3,514 research outputs found
Psychological types of female primary school teachers in Anglican state-maintained schools in England and Wales : implications for continuing professional development
A sample of 221 female primary school teachers in Anglican state-maintained schools in England and Wales completed the Francis Psychological Type Scales (FPTS). The data demonstrated clear preferences for Extraversion (E) over Introversion (I), for Sensing (S) over Intuition (N), for Feeling (F) over Thinking (T) and for Judging (J) over Perceiving (P). The two predominant types among female primary school teachers were ESFJ (27.6%) and ISFJ (18.6%). These findings confirm earlier research among trainee female primary school teachers and help to clarify the main strengths and potential challenges facing primary schools in light of knowledge about the key psychological preferences of those who shape the classroom environment. These findings also generate new insights into teacher retention and career paths in primary schools
Three religious orientations and five personality factors : an exploratory study among adults in England
In order to explore the power of the five factor model of personality to explain individual differences recorded on measures of the three religious orientations, a sample of 198 adults in England completed established measures of the three religious orientations (intrinsic, extrinsic, and quest) and the big five personality factors (neuroticism, extraversion, openness, agreeableness, and conscientiousness). The data demonstrated that individual differences in the three religious orientations were largely independent of the five personality factors, apart from a significant positive correlation between intrinsic religiosity and agreeableness. These findings support Piedmont’s contention that religiosity is largely independent of personality when personality is operationalised in terms of the big five factors
Democracy in Crisis: Corruption, Media, and Power in Turkey
In November 2013, a Freedom House delegation traveled to Turkey to meet with journalists, NGOs, business leaders, and senior government officials about the deteriorating state of media freedom in the country. The delegation's objective, and the plan for this report, was to investigate reports of government efforts to pressure and intimidate journalists and of overly close relationships between media owners and government, which, along with bad laws and overly aggressive prosecutors, have muzzled objective reporting in Turkey.Since November, events in Turkey have taken a severe turn for the worse. The police raids that revealed a corruption scandal on December 17, and the allegations of massive bidrigging and money laundering by people at the highest levels of the government, have sparked a frantic crackdown by the ruling Justice and Development (AK) Party. More journalists have been fired for speaking out. Hundreds of police officers and prosecutors have been fired or relocated across the country. Amendments to the new Internet regulation law proposed by the government would make it possible for officials to block websites without court orders. The government is also threatening the separation of powers by putting the judiciary, including criminal investigations, under direct control of the Ministry of Justice. The crisis of democracy in Turkey is not a future problem -- it is right here, right now.This report on the media recognizes that what is happening in Turkey is bigger than one institution and part of a long history that continues to shape current events. The media in Turkey have always been close to the state; as recently as 1997, large media organizations were co-opted by the military to subvert a democratically elected government. The AK Party was formed in the wake of those events. But even as it has tamed the military, the AKP has been unable to resist the temptations of authoritarianism embedded in the state the military helped create. Over the past seven years, the government has increasingly employed a variety of strong-arm tactics to suppress the media's proper role as a check on power. Some of the most disturbing efforts include the following:Intimidation: Prime Minister Recep Tayyip Erdo?an frequently attacks journalists by name after they write critical commentary. In several well-known cases, like those of Hasan Cemal and Nuray Mert, journalists have lost their jobs after these public attacks. Sympathetic courts hand out convictions in defamation cases for criticism.Mass firings: At least 59 journalists were fired or forced out in retaliation for their coverage of last summer's Gezi Park protests. The December corruption scandal has produced another string of firings of prominent columnists.Buying off or forcing out media moguls: Holding companies sympathetic to the government receive billions of dollars in government contracts, often through government bodies housed in the prime minister's office. Companies with media outlets critical of the government have been targets of tax investigations, forced to pay large fines, and likely disadvantaged in public tenders.Wiretapping: The National Security Organization has wiretapped journalists covering national security stories, using false names on the warrants in order to avoid judicial scrutiny.Imprisonment: Dozens of journalists remain imprisoned under broadly defined antiterrorism laws. A majority of those in prison are Kurds, and some analysts believe the government is using them as bargaining chips in negotiations with the Kurdish PKKThese tactics are unacceptable in a democracy. They deny Turkish citizens full access to information and constrain a healthy political debate. Journalists and government officials alike acknowledge that reporters and news organizations have practiced self-censorship to avoid angering the government, and especially Prime Minister Erdogan.The intentional weakening of Turkey's democratic institutions, including attempts to bully and censor Turkey's media, should and must be a matter of deep concern for the United States and the European Union. As the AKParty's internal coalition has grown more fragile, Erdogan has used his leverage over the media to push issues of public morality and religion and to squelch public debate of the accountability of his government. The result is an increasingly polarized political arena and society.Freedom House calls on the government of Turkey to recognize that in a democracy, a free press and other independent institutions play a very important role. There are clear and concrete steps the Turkish government must take to end the intimidation and corruption of Turkey's media. Chief among these are the following:Cease threats against journalists.Repeal the criminal defamation law and overly broad antiterrorism and "criminal organization" laws that have been used to jail dozens of journalists.Comply with European and international standards in procurement practices in order to reduce the incentive for media owners to curry favor by distorting the news. Turkish media owners themselves must make a commitment to support changes in procurement practices if they are to win back the trust of Turkey's citizens.Although building a resilient democracy is fundamentally up to Turkish citizens, the international community cannot afford to be bystanders. The European Union and the OSCE have raised strong concerns about government pressure on Turkey's media, and the EU's warnings against governmental overreach have been pointed. Unfortunately, the same cannot be said for the United States. The Obama administration has been far too slow to realize the seriousness of the threat to Turkey's democracy. U.S. criticism of the Turkish government's recent actions has come from the State Department spokesperson and White House press secretary, not from the high-ranking officials who need to be engaged in responding to a crisis of this scale. Where European governments and institutions have been specifically and publicly engaged with the government over the crisis, the Obama administration has avoided the difficult issues. It is time to speak frankly and with seriousness about the growing threat to democracy in Turkey, and to place freedom of expression and democracy at the center of the policy relationship
Pharmacologic inhibition of RGD-binding integrins ameliorates fibrosis and improves function following kidney injury
Fibrosis is a final common pathway for many causes of progressive chronic kidney disease (CKD). Arginine-glycine-aspartic acid (RGD)-binding integrins are important mediators of the pro-fibrotic response by activating latent TGF-β at sites of injury and by providing myofibroblasts information about the composition and stiffness of the extracellular matrix. Therefore, blockade of RGD-binding integrins may have therapeutic potential for CKD. To test this idea, we used small-molecule peptidomimetics that potently inhibit a subset of RGD-binding integrins in a murine model of kidney fibrosis. Acute kidney injury leading to fibrosis was induced by administration of aristolochic acid. Continuous subcutaneous administration of CWHM-12, an RGD integrin antagonist, for 28 days improved kidney function as measured by serum creatinine. CWHM-12 significantly reduced Collagen 1 (Col1a1) mRNA expression and scar collagen deposition in the kidney. Protein and gene expression markers of activated myofibroblasts, a major source of extracellular matrix deposition in kidney fibrosis, were diminished by treatment. RNA sequencing revealed that inhibition of RGD integrins influenced multiple pathways that determine the outcome of the response to injury and of repair processes. A second RGD integrin antagonist, CWHM-680, administered once daily by oral gavage was also effective in ameliorating fibrosis. We conclude that targeting RGD integrins with such small-molecule antagonists is a promising therapeutic approach in fibrotic kidney disease
Efficacy of the Unified Protocol for transdiagnostic treatment of comorbid psychopathology accompanying emotional disorders compared to treatments targeting single disorders
OBJECTIVE: This study aimed to examine whether the Unified Protocol (UP), a transdiagnostic cognitive-behavioral therapy for emotional disorders (i.e., anxiety, mood, and related disorders), is efficacious in the treatment of co-occurring emotional disorders compared to established single disorder protocols (SDPs) that target specific disorders (e.g., panic disorder).
METHOD: Participants included 179 adults seeking outpatient psychotherapy. Participant age ranged from 18 to 66 years, with an average of 30.66 years (SD = 10.77). The sample was 55% female and mostly Caucasian (83%). Diagnostic assessments were completed with the Anxiety Disorder Interview Schedule (ADIS), and disorder-specific, clinician-rated measures for the comorbid diagnoses of interest.
RESULTS: In both treatment conditions, participants' mean number of diagnoses dropped significantly from baseline to posttreatment, and baseline to 12-month follow-up. Additionally, large effects were observed for changes in comorbid generalized anxiety (ESɢ: UP = −1.72; SDP = −1.98), social anxiety (ESɢ: UP = −1.33, −0.86; SDP = −1.60, −1.54), and depression (ESɢ: UP = −0.83; SDP = −0.84). Significant differences were not observed in between-group comparisons.
CONCLUSIONS: Results suggest that both the UP and SDPs are efficacious in reducing symptoms of comorbid emotional disorders. The clinical, practical, and cost-effective advantages of transdiagnostic CBT are discussed.Please note the following financial disclosures/conflicts of interest: Dr. Barlow reported receiving royalties from Oxford University Press, United Kingdom (which includes royalties for the treatment manuals included in this study); Guilford Publications Inc., United States; Cengage Learning, United States; Pearson Publishing, United Kingdom. He reported receiving grants from the National Institute of Mental Health, United States (R01 MH090053) and the National Institute of Alcohol and Alcohol Abuse, United States (R01 AA023676). He reported serving as a consultant for and receiving honoraria from the Agency for Healthcare Research and Quality, United States; the Foundation for Informed Medical Decision Making, United States; the Department of Defense, United States; the Renfrew Center, United States; the Chinese University of Hong Kong, Hong Kong;Universidad Catolica de Santa Maria, Peru); New Zealand Psychological Association, New Zealand; Hebrew University of Jerusalem, Israel; Mayo Clinic, United States; and various American universities. (R01 MH090053 - National Institute of Mental Health, United States; R01 AA023676 - National Institute of Alcohol and Alcohol Abuse, United States)Accepted manuscrip
The Novel μ-Opioid Receptor Antagonist GSK1521498 Decreases Both Alcohol Seeking and Drinking: Evidence from a New Preclinical Model of Alcohol Seeking.
Distinct environmental and conditioned stimuli influencing ethanol-associated appetitive and consummatory behaviors may jointly contribute to alcohol addiction. To develop an effective translational animal model that illuminates this interaction, daily seeking responses, maintained by alcohol-associated conditioned stimuli (CSs), need to be dissociated from alcohol drinking behavior. For this, we established a procedure whereby alcohol seeking maintained by alcohol-associated CSs is followed by a period during which rats have the opportunity to drink alcohol. This cue-controlled alcohol-seeking procedure was used to compare the effects of naltrexone and GSK1521498, a novel selective μ-opioid receptor antagonist, on both voluntary alcohol-intake and alcohol-seeking behaviors. Rederived alcohol-preferring, alcohol-nonpreferring, and high-alcohol-drinking replicate 1 line of rats (Indiana University) first received 18 sessions of 24 h home cage access to 10% alcohol and water under a 2-bottle choice procedure. They were trained subsequently to respond instrumentally for access to 15% alcohol under a second-order schedule of reinforcement, in which a prolonged period of alcohol-seeking behavior was maintained by contingent presentations of an alcohol-associated CS acting as a conditioned reinforcer. This seeking period was terminated by 20 min of free alcohol drinking access that achieved significant blood alcohol concentrations. The influence of pretreatment with either naltrexone (0.1-1-3 mg/kg) or GSK1521498 (0.1-1-3 mg/kg) before instrumental sessions was measured on both seeking and drinking behaviors, as well as on drinking in the 2-bottle choice procedure. Naltrexone and GSK1521498 dose-dependently reduced both cue-controlled alcohol seeking and alcohol intake in the instrumental context as well as alcohol intake in the choice procedure. However, GSK1521498 showed significantly greater effectiveness than naltrexone, supporting its potential use for promoting abstinence and preventing relapse in alcohol addiction
A Matrix Model for the Null-Brane
The null-brane background is a simple smooth 1/2 BPS solution of string
theory. By tuning a parameter, this background develops a big crunch/big bang
type singularity. We construct the DLCQ description of this space-time in terms
of a Yang-Mills theory on a time-dependent space-time. Our dual Matrix
description provides a non-perturbative framework in which the fate of both
(null) time, and the string S-matrix can be studied.Comment: 26 pages, LaTeX; references adde
The role of sand lances (Ammodytes sp.) in the Northwest Atlantic ecosystem: a synthesis of current knowledge with implications for conservation and management
© The Author(s), 2020. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Staudinger, M. D., Goyert, H., Suca, J. J., Coleman, K., Welch, L., Llopiz, J. K., Wiley, D., Altman, I., Applegate, A., Auster, P., Baumann, H., Beaty, J., Boelke, D., Kaufman, L., Loring, P., Moxley, J., Paton, S., Powers, K., Richardson, D., Robbins, J., Runge, J., Smith, B., Spiegel, C., & Steinmetz, H. The role of sand lances (Ammodytes sp.) in the Northwest Atlantic ecosystem: a synthesis of current knowledge with implications for conservation and management. Fish and Fisheries, 00, (2020): 1-34, doi:10.1111/faf.12445.The American sand lance (Ammodytes americanus, Ammodytidae) and the Northern sand lance (A. dubius, Ammodytidae) are small forage fishes that play an important functional role in the Northwest Atlantic Ocean (NWA). The NWA is a highly dynamic ecosystem currently facing increased risks from climate change, fishing and energy development. We need a better understanding of the biology, population dynamics and ecosystem role of Ammodytes to inform relevant management, climate adaptation and conservation efforts. To meet this need, we synthesized available data on the (a) life history, behaviour and distribution; (b) trophic ecology; (c) threats and vulnerabilities; and (d) ecosystem services role of Ammodytes in the NWA. Overall, 72 regional predators including 45 species of fishes, two squids, 16 seabirds and nine marine mammals were found to consume Ammodytes. Priority research needs identified during this effort include basic information on the patterns and drivers in abundance and distribution of Ammodytes, improved assessments of reproductive biology schedules and investigations of regional sensitivity and resilience to climate change, fishing and habitat disturbance. Food web studies are also needed to evaluate trophic linkages and to assess the consequences of inconsistent zooplankton prey and predator fields on energy flow within the NWA ecosystem. Synthesis results represent the first comprehensive assessment of Ammodytes in the NWA and are intended to inform new research and support regional ecosystem‐based management approaches.This manuscript is the result of follow‐up work stemming from a working group formed at a two‐day multidisciplinary and international workshop held at the Parker River National Wildlife Refuge, Massachusetts in May 2017, which convened 55 experts scientists, natural resource managers and conservation practitioners from 15 state, federal, academic and non‐governmental organizations with interest and expertise in Ammodytes ecology. Support for this effort was provided by USFWS, NOAA Stellwagen Bank National Marine Sanctuary, U.S. Department of the Interior, U.S. Geological Survey, Northeast Climate Adaptation Science Center (Award # G16AC00237), an NSF Graduate Research Fellowship to J.J.S., a CINAR Fellow Award to J.K.L. under Cooperative Agreement NA14OAR4320158, NSF award OCE‐1325451 to J.K.L., NSF award OCE‐1459087 to J.A.R, a Regional Sea Grant award to H.B. (RNE16‐CTHCE‐l), a National Marine Sanctuary Foundation award to P.J.A. (18‐08‐B‐196) and grants from the Mudge Foundation. The contents of this paper are the responsibility of the authors and do not necessarily represent the views of the National Oceanographic and Atmospheric Administration, U.S. Fish and Wildlife Service, New England Fishery Management Council and Mid‐Atlantic Fishery Management Council. This manuscript is submitted for publication with the understanding that the United States Government is authorized to reproduce and distribute reprints for Governmental purposes. Any use of trade, firm or product names is for descriptive purposes only and does not imply endorsement by the U.S. Government
The unified protocol for transdiagnostic treatment of emotional disorders compared with diagnosis-specific protocols for anxiety disorders a randomized clinical trial
IMPORTANCE: Transdiagnostic interventions have been developed to address barriers to the dissemination of evidence-based psychological treatments, but only a few preliminary studies have compared these approaches with existing evidence-based psychological treatments.
OBJECTIVE: To determine whether the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders (UP) is at least as efficacious as single-disorder protocols (SDPs) in the treatment of anxiety disorders.
DESIGN, SETTING, AND PARTICIPANTS: From June 23, 2011, to March 5, 2015, a total of 223 patients at an outpatient treatment center with a principal diagnosis of panic disorder with or without agoraphobia, generalized anxiety disorder, obsessive-compulsive disorder, or social anxiety disorder were randomly assigned by principal diagnosis to the UP, an SDP, or a waitlist control condition. Patients received up to 16 sessions of the UP or an SDP for 16 to 21 weeks. Outcomes were assessed at baseline, after treatment, and at 6-month follow-up. Analysis in this equivalence trial was based on intention to treat.
INTERVENTIONS: The UP or SDPs.
MAIN OUTCOMES AND MEASURES: Blinded evaluations of principal diagnosis clinical severity rating were used to evaluate an a priori hypothesis of equivalence between the UP and SDPs.
RESULTS: Among the 223 patients (124 women and 99 men; mean [SD] age, 31.1 [11.0] years), 88 were randomized to receive the UP, 91 to receive an SDP, and 44 to the waitlist control condition. Patients were more likely to complete treatment with the UP than with SDPs (odds ratio, 3.11; 95% CI, 1.44-6.74). Both the UP (Cohen d, −0.93; 95% CI, −1.29 to −0.57) and SDPs (Cohen d, −1.08; 95% CI, −1.43 to −0.73) were superior to the waitlist control condition at acute outcome. Reductions in clinical severity rating from baseline to the end of treatment (β, 0.25; 95% CI, −0.26 to 0.75) and from baseline to the 6-month follow-up (β, 0.16; 95% CI, −0.39 to 0.70) indicated statistical equivalence between the UP and SDPs.
CONCLUSIONS AND RELEVANCE: The UP produces symptom reduction equivalent to criterion standard evidence-based psychological treatments for anxiety disorders with less attrition. Thus, it may be possible to use 1 protocol instead of multiple SDPs to more efficiently treat the most commonly occurring anxiety and depressive disorders.This study was funded by grant R01 MH090053 from the National Institute of Mental Health. (R01 MH090053 - National Institute of Mental Health)First author draf
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