Dynamic Web File Format Transformations with Grace

Web accessible content stored in obscure, unpopular or obsolete formats represents a significant problem for digital preservation. The file formats that encode web content represent the implicit and explicit choices of web site maintainers at a particular point in time. Older file formats that have fallen out of favor are obviously a problem, but so are new file formats that have not yet been fully supported by browsers. Often browsers use plug-in software for displaying old and new formats, but plug-ins can be difficult to find, install and replicate across all environments that one may use. We introduce Grace, an http proxy server that transparently converts browser-incompatible and obsolete web content into web content that a browser is able to display without the use of plug-ins. Grace is configurable on a per user basis and can be expanded to provide an array of conversion services. We illustrate how the Grace prototype transforms several image formats (XBM, PNG with various alpha channels, and JPEG 2000) so they are viewable in Internet Explorer.Comment: 12 pages, 9 figure

Evaluation of Fruit Bagging as a Pest Management Option for Direct Pests of Apple

Bagging fruit with plastic, paper, and two-layer commercial bags was evaluated for control of insect pests and diseases in an experimental apple orchard planted with ‘Red Delicious’ trees. Results from fruit damage evaluations at harvest showed that bagging significantly reduced fruit damage from direct apple pests compared with non-bagged control plots, and generally provided similar levels of fruit protection when compared with a conventional pesticide spray program. Of the three bagging materials evaluated, plastic bags provided numerically higher levels of fruit protection from insect pests, and two-layer commercial bags provided numerically higher levels of fruit protection from fruit diseases. Fruit quality as measured by percentage Brix was higher in non-bagged control plots than all other treatment plots. Fruit quality as measured by fruit diameter was not significantly different among treatments. Plastic and two-layer commercial bags generally required less time to secure around apple fruit than paper bags. The proportion of bags that remained on fruit until harvest ranged from 0.54–0.71 (commercial bags), 0.64–0.82 (plastic bags), and 0.32–0.60 (paper bags), depending on the year

Intrinsic metrics for non-local symmetric Dirichlet forms and applications to spectral theory

We present a study of what may be called an intrinsic metric for a general regular Dirichlet form. For such forms we then prove a Rademacher type theorem. For strongly local forms we show existence of a maximal intrinsic metric (under a weak continuity condition) and for Dirichlet forms with an absolutely continuous jump kernel we characterize intrinsic metrics by bounds on certain integrals. We then turn to applications on spectral theory and provide for (measure perturbation of) general regular Dirichlet forms an Allegretto-Piepenbrinck type theorem, which is based on a ground state transform, and a Shnol type theorem. Our setting includes Laplacian on manifolds, on graphs and α-stable processes

Thermal Gravitino Production and Collider Tests of Leptogenesis

Considering gravitino dark matter scenarios, we obtain the full gauge-invariant result for the relic density of thermally produced gravitinos to leading order in the Standard Model gauge couplings. For the temperatures required by thermal leptogenesis, we find gaugino mass bounds which will be probed at future colliders. We show that a conceivable determination of the gravitino mass will allow for a unique test of the viability of thermal leptogenesis in the laboratory.Comment: 5 pages, 3 figures, revised version matches published versio

MIREOT: the Minimum Information to Reference an External Ontology Term

While the Web Ontology Language (OWL) provides a mechanism to import ontologies, this mechanism is not always suitable. First, given the current state of editing tools and the issues they have working with large ontologies, direct OWL imports have sometimes proven impractical for day-to-day development. Second, ontologies chosen for integration may be under active development and not aligned with the chosen design principles. Importing heterogeneous ontologies in their entirety may lead to inconsistencies or unintended inferences. In this paper we propose a set of guidelines for importing required terms from an external resource into a target ontology. We describe the guidelines, their implementation, present some examples of application, and outline future work and extensions

Role of solvent for globular proteins in solution

The properties of the solvent affect the behavior of the solution. We propose a model that accounts for the contribution of the solvent free energy to the free energy of globular proteins in solution. For the case of an attractive square well potential, we obtain an exact mapping of the phase diagram of this model without solvent to the model that includes the solute-solvent contribution. In particular we find for appropriate choices of parameters upper critical points, lower critical points and even closed loops with both upper and lower critical points, similar to one found before [Macromolecules, 36, 5845 (2003)]. In the general case of systems whose interactions are not attractive square wells, this mapping procedure can be a first approximation to understand the phase diagram in the presence of solvent. We also present simulation results for both the square well model and a modified Lennard-Jones model.Comment: 18 pages, 9 figure

Wind tunnel results of the low-speed NLF(1)-0414F airfoil

The large performance gains predicted for the Natural Laminar Flow (NLF)(1)-0414F airfoil were demonstrated in two-dimensional airfoil tests and in wind tunnel tests conducted with a full scale modified Cessna 210. The performance gains result from maintaining extensive areas of natural laminar flow, and were verified by flight tests conducted with the modified Cessna. The lift, stability, and control characteristics of the Cessna were found to be essentially unchanged when boundary layer transition was fixed near the wing leading edge. These characteristics are very desirable from a safety and certification view where premature boundary layer transition (due to insect contamination, etc.) must be considered. The leading edge modifications were found to enhance the roll damping of the Cessna at the stall, and were therefore considered effective in improving the stall/departure resistance. Also, the modifications were found to be responsible for only minor performance penalties

Wind-tunnel investigation of a full-scale general aviation airplane equipped with an advanced natural laminar flow wing

An investigation was conducted in the Langley 30- by 60-Foot Wind Tunnel to evaluate the performance, stability, and control characteristics of a full-scale general aviation airplane equipped with an advanced laminar flow wing. The study focused on the effects of natural laminar flow and advanced boundary layer transition on performance, stability, and control, and also on the effects of several wing leading edge modifications on the stall/departure resistance of the configuration. Data were measured over an angle-of-attack range from -6 to 40 deg and an angle-of-sideslip range from -6 to 20 deg. The Reynolds number was varied from 1.4 to 2.4 x 10 to the 6th power based on the mean aerodynamic chord. Additional measurements were made using hot-film and sublimating chemical techniques to determine the condition of the wing boundary layer, and wool tufts were used to study the wing stall characteristics. The investigation showed that large regions of natural laminar flow existed on the wing which would significantly enhance cruise performance. Also, because of the characteristics of the airfoil section, artificially tripping the wing boundary layer to a turbulent condition did not significantly effect the lift, stability, and control characteristics. The addition of a leading-edge droop arrangement was found to increase the stall angle of attack at the wingtips and, therefore, was considered to be effective in improving the stall/departure resistance of the configuration. Also the addition of the droop arrangement resulted in only minor increases in drag

Discovery of the photosynthetic relatives of the "Maltese mushroom" Cynomorium

BACKGROUND: Although recent molecular phylogenetic studies have identified the photosynthetic relatives of several enigmatic holoparasitic angiosperms, uncertainty remains for the last parasitic plant order, Balanophorales, often considered to include two families, Balanophoraceae and Cynomoriaceae. The nonphotosynthetic (holoparasitic) flowering plant Cynomorium coccineum has long been known to the Muslim world as "tarthuth" and to Europeans as the "Maltese mushroom"; C. songaricum is known in Chinese medicine as "suo yang." Interest in these plants is increasing and they are being extensively collected from wild populations for use in herbal medicines. RESULTS: Here we report molecular phylogenetic analyses of nuclear ribosomal DNA and mitochondrial matR sequence data that strongly support the independent origin of Balanophoraceae and Cynomoriaceae. Analyses of single gene and combined gene data sets place Cynomorium in Saxifragales, possibly near Crassulaceae (stonecrop family). Balanophoraceae appear related to Santalales (sandalwood order), a position previously suggested from morphological characters that are often assumed to be convergent. CONCLUSION: Our work shows that Cynomorium and Balanophoraceae are not closely related as indicated in all past and present classifications. Thus, morphological features, such as inflorescences bearing numerous highly reduced flowers, are convergent and were attained independently by these two holoparasite lineages. Given the widespread harvest of wild Cynomorium species for herbal medicines, we here raise conservation concerns and suggest that further molecular phylogenetic work is needed to identify its photosynthetic relatives. These relatives, which will be easier to cultivate, should then be examined for phytochemical activity purported to be present in the more sensitive Cynomorium

Age-related changes to macrophages are detrimental to fracture healing in mice.

The elderly population suffers from higher rates of complications during fracture healing that result in increased morbidity and mortality. Inflammatory dysregulation is associated with increased age and is a contributing factor to the myriad of age-related diseases. Therefore, we investigated age-related changes to an important cellular regulator of inflammation, the macrophage, and the impact on fracture healing outcomes. We demonstrated that old mice (24 months) have delayed fracture healing with significantly less bone and more cartilage compared to young mice (3 months). The quantity of infiltrating macrophages into the fracture callus was similar in old and young mice. However, RNA-seq analysis demonstrated distinct differences in the transcriptomes of macrophages derived from the fracture callus of old and young mice, with an up-regulation of M1/pro-inflammatory genes in macrophages from old mice as well as dysregulation of other immune-related genes. Preventing infiltration of the fracture site by macrophages in old mice improved healing outcomes, with significantly more bone in the calluses of treated mice compared to age-matched controls. After preventing infiltration by macrophages, the macrophages remaining within the fracture callus were collected and examined via RNA-seq analysis, and their transcriptome resembled macrophages from young calluses. Taken together, infiltrating macrophages from old mice demonstrate detrimental age-related changes, and depleting infiltrating macrophages can improve fracture healing in old mice