The impact of resolution on the adjustment and decadal variability of the Atlantic Meridional Overturning Circulation in a coupled climate model

Variations in the Atlantic Meridional Overturning Circulation (MOC) exert an important influence on climate, particularly on decadal time scales. Simulation of the MOC in coupled climate models is compromised, to a degree that is unknown, by their lack of fidelity in resolving some of the key processes involved. There is an overarching need to increase the resolution and fidelity of climate models, but also to assess how increases in resolution influence the simulation of key phenomena such as the MOC. In this study we investigate the impact of significantly increasing the (ocean and atmosphere) resolution of a coupled climate model on the simulation of MOC variability by comparing high and low resolution versions of the same model. In both versions, decadal variability of the MOC is closely linked to density anomalies that propagate from the Labrador Sea southward along the deep western boundary. We demonstrate that the MOC adjustment proceeds more rapidly in the higher resolution model due the increased speed of western boundary waves. However, the response of the Atlantic Sea Surface Temperatures (SSTs) to MOC variations is relatively robust - in pattern if not in magnitude - across the two resolutions. The MOC also excites a coupled ocean-atmosphere response in the tropical Atlantic in both model versions. In the higher resolution model, but not the lower resolution model, there is evidence of a significant response in the extratropical atmosphere over the North Atlantic 6 years after a maximum in the MOC. In both models there is evidence of a weak negative feedback on deep density anomalies in the Labrador Sea, and hence on the MOC (with a time scale of approximately ten years). Our results highlight the need for further work to understand the decadal variability of the MOC and its simulation in climate models

Disturbing Inequities: Exploring the Relationship Between Racial Disparities in Special Education Identification and Discipline

This study examines whether exposure to novice teachers and risk for identification for special education predicated suspension rates. Identification as having emotional disturbance and specific learning disabilities were found to predict an increase in suspension rates for Black male students. The report's findings draw from 72,168 schools in nearly 7,000 school districts from nearly every state

Memory as Bayesian inference: On the connection between memory and the second law of thermodynamics

A recent theoretical paper by Leonard Mlodinow and Todd Brun suggests that the functioning of physical records or memories is never accompanied by a decrease in entropy, meaning that all memories align with the thermodynamic arrow of time. In this thesis, we characterize a class of physical systems as memories in terms of inferences that can be made about the state of the world, given certain information about these systems. Tools from Bayesian probability theory are used to quantify the informativeness and reliability associated with such inferences. Based on consideration of two model systems, one classical and one quantum, we argue in favor of Mlodinow and Brun\u27s claim that the functioning of memory systems is conditioned by thermodynamic constraints. For the classical model, we show that a memory which operates against the thermodynamic arrow, and thus remembers a relatively high-entropy state, is much less informative than a similar memory which aligns with the thermodynamic arrow. Our analysis of the quantum model, expressed in the density matrix formalism of quantum mechanics, allows us to consider the inferences that can be made when a quantum system is coupled to a simple type of quantum memory system. We ultimately show that these inferences can be expressed in terms of a probabilistic matrix completion problem

Accuracy of IOL Power Calculation Formulas for AcrySof SN60WF versus Tecnis ZCB00 Intraocular Lenses

Purpose: To compare the accuracy of various intraocular lens power formulas for two monofocal hydrophobic foldable lenses, the AcrySof SN60WF and the Tecnis ZCB00. Methods: This retrospective study included 409 eyes from 409 patients who underwent uncomplicated cataract surgery (299 eyes with SN60WF and 110 eyes with ZCB00). Biometry was performed for all eyes with an IOLMaster 700. Predicted refraction from five different IOL power formulas (Barrett Universal II, Haigis, Hoffer-Q, Holladay 2, and SRK/T) was compared to postoperative refraction at one to three months for the following axial length strata: short eyes (<22.5 mm), medium eyes (22.5–25.5 mm), and long eyes (>25.5 mm). Results: In patients with medium eyes, there were no significant differences in the mean absolute error (MAE) and the percentage of eyes within ±0.5 D (%±0.5 D) between both IOLs. In short eyes, although MAE was similar between both lenses, %±0.5 D was significantly higher for Barrett Universal II in ZCB00 than in SN60WF (P = 0.01) while Hoffer-Q and Holladay 2 performed equally for both lenses. In long eyes, ZCB00 had a higher MAE than SN60WF for Barrett Universal II, Haigis, and Hoffer-Q. Additionally, in long eyes, the percentage of eyes within %±0.5 D was significantly higher for SN60WF than ZCB00 for all formulas (P < 0.001). Conclusion: Although there were no significant differences in the formula accuracy between these two lenses in medium eyes for all formulas and in short eyes for most formulas, the accuracy decreased significantly in long eyes for ZCB00 compared to SN60WF. The effect of IOL model on the postoperative outcomes should be further investigated

Role of the Atlantic multidecadal variability in modulating East Asian climate

We assess the effects of the North Atlantic Ocean Sea Surface Temperature (NASST) on North East Asian (NEA) surface temperature. We use a set of sensitivity experiments, performed with MetUM-GOML2, an atmospheric general circulation model coupled to a multi-level ocean mixed layer model, to mimic warming and cooling over the North Atlantic Ocean. Results show that a warming of the NASST is associated with a significant warming over NEA. Two mechanisms are pointed out to explain the NASST—North East Asia surface temperature relationship. First, the warming of the NASST is associated with a modulation of the northern hemisphere circulation, due to the propagation of a Rossby wave (i.e. the circumglobal teleconnection). The change in the atmosphere circulation is associated with advections of heat from the Pacific Ocean to NEA and with an increase in net surface shortwave radiation over NEA, both acting to increase NEA surface temperature. Second, the warming of the NASST is associated with a cooling (warming) over the eastern (western) Pacific Ocean, which modulates the circulation over the western Pacific Ocean and NEA. Additional simulations, in which Pacific Ocean sea surface temperatures are kept constant, show that the modulation of the circumglobal teleconnection is key to explaining impacts of the NASST on NEA surface temperature

An anatomy of the cooling of the North Atlantic Ocean in the 1960s and 1970s

In the 1960s and early 1970s sea surface temperatures in the North Atlantic Ocean cooled rapidly. There is still considerable uncertainty about the causes of this event, although various mechanisms have been proposed. In this observational study it is demonstrated that the cooling proceeded in several distinct stages. Cool anomalies initially appeared in the mid-1960s in the Nordic Seas and Gulf Stream Extension, before spreading to cover most of the Subpolar Gyre. Subsequently, cool anomalies spread into the tropical North Atlantic before retreating, in the late 1970s, back to the Subpolar Gyre. There is strong evidence that changes in atmospheric circulation, linked to a southward shift of the Atlantic ITCZ, played an important role in the event, particularly in the period 1972-76. Theories for the cooling event must account for its distinctive space-time evolution. Our analysis suggests that the most likely drivers were: 1) The “Great Salinity Anomaly” of the late 1960s; 2) An earlier warming of the subpolar North Atlantic, which may have led to a slow-down in the Atlantic Meridional Overturning Circulation; 3) An increase in anthropogenic sulphur dioxide emissions. Determining the relative importance of these factors is a key area for future work

Non-Hodgkin lymphoma.

The term non-Hodgkin lymphoma (NHL) covers a spectrum of malignant disorders arising from cells of the immune system and manifesting predominantly as lymphadenopathy or solid tumour. The classification of NHL is complex and ever-evolving, with more than 50 different subtypes listed in the latest WHO classification of lymphoma (1). In this clinical update, we address the distinction between low-grade (indolent) and high-grade lymphoma, and discuss the principles of diagnosis and management that are of particular relevance to the non-specialist physician who may encounter patients with NHL during their initial presentation, during therapy and during periods of follow-up

Challenging perspectives on the cellular origins of lymphoma.

Both B and T lymphocytes have signature traits that set them apart from other cell types. They actively and repeatedly rearrange their DNA in order to produce a unique and functional antigen receptor, they have potential for massive clonal expansion upon encountering antigen via this receptor or its precursor, and they have the capacity to be extremely long lived as 'memory' cells. All three of these traits are fundamental to their ability to function as the adaptive immune response to infectious agents, but concurrently render these cells vulnerable to transformation. Thus, it is classically considered that lymphomas arise at a relatively late stage in a lymphocyte's development during the process of modifying diversity within antigen receptors, and when the cell is capable of responding to stimulus via its receptor. Attempts to understand the aetiology of lymphoma have reinforced this notion, as the most notable advances to date have shown chronic stimulation of the antigen receptor by infectious agents or self-antigens to be key drivers of these diseases. Despite this, there is still uncertainty about the cell of origin in some lymphomas, and increasing evidence that a subset arises in a more immature cell. Specifically, a recent study indicates that T-cell lymphoma, in particular nucleophosmin-anaplastic lymphoma kinase-driven anaplastic large cell lymphoma, may originate in T-cell progenitors in the thymus.T.I.M.M. was supported by a Bloodwise Gordon Piller Studentship.This is the final version of the article. It first appeared from The Royal Society via https://doi.org/10.1098/rsob.16023

Genetic manipulation and immortalized culture of ex vivo primary human germinal center B cells.

Next-generation sequencing has transformed our knowledge of the genetics of lymphoid malignancies. However, limited experimental systems are available to model the functional effects of these genetic changes and their implications for therapy. The majority of mature B-cell malignancies arise from the germinal center (GC) stage of B-cell differentiation. Here we describe a detailed protocol for the purification and ex vivo expansion of primary, nonmalignant human GC B cells. We present methodology for the high-efficiency transduction of these cells to enable combinatorial expression of putative oncogenes. We also describe alternative approaches for CRISPR-Cas9-mediated deletion of putative tumor suppressors. Mimicking genetic changes commonly found in lymphoid malignancies leads to immortalized growth in vitro, while engraftment into immunodeficient mice generates genetically customized, synthetic models of human lymphoma. The protocol is simple and inexpensive and can be implemented in any laboratory with access to standard cell culture and animal facilities. It can be easily scaled up to enable high-throughput screening and thus provides a versatile platform for the functional interrogation of lymphoma genomic data.D.H. was personally supported by a Clinician Scientist Fellowship from the Medical Research Council (MR/M008584/1). Research in the Hodson laboratory is supported by the Kay Kendall Leukaemia Fund, The Addenbrooke’s Charitable Trust and the Evelyn Trust. The Hodson laboratory receives core funding from Wellcome (203151/Z/16/Z) and MRC to the WellcomeMRC Cambridge Stem Cell Institute and from CRUK to the CRUK Cambridge Centre (A25117

Effect of the Atlantic Multidecadal Variability on the global monsoon

We assess the effect of the Atlantic Multidecadal Variability (AMV) on the global monsoon using idealized simulations. Warm AMV phases are associated with a significant strengthening of monsoon precipitation over Northern Africa and India, and anomalously weak monsoon precipitation over South America. Changes in monsoon precipitation are mediated by a change in atmospheric dynamics, primarily associated with a shift in the circulation related to both an enhanced interhemispheric thermal contrast and the remote impact of AMV on the Pacific Ocean, through changes in the Walker circulation. In contrast, the thermodynamic changes are less important. Further experiments show that the impact of AMV is largely due to the tropical component of the sea surface temperature anomalies. However, the extratropical Atlantic also plays a role, especially for northern Africa. Finally, we show that the effect of AMV on monsoons is not linearly related to the magnitude of warming