6,241 research outputs found

    Four Scottish indulgences at Sens

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    English interest in the great Cistercian abbey of Pontigny was stimulated by the exiles there of two archbishops of Canterbury, Thomas Becket and Stephen Langton.1 As archbishops of Canterbury, Langton and Edmund of Abingdon made gifts to Pontigny abbey in consideration of the welcome given to Becket.2 Edmund did not die at Pontigny, but was a confrater of the community, and the abbot claimed the body, asserting that Edmund had expressed a wish to be buried there. The process of canonisation was rapid.3 After Edmund's canonisation, Henry III sent a chasuble and a chalice for the first celebration of the feast, and granted money to maintain four candles round the saint's shrine.4 In 1254, en route from Gascony to meet Louis IX in Chartres and Paris,5 Henry visited Pontigny, as his brother Richard of Cornwall, who seems to have pressed for canonisation, had done in 1247.6 Archbishop Boniface of Canterbury ordered the celebration of the feast to be observed throughout his province.7 Pope Alexander IV granted a dispensation to allow Englishwomen to enter the precinct of Pontigny abbey on the feast of the translation of the relics of St Edmund8 (women were normally forbidden to enter a Cistercian monastery). Matthew Paris, the greatest English chronicler of the age, wrote a life of the saint.9 English interest continued into the fourteenth century. In 1331 an English priest was given a licence to visit the shrine,10 but it seems likely that the Hundred Years’ War made pilgrimage to Pontigny difficult.11 The indulgences preserved by the abbey reveal an interest in the shrine throughout the Western Church, granted as they were by prelates from Tortosa to Livonia and Estonia, and from Messina to LĂŒbeck.1

    Learning policy constraints through dialogue

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    The re-emergence of the B1 cell compartment : is this a pre-lymphoma stage?

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    Chronic Lymphocytic Leukemia (CLL) are in some cases stereotyped for immunoglobulin variants in different populations, suggesting emergence of B cell subsets following presentation of the same antigen. CLL cells may originate from CD5+ naĂŻve cells and from CD5 memory cells. Gene expression studies characterized a common cell of origin of the two clinical categories of CLL; the unmutated aggressive type and the mutated indolent type. The aim of this study was to investigate the presence of CD5 positive B cells in the elderly and their potential stimulation with exosomes derived from tumor cells. The findings from this study is aimed to create a model to identify instigating carcinomatous factors that may stimulate B1 cells to transform into a CLL-like model. In this study we show that CD19\textsuperscript+ cells (B cells) in cord blood have a high expression of CD5. CD19/CD5 staining of blood samples from senior citizens showed the presence of B cells which also express the CD5 marker, though at a lower expression when compared to CLL cells (CD19+/CD5 dim B cells). Measurement of clonality using λ/Κ flow cytometry staining show a monoclonal origin of the human CD19+/CD5 dim B cells. Monoclonal B cell Lymphocytosis in the elderly is a potential cell compartment that represents the origin of B cell proliferative disorders. The origin of the B cell proliferative disease requires antigen stimulation. A preliminary experiment showed that sorted lymphocytes can be stimulated by exosomes isolated from 2 cancer cells lines, A549 (lung epithelial) and PC3 (prostate cell line). In comparison with phytohaemagglutinin (PHA) and phorbolmyristate acetate (PMA), known lymphocyte stimulators, the exosomes stimulated the proliferation of monocytic-like cells. Further characterization is required to know the origin of these cells. The result shows that one can speculate that exosomes present cancer-derived antigens and stimulate cell proliferation. Further studies are required to evaluate the potential transformation capacity of cancer-derived exosomes. In addition, various cytokines were measured in the sera of senior citizens to investigate a differential release of cytokines in the presence or absence of the CD19+/CD5 dim B cells. Cytokines examined were not significantly different between the 2 groups and further evaluation of cytokine levels is required.peer-reviewe

    On a clique covering problem of orlin

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    AbstractLet T2n be the complement of a perfect matching in the complete graph on 2n vertices, and cc(T2n) be the minimum number of complete subgraphs necessary to cover all the edges of T2n Orlin posed the problem of determining the asymptotic behaviour of cc(T2n). We show that cc(T2n)=min{k:nâ©œ(k−1⌈k2⌉)} for all n>1, (which implies that limn→∞cc(T 2n)/log2n=1). This is done by applying a Sperner-type theorem on set families due to BollobĂĄs and Schönheim

    Stroke prevention and sodium restriction

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    ECO and RESOLVE: Galaxy Disk Growth in Environmental Context

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    We study the relationships between galaxy environments and galaxy properties related to disk (re)growth, considering two highly complete samples that are approximately baryonic mass limited into the high-mass dwarf galaxy regime, the Environmental COntext (ECO) catalog (data release herein) and the B-semester region of the REsolved Spectroscopy Of a Local VolumE (RESOLVE) survey. We quantify galaxy environments using both group identification and smoothed galaxy density field methods. We use by-eye and quantitative morphological classifications plus atomic gas content measurements and estimates. We find that blue early-type (E/S0) galaxies, gas-dominated galaxies, and UV-bright disk host galaxies all become distinctly more common below group halo mass ~10^11.5 Msun, implying that this low group halo mass regime may be a preferred regime for significant disk growth activity. We also find that blue early-type and blue late-type galaxies inhabit environments of similar group halo mass at fixed baryonic mass, consistent with a scenario in which blue early types can regrow late-type disks. In fact, we find that the only significant difference in the typical group halo mass inhabited by different galaxy classes is for satellite galaxies with different colors, where at fixed baryonic mass red early and late types have higher typical group halo masses than blue early and late types. More generally, we argue that the traditional morphology-environment relation (i.e., that denser environments tend to have more early types) can be largely attributed to the morphology-galaxy mass relation for centrals and the color-environment relation for satellites.Comment: 26 pages and 28 figures; v2 contains minor figure and text updates to match final published version in ApJ; ECO data table release now available at http://resolve.astro.unc.edu/pages/data.ph

    Infiltration and short-term movement of nitrogen in a silt-loam soil typical of rice cultivation in Arkansas

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    Rice production in Arkansas is one of the top three crop commodities in terms of cash receipts. Researchers and farmers report that nitrogen (N) needs to be managed according to a variety of factors with two important ones being soil and fertilizer type. The objectives of this experiment were to determine: 1) the degree to which floodwater-incorporated N applied as urea or as ammonium sulfate infiltrates intact cores (7.2-cm dia., 10-cm depth) containing DeWitt siltloam soil, and 2) the distribution of N during 12 h of ponding. Inorganic-N concentrations were analyzed at 2-cm depth intervals in cores following removal of the flood. Nitrogen from applied fertilizer was recovered as ammonium. Ammonium sulfate-N remained in the top 4 cm of soil with concentrations of 375 ”g N g-1 in the surface 2 cm and 300 ”g N g-1 at the 2 - 4 cm depth after 12 hr of ponding. At all depth intervals below 4 cm, ammonium sulfate-N remained below 30 ”g N g-1. In contrast, after 12 h of ponding, N in soil receiving urea was 105 ”g N g-1 in the top 2 cm and 173 ”g N g-1 at 2-4 cm. At 4-6, 6-8, and 8-10 cm, N was 109, 108, and 35 ”g N g-1, respectively, after 12 h of ponding. These results demonstrate immediate and deeper movement of ammonium into silt loam soil receiving urea as compared to ammonium sulfate, demonstrating how the form of N in fertilizer affects its movement into the soil profile

    Interferometric and fibre Bragg grating sensor interrogation using an arrayed waveguide grating

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    We investigate the use of an arrayed waveguide grating (AWG) to interrogate both fibre Bragg grating (FBG) and interferometric sensors. A broadband light source is used to illuminate both the FBG and interferometric sensors. Reflected spectral information is directed to an AWG with integral photodetectors providing 40 electrical outputs. To interrogate interferometric sensors we investigated the dual wavelength technique to measure the distance of a Fabry-Perot cavity, which produced a maximum unambiguous range of 1440ÎŒm with an active sensor. Three methods are described to interrogate FBG sensors. The first technique makes use of the reflected light intensity in an AWG channel passband from a narrow bandwidth grating, giving a usable range of 500ΌΔ and a dynamic strain resolution of 96nΔ/√Hz at 30Hz. The second approach utilises wide gratings larger than the channel spacing of the AWG; by monitoring the intensity present in corresponding AWG channels an improved range of 1890ΌΔ was achieved. The third method improves the dynamic range by utilising a heterodyne approach based on interferometric wavelength shift detection providing a dynamic strain resolution of 17nΔ/√Hz at 30Hz
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