74 research outputs found
Common Scaling Patterns in Intertrade Times of U. S. Stocks
We analyze the sequence of time intervals between consecutive stock trades of
thirty companies representing eight sectors of the U. S. economy over a period
of four years. For all companies we find that: (i) the probability density
function of intertrade times may be fit by a Weibull distribution; (ii) when
appropriately rescaled the probability densities of all companies collapse onto
a single curve implying a universal functional form; (iii) the intertrade times
exhibit power-law correlated behavior within a trading day and a consistently
greater degree of correlation over larger time scales, in agreement with the
correlation behavior of the absolute price returns for the corresponding
company, and (iv) the magnitude series of intertrade time increments is
characterized by long-range power-law correlations suggesting the presence of
nonlinear features in the trading dynamics, while the sign series is
anti-correlated at small scales. Our results suggest that independent of
industry sector, market capitalization and average level of trading activity,
the series of intertrade times exhibit possibly universal scaling patterns,
which may relate to a common mechanism underlying the trading dynamics of
diverse companies. Further, our observation of long-range power-law
correlations and a parallel with the crossover in the scaling of absolute price
returns for each individual stock, support the hypothesis that the dynamics of
transaction times may play a role in the process of price formation.Comment: 8 pages, 5 figures. Presented at The Second Nikkei Econophysics
Workshop, Tokyo, 11-14 Nov. 2002. A subset appears in "The Application of
Econophysics: Proceedings of the Second Nikkei Econophysics Symposium",
editor H. Takayasu (Springer-Verlag, Tokyo, 2003) pp.51-57. Submitted to
Phys. Rev. E on 25 June 200
Levels and equivalence in credit and qualifications frameworks: Contrasting the prescribed and enacted curriculum in school and college
Drawing on data from an empirical study of three matched subjects in upper secondary school and further education college in Scotland, this article explores some of the factors that result in differences emerging from the translation of the prescribed curriculum into the enacted curriculum. We argue that these differences raise important questions about equivalences which are being promoted through the development of credit and qualifications frameworks. The article suggests that the standardisation associated with the development of a rational credit and qualifications framework and an outcomes-based prescribed curriculum cannot be achieved precisely because of the multiplicity that emerges from the practices of translation
The origins and development of Zuwīla, Libyan Sahara: an archaeological and historical overview of an ancient oasis town and caravan centre
Zuwīla in southwestern Libya (Fazzān) was one of the most important early Islamic centres in the Central Sahara, but the archaeological correlates of the written sources for it have been little explored. This paper brings together for the first time a detailed consideration of the relevant historical and archaeological data, together with new AMS radiocarbon dates from several key monuments. The origins of the settlement at Zuwīla were pre-Islamic, but the town gained greater prominence in the early centuries of Arab rule of the Maghrib, culminating with the establishment of an Ibāḍī state ruled by the dynasty of the Banū Khaṭṭāb, with Zuwīla its capital. The historical sources and the accounts of early European travellers are discussed and archaeological work at Zuwīla is described (including the new radiocarbon dates). A short gazetteer of archaeological monuments is provided as an appendix. Comparisons and contrasts are also drawn between Zuwīla and other oases of the ash-Sharqiyāt region of Fazzān. The final section of the paper presents a series of models based on the available evidence, tracing the evolution and decline of this remarkable site
Performance of novel VUV-sensitive Silicon Photo-Multipliers for nEXO
Liquid xenon time projection chambers are promising detectors to search for
neutrinoless double beta decay (0), due to their response
uniformity, monolithic sensitive volume, scalability to large target masses,
and suitability for extremely low background operations. The nEXO collaboration
has designed a tonne-scale time projection chamber that aims to search for
0 of \ce{^{136}Xe} with projected half-life sensitivity of
~yr. To reach this sensitivity, the design goal for nEXO is
1\% energy resolution at the decay -value (~keV).
Reaching this resolution requires the efficient collection of both the
ionization and scintillation produced in the detector. The nEXO design employs
Silicon Photo-Multipliers (SiPMs) to detect the vacuum ultra-violet, 175 nm
scintillation light of liquid xenon. This paper reports on the characterization
of the newest vacuum ultra-violet sensitive Fondazione Bruno Kessler VUVHD3
SiPMs specifically designed for nEXO, as well as new measurements on new test
samples of previously characterised Hamamatsu VUV4 Multi Pixel Photon Counters
(MPPCs). Various SiPM and MPPC parameters, such as dark noise, gain, direct
crosstalk, correlated avalanches and photon detection efficiency were measured
as a function of the applied over voltage and wavelength at liquid xenon
temperature (163~K). The results from this study are used to provide updated
estimates of the achievable energy resolution at the decay -value for the
nEXO design
A qualitative assessment of health extension workers’ relationships with the community and health sector in Ethiopia: opportunities for enhancing maternal health performance
Whole-genome sequencing reveals host factors underlying critical COVID-19
Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2,3,4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease
An open-label, non-randomized, multi-arm, phase II trial evaluating pembrolizumab combined with cetuximab in patients with recurrent/metastatic (R/M) head and neck squamous cell carcinoma (HNSCC): Results of the interim safety analysis.
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