Combined use of arginase II inhibitors and tadalafil for the correction of monocrotaline pulmonary hypertension

The concept of the regulatory role of endothelium in the pathogenesis of pulmonary hypertension (PH) is fundamental. To study the protective effects of the selective arginase II inhibitors L207-0525 and L327-0346 in combination with tadalafil in a monocrotaline model of pulmonary hypertension in rat

Experimental approaches to the assessment of potential cardioprotective means with doxorubicin-associated cardiomyopathy

Development of methodological approaches for evaluation of cardioprotective activity of drugs in doxorubicin cardiomyopath

ВПЛИВ ЗМІШАНОЛІГАНДНОГО КОМПЛЕКСУ ЦИНКУ НА МОЛОЧНУ ПРОДУКТИВНІСТЬ ВИСОКОПРОДУКТИВНИХ КОРІВ ГОЛШТИНСЬКОЇ ПОРОДИ НІМЕЦЬКОЇ СЕЛЕКЦІЇ

The article highlights data of different levels of efficiency mixed lygand complex of Zinc to obtain clean milk from highly productive Holstein cows of German selection. Tested cows were fed with small component forage mixture that were composed with concentrated feed–sulfate salts of copper, cobalt, manganese, sodium selenite, forage mixture complemented these micronutrients to normal, and selenium concentration was adjusted to 0,3 mg / kg of dry matter and depending on various schemes of experiment levels of mixed lygand complex of Zink. Control Holstein cows were Hungarian selection in compound feed, concentrates which was mixed lygand complex of Zinc, zinc deficiency was covered by 50 %. Cows from research groups of German selection Zinc deficiency covered 85, 70, 55 and 40 % by mixed lygand complex of Zinc. Based on data obtained during the scientific and economic experiment, found that Zinc deficiency liquidation in forage mixture of 70 % by mixed lygand complex of Zinc in the diet of dairy cows of German Holstein breed in dry period and the first 100 days of lactation, cows provided 3d research group of this element and contributed to obtaining the highest productivity compared with the control group, the 2nd, the 4th and the 5th tested groups average daily milk yield in cows from the 3rd experimental group was 54,3 kg and average daily milk yield superior natural milk cows from the 1st control group to 13,62 %, 2nd research group at – 7,04 % ,4th research group to – 4,46 % and 5th research group at – 7,8 % in the fat content of milk in the 1st control group –3,54 %, 2nd – 3,55 %, 3rd – 3,59 %, 4th –3,57 % and 5th – 3,58 %. Gross milk yield per cow of 4 percent milk fat by the first 100 days of lactation was: in the 1st control group – 4778 kg, 2nd experimental – 5072 kg, 3rd – 5429 kg, 4th – 5197 kg and 5th – 5036 kg. Based on data obtained during the scientific and economic experiment proved that the best realized genetic potential highly productive cows of Holstein breed German selection in forest–steppe zone of Ukraine to the elimination of zinc deficiency by 70 % through the use of mixed lygand complex of this element.Результаты проведенных исследований свидетельствуют о том, что голштинской коровы немецкой селекции на Украине в сравнении со своими сверстницами венгерской селекции лучше реализуют свой генетический потенциал продуктивности при полноценной сбалансированной кормления. На основании данных, полученных при проведении научно-хозяйственного опыта, доказано, что голштинской коровы немецкой селекции в первые 100 дней лактации требуют и более высоких уровней смешаннолигандных комплекса цинка. Высочайшая производительность и маленькие затраты корма на молоко малая доза смешаннолигандных комплекса цинка, которая ликвидировала его дефицит в кормах в норму на 60%. Молочная продуктивность натурального молока была выше на 6,15 - 13,62,% против контроля.Результати проведених досліджень свідчать про те, що голштинські корови німецької селекції на Україні в порівняно з своїми ровесницями угорської селекції краще реалізують свій генетичний потенціал продуктивності при повноцінній збалансованій годівлі. На підставі даних, отриманих під час проведення науково–господарського досліду, доведено, що голштинські корови німецької селекції в перші 100 днів лактації потребують і більш високих рівнів змішанолігандного комплексу Цинку. Найвища продуктивність і найменші затрати корму на молоко мала доза змішанолігандного комплексу Цинку, яка ліквідовувала його дефіцит у кормах до норми на 60 %. Молочна продуктивність натурального молока була вища на 6,15 – 13,62, % проти контролю. &nbsp

Possible optical counterpart of PSR J1357-6429

(Abridged) PSR J1357-6429 is a Vela-like radio pulsar that has been recently detected in X-rays and gamma-rays. It powers a compact tail-like X-ray pulsar wind nebula and X-ray-radio plerion associated with an extended TeV source HESS J1356-645. We present our deep optical observations with the Very Large Telescope to search for an optical counterpart of the pulsar and its nebula. We detect a point-like source in V, R, and I bands whose position is within the 1-sigma error circle of the X-ray position of the pulsar, and whose colours are distinct from those of ordinary stars. We consider it as a candidate optical counterpart of the pulsar. If it is indeed the counterpart, its 5-sigma offset from the radio pulsar position, measured about 9 yr earlier, implies that the transverse velocity of the pulsar is in the range of 1600--2000 km s^{-1} at the distance of 2--2.5 kpc, making it the fastest moving pulsar known. The direction of the estimated proper motion coincides with the extension of the pulsar's X-ray tail, suggesting that this is a jet. The tentative optical luminosity and efficiency of the pulsar are similar to those of the Vela pulsar, which also supports the optical identification. However, the candidate undergoes an unusually steep dereddened flux increase towards the infrared with a spectral index of about 5, that is not typical of optical pulsars. It implies a strong double-knee spectral break in the pulsar emission between the optical and X-rays. The reasons for the spectral steepness are unclear. It may be caused by a nebula knot projected onto the jet and strongly overlapping with the pulsar, as observed for the Crab, where the knot has a significantly steeper spectrum than the pulsar. We find no other signs of the pulsar nebula in the optical. Alternatively, the detected source may be a faint AGN, that has not yet been seen at other wavelengths.Comment: 13 pages, 10 figures, 4 table

The G292.0+1.8 pulsar wind nebula in the mid-infrared

G292.0+1.8 is a Cas A-like supernova remnant that contains the young pulsar PSR J1124-5916 powering a compact torus-like pulsar wind nebula visible in X-rays. A likely counterpart to the nebula has been detected in the optical VRI bands. To confirm the counterpart candidate nature, we examined archival mid-infrared data obtained with the Spitzer Space Telescope. Broad-band images taken at 4.5, 8, 24, and 70 microns were analyzed and compared with available optical and X-ray data. The extended counterpart candidate is firmly detected in the 4.5 and 8 micron bands. It is brighter and more extended in the bands than in the optical, and its position and morphology agree well with the coordinates and morphology of the torus-like pulsar wind nebula in X-rays. The source is not visible in 24 and 70 micron images, which are dominated by bright emission from the remnant shell and filaments. We compiled the infrared fluxes of the nebula, which probably contains a contribution from an unresolved pulsar in its center, with the optical and X-ray data. The resulting unabsorbed multiwavelength spectrum is described by power laws of significantly steeper slope in the infrared-optical than in X-rays, implying a double-knee spectral break between the optical and X-rays. The 24 and 70 microns flux upper limits suggest a second break and a flatter spectrum at the long wavelength limit. These features are common to two other pulsar wind nebulae associated with the remnants B0540-69.3 and 3C 58 and observed in all three ranges. The position, morphology, and spectral properties of the detected source allow us to comfirm that it is the infrared-optical counterpart to both the pulsar and its wind nebula system in the G292.0+1.8 supernova remnant.Comment: 5 pages, 2 figure

Evaluation of cardioprotective effects of the incritinmimetics exenatideand vildagliptin in the experiment

The results of experimental and clinical trials make it clear that incretin mimetics possess pleiotropic effects and demonstrate the value in terms of assessment of their potential opportunities as cardioprotectors. Goals: To study the cardioprotective effects of exenatide and vildagliptin on the model of doxorubicin-induced cardiomyopath

Study of dose-dependent effect of 2-ethyl-6-methyl-3 hydroxypyridine succinate on the contractile function of isolated rat heat

In experiments on the isolated rat heart there were studied the effects of different doses (21.43 mg/kg/day and 85 . 72 mg/kg/day) 2-ethyl-6-methyl-3 hydroxypy ridine succinate ("EkoPharmInvest", Russia), on the contractile function of isolated hearts subjected to prior doxorubicin model (20 mg/kg, intraperitoneal) of pathology. The dynamic of the power mechanisms of ion transport was evaluated by imposing high h eart rate (480 BPM) and increase concentration of Са2+ to 5 mmol in perfusat

Pharmacological correction of L-NAME-induced oxide deficiency with derivatives of 3-(2,2,2-trimethylhydrazinium) propionate

This paper deals with the study of correction of L-NAME-induced endothelial dysfunction by means of 3-(2,2,2-trimethylhydrazinium) propionate derivative