakers (e.g., words containing /a/ were rated as more amused, cheerful, nice and pleasant laughs). They differed only with regard to a few sound-meaning relationships of an evaluative nature (e.g., words for laughing containing /u/ were rated as more feminine and graceful, and those containing /e/ were rated as less graceful and unpleasant). In contrast, for the words referring to walking, English speakers’ ratings differed greatly from native Japanese speakers’. Native Japanese speakers rated words beginning with voiced consonants as referring to a big person walking with big strides, and words beginning with voiceless consonants as more even-paced, feminine and formal walking; English speakers were sensitive only to the relation between voiced consonants and a big person walking. Hence, some sound-meaning associations were language-specific. This study also confirmed the more conventional and lexicalized nature of the mimetic words of manner.The relation between word form and meaning is considered arbitrary; however, Japanese mimetic words, giseigo and gitaigo, are exceptions. For giseigo (words mimicking voices), there is a direct resemblance (‘ico-nicity’) between the sound of the word and the sound it refers to; for gitaigo (words that mimic manners/states) there is a symbolic relationship (‘sound symbolism’) between the sound and the manner/state to which the word refers. While native speakers intuitively recognize these relationships, it is questionable whether speakers of other languages are able to access the meaning of Japanese mimetic words from their sounds. In the current study, we asked native English speakers with no prior experience with the Japanese language to listen to Japanese mimetic words for laughing (giseigo) and for walking (gitaigo), and rate each word’meaning on semantic differential scales (e.g. s “GRACEFUL-VULGAR” (laughing), “GRACEFUL-CLUMSY” (walking)). We compared English and Japanese speakers’ ratings and found that English speakers construed many of the features of laughing in a similar manner as native Japanese speakers (e.g., words containing /a/ were rated as more amused, cheerful, nice and pleasant laughs). They differed only with regard to a few sound-meaning relationships of an evaluative nature (e.g., words for laughing containing /u/ were rated as more feminine and graceful, and those containing /e/ were rated as less graceful and unpleasant). In contrast, for the words referring to walking, English speakers’ ratings differed greatly from native Japanese speakers’. Native Japanese speakers rated words beginning with voiced consonants as referring to a big person walking with big strides, and words beginning with voiceless consonants as more even-paced, feminine and formal walking; English speakers were sensitive only to the relation between voiced consonants and a big person walking. Hence, some sound-meaning associations were language-specific. This study also confirmed the more conventional and lexicalized nature of the mimetic words of manner

L AREA WASTEWATER STORAGE DRUM EVALUATION

This report documents the determination of the cause of pressurization that led to bulging deformation of a 55 gallon wastewater drum stored in L-Area. Drum samples were sent to SRNL for evaluation. The interior surface of these samples revealed blistering and holes in the epoxy phenolic drum liner and corrosion of the carbon steel drum. It is suspected that osmotic pressure drove permeation of the water through the epoxy phenolic coating which was weakened from exposure to low pH water. The coating failed at locations throughout the drum interior. Subsequent corrosion of the carbon steel released hydrogen which pressurized the drum causing deformation of the drum lid. Additional samples from other wastewater drums on the same pallet were also evaluated and limited corrosion was visible on the interior surfaces. It is suspected that, with time, the corrosion would have advanced to cause pressurization of these sealed drums

Penalty Corner Routines in Elite Women’s Indoor Field Hockey: Prediction of Outcomes based on Tactical Decisions

Indoor hockey is a highly competitive international sport, yet no research to date has investigated the key actions within this sport. As with outdoor field hockey, penalty corners represent one of the most likely situations in which goals can be scored. All 36 matches of the round-robin phase of the 2010-2011 England Hockey League Women’s Premier Division ‘Super Sixes’ competition were analysed with the purpose of establishing which factors can predict the scoring of a goal using Binary Logistic Regression analysis. Seventy two (22.6%) of the 319 observed penalty corners resulted in a goal. The strongest predictor of scoring a goal was taking the penalty corner from the goalkeeper’s right. Based on the odds ratio (OR), the odds of the attacking team scoring were 2.27 (CI = 1.41 - 3.65) times higher with penalty corners taken from the goalkeeper’s right as opposed to the left. Additionally, if the goalkeeper decided to rush to the edge of the circle, the odds of the attacking team failing to score were 2.19 (CI = 1.18 - 4.08) times higher compared to when the goalkeeper remained near the goal line. These results suggest that strategic decisions from the players and coaches have an important part to play in the success of penalty corners. Future research should investigate the impact of goalkeepers’ movement and further examine the technical and tactical intricacies of penalty corners

Minimum Technical Data Elements for Liquid Biopsy Data Submitted to Public Databases

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/154656/1/cpt1747.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/154656/2/cpt1747-sup-0001-FigS1.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/154656/3/cpt1747_am.pd

Scapular winging: anatomical review, diagnosis, and treatments

Scapular winging is a rare debilitating condition that leads to limited functional activity of the upper extremity. It is the result of numerous causes, including traumatic, iatrogenic, and idiopathic processes that most often result in nerve injury and paralysis of either the serratus anterior, trapezius, or rhomboid muscles. Diagnosis is easily made upon visible inspection of the scapula, with serratus anterior paralysis resulting in medial winging of the scapula. This is in contrast to the lateral winging generated by trapezius and rhomboid paralysis. Most cases of serratus anterior paralysis spontaneously resolve within 24 months, while conservative treatment of trapezius paralysis is less effective. A conservative course of treatment is usually followed for rhomboid paralysis. To allow time for spontaneous recovery, a 6–24 month course of conservative treatment is often recommended, after which if there is no recovery, patients become candidates for corrective surgery

Transcriptional and Post-Transcriptional Regulation of SPAST, the Gene Most Frequently Mutated in Hereditary Spastic Paraplegia

Hereditary spastic paraplegias (HSPs) comprise a group of neurodegenerative disorders that are characterized by progressive spasticity of the lower extremities, due to axonal degeneration in the corticospinal motor tracts. HSPs are genetically heterogeneous and show autosomal dominant inheritance in ∼70–80% of cases, with additional cases being recessive or X-linked. The most common type of HSP is SPG4 with mutations in the SPAST gene, encoding spastin, which occurs in 40% of dominantly inherited cases and in ∼10% of sporadic cases. Both loss-of-function and dominant-negative mutation mechanisms have been described for SPG4, suggesting that precise or stoichiometric levels of spastin are necessary for biological function. Therefore, we hypothesized that regulatory mechanisms controlling expression of SPAST are important determinants of spastin biology, and if altered, could contribute to the development and progression of the disease. To examine the transcriptional and post-transcriptional regulation of SPAST, we used molecular phylogenetic methods to identify conserved sequences for putative transcription factor binding sites and miRNA targeting motifs in the SPAST promoter and 3′-UTR, respectively. By a variety of molecular methods, we demonstrate that SPAST transcription is positively regulated by NRF1 and SOX11. Furthermore, we show that miR-96 and miR-182 negatively regulate SPAST by effects on mRNA stability and protein level. These transcriptional and miRNA regulatory mechanisms provide new functional targets for mutation screening and therapeutic targeting in HSP