5,744 research outputs found

    An inclusive approach to partnerships for the Sustainable Development Goals (SDGs): Using a relationship lens to explore the potential for transformational collaboration

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    Partnerships are positioned as critical for the achievement of the Sustainable Development Goals and the United Nations transformational agenda for 2030. The widespread use of terms such as ā€˜collaborationā€™, ā€˜partnershipā€™ and ā€˜cooperationā€™ has, however, led to debates about the expectations of such relationships and calls have been made for more rigorous clarification and classification of these related concepts. Drawing upon a comprehensive literature review, we argue in this conceptual paper that the broad spectrum of personal and organizational interactions within, between and across different sectors, domains, disciplines and contexts makes the quest to delineate and categorize these diverse forms of collaboration a seemingly impossible task. We further suggest that such efforts advance a narrow view of partnership as little more than a means to an end, thus limiting understanding of the integrative and intrinsic value of working in this way. We believe that a more inclusive understanding of partnerships may be achieved by exploring them through a relationship lens that acknowledges the importance of inter-personal connections in partnerships more deeply. In doing so, the capacity of partnerships to generate the systemic change that is at the heart of the 2030 Agenda for Sustainable Development may be enhanced and ultimately realized

    Prosomal-width-to-weight relationships in American horseshoe crabs (Limulus polyphemus): examining conversion factors used to estimate landings

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    Horseshoe crabs (Limulus polyphemus) are valued by many stakeholders, including the commercial fishing industry, biomedical companies, and environmental interest groups. We designed a study to test the accuracy of the conversion factors that were used by NOAA Fisheries and state agencies to estimate horseshoe crab landings before mandatory reporting that began in 1998. Our results indicate that the NOAA Fisheries conversion factor consistently overestimates the weight of male horseshoe crabs, particularly those from New England populations. Because of the inaccuracy of this and other conversion factors, states are now mandated to report the number (not biomass) and sex of landed horseshoe crabs. However, accurate estimates of biomass are still necessary for use in prediction models that are being developed to better manage the horseshoe crab fishery. We recommend that managers use the conversion factors presented in this study to convert current landing data from numbers to biomass of harvested horseshoe crabs for future assessments

    The ā€˜strength of weak tiesā€™ among female baboons : fitness-related benefits of social bonds

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    Thanks to Cape Nature Conservation for permission to work at De Hoop, and to all the graduate students and field assistants who contributed to our long-term data-base. LB was supported by NSERC Canada Research Chair and Discovery Programs; SPH was supported by the NRF (South Africa) and NSERC Discovery Grants during the writing of this manuscript. We are grateful to one anonymous reviewer and, in particular, Lauren Brent for invaluable feedback on earlier drafts of our manuscript.Peer reviewedPostprin

    Random plasma glucose in early pregnancy is a better predictor of gestational diabetes diagnosis than maternal obesity.

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    AIMS/HYPOTHESIS: Asymptomatic pregnant women are screened for gestational diabetes (GDM) at 24-28 weeks' gestation. Recent guidelines also recommend screening early in gestation to identify undiagnosed pre-existing overt diabetes. We assessed the performance of random plasma glucose (RPG) testing at antenatal booking in predicting GDM diagnosis later in pregnancy. METHODS: Data from 25,543 consecutive singleton pregnancies at the Rosie Hospital in Cambridge (UK) were obtained from hospital electronic records as a service evaluation. All women were invited for an antenatal RPG (12-16 weeks) and a 50 g glucose challenge test (GCT; 24-28 weeks) with a 75 g OGTT if GCT >7.7 mmol/l (139 mg/dl). RESULTS: At booking, 17,736 women had an RPG that was able to predict GDM (receiver operating characteristic AUC 0.8) according to various diagnostic criteria in common use. A cut-off point of ā‰„7.5 mmol/l (135 mg/dl) gave a sensitivity of 0.70 and a specificity of 0.90 for GDM diagnosis. Theoretically, using this screening policy, 13.2% of women would have been categorised at high risk (26.3% had GDM) and 86.8% of women at low risk (1.7% had GDM). RPG performed better than maternal age (AUC 0.60) or BMI (AUC 0.65) at predicting GDM diagnosis. CONCLUSIONS/INTERPRETATION: RPG at booking has reasonable performance as a screening test and is better than maternal age or BMI for identifying women at high risk of GDM. RPG cannot replace OGTT for diagnosis but it may be useful to exclude women who do not need further investigation for GDM and to identify women who could be prioritised for early diagnosis or lifestyle interventions.This project was not supported by any specific funding. Claire Meek receives salary funding from the European Union Seventh Framework Programme (FP7/2007-2013; grant agreement nĀ° 266408) and from the Wellcome Trust Translational Medicine and Therapeutics Programme which is funded by the Wellcome Trust in association with Glaxo SmithKline.This is the final version of the article. It was first available from Springer via http://dx.doi.org/10.1007/s00125-015-3811-

    Transition from cMyc to L-Myc during dendritic cell development coordinated by rising levels of IRF8

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    During dendritic cell (DC) development, Myc expression in progenitors is replaced by Mycl in mature DCs, but when and how this transition occurs is unknown. We evaluated DC development using reporters for MYC, MYCL, and cell cycle proteins Geminin and CDT1 in wild-type and various mutant mice. For classical type 1 dendritic cells (cDC1s) and plasmacytoid DCs (pDCs), the transition occurred upon their initial specification from common dendritic cell progenitors (CDPs) or common lymphoid progenitors (CLPs), respectively. This transition required high levels of IRF8 and interaction with PU.1, suggesting the use of EICEs within Mycl enhancers. In pDCs, maximal MYCL induction also required the +41kb Irf8 enhancer that controls pDC IRF8 expression. IRF8 also contributed to repression of MYC. While MYC is expressed only in rapidly dividing DC progenitors, MYCL is most highly expressed in DCs that have exited the cell cycle. Thus, IRF8 levels coordinate the Myc-Mycl transition during DC development

    An upper-limit on the linear polarization fraction of the GW170817 radio continuum

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    We present late-time radio observations of GW170817, the first binary neutron star merger discovered through gravitational waves by the advanced LIGO and Virgo detectors. Our observations, carried out with the Karl G. Jansky Very Large Array, were optimized to detect polarized radio emission, and thus to constrain the linear polarization fraction of GW170817. At an epoch of ~244 days after the merger, we rule out linearly polarized emission above a fraction of ~12% at a frequency of 2.8 GHz (99% confidence). Within the structured jet scenario (a.k.a. successful jet plus cocoon system) for GW170817, the derived upper-limit on the radio continuum linear polarization fraction strongly constrains the magnetic field configuration in the shocked ejecta. We show that our results for GW170817 are compatible with the low level of linear polarization found in afterglows of cosmological long gamma-ray bursts. Finally, we discuss our findings in the context of future expectations for the study of radio counterparts of binary neutron star mergers identified by ground-based gravitational-wave detectors.Comment: 5 pages, 2 figures, 1 tabl

    Kennesaw State University - Maintenance Optimization and Cost Analysis

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    The Department of Housing and Residence Life was looking for ways to improve the quality of their work while saving costs at the same time. The department allowed the team to look over their work orders where the team noticed over 50% of the work orders were related to room turnover. After this discovery, the team focused all efforts on room turnover and went over the process in detail with management. The team asked to see the standard operating procedure for room turnover and learned that most of the staff did not know they had one. The team wanted to investigate why the staff was not aware of the SOP, so the team met with the assistant director of housing facilities to discuss why the SOP was not in use. He expressed that the SOP was not specific enough to direct the technicians in what the department was looking for. This led the team to begin thinking about creating a new SOP. After some research, the team learned that reducing variability was a good way of saving costs and that standard operating procedures were a reliable way of reducing variability. The team spoke with the department and reached the decision that a new SOP was the right decision for the department. The team began by shadowing the technicians to learn how the procedure should be done and where improvements could be made. As the team shadowed, they learned that resident assistants were supposed to be performing the inspections. This inspired the team to continue with creating the SOP but to also fully shift inspection duties to the resident assistants. After discussions with the housing department management, the new SOP created by the team was accepted and the trial runs with resident directors performing the inspections began. The team recommended that the department make the new SOP available to all resident and student assistants to ensure that each inspection was done in the same manner to reduce variability and rework

    A survey of X-ray emission from 100 kpc radio jets

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    We have completed a Chandra snapshot survey of 54 radio jets that are extended on arcsec scales. These are associated with flat spectrum radio quasars spanning a redshift range z=0.3 to 2.1. X-ray emission is detected from the jet of approximately 60% of the sample objects. We assume minimum energy and apply conditions consistent with the original Felten-Morrison calculations in order to estimate the Lorentz factors and the apparent Doppler factors. This allows estimates of the enthalpy fluxes, which turn out to be comparable to the radiative luminosities.Comment: Conference Proceedings IAU Symposium No. 313, Extragalactic jets from every angle, pp. 219-224, 4 figure
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