Glioblastoma with leptomeningeal dissemination

Here we report a case of glioblastoma (GB) with leptomeningeal dissemination (LMD) in a 21 year old female presenting with generalized tonic-clonic seizures. After a brain MRI confirmed a non-enhancing left frontal lobe mass, histopathological examination and molecular analysis showed a glioblastoma with features of gliosarcoma that was an IDH wild type, MGMT unmethylated, TERT amplified tumor. She received standard care with combined chemoradiation with temozolomide and targeted radiation. MRI showing disease progression prompted the addition of bevacizumab after which the patient quickly deteriorated and died eight months after initial presentation. Incidence of LMD is an uncommon occurrence and associated with a significant decrease in overall survival when diagnosed at initial presentation. More research is needed to determine what role histopathologic variants and molecular profile plays in prognosis and treatment.peer-reviewe

SMALL FARM POLICY: WHAT ROLE FOR THE GOVERNMENT?

Agricultural and Food Policy,

Pittsburgh's Failed Industry Targeting Strategy of the 1960s

In the 1960's and early 1970's, public and private leaders made a substantial effort to promote Pittsburgh's existing transportation industry as a center for the emerging urban transportation market. The selection of the rapid transit industry for targeting in the 1960's purportedly addressed two issues. Despite national acclaim for its Renaissance redevelopment since World War II, the metropolitan region still needed an effective mass transportation system. Moreover, industrial development efforts had not substantially diversified the region's manufacturing base that still specialized in primary metals. Operating in the region's Renaissance tradition of a public and private partnership, corporate executives and public officials pursued a three-pronged strategy: build an innovative rapid transportation system for Allegheny County, use it as a showcase for testing and marketing rapid transit hardware of regional corporations, and promote the city as a center of the rapid transportation industry. They settled on Westinghouse's automated, rubber-tired vehicle running on a separate cement guideway, known locally as "Skybus," for the demonstration project and the region's mass transit solution. The mass transit plan and industry targeting strategy foundered by the early 1970's because leadership weakened in both poles of the partnership. The Westinghouse technology divided the corporate community, while populist political sentiment diminished the ability of the Democratic party's political machine to deliver key public decisions. The Pittsburgh case suggests that a successful industry targeting strategy may depend more on effective leadership and local politics than on the quality of the selection process and vigorous pursuit of traditional economic development programs in support of the targeted industry

The Don de langue and the archival pledge: Dado's Les Oiseaux d’Irène and Némirovsky's Suite française

© Edinburgh University Press. Accepted manuscript version deposited in accordance with SHERPA RoMEO guidelines. The definitive version is available at http://www.euppublishing.com/doi/abs/10.3366/nfs.2012.0031.This article considers the underlying archival poetics of the collaboration between the artist Dado (Miodrag Djuric) and the author Claude Louis-Combet. In particular I consider the collaborative work Les Oiseaux d'Irène (2007), in which a specific archival encounter is documented: Dado appeals to the imaginary figure of Irène Némirovsky while simultaneously engaging with the unique history of the manuscript of Némirovsky's Suite française. Dado's illustrations of Némirovsky's manuscript folios point to a deep ethical engagement with the archive which recalls the function of the manuscript as pledge and legacy in Némirovsky's biography. The archival function is related, via Derrida's account of the archive, to the late phase of Dado's work in which the creation of an internet archive, L'Anti-musée virtuel, is accompanied by the creation of a second Dado archive, at IMEC

Néomorts et faux vivants: communautés dépeuplées chez Beckett et Agamben

Post print version deposited in accordance with SHERPA RoMEO guidelines. The definitive version is available at http://www.rodopi.nl/senj.asp?BookId=BECKETT+17.This article reworks and recontextualises the problematic of the unspeakable in Beckett’s Le Dépeupleur by reference to the recent work of Giorgio Agamben, and in particular the analysis of the figure of the Muselmann in Ce qui reste d’Auschwitz. As well as producing textual parallels with the ‘vaincu’ in Le Dépeupleur, the association of the Muselmann with unspeakability, exclusion and exception in Agamben’s work allows new light to be shed on the elusive project of Beckett’s text. In both cases, representation is avowedly impossible: while the narrative structure of Le Dépeupleur turns on a series of internal ‘errors’, Agamben’s theory in Ce qui reste d’Auschwitz is based on the impossible testimony of the Muselmann, a figure who by definition cannot bear witness

The inadequate archive: ethical remaking in Silvia Kolbowski’s After Hiroshima mon amour

© The Author(s) 2013. Accepted version deposited in accordance with SHERPA RoMEO guidelines. The definitive version is available at http://frc.sagepub.com/content/24/4/417.abstract.This article considers Silvia Kolbowski’s video installation After Hiroshima mon amour as an instance of ethical remaking. In remaking Duras and Resnais’s Hiroshima mon amour (1959) in the shadow of the Iraq war, Kolbowski taps into an existing repetition dynamic: Kolbowski foregrounds the impossibility of an end to the conflict in Iraq by reference to a film concerned with the memorial persistence of Hiroshima. Kolbowski’s practice further recalls the concern with remaking in Derrida’s account of archive fever. In Derrida, to archive is both to record and to erase: repetition compulsion is bound up with the death drive. Kolbowski contests Derrida’s conception of the archive by reshaping the memory and amnesia of Hiroshima mon amour through two interrelated strategies: first, an iterative process focusing on a film which is itself concerned with repetition; and, second, by problematising the classification and archiving of her own work

"The winter's tale": Leontes' derangement and the chronotope of melancholy

Thesis (M.A.) University of Alaska Fairbanks, 2000To recent critical formulations regarding melancholy and its role in the Renaissance humoral body, this project contributes the argument that melancholy's trajectory from its natural to its unnatural state carries with it a fundamental shift in temporal-senses. I illustrate this shift through close analysis of Leontes' derangement in Shakespeare's 'The winter's tale.' Based on Renaissance physiological texts, as well as modern psychoanalytic, anthropological, and gender studies, I explore how melancholy's inherent volatility signifies the masculine anxieties of early modern English patriarchy. I argue that melancholy's bifurcated temporal-senses serve to clarify the subjectivity of Renaissancee passions.Introduction -- ch.1. "to be boy eternal": honor, honesty, and narcissistic shame in "The winter's tale" -- ch.2. "Hysterica passio": melancholy, madness, and the anxiety of gender in "The winter's tale" -- ch.3. "I could afflict you farther": melancholy, jealousy, and chronotopic derangement in "The winter's tale" -- "Works cited

Numerical investigation of film cooling fluid flow and heat transfer using large eddy simulations

Large eddy simulations of film cooling from discrete holes inclined at 35° with a feeding plenum chamber are performed at a density ratio of 2 and blowing ratios from 0.5 to 2.0 in order to gauge the suitability and performance of different hole shapes. Cylindrical holes at length to diameter ratios of 1.75 and 3.5 as well as shaped holes (laterally diffused and console holes) at a length to diameter ratio of 3.5 are simulated issuing into a laminar crossflow at a Reynolds number of approximately 16,000 based on freestream velocity and hole diameter. The domain extends 15 hole diameters downstream of a single coolant hole, and periodic boundary conditions on the lateral faces of the domain are used. The results are validated in terms of the flow field and surface adiabatic effectiveness to experiments for cylindrical hole cases. Horseshoe vortices, DSSN vortices, and hairpin vortices are resolved and isolated. Jetting is found to have significant effects on effectiveness in cylindrical hole cases (with less jetting at the exit plane and better cooling performance from the longer holes) and shaped hole cases (with a laterally split jetting action occurring around a central recirculation region). The performance of the shaped holes is dramatically better than the performance of the cylindrical holes in terms of surface adiabatic effectiveness, with the console holes performing slightly better than the laterally diffused holes. In terms of aerodynamic loss, the console and cylindrical hole far outperformed the laterally diffused hole

Public Opinion and the Public Schools: Three Essays on Americans' Education Policy Preferences

Learning About Schooling: The Effects of State Level Student Achievement Data on Public Opinion There is a growing literature on the effects of student achievement data on public opinion. Prior research suggests that individuals tend to overestimate student achievement in their area. The provision of current achievement levels tends to cause a decrease in confidence in the public schools. In some cases, it appears to increase support for various education reforms. However, previous experimental studies measured outcomes immediately after the provision of information about education performance, making it difficult to distinguish between long-lasting information effects and the more ephemeral consequences of priming. As a result, we do not know how large these effects truly are nor how long they last. I address these concerns by conducting a survey experiment in which I provide state level student achievement data to a randomly assigned treatment group and then measure political attitudes on education issues at three separate times: immediately, after one day, and after ten days. There is evidence that the provision of state level student achievement data temporarily reduces individuals’ confidence in their state school systems, but this effect does not persist after ten days. Schoolhouse Democracy: Education Policy Responsiveness in the States The link between public opinion and enacted public policy is referred to as policy responsiveness in the political science literature. Using new estimates of state level public opinion, I explore the relationship between support for increased education spending and average per pupil expenditures at the state level from 1984 to 2013. Within a given year, I find a modest, positive relationship between statewide public opinion on education spending and statewide per pupil expenditures. On average, states with greater support for education spending also tend to spend more per pupil. Within states over time, an increase in support for greater education spending is also associated with an increase in actual spending. However, after controlling for both between-state differences and common trends across states over time, I observe a negative relationship between public opinion and education spending levels. In circumstances in which spending levels are low relative to the state average and low relative to the year average, support for increased education spending tends to be high for that state and year. Additionally, education spending responsiveness tends to be worse in states with weak or non-existent teachers unions. Polarization and the Politics of Education: What Moves Partisan Opinion? This study explores the conditions under which partisan polarization and de-polarization occur with respect to public opinion on education issues. To guide this investigation, I pose three general questions. First, does the provision of policy-relevant information cause partisans to converge on the same position? Second, can signals from political elites with ideologically moderate views move partisans closer together? And third, does direct experience with public schools reduce the political abstraction with which one evaluates education policies? I repurpose and extend 17 existing survey experiments to help answer the first two questions, and I conduct a non-experimental data analysis to investigate the third. I find consistent evidence that the provision of education spending information has de-polarizing consequences, but the effects of ideologically moderate elite signals on polarization vary by year. I also find tentative evidence in favor of a link between direct experience with public schools and reduced polarization on education issues