PERENCANAAN STRATEGI SISTEM DAN TEKNOLOGI INFORMASI PADA PT. HARRISMA AGUNG JAYA

PERENCANAAN STRATEGI SISTEM DAN TEKNOLOGI INFORMASI PADA PT. HARRISMA AGUNG JAYA - Perencanaan, Strategi, Sistem dan Teknologi Informasi

Non-invasive depth profiling of the stratum corneum in vivo using confocal Raman microscopy considering the non-homogeneous distribution of keratin

Confocal Raman microscopy has a number of advantages in investigating the human stratum corneum (SC) in vivo and ex vivo. The penetration profiles of xenobiotics in the SC, as well as depth profiles of the physiological parameters of the SC, such as the concentration of water depending on the strength of hydrogen bonds, total water concentration, the hydrogen bonding state of water molecules, concentration of intercellular lipids, the lamellar and lateral packing order of intercellular lipids, the concentration of natural moisturizing factor molecules, carotenoids, and the secondary and tertiary structure properties of keratin are well investigated. To consider the depth-dependent Raman signal attenuation, in most cases a normalization procedure is needed, which uses the main SC’s protein keratin-related Raman peaks, based on the assumption that keratin is homogeneously distributed in the SC. We found that this assumption is not accurate for the bottom part of the SC, where the water concentration is considerably increased, thus, reducing the presence of keratin. Our results demonstrate that the bottom part of the SC depth profile should be multiplied by 0.94 in average in order to match this non-homogeneity, which result in a decrease of the uncorrected values in these depths. The correctly normalized depth profiles of the concentration of lipids, water, natural moisturizing factor and carotenoids are presented in this work. The obtained results should be taken into consideration in future skin research using confocal Raman microscopy

Carotenoids - Effective Radical Scavengers for Healthy and Beautiful Skin

Free radicals are involved in various diseases and skin aging. To reduce and prevent this risk, our body produces antioxidants that can neutralize free radicals. However, some antioxidants need to be taken up with food, so a balanced and varied diet is essential for human health and beauty, along with sufficient exercise. Vegetables, especially curly kale, show very good antioxidative capacity due to the presence of carotenoids. As the recommended daily intake of vegetables is usually not consumed, dietary supplements are a good possibility to ingest carotenoids in a controlled and natural way. The positive effect of carotenoid-based dietary supplements on the skin has already been shown in several studies on healthy volunteers. Innovative non-invasive measuring methods have shown that oil extracts from vegetables significantly reduce not only free radicals in the skin but also the age-related breakdown of collagen and have a positive effect on skin parameters such as wrinkle volume. Thus, a balanced mixture of different natural carotenoids contributes to maintaining health and beauty

¿Por qué jugar? Sport socialization among Hispanic/Latina female NCAA division I student-athletes

Representation of Hispanics/Latinas in intercollegiate athletics is lacking. During the 2014-2015 National Collegiate Athletic Association (NCAA) athletic season, only 2.2 percent of all female Division I student-athlete’s identified as Hispanic or Latina (NCAA, 2015). This low percentage of Hispanic/Latina female participants calls into question how these young women become involved in athletics and sustain their involvement within sport. While previous research has examined the socialization processes of youth athletes and parents of youth athlete participants, there is little research aimed at examining these processes for elite-level athlete participants (Dorsch, Smith, & McDonough, 2015; Greendorfer, Blinde, & Pellegrini, 1986;). Thus, the aim of this current study was to examine the potential factors that may have contributed to consistent sport participation for an elite group of Hispanic/Latina female athletes throughout their youth and collegiate careers. Participants for this study identified as current NCAA Division I Hispanic/Latina female student-athletes. Results showed that family, specifically parents and siblings, contributed to socializing Hispanic/Latina athletes into sport, while family and coaches contributed to the persistence of their athletic endeavors. Findings also show a sense of cultural indifference, youth coaches who invested in the participants long-term, and a significant involvement of the patriarch of the family in their athletic success

Diseño de anteproyecto del edificio de la Alcaldía Municipal de Tipitapa aplicando principios de la arquitectura bioclimática

Tipitapa, es un Municipio perteneciente al departamento de Managua ubicado a 22 km. de la cabecera departamental. Fue elevada a ciudad el 10 de noviembre de 1961 por decreto legislativo. El municipio se divide en dos sectores urbano y rural. La zona rural está compuesta por tres comarcas,que a la vez se subdividen en doce comunidades La Zona Urbana o el Casco Urbano, que es el objeto de estudio,se divide en ocho barrios; cinco jurisdicciones en la periferia y siete asentamientos. En él se encuentra toda la zona administrativa. Se realizó una propuesta de anteproyecto que pudiera satisfacer las necesidades de la población y de los empleados o funcionarios de esta institución. Asimismo se dará una solución para su correcta localizació

Nonscanning large-area Raman imaging for ex vivo/in vivo skin cancer discrimination

Imaging Raman spectroscopy can be used to identify cancerous tissue. Traditionally, a step-by-step scanning of the sample is applied to generate a Raman image, which, however, is too slow for routine examination of patients. By transferring the technique of integral field spectroscopy (IFS) from astronomy to Raman imaging, it becomes possible to record entire Raman images quickly within a single exposure, without the need for a tedious scanning procedure. An IFS-based Raman imaging setup is presented, which is capable of measuring skin ex vivo or in vivo. It is demonstrated how Raman images of healthy and cancerous skin biopsies were recorded and analyzed

Keratin-water-NMF interaction as a three layer model in the human stratum corneum using in vivo confocal Raman microscopy

The secondary and tertiary structure of keratin and natural moisturizing factor (NMF) are of great importance regarding the water regulating functions in the stratum corneum (SC). In this in vivo study, the depth-dependent keratin conformation and its relationship to the hydrogen bonding states of water and its content in the SC, are investigated using confocal Raman microscopy. Based on the obtained depth-profiles for the β-sheet/α-helix ratio, the stability of disulphide bonds, the amount of cysteine forming disulphide bonds, the buried/exposed tyrosine and the folding/unfolding states of keratin, a “three layer model” of the SC, regarding the keratin-water-NMF interaction is proposed. At the uppermost layers (30–0% SC depth), the keratin filaments are highly folded, entailing limited water binding sites, and NMF is mostly responsible for binding water. At the intermediate layers (70–30% SC depth), the keratin filaments are unfolded, have the most water binding sites and are prone to swelling. At the bottom layers (100–80% SC depth), the water binding sites are already occupied with water and cannot swell substantially. The hydrogen bonding states of water molecules can only be explained by considering both, the molecular structure of keratin and the contribution of NMF as a holistic system