Arriving at Consensus: Airport/Aviation Administration Advice Provided to Airport Managers by State Aeronautic Agencies

Recently a study was undertaken to determine the depth of information provided to small airport managers throughout the United States by State Aeronautical agencies. The study centered on efforts to provide formal, written advice to airport managers about airport and aviation administration matters. For the purpose of the study, advice is considered as material provided to airports exclusive of regulatory codes and rules. More specifically, such advice provides airport managers with valuable insight on how to effectively manage various aspects of airport operations. The survey material is concerned with a broad range of indigenous airport topics dealing with subject matter from General Aviation Airport Operations to Storm water compliance, and a host of topics in between. The many topics addressed in the state documents that were found in the survey were then compared with two key aviation industry sources of information to arrive at a recommended list of topics for inclusion in ANY airport management handbook for use in any state. The genesis of the study and report was a grant received by Southern Illinois University Carbondale from the Illinois Department of Transportation, Division of Aeronautics. The goal of the grant was to develop and prepare a small airport manager handbook\u27\u27 for smaller non-hub airports in Illinois. Due to the varying nature of laws and regulations concerning airport management and operations from state to state, state aeronautical agencies are in the best position to provide small airport managers with much needed and necessary information on the totality of management functions. However, not all states aeronautical agencies have the human or financial resources to author a comprehensive guide to small airport management. This study found that, at the time the survey was accomplished, only nine states provided some form of advice to airport managers

A Profile of Charter Operators: A Survey of On-Demand Carriers

Several years ago, one of the authors made a presentation before the National Air Transportation Association Convention in Tampa, Florida concerning the elements of Aircraft Charter Pricing. In research for that project, it was found that a dearth of information was available to adequately describe some of the elements to be considered in making a blanket pricing arrangement. Particularly vexing was the fact that at the meeting itself several of the operators and operator representatives present were unfamiliar with the type of business structure employed by the Fixed Base operator (FBO) and some were unfamiliar with the make up of the demand elements of their operations. In 2003 and again in late 2004, the authors set out to study this anomaly by surveying large numbers of Fixed Base Operators in the United States. Using a Likert style survey methodology, a representative sample of the on-demand air carriers listed with the National Business Aviation Association was surveyed. The survey was designed to learn something about the business structure of the FBO, their aircraft mix, how many charter flights were flown annually; the number of employees engaged in the 135 portion of the FBO operation; experience levels and a host of, heretofore, unknown elements of he business. In short, the intent was to develop a snapshot of what a typical 135 operator looks like from its business structure to its operation matrix to how it maintains and supplies its basic product, charter aircraft

Aviation Industry Employment Data Estimates Revisited

A wide variety of estimates of aviation industry employment data exist today. For example, a range of estimates from a low of 750,000 to a high of 2.1 million are reported in various industry publications and journals. This broad range raises questions not onIy about such data but also about the definition used to define the industry and thus used to arrive at employment numbers. In this paper, an overall 1995 aviation industry employment estimate is presented that is based on various secondary sources. The estimate incorporates various components of the civil aviation industry, including aircraft/aerospace manufacturing, airlines, general aviation, government aviation, and miscellaneous aviation industry employment. Active duty military personnel are a significant contributor to aviation employment. Although they are not included in previous assessments of overall civil aviation employment, they have been included in this work. One article (NewMyer, 1985) estimated aviation employment at 2,286,709. This new assessment indicates an industry increase of 62,290 employees to a total population of 2,349,399. Data collection for this new computation was obtained through replication of the methodology producing the 1985 statistics. The primary contributing factor to overall aviation industry employment increases in 1995 is the fact that there were net increases in four of the six components of the aviation industry (aviation/aerospace manufacturing, airlines, general aviation, government aviation, miscellaneous, and active duty military aviation personnel). It is concluded, however, that without the miscellaneous employment category contribution to employment statistics, there is actually a decline in industry employment over the 10-year period. Contributing to this descent have been large personnel reductions in the defense-related aircraft/aerospace manufacturing industry and active duty military aviation components

Airline Unions Since Deregulation: The Views of Selected Airline Unions

The airline industry in the United States has passed through a crucial period of post-deregulation adjustments. One of those adjustments has been in its relationship with the unions representing a large portion of the industry employees. One view of this situation that is commonly presented is that unions are “losers” in this post deregulation period. The common wisdom in the U.S. airline industry is that labor unions are the biggest losers from deregulation and the dash into consolidation. Certainly there is plenty of evidence for this view. Deregulation spawned split wage scales, futile strikes at United and Pan American, Chapter 11 bankruptcies, and the emergence of a handful of super-carriers which, on the surface at least, handed management oligopolistic bargaining powers\u27 (Gaudin). This is certainly a negative view of how unions have weathered the storm of deregulation, but is it well-founded, and is it a view shared by the airlines unions, themselves? The direction of this study is to describe the airline union viewpoint, the impact deregulation has had on their viability and on their future attitudes toward bargaining issues

Squaric Ester-Based, pH-Degradable Nanogels:Modular Nanocarriers for Safe, Systemic Administration of Toll-like Receptor 7/8 Agonistic Immune Modulators

Small-molecular Toll-like receptor 7/8 (TLR7/8) agonists hold promise as immune modulators for a variety of immune therapeutic purposes including cancer therapy or vaccination. However, due to their rapid systemic distribution causing difficult-to-control inflammatory off-target effects, their application is still problematic, in particular systemically. To address this problem, we designed and robustly fabricated pH-responsive nanogels serving as versatile immunodrug nanocarriers for safe delivery of TLR7/8-stimulating imidazoquinolines after intravenous administration. To this aim, a primary amine-reactive methacrylamide monomer bearing a pendant squaric ester amide is introduced, which is polymerized under controlled RAFT polymerization conditions. Corresponding PEG-derived squaric ester amide block copolymers self-assemble into precursor micelles in polar protic solvents. Their cores are amine-reactive and can sequentially be transformed by acid-sensitive cross-linkers, dyes, and imidazoquinolines. Remaining squaric ester amides are hydrophilized affording fully hydrophilic nanogels with profound stability in human plasma but stimuli-responsive degradation upon exposure to endolysosomal pH conditions. The immunomodulatory behavior of the imidazoquinolines alone or conjugated to the nanogels was demonstrated by macrophages in vitro. In vivo, however, we observed a remarkable impact of the nanogel: After intravenous injection, a spatially controlled immunostimulatory activity was evident in the spleen, whereas systemic off-target inflammatory responses triggered by the small-molecular imidazoquinoline analogue were absent. These findings underline the potential of squaric ester-based, pH-degradable nanogels as a promising platform to permit intravenous administration routes of small-molecular TLR7/8 agonists and, thus, the opportunity to explore their adjuvant potency for systemic vaccination or cancer immunotherapy purposes.</p

Metabolic Engineering of Cofactor F420 Production in Mycobacterium smegmatis

Cofactor F420 is a unique electron carrier in a number of microorganisms including Archaea and Mycobacteria. It has been shown that F420 has a direct and important role in archaeal energy metabolism whereas the role of F420 in mycobacterial metabolism has only begun to be uncovered in the last few years. It has been suggested that cofactor F420 has a role in the pathogenesis of M. tuberculosis, the causative agent of tuberculosis. In the absence of a commercial source for F420, M. smegmatis has previously been used to provide this cofactor for studies of the F420-dependent proteins from mycobacterial species. Three proteins have been shown to be involved in the F420 biosynthesis in Mycobacteria and three other proteins have been demonstrated to be involved in F420 metabolism. Here we report the over-expression of all of these proteins in M. smegmatis and testing of their importance for F420 production. The results indicate that co–expression of the F420 biosynthetic proteins can give rise to a much higher F420 production level. This was achieved by designing and preparing a new T7 promoter–based co-expression shuttle vector. A combination of co–expression of the F420 biosynthetic proteins and fine-tuning of the culture media has enabled us to achieve F420 production levels of up to 10 times higher compared with the wild type M. smegmatis strain. The high levels of the F420 produced in this study provide a suitable source of this cofactor for studies of F420-dependent proteins from other microorganisms and for possible biotechnological applications

Hyperprolactinemia in adults with Prader-Willi syndrome

Prader-Willi syndrome (PWS) is a rare neurodevelopmental genetic disorder typically characterized by body composition abnormalities, hyperphagia, behavioural challenges, cognitive dysfunction, and hypogonadism. Psychotic illness is common, particularly in patients with maternal uniparental disomy (mUPD), and antipsychotic medications can result in hyperprolactinemia. Information about hyperprolactinemia and its potential clinical consequences in PWS is sparse. Here, we present data from an international, observational study of 45 adults with PWS and hyperprolactinemia. Estimated prevalence of hyperprolactinemia in a subset of centres with available data was 22%, with 66% of those related to medication and 55% due to antipsychotics. Thirty-three patients were men, 12 women. Median age was 29 years, median BMI 29.8 kg/m2, 13 had mUPD. Median prolactin was 680 mIU/L (range 329–5702). Prolactin levels were higher in women and patients with mUPD, with only 3 patients having severe hyperprolactinemia. Thyroid function tests were normal, 24 were treated with growth hormone, 29 with sex steroids, and 20 with antipsychotic medications. One patient had kidney insufficiency, and one a microprolactinoma. In conclusion, severe hyperprolactinemia was rare, and the most common aetiology of hyperprolactinemia was treatment with antipsychotic medications. Although significant clinical consequences could not be determined, potential negative long-term effects of moderate or severe hyperprolactinemia cannot be excluded. Our results suggest including measurements of prolactin in the follow-up of adults with PWS, especially in those on treatment with antipsychotic

Outpatient care in acute and prehospital emergency medicine by emergency medical and patient transport service over a 10-year period: a retrospective study based on dispatch data from a German emergency medical dispatch centre (OFF-RESCUE)

Background!#!The number of operations by the German emergency medical service almost doubled between 1994 and 2016. The associated expenses increased by 380% in a similar period. Operations with treatment on-site, which retrospectively proved to be misallocated (OFF-Missions), have a substantial proportion of the assignment of the emergency medical service (EMS). Besides OFF-Missions, operations with patient transport play a dominant role (named as ON-Missions). The aim of this study is to work out the medical and economic relevance of both operation types.!##!Methods!#!This analysis examined N = 819,780 missions of the EMS and patient transport service (PTS) in the catchment area of the emergency medical dispatch centre (EMDC) Bad Kreuznach over the period from 01/01/2007 to 12/31/2016 in terms of triage and disposition, urban-rural distribution, duration of operations and economic relevance (p &amp;lt; .01).!##!Results!#!53.4% of ON-Missions are triaged with the indication non-life-threatening patient transport; however, 63.7% are processed by the devices of the EMS. Within the OFF-Mission cohort, 78.2 and 85.8% are triaged or dispatched for the EMS. 74% of all ON-Missions are located in urban areas, 26% in rural areas; 81.3% of rural operations are performed by the EMS. 66% of OFF-Missions are in cities. 93.2% of the remaining 34% of operations in rural locations are also performed by the EMS. The odds for both ON- and OFF-Missions in rural areas are significantly higher than for PTS (OR!##!Conclusions!#!This study particularly highlights the increasing utilization of emergency devices; especially in OFF-Missions, the resources of the EMS have a higher number of operations than PTS. OFF-Missions cause immensely high costs due to misallocations from an economic point of view. Appropriate patient management appears necessary from both medical and economic perspective, which requires multiple solution approaches