Toward a typeface for the transcription of facial actions in sign languages

International audienceNon-manual actions, and more specifically facial actions (FA) can be found in all Sign Languages (SL). Those actions involve all the different facial parts and can have various and intricate linguistic relations with manual signs. Unlike in vocal languages, FA in SL provide more meaning than simple expressions of feelings and emotions. Yet non-manual parameters are among the most unknown formal features in SL studies. During the past 30 years, some studies have started questioning the meanings and linguistic values and the relations between manual and non-manual signs (Crashborn et al. 2008; Crashborn & Bank 2014); more recently, SL corpora have been analysed, segmented, and transcribed to help study FA (Vogst-Svenden 2008; Bergman et al. 2008; Sutton-Spence & Day 2008).Moreover, to fill the lack of an annotation system for FA, a few manual annotation systems have integrated facial glyphs, such as HamNoSys (Prillwitz et al. 1989) and SignWriting (Sutton 1995). On one hand, HamNoSys has been developed to describe all existing SLs at a phonetic level; it allows a formal, linear, highly detailed and searchable description of manual parameters. As for non-manual parameters, HamNoSys offers the replacement of hands by another articulators. Non-manual parameters can be written as “eyes” or “mouth” and described by the same symbols developed for hands (Hanke 2004). Unfortunately only a limited number of manual symbols can be translated into FA and the annotation system remains incomplete. On the other hand, SignWriting describes SL with iconic symbols placed in a 2D space representing the signer’s body. Facial expressions are divided into mouth, eyes, nose, eyebrows, etc., and are drawn in a circular “head” much like emoticons. SignWriting offers a detailed description of posture and actions of non-manual parameters, but does not ensure compatibility with the most common annotation software used by SL linguists (e.g., ELAN).Typannot, a interdisciplinary project led by linguists, designers, and developers, which aims to set up a complete transcription system for SL that includes every SL parameter (handshape, localisation, movement, FA), has developed a different methodologie. As mentioned earlier, FA have various linguistic values (mouthings, adverbial mouth gestures, semantically empty, enacting, whole face) and also include prosody and emotional meanings. In this regard, they can be more variable and signer-related than manual parameters. To offer the best annotation tool, Typannot’s approach has been to define facial parameters and all their possible tangible configurations. The goal is to set up the most efficient, simple, yet complete and universal formula to describe all possible FA.This formula is based on a 3 dimensional grid. Indeed all the different configurations of FA can be described by its X, Y, Z axis position. As a result, all FA can be described and encoded using a restricted list of 39 qualifiers. Based on this model and to help reduce the annotation process, a set of generic glyphs has been developed. Each qualifier has its own symbolic “generic” glyph. This methodical decomposition of all facial components enables a precise and accurate transcription of a complex FA using only a few glyphs.This formula and its generic glyphs have gone through a series of tests and revisions. Recently, an 18m20s long FA corpus of two deaf signers has been recorded using two different cameras. The first one, RGB HQ, is used to capture a high quality image and the second, infrared Kinect, is used to captured the depth. The latter was linked with Brekel Proface 2 (Leong et al. 2015), a 3D animation software that enables an automatic recognition of FA. This corpus has been fully annotated using Typannot’s generic glyphs. These annotations have enabled the validation of the general structure of Typannot FAformula and to identify some minor corrections to be made. For instance, it has been shown that the description of the air used to puff out or suck in cheeks is too restrictive and the description of the opening and closure of the eyelids is too unnecessarily precise.When those changes are implemented, our next task will be to develop a morphological glyphic system that will combine the different generic glyphs used for each facial parameter into one unique morphological glyph. This means that for any given FA, all the information contained in Typannot descriptive formula will be contained within one legible glyph. Some early research and work has already begun on this topic, but needs further development before providing a statement on its typographic structure. When this system is completed, it will be released with its own virtual keyboard (Typannot Keyboard, currently in development for handshapes) to help transcription and improve annotation processes.Bibliography :-Chételat-Pelé, E. (2010). Les Gestes Non Manuels en Langue des Signes Française ; Annotation, analyse et formalisation : application aux mouvements des sourcils et aux clignements des yeux. Université de Provence - Aix-Marseille I.-Crasborn, O., Van Der Kooij, E., Waters, D., Woll, B., & Mesch, J. (2008). Frequency distribution and spreading behavior of different types of mouth actions in three sign languages. Sign Language & Linguistics, 11(1), 45–67.-Crasborn, O. A., & Bank, R. (2014). An annotation scheme for the linguistic study of mouth actions in sign languages. http://repository.ubn.ru.nl/handle/2066/132960-Fontana, S. (2008). Mouth actions as gesture in sign language. Gesture, 8(1), 104‑123.-Hanke, T. (2004). HamNoSys—Representing sign language data in language resources and language processing contexts. In Workshop on the Representation and Processing of Sign Languages on the occasion of the Fourth International Conference on Language Resources and Evaluation (p. 1‑6).-Leong, C. W., Chen, L., Feng, G., Lee, C. M., & Mulholland, M. (2015). Utilizing depth sensors for analyzing multimodal presentations: Hardware, software and toolkits (p. 547‑556).Presented at Proceedings of the 2015 ACM on International Conference on Multimodal Interaction, ACM.-Prillwitz, S., Leven, R., Zienert, H., Hanke, T., & Henning, J. (1989). Hamburg notation system for sign languages: An introductory guide. Signum Press, Hamburg.-Sandler, W. (2009). Symbiotic symbolization by hand and mouth in sign language. Semiotica, 2009(174), 241‑275. http://doi.org/10.1515/semi.2009.035-Sutton, V. (1995). Lessons in Sign Writing: Textbook. DAC, La Jolla (CA).-Sutton-Spence, R., & Boyes-Braem, P. (2001). The hands are the head of the mouth: The mouth as articulator in sign languages. Signum Press, Hamburg

0357 : Platypnea orthodeoxia syndrome: focus on predisposing anatomical factors

Platypnea orthodeoxia syndrome (POS) is a rare situation with hypoxia and breathlessness in the upright position recovering in the recumbent position. A mechanical inter-atrial septum distortion, causing redirection of flow from the right to the left atrium through a patent foramen ovale (PFO), despite normal pulmonary pressure, is suggested to explain POS. Prevalence of predisposing anatomical factors remain little knownMethodsAll patients who underwent a PFO closure for a POS were retrospectively included from 2 CHU. Predisposing anatomical factors were investigated.Results67 patients (Median age 72 y.o., interquartile range 61-80; 58.2% men) were included. All patients had dyspnea (76.2% NYHA III or IV, 53.7% under oxygen-therapy). The remaining patients had a refractory hypoxemia (38.2%) without POS. Most frequent predisposing anatomical factor was an enlarged or unwound aorta (n=29, 43.3% 95CI 31.2-56.0) with an aortic aneurysm in 25 patients (37.3%, 95CI 25.8-50.0). Other factors identified were pneumonectomy (n=8, 11.9% CI95 5.3-22.2), a history of cardiac surgery (n=7, 10.5%, 95CI 4.3-20.3), mechanical ventilation (n=6, 9.0% 95CI 3.4-18.5), kyphoscoliosis (n=4, 6.0% 95CI 1.7-14.6), hepatomegaly (n=4, 6.0% 95CI 1.7-14.6, 2 patients with hepato-renal polycystic disease, one hemochromatosis and one cirrhosis), right ventricle failure (n=2,3.0% 95CI 0.4-10.4), pericardial effusions (n=2,3.0% 95CI 0.4-10.4), right ventricle arrhythmogenic dysplasia (n=2,3.0% 95CI 0.4-10.4), diaphragmatic paralysis (n=1, 1.5% 95CI 0.1-8.0), carcinoid syndrome with tricuspid regurgitation (n=1, 1.5% 95CI 0.1-8.0), a right atrium pace-maker lead (n=1, 1.5% 95CI 0.1-8.0) and a tako-tsubo syndrome (n=1, 1.5% 95CI 0.1-8.0).ConclusionAortic aneurysm and pneumonectomy are the most frequent situation leading to a POS. Other causes were observed such as hepato-renal polycystic kidney, or atrial pacemaker probe that may be underdiagnosed in clinical practice

Cardiac Alpha-Myosin (MYH6) Is the Predominant Sarcomeric Disease Gene for Familial Atrial Septal Defects

Secundum-type atrial septal defects (ASDII) account for approximately 10% of all congenital heart defects (CHD) and are associated with a familial risk. Mutations in transcription factors represent a genetic source for ASDII. Yet, little is known about the role of mutations in sarcomeric genes in ASDII etiology. To assess the role of sarcomeric genes in patients with inherited ASDII, we analyzed 13 sarcomeric genes (MYH7, MYBPC3, TNNT2, TCAP, TNNI3, MYH6, TPM1, MYL2, CSRP3, ACTC1, MYL3, TNNC1, and TTN kinase region) in 31 patients with familial ASDII using array-based resequencing. Genotyping of family relatives and control subjects as well as structural and homology analyses were used to evaluate the pathogenic impact of novel non-synonymous gene variants. Three novel missense mutations were found in the MYH6 gene encoding alpha-myosin heavy chain (R17H, C539R, and K543R). These mutations co-segregated with CHD in the families and were absent in 370 control alleles. Interestingly, all three MYH6 mutations are located in a highly conserved region of the alpha-myosin motor domain, which is involved in myosin-actin interaction. In addition, the cardiomyopathy related MYH6-A1004S and the MYBPC3-A833T mutations were also found in one and two unrelated subjects with ASDII, respectively. No mutations were found in the 11 other sarcomeric genes analyzed. The study indicates that sarcomeric gene mutations may represent a so far underestimated genetic source for familial recurrence of ASDII. In particular, perturbations in the MYH6 head domain seem to play a major role in the genetic origin of familial ASDII

Knowledge and remaining gaps on the role of animal and human movements in the poultry production and trade networks in the global spread of avian influenza viruses – A scoping review

International audiencePoultry production has significantly increased worldwide, along with the number of avian influenza (AI) outbreaks and the potential threat for human pandemic emergence. The role of wild bird movements in this global spread has been extensively studied while the role of animal, human and fomite movement within commercial poultry production and trade networks remains poorly understood. The aim of this work is to better understand these roles in relation to the different routes of AI spread. A scoping literature review was conducted according to the PRISMA guidelines (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) using a search algorithm combining twelve domains linked to AI spread and animal/human movements within poultry production and trade networks. Only 28 out of 3,978 articles retrieved dealt especially with the role of animal, human and fomite movements in AI spread within the international trade network (4 articles), the national trade network (8 articles) and the production network (16 articles). While the role of animal movements in AI spread within national trade networks has been largely identified, human and fomite movements have been considered more at risk for AI spread within national production networks. However, the role of these movements has never been demonstrated with field data, and production networks have only been partially studied and never at international level. The complexity of poultry production networks and the limited access to production and trade data are important barriers to this knowledge. There is a need to study the role of animal and human movements within poultry production and trade networks in the global spread of AI in partnership with both public and private actors to fill this gap

Septal alcoholization in hypertrophic cardiomyopathy: about 11 cases

International audienceOutcomes of septal alcoholization in hypertrophic obstructive cardiomyopathy are not enough studied in all centers. The purpose of this study was to determine the outcomes of septal alcoholization in hypertrophic obstructive cardiomyopathy in our hospital. A retrospective and prospective descriptive study focused on all patients aged at least 18 years treated by alcohol septal ablation between July 2005 and June 2010 in the cardiology unit of Clermont-Ferrand teaching Hospital. The inclusion criteria were, hypertrophic obstructive cardiomyopathy with left ventricular outflow tract obstruction ≥ 50 mmHg, symptomatic despite optimal medical therapy. The clinical, paraclinical data and the results of alcohol ablation were collected from medical records of patients and a telephone conversation with the patients or their physicians. These data were analyzed by EPI info 6.04. Eleven patients with average age of 56.27 ± 15, 83 were included of which 81.8% of men. The main indications of alcohol septal were dyspnea stage NYHA II-IV (45.5%), lipothymia (18.2%) and invalidating angina (18.2%). Main electrocardiographic abnormalities were left ventricular hypertrophy and disorders of repolarization with 72.7% each. Minor conductive disorders were found in 45.5% of the cases. The left ventricular outflow tract obstruction was 98.18 ± 25.93 mmHg before alcohol septal ablation and 18.91 ± 31.97 mmHg after a follow-up of 25.64 ± 21.97 months. The success rate was 81.8%. Conductive disorders (45.5%) required the establishment of a definitive pacemaker in 36.4% of the patients. A cardiac defibrillator was implanted at 27.3%. Septal alcoholization was succesful

Evaluation of vaccination strategies to control an avian influenza outbreak in French poultry production networks using EVACS tool

International audienceFrance recently faced two epizootic waves of highly pathogenic avian influenza (HPAI) in poultry (H5N6 in 2015–2016 and H5N8 in 2016–2017), mainly in the fattening duck production sector. Vaccination against avian influenza (AI) is currently not authorised in France even though its potential benefits were discussed during these epizootic events. The objective of this work was to evaluate the potential efficiency of different vaccination strategies that could be applied against AI in France.The EVACS tool, which is a decision support tool developed to evaluate vaccination strategies, was applied in several French poultry production sectors: broiler, layer, turkey, duck and guinea fowl. EVACS was used to simulate the performance of vaccination strategies in terms of vaccination coverage, immunity levels and spatial distribution of the immunity level. A cost-benefit analysis was then applied based on EVACS results to identify the most efficient strategy. For each sector, vaccination protocols were tested according to the production type (breeders/production, indoor/outdoor), the integration level (integrated/independent) and the type of vaccine (hatchery vaccination using a recombinant vaccine/farm vaccination using an inactivated vaccine). The most efficient protocols for each sector were then combined to test different overall vaccination strategies at the national level. Even if it was not possible to compare vaccination protocols with the two vaccines types in “foie gras” duck, meat duck and guinea fowl production sectors as no hatchery vaccine currently exist for these species, these production sectors were also described and included in this simulation.Both types of vaccination (at hatchery and farm level) enabled protective immunity levels for the control of AI, but higher poultry population immunity level was reached (including independent farms) using hatchery vaccination. We also showed that hatchery vaccination was more efficient (higher benefit-cost ratio) than farm vaccination. Sufficient and homogeneously spatially distributed protective levels were reached in the overall poultry population with vaccination strategies targeting breeders, chicken layers and broilers and turkeys, without the need to include ducks and guinea fowls. However, vaccination strategies involving the highest number of species and production types were the most efficient in terms of cost-benefit.This study provides critical information on the efficiency of different vaccination strategies to support future decision making in case vaccination was applied to prevent and control HPAI in France

Septal alcoholization in hypertrophic cardiomyopathy: about 11 cases

Outcomes of septal alcoholization in hypertrophic obstructive cardiomyopathy are not enough studied in all centers. The purpose of this study was to determine the outcomes of septal alcoholization in hypertrophic obstructive cardiomyopathy in our hospital. A retrospective and prospective descriptive study focused on all patients aged at least 18 years treated by alcohol septal ablation between July 2005 and June 2010 in the cardiology unit of Clermont-Ferrand teaching Hospital. The inclusion criteria were, hypertrophic obstructive cardiomyopathy with left ventricular outflow tract obstruction ≥ 50 mmHg, symptomatic despite optimal medical therapy. The clinical, paraclinical data and the results of alcohol ablation were collected from medical records of patients and a telephone conversation with the patients or their physicians. These data were analyzed by EPI info 6.04. Eleven patients with average age of 56.27 ± 15, 83 were included of which 81.8% of men. The main indications of alcohol septal were dyspnea stage NYHA II-IV (45.5%), lipothymia (18.2%) and invalidating angina (18.2%). Main electrocardiographic abnormalities were left ventricular hypertrophy and disorders of repolarization with 72.7% each. Minor conductive disorders were found in 45.5% of the cases. The left ventricular outflow tract obstruction was 98.18 ± 25.93 mmHg before alcohol septal ablation and 18.91 ± 31.97 mmHg after a follow-up of 25.64 ± 21.97 months. The success rate was 81.8%. Conductive disorders (45.5%) required the establishment of a definitive pacemaker in 36.4% of the patients. A cardiac defibrillator was implanted at 27.3%. Septal alcoholization was succesful.Keywords: Hypertrophic obstructive cardiomyopathy, therapy, septal alcohol ablatio