64 research outputs found

    Recovering the mass and the charge of a Reissner-Nordstr\"om black hole by an inverse scattering experiment

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    In this paper, we study inverse scattering of massless Dirac fields that propagate in the exterior region of a Reissner-Nordstr\"om black hole. Using a stationary approach we determine precisely the leading terms of the high-energy asymptotic expansion of the scattering matrix that, in turn, permit us to recover uniquely the mass of the black hole and its charge up to a sign

    Local energy decay of massive Dirac fields in the 5D Myers-Perry metric

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    We consider massive Dirac fields evolving in the exterior region of a 5-dimensional Myers-Perry black hole and study their propagation properties. Our main result states that the local energy of such fields decays in a weak sense at late times. We obtain this result in two steps: first, using the separability of the Dirac equation, we prove the absence of a pure point spectrum for the corresponding Dirac operator; second, using a new form of the equation adapted to the local rotations of the black hole, we show by a Mourre theory argument that the spectrum is absolutely continuous. This leads directly to our main result.Comment: 40 page

    Current and emerging strategies for organophosphate decontamination: special focus on hyperstable enzymes

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    © 2016, Springer-Verlag Berlin Heidelberg.Organophosphorus chemicals are highly toxic molecules mainly used as pesticides. Some of them are banned warfare nerve agents. These compounds are covalent inhibitors of acetylcholinesterase, a key enzyme in central and peripheral nervous systems. Numerous approaches, including chemical, physical, and biological decontamination, have been considered for developing decontamination methods against organophosphates (OPs). This work is an overview of both validated and emerging strategies for the protection against OP pollution with special attention to the use of decontaminating enzymes. Considerable efforts have been dedicated during the past decades to the development of efficient OP degrading biocatalysts. Among these, the promising biocatalyst SsoPox isolated from the archaeon Sulfolobus solfataricus is emphasized in the light of recently published results. This hyperthermostable enzyme appears to be particularly attractive for external decontamination purposes with regard to both its catalytic and stability properties

    Organophosphorus poisoning in animals and enzymatic antidotes

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    © 2018 Springer-Verlag GmbH Germany, part of Springer Nature Organophosphorus compounds (OPs) are neurotoxic molecules developed as pesticides and chemical warfare nerve agents (CWNAs). Most of them are covalent inhibitors of acetylcholinesterase (AChE), a key enzyme in nervous systems, and are therefore responsible for numerous poisonings around the world. Many animal models have been studied over the years in order to decipher the toxicity of OPs and to provide insights for therapeutic and decontamination purposes. Environmental impact on wild animal species has been analyzed to understand the consequences of OP uses in agriculture. In complement, various laboratory models, from invertebrates to aquatic organisms, rodents and primates, have been chosen to study chronic and acute toxicity as well as neurobehavioral impact, immune response, developmental disruption, and other pathological signs. Several decontamination approaches were developed to counteract the poisoning effects of OPs. Among these, enzyme-based strategies are particularly attractive as they allow efficient external decontamination without toxicity or environmental impact and may be of interest for treatment. Approaches using bioscavengers for prophylaxis, treatment, and external decontamination are emphasized and their potential is discussed in the light of toxicological observations from various animal models. The relevance of animal models, regarding their cholinergic system and the abundance of naturally protecting enzymes, is also discussed for better extrapolation of results to human

    Widespread fear of dengue transmission but poor practices of dengue prevention : A study in the slums of Delhi, India

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    Background This study has been conducted to throw light on the knowledge and practices related to dengue fever among the poor population living in Delhi's slums. Materials A household survey was conducted in 2013 among 3,350 households. The households were stratified by a number of variables related to socio-economic status and health events such as hospitalisation. The data collection was completed through face-to-face interviews conducted with the help of 25 field investigators. Results About 8% of the households had at least one diagnosed dengue case. In comparison to the population surveyed, teenagers (15-19 years) and adults (30-34 years) were more affected whereas children under four years of age were underrepresented. Housewives are more affected by dengue (24%) compared to their share of the population surveyed (17%). Despite the fact that 77% of the respondents are worried about mosquitoes, only 43% of them monitor environment to avoid the presence of breeding sites. Conclusion One cannot exclude the possibility that though young children under the age of four years are exposed to the virus, either their cases were asymptomatic or family members infected during this period had potentially more serious symptoms leading to hospitalisation. This result could thus be explained by budget-related health choices made by this population which do not favour small children. Educational programs should target housewives to improve their impact, as they are the ones mostly responsible for water storage and cleanliness of the house and its neighbourhood. Even with a dengue experience and potentially an acute perception of the risk and its factors, a proper management of environmental conditions is lacking. This along with the fact that word-of-mouth is the main source of information quoted should be a message for municipality health workers to give door-to-door information on how to prevent breeding sites and dengue infection

    Trypanosomatid comparative genomics: contributions to the study of parasite biology and different parasitic diseases

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    Back to the future in Chagas disease: from animal models to patient cohort studies, progress in immunopathogenesis research

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    Intoxication aux organophosphorés : vers des traitements enzymatiques

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    Minimization of the stray inductance in metallized capacitors: Connections and winding geometry dependence

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    Stray inductance in power electronics capacitors is due to the magnetic field created by the currents in winding and connections. We review different connection schemes that could be used in metallized capacitors. For each of these connections, the stray inductance expression depends of winding geometries. The proposed method to minimize this inductance can be divided in two parts. The first part consists in optimizing the winding geometry for a particular connection. The second is the choice of a low-inductance connection for the previously determined winding. The best results are obtained with large inner and outer radii and through the use of inner annular conductors
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