The Effects of Type 2 Diabetes Mellitus on Organ Metabolism and the Immune System

Metabolic abnormalities such as dyslipidemia, hyperinsulinemia, or insulin resistance and obesity play key roles in the induction and progression of type 2 diabetes mellitus (T2DM). The field of immunometabolism implies a bidirectional link between the immune system and metabolism, in which inflammation plays an essential role in the promotion of metabolic abnormalities (e.g., obesity and T2DM), and metabolic factors, in turn, regulate immune cell functions. Obesity as the main inducer of a systemic low-level inflammation is a main susceptibility factor for T2DM. Obesity-related immune cell infiltration, inflammation, and increased oxidative stress promote metabolic impairments in the insulin-sensitive tissues and finally, insulin resistance, organ failure, and premature aging occur. Hyperglycemia and the subsequent inflammation are the main causes of micro- and macroangiopathies in the circulatory system. They also promote the gut microbiota dysbiosis, increased intestinal permeability, and fatty liver disease. The impaired immune system together with metabolic imbalance also increases the susceptibility of patients to several pathogenic agents such as the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Thus, the need for a proper immunization protocol among such patients is granted. The focus of the current review is to explore metabolic and immunological abnormalities affecting several organs of T2DM patients and explain the mechanisms, whereby diabetic patients become more susceptible to infectious diseases.Peer reviewe

The role of T helper 9(Th9) against Infectious Diseases

Background and aims: Infectious diseases are disorders caused by organisms such as bacteria, viruses, fungi or parasites .The Th9 subset develops in response to combined signals from TGF-b and IL-4 among a cacophony of other cytokines in an extracellular milieu. T helper 9 (Th9) cells, as a novel CD4 T cell subset, seem to play a complex role in the outcome of specific immune responses. In this article, we aimed to review the role of these cells in infectious disease. Methods: In this mini-review study, we study 25 novel articles since 2009 to 2014 about the role of T helper 9 in some Infectious Diseases. Results: Pleural mesothelial cells promoted Th9 cell differentiation by presenting antigen. It significantly differentiated Th17, but not Th9 cells in the development of CVB3-induced VMC. The microenvironment of VMC seemed to contribute to the differentiation and proliferation of Th17 rather than to differentiation of Th9 cells. Having reviewed the limited number of articles considering this relevance, we came to this result that Lymphatic Filariasis and mycobacterium tuberculosis infections confirmed the existence of such relationship. In addition, Rapamycin resistant murine Th9 cells have a stable in vivo phenotype and inhibit graft-versus-host reactivity but concerning Viral Myocarditis, Th9 cells could not protect against it. Conclusion: The accurate molecular mechanisms underlying the generation and differentiation of human Th9 cells are not elucidated completely. Th9 cells exhibit Ag specific expansion in a chronic helminth infection (lymphatic filariasis), but in relevance to viral myocarditis, Th9 cells did not play an efficient role against it. However; knowing that whether Th9 cells participate in the protection against infections needs further research

Effect of Prefabricated Insole with Shock Absorb Canal and Custom-Molded Insole on Pain and Function in Subjects with Plantar Fasciitis: A Pilot Study: Effect of insoles on pain and function in plantar fasciitis

Introduction: The purpose of this study was comparison of the effect of custom-molded insole and prefabricated insole with shock absorb canal on pain and function in subjects with plantar fasciitis. Methods and Materials: In this pilot study, fourteen patients with plantar fasciitis were non-randomly assigned to two groups of 7 people. A group received the custom-molded insoles and another group received the prefabricated insoles with shock absorb canal. Before the use of the insoles in each group, the patients ' pain and function were recorded. The pain score was measured by Visual Analog Scale (VAS). For evaluating the function, patients were asked to complete the foot and ankle ability measurement questionnaire (FAAM).Then, patients in both groups used insoles for 6 weeks. After a 6-week use of the insoles, the pain and function were recorded for the second time. Wilcoxon test was used for the effect of insoles in each group (comparison before and after the intervention) and Mann-Whitney test for comparison between two groups. Results: In comparison within each group, the findings showed that the use of both insoles after 6 weeks led to a significant decrease in pain score and a significant increase in the score of daily activities as well as sports activities compared with before use of insoles (P<0.05). There were no statistically significant differences in pain and function scores between the two groups after using the insoles (P>0.05). Conclusion: According to the findings, there was no significant difference between the custom-molded insole and the prefabricated insole in improving pain and function of patients with plantar fasciitis. However, both types of insoles reduced pain and improved the function, with more acceptable to the prefabricated insole

Data on evaluation of AQI for different season in Kerman, Iran, 2015

The purpose of this data, was to evaluate the air quality index of Kerman city in different season of 2015. The data showed that the PM10 and O3 were highest in the winter season and PM2.5, CO, SO2 and NO2 in the spring season as the air quality indexes. The highest number of unhealthy days was observed in spring in relation to PM2.5 and PM10 pollutants. The data showed that 33 and 9 days of the spring season had unfavorable conditions in relation PM2.5 and PM10 pollutants respectively. Therefore, the pollutant responsible for air pollution in Kerman was PM2.5. By comparing the air quality index in different seasons of 2015 in terms of different pollutants, it was found that in most of the seasons, Kerman has a desirable air quality index. Keywords: Air pollution, AQI, Season, Kerman, Ira