32 research outputs found
Reconsidering the Tribal-State Compact Process
This essay evaluates the tribalâstate compact process, as one of several alternative, nonadversarial processes, warranting attention. It argues that, because of its binding character and relatively low cost (in contrast to litigation), and because it is based in the idea of tribes and states exhibiting mutual respect, the compact process is an advanced version of negotiation and bargaining that tribes and states should consider where appropriate
Mid-Infrared Imaging of Candidate Vega-Like Systems
We have conducted deep mid-infrared imaging of a relatively nearby sample of
candidate Vega-like stars using the OSCIR instrument on the CTIO 4-meter and
Keck II 10-meter telescopes. Our discovery of a spatially-resolved disk around
HR 4796A has already been reported (Jayawardhana et al. 1998). Here we present
imaging observations of the other members of the sample, including the
discovery that only the primary in the HD 35187 binary system appears to harbor
a substantial circumstellar disk and the possible detection of extended disk
emission around 49 Ceti. We derive global properties of the dust disks, place
constraints on their sizes, and discuss several interesting cases in detail.
Although our targets are believed to be main sequence stars, we note that
several have large infrared excesses compared to prototype Vega-like systems,
and may therefore be somewhat younger. The disk size constraints we derive, in
many cases, imply emission from relatively large ( 10m) particles
at mid-infrared wavelengths.Comment: 15 pages and 2 PostScript figures, accepted for publication in The
Astronomical Journa
A Broadly Implementable Research Course in Phage Discovery and Genomics for First-Year Undergraduate Students
Engaging large numbers of undergraduates in authentic scientific discovery is desirable but difficult to achieve. We have developed a general model in which faculty and teaching assistants from diverse academic institutions are trained to teach a research course for first-year undergraduate students focused on bacteriophage discovery and genomics. The course is situated within a broader scientific context aimed at understanding viral diversity, such that faculty and students are collaborators with established researchers in the field. The Howard Hughes Medical Institute (HHMI) Science Education Alliance Phage Hunters Advancing Genomics and Evolutionary Science (SEA-PHAGES) course has been widely implemented and has been taken by over 4,800 students at 73 institutions. We show here that this alliance-sourced model not only substantially advances the field of phage genomics but also stimulates studentsâ interest in science, positively influences academic achievement, and enhances persistence in science, technology, engineering, and mathematics (STEM) disciplines. Broad application of this model by integrating other research areas with large numbers of early-career undergraduate students has the potential to be transformative in science education and research training
A Broadly Implementable Research Course in Phage Discovery and Genomics for First-Year Undergraduate Students
Engaging large numbers of undergraduates in authentic scientific discovery is desirable but difficult to achieve. We have developed a general model in which faculty and teaching assistants from diverse academic institutions are trained to teach a research course for first-year undergraduate students focused on bacteriophage discovery and genomics. The course is situated within a broader scientific context aimed at understanding viral diversity, such that faculty and students are collaborators with established researchers in the field. The Howard Hughes Medical Institute (HHMI) Science Education Alliance Phage Hunters Advancing Genomics and Evolutionary Science (SEA-PHAGES) course has been widely implemented and has been taken by over 4,800 students at 73 institutions. We show here that this alliance-sourced model not only substantially advances the field of phage genomics but also stimulates studentsâ interest in science, positively influences academic achievement, and enhances persistence in science, technology, engineering, and mathematics (STEM) disciplines. Broad application of this model by integrating other research areas with large numbers of early-career undergraduate students has the potential to be transformative in science education and research training
Novel Effector Molecules in Type 2 Inflammation: Lessons Drawn from Helminth Infection and Allergy
Intestinal Helminth Infection Immunity and Inflammation following Magnitude of Th2 Cytokine-Dependent IL-31-IL-31R Interactions Limit the
IL-31-IL-31R Interactions Limit the Magnitude of Th2 Cytokine-Dependent Immunity and Inflammation following Intestinal Helminth Infection
The Role Actin Filaments Play in Providing the Characteristic Curved Form of Drosophila Bristles
Drosophila bristles display a precise orientation and curvature. An asymmetric extension of the socket cell overlies the newly emerging bristle rudiment to provide direction for bristle elongation, a process thought to be orchestrated by the nerve dendrite lying between these cells. Scanning electron microscopic analysis of individual bristles showed that curvature is planar and far greater near the bristle base. Correlated with this, as development proceeds the pupa gradually recedes from the inner pupal case (an extracellular layer that encloses the pupa) leading to less bristle curvature along the shaft. We propose that the inner pupal case induces elongating bristles to bend when they contact this barrier. During elongation the actin cytoskeleton locks in this curvature by grafting together the overlapping modules that comprise the long filament bundles. Because the bristle is curved, the actin bundles on the superior side must be longer than those on the inferior side. This is accomplished during grafting by greater elongation of superior side modules. Poor actin cross-bridging in mutant bristles results in altered curvature. Thus, the pattern of bristle curvature is a product of both extrinsic factorsâthe socket cell and the inner pupal caseâand intrinsic factorsâactin cytoskeleton assembly