Metastable anisotropy orientation of nematic quantum Hall fluids

We analyze the experimental observation of metastable anisotropy resistance orientation at half filled quantum Hall fluids by means of a model of a quantum nematic liquid in an explicit symmetry breaking potential. We interpret the observed ``rotation'' of the anisotropy axis as a process of nucleation of nematic domains and compute the nucleation rate within this model. By comparing with experiment, we are able to predict the critical radius of nematic bubbles, $R_c\sim 2.6 \mu m$. Each domain contains about $10^4$ electrons.Comment: 10 pages, 8 figures, final version as will appear in PR

Forecasting temporal dynamics of cutaneous leishmaniasis in Northeast Brazil.

IntroductionCutaneous leishmaniasis (CL) is a vector-borne disease of increasing importance in northeastern Brazil. It is known that sandflies, which spread the causative parasites, have weather-dependent population dynamics. Routinely-gathered weather data may be useful for anticipating disease risk and planning interventions.Methodology/principal findingsWe fit time series models using meteorological covariates to predict CL cases in a rural region of Bahía, Brazil from 1994 to 2004. We used the models to forecast CL cases for the period 2005 to 2008. Models accounting for meteorological predictors reduced mean squared error in one, two, and three month-ahead forecasts by up to 16% relative to forecasts from a null model accounting only for temporal autocorrelation.SignificanceThese outcomes suggest CL risk in northeastern Brazil might be partially dependent on weather. Responses to forecasted CL epidemics may include bolstering clinical capacity and disease surveillance in at-risk areas. Ecological mechanisms by which weather influences CL risk merit future research attention as public health intervention targets

Radio Properties of z>4 Optically-Selected Quasars

We report on two programs to address differential evolution between the radio-loud and radio-quiet quasar populations at high (z>4) redshift. Both programs entail studying the radio properties of optically-selected quasars. First, we have observed 32 optically-selected, high-redshift (z>4) quasars with the VLA at 6 cm (5 GHz). These sources comprise a statistically complete and well-understood sample. We detect four quasars above our 3-sigma limit of ~0.15 mJy, which is sufficiently sensitive to detect all radio-loud quasars at the probed redshift range. Second, we have correlated 134 z>4 quasars, comprising all such sources that we are aware of as of mid-1999, with FIRST and NVSS. These two recent 1.4 GHz VLA sky surveys reach 3-sigma limits of approximately 0.6 mJy and 1.4 mJy respectively. We identify a total of 15 z>4 quasars, of which six were not previously known to be radio-loud. The depth of these surveys does not reach the radio-loud/radio-quiet demarcation luminosity density (L(1.4 GHz) = 10^32.5 h(50)^(-2) ergs/s/Hz) at the redshift range considered; this correlation therefore only provides a lower limit to the radio-loud fraction of quasars at high-redshift. The two programs together identify eight new radio-loud quasars at z>4, a significant increase over the seven currently in the published literature. We find no evidence for radio-loud fraction depending on optical luminosity for -25 > M_B > -28 at z~2, or for -26>M_B>-28 at z>4. Our results also show no evolution in the radio-loud fraction between z~2 and z>4 (-26>M_B>-28).Comment: 19 pages, 7 figures; to appear in The Astronomical Journal (April 2000

PIG-1 MELK-dependent phosphorylation of nonmuscle myosin II promotes apoptosis through CES-1 Snail partitioning

The mechanism(s) through which mammalian kinase MELK promotes tumorigenesis is not understood. We find that theC.elegansorthologue of MELK, PIG-1, promotes apoptosis by partitioning an anti-apoptotic factor. TheC.elegansNSM neuroblast divides to produce a larger cell that differentiates into a neuron and a smaller cell that dies. We find that in this context, PIG-1 is required for partitioning of CES-1 Snail, a transcriptional repressor of the pro-apoptotic geneegl-1BH3-only.pig-1MELK is controlled by both aces-1Snail- andpar-4LKB1-dependent pathway, and may act through phosphorylation and cortical enrichment of nonmuscle myosin II prior to neuroblast division. We propose thatpig-1MELK-induced local contractility of the actomyosin network plays a conserved role in the acquisition of the apoptotic fate. Our work also uncovers an auto-regulatory loop through whichces-1Snail controls its own activity through the formation of a gradient of CES-1 Snail protein. Author summary Apoptosis is critical for the elimination of 'unwanted' cells. What distinguishes wanted from unwanted cells in developing animals is poorly understood. We report that in theC.elegansNSM neuroblast lineage, the level of CES-1, a Snail-family member and transcriptional repressor of the pro-apoptotic geneegl-1, contributes to this process. In addition, we demonstrate thatC.elegansPIG-1, the orthologue of mammalian proto-oncoprotein MELK, plays a critical role in controlling CES-1(Snail)levels. Specifically, during NSM neuroblast division, PIG-1(MELK)controls partitioning of CES-1(Snail)into one but not the other daughter cell thereby promoting the making of one wanted and one unwanted cell. Furthermore, we present evidence that PIG-1(MELK)acts prior to NSM neuroblast division by locally activating the actomyosin network

The role of isotope mass and transport for H-mode access in tritium containing plasmas at JET with ITER-like wall

Special Issue Featuring the Invited Talks from the 48th EPS Conference on Plasma Physics, 27 June - 1 July 2022The required heating power, , to access the high confinement regime (H-mode) in tritium containing plasmas is investigated in JET with ITER-like wall at a toroidal magnetic field of T and a plasma current of MA. , also referred to as the L-H power threshold, is determined in plasmas of pure tritium as well as mixtures of hydrogen with tritium (H-T) and mixtures of deuterium with tritium (D-T), and is compared to the L-H power threshold in plasmas of pure hydrogen and pure deuterium. It is found that, for otherwise constant parameters, is not the same in plasmas with the same effective isotope mass, , when they differ in their isotope composition. Thus, is not sufficient to describe the isotope effect of in a consistent manner for all considered isotopes and isotope mixtures. The electron temperature profiles measured at the L-H transition in the outer half of the radius are very similar for all isotopes and isotope mixtures, despite the fact that the L-H power threshold varies by a factor of about six. This finding, together with the observation of an offset linear relation between the L-H power threshold, , and an effective heat diffusivity, , indicates that the composition-dependent heat transport in the low confinement mode (L-mode) determines, how much power is needed to reach the necessary electron temperatures at the edge, and hence PLH.This work has been carried out within the framework of the EUROfusion Consortium, funded by the European Union via the Euratom Research and Training Programme (Grant Agreement No. 101052200—EUROfusion). Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or the European Commission. Neither the European Union nor the European Commission can be held responsible for them. G Birkenmeier received funding from the Helmholtz Association under Grant No. VH-NG-1350Peer Reviewed"Article signat per 50 autors/es: G Birkenmeier, E R Solano, I S Carvalho, J C Hillesheim, E Delabie, E Lerche, D Taylor, D Gallart, M J Mantsinen, C Silva, C Angioni, F Ryter, P Carvalho, M Fontana, E Pawelec, S A Silburn, P Sirén, S Aleiferis, J Bernardo, A Boboc, D Douai, P Puglia, P Jacquet, E Litherland-Smith, I Jepu, D Kos, H J Sun, A Shaw, D King, B Viola, R Henriques, K K Kirov, M Baruzzo, J Garcia, A Hakola, A Huber, E Joffrin, D Keeling, A Kappatou, M Lennholm, P Lomas, E de la Luna, C F Maggi, J Mailloux, M Maslov, F G Rimini, N Vianello, G Verdoolaege, H Weisen, M Wischmeier and JET Contributors"Postprint (published version

Classification of endoscopic capsule images by using color wavelet features, higher order statistics and radial basis functions

This paper presents a system to support medical diagnosis and detection of abnormal lesions by processing capsule endoscopic images. Endoscopic images possess rich information expressed by texture. Texture information can be efficiently extracted from medium scales of the wavelet transform. The set of features proposed in this paper to code textural information is named color wavelet covariance (CWC). CWC coefficients are based on the covariances of second order textural measures, an optimum subset of them is proposed. Third and forth order moments are added to cope with distributions that tend to become non-Gaussian, especially in some pathological cases. The proposed approach is supported by a classifier based on radial basis functions procedure for the characterization of the image regions along the video frames. The whole methodology has been applied on real data containing 6 full endoscopic exams and reached 95% specificity and 93% sensitivity.Centre Algoritm

Binocular Integrated Visual Field Deficits Are Associated With Changes in Local Network Function in Primary Open-Angle Glaucoma:A Resting-State fMRI Study

In glaucoma participants, both structural and functional brain changes have been observed, but we still have insufficient understanding of how these changes also affect the integrity of cortical functional networks, and how these changes relate to visual function. This is relevant, as functional network integrity may affect the applicability of future treatments, as well as the options for rehabilitation or training. Here, we compare global and local functional connectivity in local and global brain networks between glaucoma and control participants. Moreover, we study the relationship between functional connectivity and visual field (VF) loss. For our study, 20 subjects with primary open-angle glaucoma (POAG) and 24 age-similar healthy participants were recruited to undergo an ophthalmic assessment followed by two resting-state (RS) (f)MRI scans. For each scan and for each group, the ROIs with eigenvector centrality (EC) values higher than the 95th percentile were considered the most central brain regions (“hubs”). Hubs for which we found a significant difference in EC in both scans between glaucoma and healthy participants were considered to provide evidence for network changes. In addition, we tested the notion that a brain region's hub function in POAG might relate to the severity of a participant's VF defect, irrespective of which eye contributed mostly to this. To determine this, for each participant, eye-independent scores were derived for: (1) sensitivity of the worse eye – indicating disease severity, (2) sensitivity of both eyes combined – with one eye potentially compensating for loss in the other, or (3) difference in eye sensitivity – potentially requiring additional network interactions. By correlating each of these VF scores and the EC values, we assessed whether VF defects could be associated with centrality alterations in POAG. Our results show that no functional connectivity disruptions were found at the global brain level in POAG participants. This indicates that in glaucoma global brain network communication is preserved. Furthermore, for the Lingual Gyrus, identified as a brain hub, we found a positive correlation between the EC value and the VF sensitivity of both eyes combined. The fact that reduced local network functioning is associated with reduced binocular VF sensitivity suggests the presence of local brain reorganization that has a bearing on functional visual abilities

Rational design of a (S)-selective-transaminase for asymmetric synthesis of (1S)-1-(1,1′-biphenyl-2-yl)ethanamine

Amine transaminases offer an environmentally sustainable synthesis route for the production of pure chiral amines. However, their catalytic efficiency toward bulky ketone substrates is greatly limited by steric hindrance and therefore presents a great challenge for industrial synthetic applications. We hereby report an example of rational transaminase enzyme design to help alleviate these challenges. Starting from the Vibrio fluvialis amine transaminase that has no detectable catalytic activity toward the bulky aromatic ketone 2-acetylbiphenyl, we employed a rational design strategy combining in silico and in vitro studies to engineer the transaminase enzyme with a minimal number of mutations, achieving an high catalytic activity and high enantioselectivity. We found that, by introducing two mutations W57G/R415A, detectable enzyme activity was achieved. The rationally designed variant, W57F/R88H/V153S/K163F/I259M/R415A/V422A, showed an improvement in reaction rate by more than 1716-fold toward the bulky ketone under study, producing the corresponding enantiomeric pure (S)-amine (enantiomeric excess (ee) value of >99%)

IS THERE ANY TRANSFER BETWEEN COUNTERMOVEMENT JUMP AND SWIMMING TRACK START PERFORMANCE?

The aim of this study was to determine if the countermovement jump could predict swimming starts performance. Ten elite swimmers performed one maximal countermovement jump on an extensometric force platform and three maximal track start on an instrumented starting block. Results showed an inverse relationship between 15 m starting time and jump variables (r = -0.86, -0.64 and -0.92 for jump height, peak vertical force and peak power, respectively; p \u3c 0.05) and no significant correlation between relative peak vertical force and start variables. Regression equation for 15 m time prediction was defined by jump height and peak vertical force (r = 0.890, adjusted r2 = 0.734). In addition, results suggest that swimmers with higher jumps and higher peak vertical force are faster on the 15m mark when using a track start

Anaerobic Threshold Biophysical Characterisation of the Four Swimming Techniques

The anaerobic threshold (AnT) seems to be not only a physiologic boundary but also a transition after which swimmers technique changes, modifying their biomechanical behaviour. We expanded the AnT concept to a biophysical construct in the four conventional swimming techniques. Seventy-two elite swimmers performed a 5×200 m incremental protocol in their preferred swimming technique (with a 0.05 m·s-1 increase and a 30 s interval between steps). A capillary blood samples were collected from the fingertip and stroke rate (SR) and length (SL) determined for the assessment of [La], SR and SL vs. velocity inflexion points (using the interception of a pair of linear and exponential regression curves). The [La] values at the AnT were 3.3±1.0, 3.9±1.1, 2.9±1 .34 and 4.5±1.4 mmol·l-1 (mean±SD) for front crawl, backstroke, breaststroke and butterfly, and its corresponding velocity correlated highly with those at SR and SL inflection points (r=0.91-0.99, p<0.001). The agreement analyses confirmed that AnT represents a biophysical boundary in the four competitive swimming techniques and can be determined individually using [La] and/or SR/SL. Blood lactate increase speed can help characterise swimmers' anaerobic behaviour after AnT and between competitive swimming techniques.info:eu-repo/semantics/acceptedVersio