Meaningful learning in management: recombining strands of knowledge DNA through engaged dialog and generative conflict

This paper explores how meaningful learning objectives in management classes are pursued when the focus is on classroom activities and strategies that foster transformative thought, adaptive growth, and commitment from both instructors and students to achieve meaningful learning. To this end, we offer a metaphor and a context for this approach to learning. The DNA of learning metaphor details effective pedagogical practices and encourages instructors to take a more challenging and possibly transformative approach to their course design and classroom experiences

Siren

Siren is a ritualized performance inspired by the Aveiro para-hydromorphic Regosal - the constantly changing boundary between land and water. Breathing, voluntary and involuntary muscle movements and dual heartbeats compose the sound. The performance is accompanied by an interactive video-art piece edited from a film taken from a site-specific performance at the Aveiro wetlands

Positron emission tomography with f18-fluorodeoxyglucose in the staging and preoperative evaluation of malignant pleural mesothelioma

AbstractObjectives: The purpose of this study was to evaluate the utility of positron emission tomography with F18-fluorodeoxyglucose in the preoperative evaluation and staging of malignant mesothelioma in patients who were candidates for aggressive combined modality therapy. Methods: Eighteen consecutive patients with biopsy-proven malignant mesothelioma underwent positron emission tomographic scanning. The results of positron emission tomographic imaging were compared with results obtained by computed tomography, mediastinoscopy, thoracoscopy, and pathologic examination of surgical specimens. All patients fasted and received an average of 14.5 ± 2.7 mCi of F18-fluorodeoxyglucose for positron emission tomographic scanning. Attenuation-corrected whole-body and regional emission images of the chest and upper abdomen were acquired and formatted into transaxial, coronal, and sagittal images. Results: All primary malignant mesotheliomas accumulated F18-fluorodeoxyglucose, and the mean standardized uptake value was 7.6 (range, 3.33-14.85; n = 9). There were no false-negative results of positron emission tomography. Identification of occult extrathoracic metastases by positron emission tomography was the basis for excluding two patients from surgical therapy. There were two false-positive results of positron emission tomography: increased F18-fluorodeoxyglucose uptake in the contralateral chest that was negative by thoracoscopic biopsy (n = 1) and increased abdominal F18-fluorodeoxyglucose uptake after partial colectomy for diverticular disease (n = 1). Conclusions: Positron emission tomography can identify malignant pleural mesothelioma and appears to be a useful noninvasive staging modality for patients being considered for aggressive combined modality therapy. (J Thorac Cardiovasc Surg 2000;120:128-33

Testing of a 10-meter Quadrant Solar Sail

The purpose of this paper is to address the technical challenges and requirements of modal testing a solar sail system (Fig. 1). Specific objectives of this work are to investigate the effectiveness (i.e. accuracy, precision, repeatability, etc.) of laser vibrometer measurements obtained on solar sail components (i.e. sail membrane quadrant and masts) actuated with various excitation methods in vacuum conditions. Results from this work will be used to determine the appropriate test technique for testing large scale full quadrant flight-like solar sail system hardware in vacuum conditions. This paper will focus on the dynamic tests conducted in-vacuum on a 10-meter solar sail quadrant development by AEC-ABLE as part of a ground demonstrator system development program funded by NASA's In-Space Propulsion program. One triangular shaped quadrant of a solar sail membrane (Fig. 2) was modal tested in a 1 Torr vacuum environment using various excitation techniques including, shaker excitation through the masts, magnetic excitation (Ref. 3), and surface-bonded piezoelectric patch actuators (Ref. 4 & 5). The excitation methods are evaluated for their applicability to in-vacuum ground testing and their traceability to the development of on-orbit flight test techniques. The solar sail masts (Fig. 3) were also tested in ambient atmospheric conditions and vacuum using various excitation techniques and these methods will also be assessed for their ground test capabilities and traceability to on-orbit flight testing

Concert recording 2022-11-17

[Track 1]. Viking Horn Trio, No. 8, “The Sacred Oak Tree” / Robert Martin -- [Track 2]. Dorn Horn Trio. 1. Maestoso ; 3. Moving right along / Fred W. Teuber -- [Track 3]. Concerto in C minor, op. 8. Allegro molto / Franz Strauss -- [Track 4]. Selected duets for horn. Moderato ; Cantabile / Voxman -- [Track 5]. Romance, op. 67 / Camille Saint-Saëns -- [Track 6]. Four Duets for Horn. 1. Introduction ; 2. Watlz ; 4. Intermezzo / Kerry Turner -- [Track 7]. Three for Five. 1-3 / James Naigus -- [Track 8]. Benedixti / Giovanni Gabrielli -- [Track 9]. Let Me Fly / arr. Robert Cormier ; Chris Dorner

Concert recording 2022-11-17

[Track 1]. Viking Horn Trio, No. 8, “The Sacred Oak Tree” / Robert Martin -- [Track 2]. Dorn Horn Trio. 1. Maestoso ; 3. Moving right along / Fred W. Teuber -- [Track 3]. Concerto in C minor, op. 8. Allegro molto / Franz Strauss -- [Track 4]. Selected duets for horn. Moderato ; Cantabile / Voxman -- [Track 5]. Romance, op. 67 / Camille Saint-Saëns -- [Track 6]. Four Duets for Horn. 1. Introduction ; 2. Watlz ; 4. Intermezzo / Kerry Turner -- [Track 7]. Three for Five. 1-3 / James Naigus -- [Track 8]. Benedixti / Giovanni Gabrielli -- [Track 9]. Let Me Fly / arr. Robert Cormier ; Chris Dorner

Computational Social Science

A field is emerging that leverages the capacity to collect and analyze data at a scale that may reveal patterns of individual and group behaviors.Governmen

RoSETZ: Roman Survey of the Earth Transit Zone -- a SETI-optimized survey for habitable-zone exoplanets

In this White Paper for Nancy Grace Roman Space Telescope (Roman) science, we propose the Roman Survey of the Earth Transit Zone (RoSETZ), a transit search for rocky planets within the habitable zones (HZs) of stars located within the Earth Transit Zone (ETZ). The ETZ holds special interest in the search for extra-terrestrial intelligence (SETI) - observers on planets within the ETZ can see Earth as a transiting planet. RoSETZ would augment the Roman Galactic Bulge Time Domain Survey (GBTDS) as an additional field located $\sim 5$~degrees away from other GBTDS fields. Our simulations show that RoSETZ alone can find from 120 to 630 Earth-sized HZ planets around K- and M-type hosts, with the range reflecting different survey design assumptions. These yields are 5-20 times the number currently known. Such a sample will transform our knowledge of ``Eta-Earth'' ($\eta_{\oplus}$) -- the occurrence of Earth-sized HZ planets -- and would be the first catalogue of exoplanets selected in a manner optimized according to the Mutual Detectability targetted-SETI strategy. If it can be accommodated alongside the existing GBTDS design, we favour a RoSETZ-Max design that is observed for the duration of the GBTDS. If not, we show that a slimmed-down RoSETZ-Lite design, occupying two GBTDS seasons, would not significantly impact overall GBTDS exoplanet yields, even if time allocated to it had to come from time allocations to other fields. We argue that the angular separation of RoSETZ from other GBTDS fields permits self-calibration of systematic uncertainties that would otherwise hamper exoplanet demographic modelling of both microlensing and transit datasets. Other science possible with RoSETZ data include studies of small solar system bodies and high resolution 3D extinction mapping.Comment: 20 pages. Submission to the NASA Roman Core Community Surveys White Paper Cal

A systematic review on health resilience to economic crises

Background The health effects of recent economic crises differ markedly by population group. The objective of this systematic review is to examine evidence from longitudinal studies on factors influencing resilience for any health outcome or health behaviour among the general population living in countries exposed to financial crises. Methods We systematically reviewed studies from six electronic databases (EMBASE, Global Health, MEDLINE, PsycINFO, Scopus, Web of Science) which used quantitative longitudinal study designs and included: (i) exposure to an economic crisis; (ii) changes in health outcomes/behaviours over time; (iii) statistical tests of associations of health risk and/or protective factors with health outcomes/behaviours. The quality of the selected studies was appraised using the Quality Assessment Tool for Quantitative Studies. PRISMA reporting guidelines were followed. Results From 14,584 retrieved records, 22 studies met the eligibility criteria. These studies were conducted across 10 countries in Asia, Europe and North America over the past two decades. Ten socio-demographic factors that increased or protected against health risk were identified: gender, age, education, marital status, household size, employment/occupation, income/ financial constraints, personal beliefs, health status, area of residence, and social relations. These studies addressed physical health, mortality, suicide and suicide attempts, mental health, and health behaviours. Women’s mental health appeared more susceptible to crises than men’s. Lower income levels were associated with greater increases in cardiovascular disease, mortality and worse mental health. Employment status was associated with changes in mental health. Associations with age, marital status, and education were less consistent, although higher education was associated with healthier behaviours. Conclusions Despite widespread rhetoric about the importance of resilience, there was a dearth of studies which operationalised resilience factors. Future conceptual and empirical research is needed to develop the epidemiology of resilience

Avelumab in paediatric patients with refractory or relapsed solid tumours: dose-escalation results from an open-label, single-arm, phase 1/2 trial

Background: We report dose-escalation results from an open-label, phase 1/2 trial evaluating avelumab (anti-PD-L1) in paediatric patients with refractory/relapsed solid tumours. Methods: In phase 1, patients aged \u3c 18 years with solid (including central nervous system [CNS]) tumours for which standard therapy did not exist or had failed were enrolled in sequential cohorts of 3–6 patients. Patients received avelumab 10 or 20 mg/kg intravenously every 2 weeks. Primary endpoints were dose-limiting toxicities (DLTs) and grade ≥ 3 treatment-emergent adverse events (AEs). Results: At data cut-off (27 July 2021), 21 patients aged 3–17 years had received avelumab 10 mg/kg (n = 6) or 20 mg/kg (n = 15). One patient had three events that were classified as a DLT (fatigue with hemiparesis and muscular weakness associated with pseudoprogression; 20 mg/kg cohort). Grade ≥ 3 AEs occurred in five (83%) and 11 (73%) patients in the 10 and 20 mg/kg cohorts, respectively, and were treatment-related in one patient (7%; grade 3 [DLT]) in the 20 mg/kg cohort. Avelumab exposure in paediatric patients receiving 20 mg/kg dosing, but not 10 mg/kg, was comparable or higher compared with approved adult dosing (10 mg/kg or 800 mg flat dose). No objective responses were observed. Four patients with CNS tumours (20 mg/kg cohort) achieved stable disease, which was ongoing in two patients with astrocytoma at cut-off (for 24.7 and 30.3 months). Conclusion: In paediatric patients with refractory/relapsed solid tumours, avelumab monotherapy showed a safety profile consistent with previous adult studies, but clinical benefits were limited