Sex and age differences and outcomes in acute coronary syndromes

Background: There is conflicting information about sex differences in presentation, treatment, and outcome after acute coronary syndromes (ACS) in the era of reperfusion therapy and percutaneous coronary intervention. The aim of this study was to examine presentation, acute therapy, and outcomes of men and women with ACS with special emphasis on their relationship with younger age ( lt = 65 years). Methods: From January 2010 to June 2015, we enrolled 5140 patients from 3 primary PCI capable hospitals. Patients were registered according to the International Survey of Acute Coronary Syndrome in Transitional Countries (ISACS-TC) registry protocol (ClinicalTrials.gov: NCT01218776). The primary outcome was the incidence of in-hospital mortality. Results: The study population was constituted by 2876 patients younger than 65 years and 2294 patients older. Women were older than men in both the young (56.2 +/- 6.6 vs. 54.1 +/- 7.4) and old (74.9 +/- 6.4 vs. 73.6 +/- 6.0) age groups. There were 3421 (66.2%) patients with ST elevation ACS (STE-ACS) and 1719 (33.8%) patients without ST elevation ACS (NSTE-ACS). In STE-ACS, the percentage of patients who failed to receive reperfusion was higher in women than in men either in the young (21.7% vs. 15.8%) than in the elderly (35.2% vs. 29.6%). There was a significant higher mortality in women in the younger age group (age-adjusted OR 1.52, 95% CI: 1.01-2.29), but there was no sex difference in the older group (age-adjusted OR 1.10, 95% CI: 0.87-1.41). Significantly sex differences in mortality were not seen in NSTE-ACS patients. Conclusions: In-hospital mortality from ACS is not different between older men and women. A higher short-term mortality can be seen only in women with STEMI and age of 65 or less

Antibakterijska aktivnost Platina (ii) i Paladijum(ii) kompleksa sa alkil estrima (s,s)-etilendiamin-n,n'-di-(2,2'-di(4-hidroksi)-benzil sirćetne kiseline

Antibiotics are used to treat many infections which are causing by different microorganisms. The vast majority of cases where antibiotics are used, the microorganisms have found a way to evade or resist the antimicrobial agent [1,2]. The work was conceived with the intention to investigate the antibacterial activity of newly synthesized ligands and complexes [3] on the selected bacterial strains with the aim to find potential synthetic preservatives.Antibakterijska sredstva se koriste u lečenju mnogih infekcija koje uzrokuju različiti mikroorganizmi. U najvećem broju slučajeva, u kojima se koriste antibakterijska sredstva, mikroorganizmi su pronašli način da se odupru ili izbegnu antimikrobni agens [1,2]. Rad je koncipiran sa namerom da ispita antibakterijsku aktivnost novosintetisanih i liganada i kompleksa [9] na odabranim bakterijskim sojevima u cilju pronalaženja novih potencijalnih sintetičkih konzervanasa

The synthesis and characterization of facial and meridional isomers of uns-cis-(ethylenediamine-N-N-di-3-propionato) cobalt(III) complexes with S-lysine and S-histidine

In the reaction of sodium uns-cis-(ethylenediamine-N-N-di-3-propionato)-(carbonato)cobaltate(III) dihydrate and the corresponding amino acid (S-lysine or S-histidine) at 70"C, both the theoretically possible facial and meridional isomers of the uns-cis-(ethylenediamine-N-N-di-3-propionato)(aminoacidato)cobalt(III) complexes were prepared. The complexes were isolated chromatographically and characterized by elemental analyses, as well as by electron absorption and infrared spectroscopy

Effect of low temperature on rooting rate and carbohydrate content of Fritillaria meleagris bulbs formed in culture in vitro

Projekat ministarstva br. 143026

The current status of conservation of plant genetic resources in IBISS and related cryopreservation activities

The presentation has two parts: to describe the current status of genetic resources stored in plant tissue culture at Institute for Biological Research Sinisa Stankovic (IBISS), Belgrade, Serbia and to present some results on fundamental aspects of cryopreservation research. The IBISS represents the largest and the most complete research institution in the field of biological sciences in Serbia. The researchers at the IBISS are primarily focused on fundamental studies in biology and are included in projects supported by Ministry of Science of Republic of Serbia. The IBISS is organized on the basis of research teams working within specific departments. The profile of researches performed at Department of Plant Physiology is characterized by basic lines of developmental plant physiology (photomorphogenesis, in vitro morphogenesis and cytodifferentiation) as well as of experimental plant biology (genetic engineering, secondary metabolite production, fungal growth and development). The IBISS has a specialized unit for experiments on in vitro plant cultures (160 m2) and developed protocols for micropropagation of more than 50 plant species. The summary of endemic, endangered and pharmaceuticaly valuable plant species kept as in vitro cultures in IBISS will be presented. Cryopreservation is a valuable alternative to the in vitro collection for conserving different types of the plant material which is planed to develop in future. Second part of presentation is some fundamental aspects of cryoprotection. This study investigated the effects of one month acclimation on the accumulation of soluble sugars (sucrose, fructose and glucose) and polyols in Fritallaria meleagris bulbs formed in culture in vitro. Analysis of carbohydrate content revealed that sucrose was the dominant soluble carbohydrate in bulblets of F. meleagris. There was no high increase of sucrose accumulation in bulblets after low temperature storage. Monosacharides (glucose and fructose) are present at significantly lower content than sucrose at standard conditions. The significantly increased accumulation of glucose and fructose in bulblets was observed after low temperature treatment but the magnitude of change was much less for glucose than for fructose. The analyses of polyol content in bulblets of F. meleagris revealed more than twice higher accumulation of sugar alcohols after low temperature treatment (Table 1). Also the SOD activity during and after acclimation will be presented.vokMyynti MTT, Tietopalvelut 31600 Jokioine

Cortical Ablation Induces Time-Dependent Changes in Rat Pituitary Somatotrophs and Upregulates Growth Hormone Receptor Expression in the Injured Cortex

The pituitary appears to be vulnerable to brain trauma, and its dysfunction is a common feature after traumatic brain injury. The role of pituitary growth hormone (GH) in brain repair after injury has been envisaged, but more studies must be performed to understand completely the importance of GH in these processes. Because some of the neuroprotective effects of GH are mediated directly through the GH receptor (GHR), we examined GHR expression in the rat cerebral cortex after sensorimotor cortex ablation. RT-PCR, immunohistochemistry, and double immunofluorescence had been performed to analyze the correlation between GHR expression in the injured cortex and activity of GH cells in the pituitary. Our results showed that the volume of GH-immunopositive cells was reduced at days 2 and 7 postsurgery (dps), and volume density of GH cells was significantly decreased at 14 dps, all compared with appropriate sham controls. At 30 dps all investigated parameters had returned to control level. In the injured cortex, GHR expression was transiently upregulated. Increased GHR immunoreactivity was observed in reactive astrocytes at 7 and particularly at 14 dps. In neuronal cells, an increase of GHR immunoreactivity was seen in neuronal cell bodies and well-defined primary dendrites at 14 and especially at 30 dps. The results presented here suggest that, during recovery from brain injury, changes in activity of pituitary GH cells result in upregulation of GHR that may have a role in neuronal arborization and glial proliferation in the injured cortex. (C) 2014 Wiley Periodicals, Inc.Ministry of Education, Science, and Technological Development of the Republic of Serbia {[}III 41014, ON 173009