Development of SRF Cavity Tuners for CERN

Superconducting RF cavity developments are currently on-going for new accelerator projects at CERN such as HIE ISOLDE and HL-LHC. Mechanical RF tuning systems are required to compensate cavity frequency shifts of the cavities due to temperature, mechanical, pressure and RF effects on the cavity geometry. A rich history and experience is available for such mechanical tuners developed for existing RF cavities. Design constraints in the context of HIE ISOLDE and HL-LHC such as required resolution, space limitation, reliability and maintainability have led to new concepts in the tuning mechanisms. This paper will discuss such new approaches, their performances and planned developments

GRE quantitative reasoning: quickstudy reference guide

La gestion du territoire est complexe, pluridisciplinaire… et conflictuelle. Chaque acteur public en a sa propre représentation qui, ­combinée à sa conception de l’intérêt général, génère des concurrences institutionnelles, des divergences sur le fond même des politiques à conduire, des antagonismes. Cet ouvrage trouve son origine dans un séminaire entre géographes, politistes, juristes, économistes et décideurs territoriaux qui ont ­cherché à mettre en lumière les interactions des différents niveaux de l’action publique. Les sujets abordés sont divers : le concept de cohésion territoriale au sein de l’Union européenne et son évolution, les rapports entre ­Washington et les États fédérés, la décentralisation italienne, l’importance des régions métropolitaines aux États-Unis, le Grand Paris, la réforme du fédéralisme allemand, la Catalogne et son expérience de réhabilitation urbaine. À partir de ces exemples, les auteurs démontrent que la gouvernance des territoires est une question éminemment géopolitique. Les affrontements qui en résultent compromettent souvent la réussite des politiques publiques et la compétitivité des territoires. Parfois, au contraire, ils font surgir innovation et dynamisme.Under the editorship of Giuseppe Bettoni Territorial management is a complicated, multidisciplinary and conflict-ridden business. Public players all have their own vision of what it is. This, combined with their perception of what constitutes the public interest, generates institutional competition, divergences on the very essence of the policies to be conducted, and antagonism. This book was inspired by a conference of geographers, political scientists, legal experts, economists, and local and regional decision-makers who decided to try and make sense of the interactions between the different levels of public action. It addresses a range of subjects: the concept of territorial cohesion in the European Union and how it has developed, relations between Washington and the federal states, Italian decentralisation, the importance of the metropolitan regions in the United States, the creation of the Greater Paris Area, the reform of German federalism, and Catalonia and its experience of urban regeneration. The authors draw on these case studies to demonstrate that territorial governance is an eminently geopolitical matter. Resulting conflicts often compromise the success of public policies and the competitiveness of the territories. Sometimes, however, they trigger innovation and initiative.Bajo la dirección científica de Giuseppe Bettoni La gestión del territorio es compleja, multidisciplinaria… y conflictiva. Cada actor público posee una concepción propia de dicha gestión que, unida a su entendimiento del interés general, genera competencia en el ámbito institucional, divergencias en cuanto al fondo de las políticas que deben llevarse a cabo, y antagonismos. Esta obra tiene su origen en un seminario celebrado entre geógrafos, politólogos, juristas, economistas y responsables de la toma de decisiones en el ámbito territorial, con el objetivo de arrojar luz sobre la interacción entre los diferentes niveles de la actuación pública. Se abordan temas de diversa índole: el concepto de cohesión territorial en el seno de la Unión Europea y su evolución, las relaciones entre Washington y los Estados federados, la descentralización italiana, la importancia de las regiones metropolitanas en los Estados Unidos, la zona metropolitana parisina, la reforma del federalismo alemán, Cataluña y su experiencia de rehabilitación urbana… Partiendo de estos ejemplos concretos, los autores demuestran que la gobernanza de los territorios constituye una cuestión eminentemente geopolítica. A menudo, los enfrentamientos derivados ponen en peligro el éxito de las políticas públicas y la competitividad de los territorios. En ocasiones, por el contrario, estos mismos conflictos suscitan innovación y dinamismo

Comprehensive classification of symptoms and signs reported among 218 patients with acute HIV-1 infection

Acute HIV-1 illness presents a wide range of clinical manifestations. We assessed a classification and data reduction of clinical features among 218 patients with acute HIV-1 infection enrolled in four prospective seroincidence studies. Factor analysis allows the definition of eight factors based on groups of symptoms and signs: gastrointestinal transit disturbances, weight loss/abdominal pain, lymphadenopathy, myalgia/arthralgia, neurologic features, constitutional and mucocutaneous features, oral candidiasis, and anorexia/pharyngitis. These groups reflected the main target systems involved at the time of acute HIV-1 disease. Grouping of symptoms and signs based on groups of patients is potentially more informative than observations made on individual patients. It might facilitate diagnosis, suggest pathogenic mechanisms and reduce the number of variables for characterizing acute HIV-1 illness

Molecular characterization of the intact mouse muscle spindle using a multi-omics approach

The proprioceptive system is essential for the control of coordinated movement, posture, and skeletal integrity. The sense of proprioception is produced in the brain using peripheral sensory input from receptors such as the muscle spindle, which detects changes in the length of skeletal muscles. Despite its importance, the molecular composition of the muscle spindle is largely unknown. In this study, we generated comprehensive transcriptomic and proteomic datasets of the entire muscle spindle isolated from the murine deep masseter muscle. We then associated differentially expressed genes with the various tissues composing the spindle using bioinformatic analysis. Immunostaining verified these predictions, thus establishing new markers for the different spindle tissues. Utilizing these markers, we identified the differentiation stages the spindle capsule cells undergo during development. Together, these findings provide comprehensive molecular characterization of the intact spindle as well as new tools to study its development and function in health and disease

L'hospitalisation en psychiatrie : point de vue des patients et perspectives éthiques

International audienc

Manuel du HCB pour l’utilisation confinée d’organismes génétiquement modifiés

Manuel du HCB pour l’utilisation confinée d’organismes génétiquement modifiésManuel du HCB pour l’utilisation confinée d’organismes génétiquement modifié

Manuel du HCB pour l’utilisation confinée d’organismes génétiquement modifiés

Manuel du HCB pour l’utilisation confinée d’organismes génétiquement modifiés>>> ATTENTION: une version plus récente peut avoir été publiée par le HCB; la présente version est une archive qui ne doit pas être utilisée comme guide de référence sans avoir d'abord vérifié qu'elle est à jour

Development of SRF cavity tuners for CERN

Superconducting RF cavity developments are currently on-going for new accelerator projects at CERN such as HIE ISOLDE and HL-LHC. Mechanical RF tuning systems are required to compensate cavity frequency shifts of the cavities due to temperature, mechanical, pressure and RF effects on the cavity geometry. A rich history and experience is available for such mechanical tuners developed for existing RF cavities. Design constraints in the context of HIE ISOLDE and HL-LHC such as required resolution, space limitation, reliability and maintainability have led to new concepts in the tuning mechanisms. This paper will discuss such new approaches, their performances and planned developments