Learning incoherent dictionaries for sparse approximation using iterative projections and rotations

This work was supported by the Queen Mary University of London School Studentship, the EU FET-Open project FP7- ICT-225913-SMALL. Sparse Models, Algorithms and Learning for Large-scale data and a Leadership Fellowship from the UK Engineering and Physical Sciences Research Council (EPSRC)

Dictionary Learning of Convolved Signals

Assuming that a set of source signals is sparsely representable in a given dictionary, we show how their sparse recovery fails whenever we can only measure a convolved observation of them. Starting from this motivation, we develop a block coordinate descent method which aims to learn a convolved dictionary and provide a sparse representation of the observed signals with small residual norm. We compare the proposed approach to the K-SVD dictionary learning algorithm and show through numerical experiment on synthetic signals that, provided some conditions on the problem data, our technique converges in a fixed number of iterations to a sparse representation with smaller residual norm

Sparse Approximation and Dictionary Learning with Applications to Audio Signals

PhDOver-complete transforms have recently become the focus of a wide wealth of research in signal processing, machine learning, statistics and related fields. Their great modelling flexibility allows to find sparse representations and approximations of data that in turn prove to be very efficient in a wide range of applications. Sparse models express signals as linear combinations of a few basis functions called atoms taken from a so-called dictionary. Finding the optimal dictionary from a set of training signals of a given class is the objective of dictionary learning and the main focus of this thesis. The experimental evidence presented here focuses on the processing of audio signals, and the role of sparse algorithms in audio applications is accordingly highlighted. The first main contribution of this thesis is the development of a pitch-synchronous transform where the frame-by-frame analysis of audio data is adapted so that each frame analysing periodic signals contains an integer number of periods. This algorithm presents a technique for adapting transform parameters to the audio signal to be analysed, it is shown to improve the sparsity of the representation if compared to a non pitchsynchronous approach and further evaluated in the context of source separation by binary masking. A second main contribution is the development of a novel model and relative algorithm for dictionary learning of convolved signals, where the observed variables are sparsely approximated by the atoms contained in a convolved dictionary. An algorithm is devised to learn the impulse response applied to the dictionary and experimental results on synthetic data show the superior approximation performance of the proposed method compared to a state-of-the-art dictionary learning algorithm. Finally, a third main contribution is the development of methods for learning dictionaries that are both well adapted to a training set of data and mutually incoherent. Two novel algorithms namely the incoherent k-svd and the iterative projections and rotations (ipr) algorithm are introduced and compared to different techniques published in the literature in a sparse approximation context. The ipr algorithm in particular is shown to outperform the benchmark techniques in learning very incoherent dictionaries while maintaining a good signal-to-noise ratio of the representation

Learning Incoherent Subspaces: Classification via Incoherent Dictionary Learning

In this article we present the supervised iterative projections and rotations (s-ipr) algorithm, a method for learning discriminative incoherent subspaces from data. We derive s-ipr as a supervised extension of our previously proposed iterative projections and rotations (ipr) algorithm for incoherent dictionary learning, and we employ it to learn incoherent sub-spaces that model signals belonging to different classes. We test our method as a feature transform for supervised classification, first by visualising transformed features from a synthetic dataset and from the ‘iris’ dataset, then by using the resulting features in a classification experiment

High-grade serous carcinoma of unknown primary origin associated with STIC clinically presented as isolated inguinal lymphadenopathy: a case report

Serous tubal intraepithelial carcinoma (STIC) is a precancerous lesion of high-grade serous ovarian carcinoma (HGSOC). Usually, it arises from the fimbrial end of the tube, and it is associated with metastatic potential. On average, the time to progress from STIC to HGSOC is 6.5 years. Therefore, whenever a STIC lesion is found, surgical staging and prophylactic salpingectomy are recommended in order to prevent ovarian cancer. We report a rare case of a 45-year-old female patient who clinically presented an isolated right inguinal lymphadenopathy. The remaining clinical examination was normal. Therefore, an excisional biopsy of the lymph node was performed. Pathological analysis revealed a high-grade serous carcinoma, most likely of gynecological origin. Due to histological evidence, a computed tomography (CT) scan was carried out. There was no CT evidence of ovarian disease, pelvic involvement, intra-abdominal lymphadenopathies, metastatic disease, or ascites. All tumor markers were negative. The patient underwent laparoscopic hysterectomy and bilateral salpingo-oophorectomy followed by surgical staging. Surprisingly, pathological examination showed a STIC lesion in the fimbria of the left fallopian tube. We aim to report the potential capability of STIC to spread particularly through lymphatic pathways rather than peritoneal dissemination

Off-label long acting injectable antipsychotics in real-world clinical practice: a cross-sectional analysis of prescriptive patterns from the STAR Network DEPOT study

Introduction Information on the off-label use of Long-Acting Injectable (LAI) antipsychotics in the real world is lacking. In this study, we aimed to identify the sociodemographic and clinical features of patients treated with on- vs off-label LAIs and predictors of off-label First- or Second-Generation Antipsychotic (FGA vs. SGA) LAI choice in everyday clinical practice. Method In a naturalistic national cohort of 449 patients who initiated LAI treatment in the STAR Network Depot Study, two groups were identified based on off- or on-label prescriptions. A multivariate logistic regression analysis was used to test several clinically relevant variables and identify those associated with the choice of FGA vs SGA prescription in the off-label group. Results SGA LAIs were more commonly prescribed in everyday practice, without significant differences in their on- and off-label use. Approximately 1 in 4 patients received an off-label prescription. In the off-label group, the most frequent diagnoses were bipolar disorder (67.5%) or any personality disorder (23.7%). FGA vs SGA LAI choice was significantly associated with BPRS thought disorder (OR = 1.22, CI95% 1.04 to 1.43, p = 0.015) and hostility/suspiciousness (OR = 0.83, CI95% 0.71 to 0.97, p = 0.017) dimensions. The likelihood of receiving an SGA LAI grew steadily with the increase of the BPRS thought disturbance score. Conversely, a preference towards prescribing an FGA was observed with higher scores at the BPRS hostility/suspiciousness subscale. Conclusion Our study is the first to identify predictors of FGA vs SGA choice in patients treated with off-label LAI antipsychotics. Demographic characteristics, i.e. age, sex, and substance/alcohol use co-morbidities did not appear to influence the choice towards FGAs or SGAs. Despite a lack of evidence, clinicians tend to favour FGA over SGA LAIs in bipolar or personality disorder patients with relevant hostility. Further research is needed to evaluate treatment adherence and clinical effectiveness of these prescriptive patterns

The Role of Attitudes Toward Medication and Treatment Adherence in the Clinical Response to LAIs: Findings From the STAR Network Depot Study

Background: Long-acting injectable (LAI) antipsychotics are efficacious in managing psychotic symptoms in people affected by severe mental disorders, such as schizophrenia and bipolar disorder. The present study aimed to investigate whether attitude toward treatment and treatment adherence represent predictors of symptoms changes over time. Methods: The STAR Network \u201cDepot Study\u201d was a naturalistic, multicenter, observational, prospective study that enrolled people initiating a LAI without restrictions on diagnosis, clinical severity or setting. Participants from 32 Italian centers were assessed at three time points: baseline, 6-month, and 12-month follow-up. Psychopathological symptoms, attitude toward medication and treatment adherence were measured using the Brief Psychiatric Rating Scale (BPRS), the Drug Attitude Inventory (DAI-10) and the Kemp's 7-point scale, respectively. Linear mixed-effects models were used to evaluate whether attitude toward medication and treatment adherence independently predicted symptoms changes over time. Analyses were conducted on the overall sample and then stratified according to the baseline severity (BPRS < 41 or BPRS 65 41). Results: We included 461 participants of which 276 were males. The majority of participants had received a primary diagnosis of a schizophrenia spectrum disorder (71.80%) and initiated a treatment with a second-generation LAI (69.63%). BPRS, DAI-10, and Kemp's scale scores improved over time. Six linear regressions\u2014conducted considering the outcome and predictors at baseline, 6-month, and 12-month follow-up independently\u2014showed that both DAI-10 and Kemp's scale negatively associated with BPRS scores at the three considered time points. Linear mixed-effects models conducted on the overall sample did not show any significant association between attitude toward medication or treatment adherence and changes in psychiatric symptoms over time. However, after stratification according to baseline severity, we found that both DAI-10 and Kemp's scale negatively predicted changes in BPRS scores at 12-month follow-up regardless of baseline severity. The association at 6-month follow-up was confirmed only in the group with moderate or severe symptoms at baseline. Conclusion: Our findings corroborate the importance of improving the quality of relationship between clinicians and patients. Shared decision making and thorough discussions about benefits and side effects may improve the outcome in patients with severe mental disorders

Deliverable 3.2: Report on Discovering Structure within Dictionary Learning

In this work package (WP), we investigate the possibility of discovering structure within dictionary learning. This could range from exploring groups of atoms that appear in clusters - a form of molecule learning - to learning graphical dependencies across the dictionary elements. In modeling a signal as a sparse combination of atoms, ties between atoms can be enforced. For example harmonic models Gabor dictionaries can be seen as this type of model. Here we aim to explore the "molecule-learning" problem - learning clusters of tied atoms - by generalizing existing dictionary learning methods. Our aim is to show that with this added feature, models tend to be more reliable towards the signals represented