NEOANTIGEN CHARACTERIZATION AS A FUNCTION OF RESPONSE TO PD-1 BLOCKADE IN LUNG CANCER

PD-1 blockade can reprogram immune responses and induces durable response in a subset of non-small cell lung cancer (NSCLC) patients, however most do not derive clinical benefit. We aimed to understand these responses and how neoantigen biochemical properties contribute to T cell reactivity. We developed a bioinformatic platform, Mutation Associated Neoantigen Polarity (MANAPoly), that can analyze genomic data to assess potential biochemical determinants of neoantigen immunogenicity relative to nonmutated forms. Of recognized neoepitopes in NSCLC patients treated with checkpoint blockade, we observed increased T cell responses to concentrated locations of point mutation consequences. We also observed an association between polar-to-nonpolar amino acid substitutions in patients with durable clinical outcomes. We further used MANAPoly to analyze publicly available data of 83 clinically annotated patients with NSCLC, revealing increased hydropathy of frameshift-derived neoepitopes in patients with durable clinical responses. Our study reveals the significance of neoantigen features and their relationship with clinical outcomes

sj-docx-4-hss-10.1177_15563316231211318 – Supplemental material for RAPT and AM-PAC “6-Clicks”: Do They Correlate on Predicting Discharge Destination After Total Joint Arthroplasty?

Supplemental material, sj-docx-4-hss-10.1177_15563316231211318 for RAPT and AM-PAC “6-Clicks”: Do They Correlate on Predicting Discharge Destination After Total Joint Arthroplasty? by Sharlynn Tuohy, Jessica Schwartz-Dillard, Danielle McInerney, Joseph Nguyen and Danielle Edwards in HSS Journal®</p

sj-docx-3-hss-10.1177_15563316231211318 – Supplemental material for RAPT and AM-PAC “6-Clicks”: Do They Correlate on Predicting Discharge Destination After Total Joint Arthroplasty?

Supplemental material, sj-docx-3-hss-10.1177_15563316231211318 for RAPT and AM-PAC “6-Clicks”: Do They Correlate on Predicting Discharge Destination After Total Joint Arthroplasty? by Sharlynn Tuohy, Jessica Schwartz-Dillard, Danielle McInerney, Joseph Nguyen and Danielle Edwards in HSS Journal®</p

sj-docx-1-hss-10.1177_15563316231211318 – Supplemental material for RAPT and AM-PAC “6-Clicks”: Do They Correlate on Predicting Discharge Destination After Total Joint Arthroplasty?

Supplemental material, sj-docx-1-hss-10.1177_15563316231211318 for RAPT and AM-PAC “6-Clicks”: Do They Correlate on Predicting Discharge Destination After Total Joint Arthroplasty? by Sharlynn Tuohy, Jessica Schwartz-Dillard, Danielle McInerney, Joseph Nguyen and Danielle Edwards in HSS Journal®</p

sj-docx-2-hss-10.1177_15563316231211318 – Supplemental material for RAPT and AM-PAC “6-Clicks”: Do They Correlate on Predicting Discharge Destination After Total Joint Arthroplasty?

Supplemental material, sj-docx-2-hss-10.1177_15563316231211318 for RAPT and AM-PAC “6-Clicks”: Do They Correlate on Predicting Discharge Destination After Total Joint Arthroplasty? by Sharlynn Tuohy, Jessica Schwartz-Dillard, Danielle McInerney, Joseph Nguyen and Danielle Edwards in HSS Journal®</p

sj-docx-5-hss-10.1177_15563316231211318 – Supplemental material for RAPT and AM-PAC “6-Clicks”: Do They Correlate on Predicting Discharge Destination After Total Joint Arthroplasty?

Supplemental material, sj-docx-5-hss-10.1177_15563316231211318 for RAPT and AM-PAC “6-Clicks”: Do They Correlate on Predicting Discharge Destination After Total Joint Arthroplasty? by Sharlynn Tuohy, Jessica Schwartz-Dillard, Danielle McInerney, Joseph Nguyen and Danielle Edwards in HSS Journal®</p

Wastewater Reclamation (Spring 2002) IPRO 304C

The main aim of this project is Wastewater reclamation to save the fast depleting Groundwater resourcesSponsorship: NAProject Plan for IPRO 304C: Wastewater Reclamation for the Spring 2002 semeste

CHIP phosphorylation by protein kinase G enhances protein quality control and attenuates cardiac ischemic injury

Carboxyl terminus of Hsc70-interacting protein (CHIP) is proteostasis regulator. Here the authors show that CHIP-mediated protein turnover is enhanced by PKG-mediated phosphorylation, which results in attenuated cardiac ischemic proteotoxicity