Biofortification with magnesium nanofertilizer on bioactive compounds and antioxidant capacity in green beans

The use of nanofertilizers has the potential to be used to enrich edible organs with nutrients (biofortification) and improve the biosynthesis of bioactive compounds and their antioxidant capacity. Therefore, the objective of this study was to evaluate the effect of biofortification with magnesium (Mg) nanofertilizer on the accumulation of bioactive compounds and antioxidant capacity in green bean cv. Strike compared to a conventional fertilizer (Mg sulfate). Two sources of Mg were applied via foliar: Nanofertilizer and Mg Sulfate at doses of 0, 50, 100, 200, and 300 mg/L of Mg. The accumulation of total polyphenols, flavonoids, anthocyanins, bioactive compounds, and antioxidant capacity was evaluated in pods. The results obtained in this research confirm the effect of green bean pods biofortified with Mg nanofertilizers on the production and accumulation of bioactive compounds and antioxidant capacity, improving the nutrition and nutraceutical quality of green beans. The 50 mg/L dose of Mg nanofertilizer was the most effective treatment to increase bioactive compounds and antioxidant capacity compared to high doses of Mg sulfate (300 mg/L). This is one of the first studies focused on biofortification with Mg nanofertilizers and their effect on the nutraceutical quality of green beans

Pion and proton showers in the CALICE scintillator-steel analogue hadron calorimeter

Showers produced by positive hadrons in the highly granular CALICE scintillator-steel analogue hadron calorimeter were studied. The experimental data were collected at CERN and FNAL for single particles with initial momenta from 10 to 80 GeV/c. The calorimeter response and resolution and spatial characteristics of shower development for proton- and pion-induced showers for test beam data and simulations using Geant4 version 9.6 are compared.Comment: 26 pages, 16 figures, JINST style, changes in the author list, typos corrected, new section added, figures regrouped. Accepted for publication in JINS

A new path to first light for the Magdalena Ridge Observatory Interferometer

The Magdalena Ridge Observatory Interferometer (MROI) was the most ambitious infrared interferometric facility conceived of in 2003 when funding began. Today, despite having suffered some financial short-falls, it is still one of the most ambitious interferometric imaging facilities ever designed. With an innovative approach to attaining the original goal of fringe tracking to H = 14$^{th}$ magnitude via completely redesigned mobile telescopes, and a unique approach to the beam train and delay lines, the MROI will be able to image faint and complex objects with milliarcsecond resolutions for a fraction of the cost of giant telescopes or space-based facilities. The design goals of MROI have been optimized for studying stellar astrophysical processes such as mass loss and mass transfer, the formation and evolution of YSOs and their disks, and the environs of nearby AGN. The global needs for Space Situational Awareness (SSA) have moved to the forefront in many communities as Space becomes a more integral part of a national security portfolio. These needs drive imaging capabilities ultimately to a few tens of centimeter resolution at geosynchronous orbits. Any array capable of producing images on faint and complex geosynchronous objects in just a few hours will be outstanding not only as an astrophysical tool, but also for these types of SSA missions. With the recent infusion of new funding from the Air Force Research Lab (AFRL) in Albuquerque, NM, MROI will be able to attain first light, first fringes, and demonstrate bootstrapping with three telescopes by 2020. MROI’s current status along with a sketch of our activities over the coming 5 years will be presented, as well as clear opportunities to collaborate on various aspects of the facility as it comes online. Further funding is actively being sought to accelerate the capability of the array for interferometric imaging on a short time-scale so as to achieve the original goals of this ambitious facility.AFRL (Cooperative Agreement FA9453-15-2-0086 titled “Amplitude Interferometer Research for Geosynchronous Earth Orbit (GEO) Space Situational Awareness (SSA)”), Congressional Delegation of the State of New Mexico, Science and Technology Facilities CouncilThis is the author accepted manuscript. The final version is available from SPIE via http://dx.doi.org/10.1117/12.223391

Testing Hadronic Interaction Models using a Highly Granular Silicon-Tungsten Calorimeter

A detailed study of hadronic interactions is presented using data recorded with the highly granular CALICE silicon-tungsten electromagnetic calorimeter. Approximately 350,000 selected negatively charged pion events at energies between 2 and 10 GeV have been studied. The predictions of several physics models available within the Geant4 simulation tool kit are compared to this data. A reasonable overall description of the data is observed; the Monte Carlo predictions are within 20% of the data, and for many observables much closer. The largest quantitative discrepancies are found in the longitudinal and transverse distributions of reconstructed energy.Comment: 28 pages, 24 figures, accepted for publication in NIM

Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction, GALACTIC‐HF: baseline characteristics and comparison with contemporary clinical trials

Aims: The safety and efficacy of the novel selective cardiac myosin activator, omecamtiv mecarbil, in patients with heart failure with reduced ejection fraction (HFrEF) is tested in the Global Approach to Lowering Adverse Cardiac outcomes Through Improving Contractility in Heart Failure (GALACTIC‐HF) trial. Here we describe the baseline characteristics of participants in GALACTIC‐HF and how these compare with other contemporary trials. Methods and Results: Adults with established HFrEF, New York Heart Association functional class (NYHA) ≥ II, EF ≤35%, elevated natriuretic peptides and either current hospitalization for HF or history of hospitalization/ emergency department visit for HF within a year were randomized to either placebo or omecamtiv mecarbil (pharmacokinetic‐guided dosing: 25, 37.5 or 50 mg bid). 8256 patients [male (79%), non‐white (22%), mean age 65 years] were enrolled with a mean EF 27%, ischemic etiology in 54%, NYHA II 53% and III/IV 47%, and median NT‐proBNP 1971 pg/mL. HF therapies at baseline were among the most effectively employed in contemporary HF trials. GALACTIC‐HF randomized patients representative of recent HF registries and trials with substantial numbers of patients also having characteristics understudied in previous trials including more from North America (n = 1386), enrolled as inpatients (n = 2084), systolic blood pressure < 100 mmHg (n = 1127), estimated glomerular filtration rate < 30 mL/min/1.73 m2 (n = 528), and treated with sacubitril‐valsartan at baseline (n = 1594). Conclusions: GALACTIC‐HF enrolled a well‐treated, high‐risk population from both inpatient and outpatient settings, which will provide a definitive evaluation of the efficacy and safety of this novel therapy, as well as informing its potential future implementation

Is the writing on the skull?

No abstract availabl

Monitor the quality of cardiopulmonary resuscitation in 2020.

PURPOSE OF REVIEW: The current review will give an overview of different possibilities to monitor quality of cardiopulmonary resuscitation (CPR) from a physiologic and a process point of view and how these two approaches can/should overlap. RECENT FINDINGS: Technology is evolving fast with a lot of opportunities to improve the CPR quality. The role of smartphones and wearables are step-by-step identified as also the possibilities to perform patient tailored CPR based on physiologic parameters. The first steps have been taken, but more are to be expected. In this context, the limits of what is possible with human providers will become more and more clear. SUMMARY: To perform high-quality CPR, at first, one should optimize rate, depth and pause duration supported by process monitoring tools. Second, the evolving technological evolution gives opportunities to measure physiologic parameters in real-time which will open the way for patient-tailored CPR. The role of ultrasound, cerebral saturation and end-tidal CO2 in measuring the quality of CPR needs to be further investigated as well as the possible ways of influencing these measured parameters to improve neurological outcome and survival

Sudden Electrocardiogram Rhythm Changes after Return of Spontaneous Circulation in Porcine Models of Out-of-Hospital Cardiac Arrest: A Phenomenological Report.

OBJECTIVE: We sought to identify, quantify, and characterize post-ROSC SERC in successfully resuscitated swine. METHODS: We reviewed all LabChart data from resuscitated approximately 4- to 6-month-old swine used for various experimental protocols from 2006 to 2019. We identified those that achieved sustained ROSC and analyzed their entire post-ROSC periods for evidence of SERC in the ECG, and arterial and venous pressure tracings. Presence or absence of SERC was confirmed independently by two reviewers (ACK, DDS). We measured the interval from ROSC to first SERC, analyzed the following metrics, and calculated the change from 60 sec pre-SERC (or from ROSC if less than 60 sec) to 60 sec post-SERC: heart rate, central arterial pressure (CAP), and central venous pressure (CVP). RESULTS: A total of 52 pigs achieved and sustained ROSC. Of these, we confirmed at least one SERC in 25 (48.1%). Two pigs (8%) each had two unique SERC events. Median interval from ROSC to first SERC was 3.8 min (inter-quartile range 1.0-6.9 min; range 16 sec to 67.5 min). We observed two distinct types of SERC: type 1) the post-SERC heart rate and arterial pressure increased (72% of cases); and type 2) the post-SERC heart rate and arterial pressure decreased (28% of cases). For type 1 cases, the mean (standard deviation [SD]) heart rate increased by 33.6 (45.7) beats per minute (bpm). The mean (SD) CAP increased by 20.6 (19.2) mmHg. For type 2 cases, the mean (SD) heart rate decreased by 39.7 (62.3) bpm. The mean (SD) CAP decreased by 21.9 (15.6) mmHg. CONCLUSIONS: SERC occurred in nearly half of all cases with sustained ROSC and can occur multiple times per case. First SERC most often occurred within the first 4 minutes following ROSC. Heart rate, CAP, and CVP changed at the moment of SERC. We are proceeding to examine whether this phenomenon occurs in humans post-cardiac arrest and ROSC