The Role of Risk: Mentoring Experiences and Outcomes for Youth with Varying Risk Profiles

This report presents results from the nation's first large-scale study to examine how youth's levels and sources of risk may influence their mentoring relationships and the benefits they derive from participating in mentoring programs. More and more, mentoring programs are being asked to serve young people who are considered "higher risk." And while mentoring has a strong research base generally, until now relatively little has been known about programs' capacities to serve and produce benefits for these youth.Funded by the Bill & Melinda Gates Foundation, the study involved more than 1,300 youth, drawn from seven programs serving young people in Washington State. Oversight and support for the project were provided by Washington State Mentors. The study looked closely at the backgrounds of participating youth and their mentors, the mentoring relationships that formed, the program supports that were offered, and the benefits youth received -- and examined how these varied for youth with differing profiles (i.e., levels and types) of risk."The Role of Risk" describes the study's methods and findings and considers their implications for practitioners and funders. Overall, the study's results suggest that mentoring programs can benefit youth with a broad range of backgrounds and characteristics. The findings also highlight the importance of youth risk in shaping match experiences, and suggest that programs should do more to tailor training and support based on the specific risks youth face

The Role of Risk: Mentoring Experiences and Outcomes for Youth with Varying Risk Profiles (Executive Summary)

This summary highlights key findings and implications from the nation's first large-scale study to examine how youth's levels and sources of risk may influence their mentoring relationships and the benefits they derive from participating in mentoring programs. More and more, mentoring programs are being asked to serve young people who are considered "higher risk." And while mentoring has a strong research base generally, until now relatively little has been known about programs' capacities to serve and produce benefits for these youth.Funded by the Bill & Melinda Gates Foundation, the study involved more than 1,300 youth, drawn from seven programs serving young people in Washington State. Oversight and support for the project were provided by Washington State Mentors. The study looked closely at the backgrounds of participating youth and their mentors, the mentoring relationships that formed, the program supports that were offered, and the benefits youth received -- and examined how these varied for youth with differing profiles (i.e., levels and types) of risk."The Role of Risk" executive summary describes the study's methods and findings and considers their implications for practitioners and funders. Overall, the study's results suggest that mentoring programs can benefit youth with a broad range of backgrounds and characteristics. The findings also highlight the importance of youth risk in shaping match experiences, and suggest that programs should do more to tailor training and support based on the specific risks youth face

Youth Mentoring: Investigation of Relationship Characteristics and Perceived Benefits

This research examined associations among characteristics of relationships formed in two community-based mentoring programs and their linkages with ratings of perceived benefits for youth

Evaluation of person-level heterogeneity of treatment effects in published multiperson N-of-1 studies: systematic review and reanalysis.

OBJECTIVE:Individual patients with the same condition may respond differently to similar treatments. Our aim is to summarise the reporting of person-level heterogeneity of treatment effects (HTE) in multiperson N-of-1 studies and to examine the evidence for person-level HTE through reanalysis. STUDY DESIGN:Systematic review and reanalysis of multiperson N-of-1 studies. DATA SOURCES:Medline, Cochrane Controlled Trials, EMBASE, Web of Science and review of references through August 2017 for N-of-1 studies published in English. STUDY SELECTION:N-of-1 studies of pharmacological interventions with at least two subjects. DATA SYNTHESIS:Citation screening and data extractions were performed in duplicate. We performed statistical reanalysis testing for person-level HTE on all studies presenting person-level data. RESULTS:We identified 62 multiperson N-of-1 studies with at least two subjects. Statistical tests examining HTE were described in only 13 (21%), of which only two (3%) tested person-level HTE. Only 25 studies (40%) provided person-level data sufficient to reanalyse person-level HTE. Reanalysis using a fixed effect linear model identified statistically significant person-level HTE in 8 of the 13 studies (62%) reporting person-level treatment effects and in 8 of the 14 studies (57%) reporting person-level outcomes. CONCLUSIONS:Our analysis suggests that person-level HTE is common and often substantial. Reviewed studies had incomplete information on person-level treatment effects and their variation. Improved assessment and reporting of person-level treatment effects in multiperson N-of-1 studies are needed

A Cognitively-Oriented Approach to Task Analysis and Test Development

Clear descriptions of job expertise are required to support applications and improvements in personnel training and job performance. This report describes a practical approach to task analysis that integrates the issues, content, and methods of cognitive science and personnel psychology. Cognitively oriented task analysis employs a breadth, then depth, strategy for identifying job expertise. Starting with a task-by-knowledge framework, job expertise is successively elaborated using interviews, expert ratings, and protocol analyses. The application of task analysis results to the development of written performance measures is described to illustrate the contributions of this approach to measurement validity. Task analysis results show that much of what has been missing in using existing task analysis methods is the mental aspects of performance related to interactions among task dimensions, task characteristics, and contexts. Two appendixes provide an example of knowledge elicitation and representation and item writing guidelines for performance measures

Direct and mediated effects of a social-emotional and character development program on adolescent substance use

Mitigating and preventing substance use among adolescents requires approaches that address the multitude of factors that influence this behavior. Such approaches must be tested, not only for evidence of empirical effectiveness, but also to determine the mechanisms by which they are successful. The aims of the present study were twofold: 1) To determine the effectiveness of a school-based social-emotional and character development (SECD) program, Positive Action (PA), in reducing substance use (SU) among a sample of U.S. youth living in a low-income, urban environment, and 2) to test one mechanism by which the program achieves its success. We used longitudinal mediation analysis to test the hypotheses that: 1) students attending PA intervention schools engage in significantly less SU than students attending control schools, 2) students attending PA intervention schools show significantly better change in SECD than students attending control schools, and 3) the effect of the PA intervention on SU is mediated by the change in SECD. Analyses revealed program effects on both SECD and SU, a relationship between SECD and SU, and the effects of PA on SU were completely mediated by changes in SECD. Future research directions and implications for schoolbased social-emotional and character development efforts and substance use prevention are addressed.peer-reviewe

Effects of a School-Based Social-Emotional and Character Development Program on Peer, Family, School, and Neighborhood Contexts: A Cluster-Randomized Controlled Trial

Aims: To evaluate the impact of a school-based social-emotional and character development program on the various socializing contexts of youth. Methods: A matched-pair, cluster-randomized controlled trial included 1,170 students from 14, low-income, urban, Chicago Public Schools. Outcomes were assessed longitudinally for a cohort of youth followed from grades 3 to 8. Multilevel growth-curve modeling and endpoint analyses were conducted on indicators of peer, family, school, and neighborhood contexts. Results: Students in PA schools had slower rates of decline and higher end-point scores than students in non-PA schools across all of the contexts examined. For example, impacts were observed for positive school orientation, peer victimization, parent attachment, and neighborhood context. Conclusion: Results illustrate that school-based social-emotional and character development programs have the capacity to affect youth experiences in a range of environmental contexts that are key for youth development and functioning

Evolution and Distribution of Magnetic Fields from AGNs in Galaxy Clusters. I. The Effect of Injection Energy and Redshift

We present a series of cosmological magnetohydrodynamic (MHD) simulations that simultaneously follow the formation of a galaxy cluster and evolution of magnetic fields ejected by an Active Galactic Nucleus (AGN). Specifically, we investigate the influence of both the epoch of AGN (z $\sim$ 3-0.5) and the AGN energy ($\sim$ 3 $\times$ 10$^{57}$ - 2 $\times$ 10$^{60}$ ergs)on the final magnetic field distribution in a relatively massive cluster (M$_{vir}$ $\sim$10$^{15}$ M$_\odot$). We find that as long as the AGN magnetic fields are ejected before the major mergers in the cluster formation history, magnetic fields can be transported throughout the cluster and can be further amplified by the intra-cluster medium (ICM) turbulence cause by hierarchical mergers during the cluster formation process. The total magnetic energy in the cluster can reach $\sim$ $10^{61}$ ergs, with micro Gauss fields distributed over $\sim$ Mpc scale. The amplification of the total magnetic energy by the ICM turbulence can be significant, up to $\sim$1000 times in some cases. Therefore even weak magnetic fields from AGNs can be used to magnetize the cluster to the observed level. The final magnetic energy in the ICM is determined by the ICM turbulent energy, with a weak dependence on the AGN injection energy. We discuss the properties of magnetic fields throughout the cluster and the synthetic Faraday rotation measure maps they produce. We also show that high spatial resolution over most of the magnetic regions of the cluster is very important to capture the small scale dynamo process and maintain the magnetic field structure in our simulations.Comment: 38 pages, 18 figures, Accepted for publication in Ap

Detection of circulating tumour DNA is associated with inferior outcomes in Ewing sarcoma and osteosarcoma: a report from the Children's Oncology Group.

BackgroundNew prognostic markers are needed to identify patients with Ewing sarcoma (EWS) and osteosarcoma unlikely to benefit from standard therapy. We describe the incidence and association with outcome of circulating tumour DNA (ctDNA) using next-generation sequencing (NGS) assays.MethodsA NGS hybrid capture assay and an ultra-low-pass whole-genome sequencing assay were used to detect ctDNA in banked plasma from patients with EWS and osteosarcoma, respectively. Patients were coded as positive or negative for ctDNA and tested for association with clinical features and outcome.ResultsThe analytic cohort included 94 patients with EWS (82% from initial diagnosis) and 72 patients with primary localised osteosarcoma (100% from initial diagnosis). ctDNA was detectable in 53% and 57% of newly diagnosed patients with EWS and osteosarcoma, respectively. Among patients with newly diagnosed localised EWS, detectable ctDNA was associated with inferior 3-year event-free survival (48.6% vs. 82.1%; p = 0.006) and overall survival (79.8% vs. 92.6%; p = 0.01). In both EWS and osteosarcoma, risk of event and death increased with ctDNA levels.ConclusionsNGS assays agnostic of primary tumour sequencing results detect ctDNA in half of the plasma samples from patients with newly diagnosed EWS and osteosarcoma. Detectable ctDNA is associated with inferior outcomes