Anderson, David A., III

Eisenman, Robert N.

Murphy, Kenneth M.

Murphy, Theresa L.

English

Digital Commons@Becker

Supplementary Information for  The MYCL and MXD1 transcription factors regulate the fitness of murine dendritic cells   David A. Anderson III, Theresa L. Murphy, Robert N. Eisenman, Kenneth M. Murphy  Email:  kmurphy@wustl.edu   This PDF file includes:  Tables S1 to S6                                    www.pnas.org/cgi/doi/10.1073/pnas.1915060117 Gene Set SIZE NES p-val q-val GO_RIBOSOME_BIOGENESIS 247 2.03 0.00 0.03 GO_RRNA_METABOLIC_PROCESS 203 2.02 0.00 0.02 GO_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_NONSENSE_MEDIATED_DECAY 98 2.02 0.00 0.01 GO_TRANSLATIONAL_INITIATION 122 1.99 0.00 0.02 GO_FORMATION_OF_TRANSLATION_PREINITIATION_COMPLEX 17 1.95 0.00 0.03 GO_RIBONUCLEOPROTEIN_COMPLEX_BIOGENESIS 351 1.94 0.00 0.02 GO_POSITIVE_REGULATION_OF_TELOMERE_MAINTENANCE 40 1.91 0.00 0.03 GO_RIBOSOMAL_SMALL_SUBUNIT_BIOGENESIS 41 1.90 0.00 0.03 GO_RIBOSOMAL_LARGE_SUBUNIT_BIOGENESIS 38 1.89 0.00 0.03 GO_POSITIVE_REGULATION_OF_TELOMERE_MAINTENANCE_VIA_TELOMERE_LENGTHENING 30 1.88 0.00 0.04 GO_NCRNA_PROCESSING 312 1.86 0.00 0.04 GO_MATURATION_OF_SSU_RRNA 31 1.86 0.00 0.04 GO_RNA_CATABOLIC_PROCESS 195 1.85 0.00 0.04 GO_REGULATION_OF_TELOMERE_MAINTENANCE_VIA_TELOMERE_LENGTHENING 44 1.85 0.00 0.04 GO_MATURATION_OF_5_8S_RRNA 25 1.85 0.00 0.04 GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_ENDOPLASMIC_RETICULUM 85 1.84 0.00 0.04 GO_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_REMOVAL 98 1.83 0.00 0.05 GO_NCRNA_METABOLIC_PROCESS 441 1.80 0.00 0.06 GO_REGULATION_OF_LIPOPROTEIN_LIPASE_ACTIVITY 15 1.79 0.00 0.07 GO_POSITIVE_REGULATION_OF_GLIAL_CELL_DIFFERENTIATION 29 1.79 0.00 0.07 GO_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY 24 1.78 0.00 0.07 GO_NCRNA_CATABOLIC_PROCESS 18 1.77 0.00 0.08 GO_S_ADENOSYLMETHIONINE_METABOLIC_PROCESS 18 1.76 0.00 0.08 GO_CYTOPLASMIC_TRANSLATION 34 1.76 0.00 0.08 GO_MULTI_ORGANISM_METABOLIC_PROCESS 113 1.75 0.00 0.09 GO_PROTEIN_TRANSMEMBRANE_TRANSPORT 44 1.75 0.00 0.09 GO_OXIDATIVE_PHOSPHORYLATION 71 1.74 0.00 0.09 GO_REGULATION_OF_TRANSLATIONAL_ELONGATION 19 1.74 0.00 0.09 GO_EPITHELIAL_STRUCTURE_MAINTENANCE 18 1.73 0.01 0.10 GO_NEGATIVE_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY 16 1.73 0.00 0.09 GO_PROTEIN_LOCALIZATION_TO_MITOCHONDRION 58 1.73 0.00 0.09 GO_MITOCHONDRIAL_TRANSMEMBRANE_TRANSPORT 47 1.72 0.00 0.10 GO_CELLULAR_RESPIRATION 123 1.72 0.00 0.11 GO_RIBONUCLEOPROTEIN_COMPLEX_SUBUNIT_ORGANIZATION 162 1.71 0.00 0.11 GO_REGULATION_OF_MRNA_METABOLIC_PROCESS 98 1.71 0.00 0.11 GO_RNA_SECONDARY_STRUCTURE_UNWINDING 38 1.71 0.00 0.11 GO_AMIDE_BIOSYNTHETIC_PROCESS 425 1.70 0.00 0.11 GO_TRNA_MODIFICATION 49 1.70 0.00 0.11 GO_RIBOSOME_ASSEMBLY 46 1.70 0.00 0.11 GO_MATURATION_OF_SSU_RRNA_FROM_TRICISTRONIC_RRNA_TRANSCRIPT_SSU_RRNA_5_8S_RRNA_LSU_RRNA_ 24 1.69 0.00 0.12 GO_RNA_SPLICING_VIA_TRANSESTERIFICATION_REACTIONS 216 1.69 0.00 0.11 GO_NEGATIVE_REGULATION_OF_MRNA_METABOLIC_PROCESS 28 1.69 0.00 0.12 GO_RNA_MODIFICATION 93 1.69 0.00 0.12 GO_HISTONE_MONOUBIQUITINATION 18 1.69 0.01 0.12 GO_CALCIUM_DEPENDENT_CELL_CELL_ADHESION_VIA_PLASMA_MEMBRANE_CELL_ADHESION_MOLECULES 17 -1.71 0.00 0.13 GO_CELLULAR_DEFENSE_RESPONSE 36 -1.79 0.00 0.09 GO_REGULATION_OF_B_CELL_MEDIATED_IMMUNITY 31 -1.82 0.00 0.07 GO_POSITIVE_REGULATION_OF_ACUTE_INFLAMMATORY_RESPONSE 25 -2.14 0.00 0.01 GO_MEMBRANE_RAFT_ORGANIZATION 16 -2.21 0.00 0.01 GO_POSITIVE_REGULATION_OF_B_CELL_MEDIATED_IMMUNITY 21 -2.42 0.00 0.00  Table S1. GO-based GSEA results for expression microarray experiment on splenic cDC1s isolated at steady state from Mycl+/+ and Myclgfp/gfp mice. The top 50 gene sets are reported and their ranked normalized enrichment scores.  Gene Set SIZE NES p-val q-val GO_RRNA_METABOLIC_PROCESS 203 2.62 0.00 0.00 GO_RIBOSOME_BIOGENESIS 247 2.56 0.00 0.00 GO_TRANSLATIONAL_INITIATION 122 2.47 0.00 0.00 GO_RIBONUCLEOPROTEIN_COMPLEX_BIOGENESIS 351 2.45 0.00 0.00 GO_NCRNA_PROCESSING 312 2.40 0.00 0.00 GO_MULTI_ORGANISM_METABOLIC_PROCESS 113 2.40 0.00 0.00 GO_NCRNA_METABOLIC_PROCESS 441 2.35 0.00 0.00 GO_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_NONSENSE_MEDIATED_DECAY 98 2.34 0.00 0.00 GO_RIBOSOMAL_SMALL_SUBUNIT_BIOGENESIS 41 2.32 0.00 0.00 GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_ENDOPLASMIC_RETICULUM 85 2.28 0.00 0.00 GO_RIBOSOMAL_LARGE_SUBUNIT_BIOGENESIS 38 2.23 0.00 0.00 GO_RIBONUCLEOPROTEIN_COMPLEX_LOCALIZATION 89 2.21 0.00 0.00 GO_RNA_CATABOLIC_PROCESS 195 2.21 0.00 0.00 GO_TRANSLATIONAL_TERMINATION 84 2.20 0.00 0.00 GO_MITOCHONDRIAL_TRANSLATION 96 2.19 0.00 0.00 GO_AMIDE_BIOSYNTHETIC_PROCESS 426 2.19 0.00 0.00 GO_MRNA_METABOLIC_PROCESS 490 2.19 0.00 0.00 GO_MATURATION_OF_SSU_RRNA 31 2.18 0.00 0.00 GO_TRNA_METABOLIC_PROCESS 151 2.18 0.00 0.00 GO_AMINO_ACID_ACTIVATION 46 2.17 0.00 0.00 GO_MATURATION_OF_5_8S_RRNA 25 2.17 0.00 0.00 GO_RIBONUCLEOPROTEIN_COMPLEX_SUBUNIT_ORGANIZATION 162 2.16 0.00 0.00 GO_CLEAVAGE_INVOLVED_IN_RRNA_PROCESSING 16 2.16 0.00 0.00 GO_CELLULAR_PROTEIN_COMPLEX_DISASSEMBLY 110 2.15 0.00 0.00 GO_RNA_3_END_PROCESSING 76 2.15 0.00 0.00 GO_RNA_SPLICING_VIA_TRANSESTERIFICATION_REACTIONS 216 2.15 0.00 0.00 GO_OXIDATIVE_PHOSPHORYLATION 71 2.14 0.00 0.00 GO_NUCLEAR_EXPORT 114 2.14 0.00 0.00 GO_TRANSLATIONAL_ELONGATION 99 2.14 0.00 0.00 GO_REGULATION_OF_TRANSLATIONAL_ELONGATION 19 2.13 0.00 0.00 GO_MATURATION_OF_5_8S_RRNA_FROM_TRICISTRONIC_RRNA_TRANSCRIPT_SSU_RRNA_5_8S_RRNA_LSU_RRNA_ 17 2.13 0.00 0.00 GO_DNA_TEMPLATED_TRANSCRIPTION_TERMINATION 80 2.13 0.00 0.00 GO_MRNA_3_END_PROCESSING 56 2.12 0.00 0.00 GO_RNA_LOCALIZATION 141 2.11 0.00 0.00 GO_MATURATION_OF_SSU_RRNA_FROM_TRICISTRONIC_RRNA_TRANSCRIPT_SSU_RRNA_5_8S_RRNA_LSU_RRNA_ 24 2.10 0.00 0.00 GO_PROTEIN_LOCALIZATION_TO_ENDOPLASMIC_RETICULUM 103 2.08 0.00 0.00 GO_DNA_REPLICATION_INITIATION 21 2.08 0.00 0.00 GO_RNA_SPLICING 284 2.08 0.00 0.00 GO_RIBOSOME_ASSEMBLY 46 2.08 0.00 0.00 GO_MRNA_PROCESSING 339 2.07 0.00 0.00 GO_RRNA_MODIFICATION 18 2.07 0.00 0.00 GO_SPLICEOSOMAL_SNRNP_ASSEMBLY 30 2.06 0.00 0.00 GO_TERMINATION_OF_RNA_POLYMERASE_II_TRANSCRIPTION 46 2.06 0.00 0.00 GO_NEURON_FATE_SPECIFICATION 29 -2.09 0.00 0.01 GO_REGULATION_OF_SYNCYTIUM_FORMATION_BY_PLASMA_MEMBRANE_FUSION 22 -2.21 0.00 0.00 GO_ORGAN_MATURATION 16 -2.25 0.00 0.00 GO_REGULATION_OF_MYOBLAST_FUSION 17 -2.34 0.00 0.00 GO_CHEMOKINE_MEDIATED_SIGNALING_PATHWAY 49 -2.48 0.00 0.00 GO_PHOSPHOLIPASE_C_ACTIVATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY 67 -2.48 0.00 0.00 GO_CALCIUM_INDEPENDENT_CELL_CELL_ADHESION_VIA_PLASMA_MEMBRANE_CELL_ADHESION_MOLECULES 19 -2.68 0.00 0.00 Table S2. GO-based GSEA results for expression microarray experiment on splenic cDC1s isolated at steady state from Myclgfp/+ and Myclgfp/gfp mice. The top 50 gene sets are reported and their ranked normalized enrichment scores. Gene Set SIZE NES p-val q-val GO_RIBOSOME_BIOGENESIS 247 3.66 0.00 0.00 GO_RRNA_METABOLIC_PROCESS 203 3.66 0.00 0.00 GO_TRANSLATIONAL_INITIATION 122 3.64 0.00 0.00 GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_ENDOPLASMIC_RETICULUM 85 3.64 0.00 0.00 GO_MULTI_ORGANISM_METABOLIC_PROCESS 113 3.58 0.00 0.00 GO_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_NONSENSE_MEDIATED_DECAY 98 3.57 0.00 0.00 GO_RIBONUCLEOPROTEIN_COMPLEX_BIOGENESIS 351 3.53 0.00 0.00 GO_PROTEIN_LOCALIZATION_TO_ENDOPLASMIC_RETICULUM 103 3.48 0.00 0.00 GO_NCRNA_PROCESSING 312 3.41 0.00 0.00 GO_NCRNA_METABOLIC_PROCESS 441 3.31 0.00 0.00 GO_RNA_CATABOLIC_PROCESS 195 3.29 0.00 0.00 GO_PROTEIN_TARGETING_TO_MEMBRANE 132 3.23 0.00 0.00 GO_MRNA_METABOLIC_PROCESS 487 3.12 0.00 0.00 GO_RIBOSOME_ASSEMBLY 46 3.01 0.00 0.00 GO_AMIDE_BIOSYNTHETIC_PROCESS 425 2.99 0.00 0.00 GO_RIBONUCLEOPROTEIN_COMPLEX_SUBUNIT_ORGANIZATION 162 2.94 0.00 0.00 GO_VIRAL_LIFE_CYCLE 236 2.90 0.00 0.00 GO_RIBOSOMAL_SMALL_SUBUNIT_BIOGENESIS 41 2.89 0.00 0.00 GO_PEPTIDE_METABOLIC_PROCESS 469 2.89 0.00 0.00 GO_TRNA_METABOLIC_PROCESS 151 2.86 0.00 0.00 GO_RIBOSOMAL_LARGE_SUBUNIT_BIOGENESIS 38 2.84 0.00 0.00 GO_AMINO_ACID_ACTIVATION 46 2.82 0.00 0.00 GO_CHROMOSOME_SEGREGATION 211 2.76 0.00 0.00 GO_CYTOPLASMIC_TRANSLATION 34 2.71 0.00 0.00 GO_SISTER_CHROMATID_SEGREGATION 147 2.66 0.00 0.00 GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_ORGANELLE 296 2.65 0.00 0.00 GO_MITOCHONDRIAL_TRANSLATION 96 2.64 0.00 0.00 GO_MATURATION_OF_SSU_RRNA 31 2.63 0.00 0.00 GO_RNA_SECONDARY_STRUCTURE_UNWINDING 38 2.62 0.00 0.00 GO_NUCLEAR_CHROMOSOME_SEGREGATION 176 2.62 0.00 0.00 GO_SISTER_CHROMATID_COHESION 98 2.62 0.00 0.00 GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_MEMBRANE 224 2.59 0.00 0.00 GO_RIBOSOMAL_LARGE_SUBUNIT_ASSEMBLY 22 2.57 0.00 0.00 GO_RIBONUCLEOPROTEIN_COMPLEX_LOCALIZATION 89 2.56 0.00 0.00 GO_RNA_SPLICING_VIA_TRANSESTERIFICATION_REACTIONS 215 2.56 0.00 0.00 GO_RNA_SPLICING 282 2.53 0.00 0.00 GO_RNA_LOCALIZATION 141 2.52 0.00 0.00 GO_TRANSLATIONAL_ELONGATION 99 2.51 0.00 0.00 GO_MRNA_PROCESSING 336 2.51 0.00 0.00 GO_RNA_MODIFICATION 93 2.50 0.00 0.00 GO_TRNA_MODIFICATION 49 2.49 0.00 0.00 GO_MITOTIC_SISTER_CHROMATID_SEGREGATION 74 2.48 0.00 0.00 GO_TRANSLATIONAL_TERMINATION 84 2.47 0.00 0.00 GO_MATURATION_OF_SSU_RRNA_FROM_TRICISTRONIC_RRNA_TRANSCRIPT_SSU_RRNA_5_8S_RRNA_LSU_RRNA_ 24 2.45 0.00 0.00 GO_ORGANIC_CYCLIC_COMPOUND_CATABOLIC_PROCESS 349 2.45 0.00 0.00 GO_CELLULAR_PROTEIN_COMPLEX_DISASSEMBLY 111 2.45 0.00 0.00 GO_TRANSCRIPTION_COUPLED_NUCLEOTIDE_EXCISION_REPAIR 63 2.44 0.00 0.00 GO_MITOCHONDRIAL_RESPIRATORY_CHAIN_COMPLEX_I_BIOGENESIS 46 2.42 0.00 0.00 GO_OXIDATIVE_PHOSPHORYLATION 71 2.41 0.00 0.00 GO_MULTI_ORGANISM_LOCALIZATION 54 2.40 0.00 0.00 Table S3. GO-based GSEA results for expression microarray experiment on splenic cDC1s isolated after activation with poly I:C from Mycl+/+ and Myclgfp/gfp mice. The top 50 gene sets are reported and their ranked normalized enrichment scores.  NAME SIZE NES p-val q-val GO_SISTER_CHROMATID_COHESION 101 -2.16 0.00 0.00 GO_DNA_REPLICATION_INITIATION 21 -2.15 0.00 0.00 GO_SISTER_CHROMATID_SEGREGATION 150 -2.14 0.00 0.00 GO_MITOTIC_RECOMBINATION 36 -2.12 0.00 0.00 GO_NUCLEAR_CHROMOSOME_SEGREGATION 182 -2.11 0.00 0.00 GO_DNA_DEPENDENT_DNA_REPLICATION 77 -2.08 0.00 0.00 GO_DNA_GEOMETRIC_CHANGE 67 -2.07 0.00 0.00 GO_CHROMOSOME_SEGREGATION 218 -2.06 0.00 0.00 GO_DNA_REPLICATION 166 -2.04 0.00 0.00 GO_MITOTIC_SISTER_CHROMATID_SEGREGATION 74 -2.02 0.00 0.00 GO_MITOTIC_NUCLEAR_DIVISION 306 -2.02 0.00 0.00 GO_TELOMERE_MAINTENANCE_VIA_RECOMBINATION 30 -2.01 0.00 0.00 GO_MEIOTIC_CHROMOSOME_SEGREGATION 45 -1.97 0.00 0.00 GO_DNA_TEMPLATED_TRANSCRIPTION_TERMINATION 80 -1.97 0.00 0.00 GO_TRNA_METABOLIC_PROCESS 151 -1.95 0.00 0.00 GO_RIBONUCLEOPROTEIN_COMPLEX_BIOGENESIS 351 -1.95 0.00 0.00 GO_ORGANELLE_FISSION 400 -1.94 0.00 0.00 GO_MEIOTIC_CELL_CYCLE_PROCESS 113 -1.94 0.00 0.00 GO_CELL_CYCLE_G1_S_PHASE_TRANSITION 93 -1.94 0.00 0.00 GO_MITOTIC_SPINDLE_ORGANIZATION 55 -1.93 0.00 0.00 GO_SPINDLE_CHECKPOINT 24 -1.93 0.00 0.00 GO_DNA_SYNTHESIS_INVOLVED_IN_DNA_REPAIR 55 -1.92 0.00 0.00 GO_CHROMOSOME_ORGANIZATION_INVOLVED_IN_MEIOTIC_CELL_CYCLE 35 -1.92 0.00 0.00 GO_DNA_BIOSYNTHETIC_PROCESS 92 -1.91 0.00 0.00 GO_DNA_CONFORMATION_CHANGE 185 -1.91 0.00 0.00 GO_RNA_MODIFICATION 93 -1.91 0.00 0.00 GO_RECOMBINATIONAL_REPAIR 57 -1.91 0.00 0.00 GO_DNA_DEPENDENT_DNA_REPLICATION_MAINTENANCE_OF_FIDELITY 19 -1.90 0.00 0.00 GO_SPLICEOSOMAL_SNRNP_ASSEMBLY 30 -1.90 0.00 0.00 GO_RECIPROCAL_DNA_RECOMBINATION 31 -1.90 0.00 0.00 GO_DOUBLE_STRAND_BREAK_REPAIR 124 -1.89 0.00 0.00 GO_TRNA_PROCESSING 95 -1.89 0.00 0.00 GO_RRNA_MODIFICATION 18 -1.89 0.00 0.00 GO_RIBOSOME_BIOGENESIS 247 -1.89 0.00 0.00 GO_FORMATION_OF_TRANSLATION_PREINITIATION_COMPLEX 17 -1.89 0.00 0.00 GO_STRAND_DISPLACEMENT 22 -1.88 0.00 0.00 GO_MITOTIC_SPINDLE_ASSEMBLY 32 -1.88 0.00 0.00 GO_CHROMOSOME_LOCALIZATION 47 -1.88 0.00 0.00 GO_HISTONE_MRNA_METABOLIC_PROCESS 26 -1.87 0.00 0.00 GO_SPINDLE_ASSEMBLY 58 -1.87 0.00 0.00 GO_RIBONUCLEOPROTEIN_COMPLEX_SUBUNIT_ORGANIZATION 162 -1.87 0.00 0.00 GO_NCRNA_PROCESSING 312 -1.87 0.00 0.00 GO_MATURATION_OF_5_8S_RRNA 25 -1.87 0.00 0.00 GO_DNA_INTEGRITY_CHECKPOINT 122 -1.86 0.00 0.00 GO_COENZYME_BIOSYNTHETIC_PROCESS 108 -1.86 0.00 0.00 GO_REGULATION_OF_CHROMOSOME_SEGREGATION 74 -1.86 0.00 0.00 GO_TRANSCRIPTION_FROM_RNA_POLYMERASE_I_PROMOTER 33 -1.86 0.00 0.00 GO_CELL_CYCLE_PHASE_TRANSITION 213 -1.86 0.00 0.00 GO_CELLULAR_RESPIRATION 124 -1.86 0.00 0.00 GO_REGULATION_OF_TRANSCRIPTION_INVOLVED_IN_G1_S_TRANSITION_OF_MITOTIC_CELL_CYCLE 22 -1.85 0.00 0.00 Table S4. GO-based GSEA results for expression microarray experiment on splenic cDC1s isolated after activation with poly I:C from Mxd1+/+ and Mxd1-/- mice. The top 50 gene sets are reported and their ranked normalized enrichment scores.  NAME SIZE NES p-val q-val E2F1_Q6 193 -1.89 0.00 0.00 GKCGCNNNNNNNTGAYG_UNKNOWN 49 -1.88 0.00 0.00 E2F_Q6 192 -1.87 0.00 0.00 E2F_02 195 -1.86 0.00 0.00 E2F_Q4 196 -1.85 0.00 0.00 E2F1DP1_01 195 -1.83 0.00 0.00 E2F_03 209 -1.83 0.00 0.00 E2F1DP2_01 195 -1.83 0.00 0.00 E2F_Q3 190 -1.82 0.00 0.00 E2F1_Q6_01 203 -1.82 0.00 0.00 E2F4DP1_01 198 -1.82 0.00 0.00 E2F1DP1RB_01 185 -1.82 0.00 0.00 E2F4DP2_01 195 -1.81 0.00 0.00 E2F1_Q3 200 -1.80 0.00 0.00 SGCGSSAAA_E2F1DP2_01 137 -1.80 0.00 0.00 E2F_Q4_01 204 -1.78 0.00 0.00 E2F1_Q4_01 198 -1.74 0.00 0.00 TMTCGCGANR_UNKNOWN 137 -1.74 0.00 0.00 E2F_Q3_01 203 -1.73 0.00 0.00 E2F_Q6_01 204 -1.72 0.00 0.00 CGGAARNGGCNG_UNKNOWN 45 -1.71 0.00 0.00 KTGGYRSGAA_UNKNOWN 58 -1.71 0.00 0.00 E2F_01 58 -1.71 0.00 0.00 E2F1_Q4 209 -1.65 0.00 0.00 GGAANCGGAANY_UNKNOWN 81 -1.63 0.00 0.00 TCCCRNNRTGC_UNKNOWN 175 -1.61 0.00 0.01 ELK1_02 209 -1.59 0.00 0.01 GABP_B 203 -1.58 0.00 0.01 YGCANTGCR_UNKNOWN 104 -1.56 0.00 0.01 KCCGNSWTTT_UNKNOWN 93 -1.56 0.00 0.01 ACTAYRNNNCCCR_UNKNOWN 363 -1.56 0.00 0.01 ETS_Q4 219 -1.54 0.00 0.01 GGCNKCCATNK_UNKNOWN 104 -1.52 0.00 0.02 NRF2_01 211 -1.52 0.00 0.02 GCCATNTTG_YY1_Q6 354 -1.52 0.00 0.02 NFMUE1_Q6 202 -1.51 0.00 0.02 NRF1_Q6 213 -1.51 0.00 0.02 KMCATNNWGGA_UNKNOWN 73 -1.50 0.01 0.02 MYCMAX_01 210 -1.48 0.00 0.02 MYC_Q2 157 -1.47 0.00 0.03 USF_01 214 -1.47 0.00 0.03 MYCMAX_03 207 -1.47 0.00 0.03 CETS1P54_01 204 -1.46 0.00 0.03 TGCGCANK_UNKNOWN 448 -1.46 0.00 0.03 MAX_01 216 -1.45 0.00 0.03 AACWWCAANK_UNKNOWN 113 -1.45 0.00 0.04 GCGNNANTTCC_UNKNOWN 97 -1.44 0.00 0.04 YY1_02 203 -1.44 0.00 0.04 MYOGNF1_01 39 1.45 0.05 0.24 NFKB_Q6_01 203 1.57 0.00 0.23 Table S5. Transcription factor motif-based GSEA results for expression microarray experiment on splenic cDC1s isolated after activation with poly I:C from Mxd1+/+ and Mxd1-/- mice. The top 50 gene sets and reported by their ranked normalized enrichment scores.  NAME SIZE NES p-val q-val Maturation On 248 3.58 0 0 Cluster 30 66 -2.40 0 0 Cluster 31 67 -2.26 0 0 Table S6. cDC1 maturation gene set-based GSEA results for expression microarray experiment on splenic cDC1s isolated after activation with poly I:C from Mxd1+/+ and Mxd1-/- mice.  

The MYCL and MXD1 transcription factors regulate the fitness of murine dendritic cells

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The MYCL and MXD1 transcription factors regulate the fitness of murine dendritic cells

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