4 research outputs found
Genetic variability and structure of jaguar (Panthera onca) in Mexican zoos
ArtículoGenealogical records of animals (studbook) are
created to avoid reproduction between closely related
individuals, which could cause inbreeding, particularly for
such endangered species as the Panthera onca (Linnaeus,
1758). Jaguar is the largest felid in the Americas and is
considered an important ecological key species. In Mexico,
wild jaguar populations have been significantly reduced in
recent decades, and population decline typically accompany decreases in genetic variation. There is no current
census of captive jaguars in Mexico, and zoos do not follow a standardized protocol in breeding programs based on
genetic studies. Here, we emphasise the importance of
maintaining an adequate level of genetic variation and
propose the implementation of standardised studbooks for
jaguars in Mexico, mainly to avoid inbreeding. In addition,
achieving the aims of studbook registration would provide
a population genetic characterisation that could serve as a
basis for ex situ conservation programmes
La respuesta inflamatoria medida a través de la cuantificación de citosinas pro - inflamatorias (tnf-a, il-1β, il-6) en pacientes tratados con electroacupuntura post-lumbalgia
Tesina (Especialidad en Acupuntura Humana), Instituto Politécnico Nacional, SEPI, ENMH, 2010, 1 archivo PDF, (37 páginas). tesis.ipn.m
Electroacupuncture efficacy in diabetic polyneuropathy: Study protocol for a double-blinded randomized controlled multicenter clinical trial
Abstract Background Diabetic peripheral neuropathy (DPN) is the most common complication of type 2 diabetes mellitus (T2DM); its diagnosis and treatment are based on symptomatic improvement. However, as pharmacological therapy causes multiple adverse effects, the implementation of acupunctural techniques, such as electroacupuncture (EA) has been suggested as an alternative treatment. Nonetheless, there is a lack of scientific evidence, and its mechanisms are still unclear. We present the design and methodology of a new clinical randomized trial, that investigates the effectiveness of EA for the treatment of DPN. Methods This study is a four-armed, randomized, controlled, multicenter clinical trial (20-week intervention period, plus 12 weeks of follow-up after concluding intervention). A total of 48 T2DM patients with clinical signs and symptoms of DPN; and electrophysiological signs in the Nerve Conduction Study (NCS); will be treated by acupuncture specialists in outpatient units in Mexico City. Patients will be randomized in a 1:1 ratio to one of the following four groups: (a) short fibre DPN with EA, (b) short fibre DPN with sham EA, (c) axonal DPN with EA and (d) axonal DPN with sham EA treatment. The intervention will consist of 32 sessions, 20 min each, per patient over two cycles of intervention of 8 weeks each and a mid-term rest period of 4 weeks. The primary outcome will be NCS parameters, and secondary outcomes will include DPN-related symptoms and pain by Michigan Neuropathy Screening Instrument (MNSI), Michigan Diabetic Neuropathy Score (MDNS), Dolour Neuropatique Score (DN-4), Semmes-Westein monofilament, Numerical Rating Scale (NRS) for pain assessment, and the 36-item Short Form Health Survey (SF-36). To measure quality of life and improve oxidative stress, the inflammatory response; and genetic expression; will be analysed at the beginning and at the end of treatment. Discussion This study will be conducted to compare the efficacy of EA versus sham EA combined with conventional diabetic and neuropathic treatments if needed. EA may improve NCS, neuropathic pain and symptoms, oxidative stress, inflammatory response, and genetic expression, and it could be considered a potential coadjutant treatment for the management of DPN with a possible remyelinating effect. Trial registration ClinicalTrials.gov. NCT05521737 Registered on 30 August 2022. International Clinical Trials Registry Platform (ICTRP) ISRCTN97391213 Registered on 26 September 2022 [2b]
Additional file 1 of Electroacupuncture efficacy in diabetic polyneuropathy: Study protocol for a double-blinded randomized controlled multicenter clinical trial
Additional file 1. SPIRIT figure of the phases of the trial and data collection time points