Layout Redesign to Eliminate Stagnation Using Blocplan to Increase Production Efficiency

The rapid growth of the automotive industry was also followed by growth in subsidiary companies. One of the subsidiary companies is a company that produces auto parts such as wheels. Sales volume in 2021 increased to more than 2 million products while for 2022 to April it was more than 1 million products. High demand is not accommodated due to inadequate production capacity, one of which is the machining area. This study aims to increase efficiency by redesigning the layout of the factory which is considered to increase production results in the machining area. The method used in this research is Block Layout Overview with Computerized Planning using Logic and Algorithm (Blocplan). The results showed that the redesign of the machining area could reduce stagnation by adding 1 unit of multi drill machine. Relayout in the machining area can reduce 93” time stagnation for the K2SA rear ABS type which can produce 2 outputs at once. The delay in the machining area can be reduced from 4,863 seconds to 0 seconds

The Influence of Slopes to the Stability of Stones in front of Seawall

Seawall is a coastal protection structure to prevent coastal erosion from wave forces. In this research, rubble-mound of stones are used as armor due to the availability of the material in coastal areas and ease of construction. A series of physical model tests with a scale of 1:25 with a variation of four wave heights (H), two wave periods (T), and three different slopes of rubble-mound in front of seawall were performed. Parameters used in the research are stability coefficient (KD),wave steepness (H/gT2), and percentage of damages (Do). The slope variations of rubble-mound were 1:1.15, 1:1.5, and 1:2. The experiments also displayed that the stone stability coefficient (KD) directly proportional with wave steepness (H/gT2). The value of KD for the seawall model with the slope angle of cot = 1.15 is 4.4, cot = 1.5 is 4.28 and cot = 2 is 3.02. From all three variations of slope, the most stable is on the slope 1:2 with the least damage impact on the model. The gentlest slope is the most stable structure

Layout Redesign to Eliminate Stagnation Using Blocplan to Increase Production Efficiency

The rapid growth of the automotive industry was also followed by growth in subsidiary companies. One of the subsidiary companies is a company that produces auto parts such as wheels. Sales volume in 2021 increased to more than 2 million products while for 2022 to April it was more than 1 million products. High demand is not accommodated due to inadequate production capacity, one of which is the machining area. This study aims to increase efficiency by redesigning the layout of the factory which is considered to increase production results in the machining area. The method used in this research is Block Layout Overview with Computerized Planning using Logic and Algorithm (Blocplan). The results showed that the redesign of the machining area could reduce stagnation by adding 1 unit of multi drill machine. Relayout in the machining area can reduce 93” time stagnation for the K2SA rear ABS type which can produce 2 outputs at once. The delay in the machining area can be reduced from 4,863 seconds to 0 seconds

Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK.

BACKGROUND: A safe and efficacious vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), if deployed with high coverage, could contribute to the control of the COVID-19 pandemic. We evaluated the safety and efficacy of the ChAdOx1 nCoV-19 vaccine in a pooled interim analysis of four trials. METHODS: This analysis includes data from four ongoing blinded, randomised, controlled trials done across the UK, Brazil, and South Africa. Participants aged 18 years and older were randomly assigned (1:1) to ChAdOx1 nCoV-19 vaccine or control (meningococcal group A, C, W, and Y conjugate vaccine or saline). Participants in the ChAdOx1 nCoV-19 group received two doses containing 5 × 1010 viral particles (standard dose; SD/SD cohort); a subset in the UK trial received a half dose as their first dose (low dose) and a standard dose as their second dose (LD/SD cohort). The primary efficacy analysis included symptomatic COVID-19 in seronegative participants with a nucleic acid amplification test-positive swab more than 14 days after a second dose of vaccine. Participants were analysed according to treatment received, with data cutoff on Nov 4, 2020. Vaccine efficacy was calculated as 1 - relative risk derived from a robust Poisson regression model adjusted for age. Studies are registered at ISRCTN89951424 and ClinicalTrials.gov, NCT04324606, NCT04400838, and NCT04444674. FINDINGS: Between April 23 and Nov 4, 2020, 23 848 participants were enrolled and 11 636 participants (7548 in the UK, 4088 in Brazil) were included in the interim primary efficacy analysis. In participants who received two standard doses, vaccine efficacy was 62·1% (95% CI 41·0-75·7; 27 [0·6%] of 4440 in the ChAdOx1 nCoV-19 group vs71 [1·6%] of 4455 in the control group) and in participants who received a low dose followed by a standard dose, efficacy was 90·0% (67·4-97·0; three [0·2%] of 1367 vs 30 [2·2%] of 1374; pinteraction=0·010). Overall vaccine efficacy across both groups was 70·4% (95·8% CI 54·8-80·6; 30 [0·5%] of 5807 vs 101 [1·7%] of 5829). From 21 days after the first dose, there were ten cases hospitalised for COVID-19, all in the control arm; two were classified as severe COVID-19, including one death. There were 74 341 person-months of safety follow-up (median 3·4 months, IQR 1·3-4·8): 175 severe adverse events occurred in 168 participants, 84 events in the ChAdOx1 nCoV-19 group and 91 in the control group. Three events were classified as possibly related to a vaccine: one in the ChAdOx1 nCoV-19 group, one in the control group, and one in a participant who remains masked to group allocation. INTERPRETATION: ChAdOx1 nCoV-19 has an acceptable safety profile and has been found to be efficacious against symptomatic COVID-19 in this interim analysis of ongoing clinical trials. FUNDING: UK Research and Innovation, National Institutes for Health Research (NIHR), Coalition for Epidemic Preparedness Innovations, Bill & Melinda Gates Foundation, Lemann Foundation, Rede D'Or, Brava and Telles Foundation, NIHR Oxford Biomedical Research Centre, Thames Valley and South Midland's NIHR Clinical Research Network, and AstraZeneca

Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK

Background A safe and efficacious vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), if deployed with high coverage, could contribute to the control of the COVID-19 pandemic. We evaluated the safety and efficacy of the ChAdOx1 nCoV-19 vaccine in a pooled interim analysis of four trials. Methods This analysis includes data from four ongoing blinded, randomised, controlled trials done across the UK, Brazil, and South Africa. Participants aged 18 years and older were randomly assigned (1:1) to ChAdOx1 nCoV-19 vaccine or control (meningococcal group A, C, W, and Y conjugate vaccine or saline). Participants in the ChAdOx1 nCoV-19 group received two doses containing 5 × 1010 viral particles (standard dose; SD/SD cohort); a subset in the UK trial received a half dose as their first dose (low dose) and a standard dose as their second dose (LD/SD cohort). The primary efficacy analysis included symptomatic COVID-19 in seronegative participants with a nucleic acid amplification test-positive swab more than 14 days after a second dose of vaccine. Participants were analysed according to treatment received, with data cutoff on Nov 4, 2020. Vaccine efficacy was calculated as 1 - relative risk derived from a robust Poisson regression model adjusted for age. Studies are registered at ISRCTN89951424 and ClinicalTrials.gov, NCT04324606, NCT04400838, and NCT04444674. Findings Between April 23 and Nov 4, 2020, 23 848 participants were enrolled and 11 636 participants (7548 in the UK, 4088 in Brazil) were included in the interim primary efficacy analysis. In participants who received two standard doses, vaccine efficacy was 62·1% (95% CI 41·0–75·7; 27 [0·6%] of 4440 in the ChAdOx1 nCoV-19 group vs71 [1·6%] of 4455 in the control group) and in participants who received a low dose followed by a standard dose, efficacy was 90·0% (67·4–97·0; three [0·2%] of 1367 vs 30 [2·2%] of 1374; pinteraction=0·010). Overall vaccine efficacy across both groups was 70·4% (95·8% CI 54·8–80·6; 30 [0·5%] of 5807 vs 101 [1·7%] of 5829). From 21 days after the first dose, there were ten cases hospitalised for COVID-19, all in the control arm; two were classified as severe COVID-19, including one death. There were 74 341 person-months of safety follow-up (median 3·4 months, IQR 1·3–4·8): 175 severe adverse events occurred in 168 participants, 84 events in the ChAdOx1 nCoV-19 group and 91 in the control group. Three events were classified as possibly related to a vaccine: one in the ChAdOx1 nCoV-19 group, one in the control group, and one in a participant who remains masked to group allocation. Interpretation ChAdOx1 nCoV-19 has an acceptable safety profile and has been found to be efficacious against symptomatic COVID-19 in this interim analysis of ongoing clinical trials

Pengaruh struktur keuangan terhadap kinerja keuangan dengan ukuran dan pertumbuhan perusahaan sebagai variabel moderasi pada kelompok perusahaan LQ45 non-keuangan

Di tengah kondisi perekonomian nasional maupun mancanegara yang tidak menentu, hal ini menjadi tantangan bagi perusahaan untuk menjaga kelangsungan usaha maupun meningkatkan labanya. Resikonya akan menjadi lebih besar lagi bagi perusahaan yang banyak menggunakan pendanaan hutang karena mereka akan menanggung beban bunga. Harapan dari penggunaan hutang ini adalah meningkatnya pendapatan dan laba bagi perusahaan sehingga perusahaan bisa memperoleh manfaat yang besar dari hutang. Masing-masing perusahaan memiliki karakteristik yang berbeda-beda sehingga akan dilakukan penggolongan perusahaan yang menggunakan ukuran dan pertumbuhan perusahaan sebagai variabel moderasi. Ukuran perusahaan untuk melihat besar kecilnya suatu perusahaan sedangkan pertumbuhan perusahaan untuk menentukan apakah perusahaan ini sedang bertumbuh, dewasa atau bahkan sudah memasuki masa penurunan. Obyek yang digunakan adalah perusahaan kelompok LQ45 non-keuangan karena merupakan kumpulan perusahaan yang banyak diminati oleh investor. Tujuan dari penelitian ini adalah untuk melihat pengaruh total hutang terhadap kinerja keuangan dengan/tanpa ukuran dan pertumbuhan perusahaan sebagai variabel moderasi pada perusahaan kelompok LQ45 non-keuangan. Data dalam penelitian ini diambil dari Bursa Efek Indonesia hanya untuk perusahaan yang masuk dalam kelompok LQ45 non-keuangan tahun 2013-2017. Pengambilan data diambil dengan metode purposive sampling. Teknik analisis menggunakan analisis regresi linear berganda dan menggunakan SPSS sebagai alat pengolahan data. Berdasarkan hasil penelitian ini total hutang terbukti berpengaruh positif signifikan terhadap kinerja keuangan, pertumbuhan perusahaan memoderasi pengaruh total hutang terhadap kinerja keuangan semakin lemah namun tidak signifikan serta ukuran perusahaan memoderasi pengaruh total hutang terhadap kinerja keuangan semakin lemah dan signifikan

Pengaruh struktur keuangan terhadap kinerja keuangan dengan ukuran dan pertumbuhan perusahaan sebagai variabel moderasi pada kelompok perusahaan LQ45 non-keuangan

Di tengah kondisi perekonomian nasional maupun mancanegara yang tidak menentu, hal ini menjadi tantangan bagi perusahaan untuk menjaga kelangsungan usaha maupun meningkatkan labanya. Resikonya akan menjadi lebih besar lagi bagi perusahaan yang banyak menggunakan pendanaan hutang karena mereka akan menanggung beban bunga. Harapan dari penggunaan hutang ini adalah meningkatnya pendapatan dan laba bagi perusahaan sehingga perusahaan bisa memperoleh manfaat yang besar dari hutang. Masing-masing perusahaan memiliki karakteristik yang berbeda-beda sehingga akan dilakukan penggolongan perusahaan yang menggunakan ukuran dan pertumbuhan perusahaan sebagai variabel moderasi. Ukuran perusahaan untuk melihat besar kecilnya suatu perusahaan sedangkan pertumbuhan perusahaan untuk menentukan apakah perusahaan ini sedang bertumbuh, dewasa atau bahkan sudah memasuki masa penurunan. Obyek yang digunakan adalah perusahaan kelompok LQ45 non-keuangan karena merupakan kumpulan perusahaan yang banyak diminati oleh investor. Tujuan dari penelitian ini adalah untuk melihat pengaruh total hutang terhadap kinerja keuangan dengan/tanpa ukuran dan pertumbuhan perusahaan sebagai variabel moderasi pada perusahaan kelompok LQ45 non-keuangan. Data dalam penelitian ini diambil dari Bursa Efek Indonesia hanya untuk perusahaan yang masuk dalam kelompok LQ45 non-keuangan tahun 2013-2017. Pengambilan data diambil dengan metode purposive sampling. Teknik analisis menggunakan analisis regresi linear berganda dan menggunakan SPSS sebagai alat pengolahan data. Berdasarkan hasil penelitian ini total hutang terbukti berpengaruh positif signifikan terhadap kinerja keuangan, pertumbuhan perusahaan memoderasi pengaruh total hutang terhadap kinerja keuangan semakin lemah namun tidak signifikan serta ukuran perusahaan memoderasi pengaruh total hutang terhadap kinerja keuangan semakin lemah dan signifikan

Analisa Stabilitas Batu Pecah pada Seawall dengan Variasi Sudut Kemiringan

Seawall merupakan bangunan pelindung pantai yang memiliki fungsi untuk memperkuat tepi pantai agar tidak terjadi pengikisan akibat gempuran gelombang. Dalam penelitian ini digunakan batu pecah sebagai pelindung bangunan dengan pertimbangan bahan yang mudah didapat di kawasan pesisir pantai dan umum digunakan sebagai pelindung struktur seawall sehingga penelitian stabilitas batu pecah ini perlu untuk dilakukan. Penelitian ini melakukan pengujian model fisik berskala 1:25 dengan empat variasi tinggi gelombang (H), dua variasi periode gelombang (T), dan tiga sudut kemiringan batuan pelindung. Parameter yang digunakan dalam penelitian adalah koefisien stabilitas (KD), kecuraman gelombang (H/gT2), dan damage percent (Do). Hasil penelitian menunjukkan bahwa nilai koefisien stabilitas (KD) akan berbanding lurus dengan kecuraman gelombang (H/gT2), sedangkan tinggi gelombang (H) akan berbanding lurus dengan damage percent (Do). Nilai KD untuk model seawall dengan sudut kemiringan cot = 1.15 adalah 3.7986, sudut kemiringan cot = 1.5 adalah 3.6948 dan sudut kemiringan cot = 2 adalah 3.4825. Adapun dari ketiga variasi sudut kemiringan batuan pelindung yaitu 1:1.15, 1:5, dan 1:2 yang paling stabil adalah pada kemiringan 1:2 dengan dampak kerusakan pada model yang paling sedikit. Semakin landai kemiringan berdampak pada semakin stabilnya model. ============================================================================================= Seawall is coastal protection structure which has function for strengthen the shore in order to reduce shoreline erosion due to incoming wave. This research used stone as structure protection with consideration the material is easy to get in shore area and commonly used as structure protection of seawall. Therefore this stability analysis of stone research is necessary. This research use 1:25 physical model scale with four variations of wave height (H), two variations of wave period (T), and three variations of slope. The parameters used in test is coefficient of stability (KD), wave steepness (H/gT2), and damage percent (Do). The result show that value of KD directly proportional with wave steepness (H/gT2), while wave height (H) proportional with damage percent (Do). The value of KD for the model with slope cot Ɵ = 1.15 is 3.7986, model with slope cot Ɵ = 1.15 is 3.6948 and model with slope cot Ɵ = 2 is 3.4825. From all three variations of slopes, the most stable is on the slope 1:2 with the least damage impact on the model. More declivious of the slope, more stable of the sctructures