1,385 research outputs found
Monetary policy and economic activity: a postwar review
Monetary policy ; Financial markets ; Economic conditions
Estrogen-Like Activity of Perfluoroalkyl Acids In Vivo and Interaction with Human and Rainbow Trout Estrogen Receptors In Vitro
The objectives of this study were to determine the structural characteristics of perfluoroalkyl acids (PFAAs) that confer estrogen-like activity in vivo using juvenile rainbow trout (Oncorhynchus mykiss) as an animal model and to determine whether these chemicals interact directly with the estrogen receptor (ER) using in vitro and in silico species comparison approaches. Perfluorooctanoic (PFOA), perfluorononanoic (PFNA), perfluorodecanoic (PFDA), and perfluoroundecanoic (PFUnDA) acids were all potent inducers of the estrogen-responsive biomarker protein vitellogenin (Vtg) in vivo, although at fairly high dietary exposures. A structure-activity relationship for PFAAs was observed, where eight to ten fluorinated carbons and a carboxylic acid end group were optimal for maximal Vtg induction. These in vivo findings were corroborated by in vitro mechanistic assays for trout and human ER. All PFAAs tested weakly bound to trout liver ER with half maximal inhibitory concentration (IC50) values of 15.2-289μM. Additionally, PFOA, PFNA, PFDA, PFUnDA, and perlfuorooctane sulfonate (PFOS) significantly enhanced human ERα-dependent transcriptional activation at concentrations ranging from 10-1000nM. Finally, we employed an in silico computational model based upon the crystal structure for the human ERα ligand-binding domain complexed with E2 to structurally investigate binding of these putative ligands to human, mouse, and trout ERα. PFOA, PFNA, PFDA, and PFOS all efficiently docked with ERα from different species and formed a hydrogen bond at residue Arg394/398/407 (human/mouse/trout) in a manner similar to the environmental estrogens bisphenol A and nonylphenol. Overall, these data support the contention that several PFAAs are weak environmental xenoestrogens of potential concer
Performance of international medical students in psychosocial medicine
Background: Particularly at the beginning of their studies, international medical students face a number of language-related, social and intercultural challenges. Thus, they perform poorer than their local counterparts in written and oral examinations as well as in Objective Structured Clinical Examinations (OSCEs) in the fields of internal medicine and surgery. It is still unknown how international students perform in an OSCE in the field of psychosocial medicine compared to their local fellow students. Methods: All students (N = 1033) taking the OSCE in the field of psychosocial medicine and an accompanying written examination in their eighth or ninth semester between 2012 and 2015 were included in the analysis. The OSCE consisted of four different stations, in which students had to perform and manage a patient encounter with simulated patients suffering from 1) post-traumatic stress disorder, 2) schizophrenia, 3) borderline personality disorder and 4) either suicidal tendency or dementia. Students were evaluated by trained lecturers using global checklists assessing specific professional domains, namely building a relationship with the patient, conversational skills, anamnesis, as well as psychopathological findings and decision-making. Results: International medical students scored significantly poorer than their local peers (p < .001; η2 = .042). Within the specific professional domains assessed, they showed poorer scores, with differences in conversational skills showing the highest effect (p < .001; η2 = .053). No differences emerged within the multiple-choice examination (p = .127). Conclusion: International students showed poorer results in clinical-practical exams in the field of psychosocial medicine, with conversational skills yielding the poorest scores. However, regarding factual and practical knowledge examined via a multiple-choice test, no differences emerged between international and local students. These findings have decisive implications for relationship building in the doctor-patient relationship
The Lantern Vol. 11, No. 1, December 1942
• Friends of the Aquarium • Espionage • Fuss-Budget • Dress Blues • Alone • One Easy Lesson in How Not to Study • A Thumbtack Sketch • One Star • A Colonial Inn • Thoughts on a Dark Day • Query • Paul Revere and the World He Lived In • Sunsetshttps://digitalcommons.ursinus.edu/lantern/1028/thumbnail.jp
Five Kepler target stars that show multiple transiting exoplanet candidates
We present and discuss five candidate exoplanetary systems identified with
the Kepler spacecraft. These five systems show transits from multiple exoplanet
candidates. Should these objects prove to be planetary in nature, then these
five systems open new opportunities for the field of exoplanets and provide new
insights into the formation and dynamical evolution of planetary systems. We
discuss the methods used to identify multiple transiting objects from the
Kepler photometry as well as the false-positive rejection methods that have
been applied to these data. One system shows transits from three distinct
objects while the remaining four systems show transits from two objects. Three
systems have planet candidates that are near mean motion
commensurabilities---two near 2:1 and one just outside 5:2. We discuss the
implications that multitransiting systems have on the distribution of orbital
inclinations in planetary systems, and hence their dynamical histories; as well
as their likely masses and chemical compositions. A Monte Carlo study indicates
that, with additional data, most of these systems should exhibit detectable
transit timing variations (TTV) due to gravitational interactions---though none
are apparent in these data. We also discuss new challenges that arise in TTV
analyses due to the presence of more than two planets in a system.Comment: Accepted to Ap
Accelerated development of arthritis in mice lacking endothelial selectins
The selectins, along with very late antigen-4 and CD44, have been implicated in mediating leukocyte rolling interactions that lead to joint recruitment and inflammation during the pathogenesis of rheumatoid arthritis. Previously, we showed that P-selectin deficiency in mice resulted in accelerated onset of joint inflammation in the murine collagen-immunized arthritis model. Here, we report that mice deficient either in E-selectin or in E-selectin and P-selectin (E/P-selectin mutant) also exhibit accelerated development of arthritis compared with wild type mice in the CIA model, suggesting that these adhesion molecules perform overlapping functions in regulating joint disease. Analyses of cytokine and chemokine expression in joint tissue from E/P-selectin mutant mice before the onset of joint swelling revealed significantly higher joint levels of macrophage inflammatory protein-1α and IL-1β compared to wild-type mice. IL-1β remained significantly increased in E/P-selectin mutant joint tissue during the early and chronic phases of arthritis. Overall, these data illustrate the novel finding that E-selectin and P-selectin expression can significantly influence cytokine and chemokine production in joint tissue, and suggest that these adhesion molecules play important regulatory roles in the development of arthritis in E/P-selectin mutant mice
Transit Timing Observations from Kepler: VI. Potentially interesting candidate systems from Fourier-based statistical tests
We analyze the deviations of transit times from a linear ephemeris for the
Kepler Objects of Interest (KOI) through Quarter six (Q6) of science data. We
conduct two statistical tests for all KOIs and a related statistical test for
all pairs of KOIs in multi-transiting systems. These tests identify several
systems which show potentially interesting transit timing variations (TTVs).
Strong TTV systems have been valuable for the confirmation of planets and their
mass measurements. Many of the systems identified in this study should prove
fruitful for detailed TTV studies.Comment: 32 pages, 6 of text and one long table, Accepted to Ap
Tomography of Feshbach resonance states
Feshbach resonances are fundamental to interparticle interactions and become particularly important in cold collisions with atoms, ions, and molecules. In this work, we present the detection of Feshbach resonances in a benchmark system for strongly interacting and highly anisotropic collisions: molecular hydrogen ions colliding with noble gas atoms. The collisions are launched by cold Penning ionization, which exclusively populates Feshbach resonances that span both short- and long-range parts of the interaction potential. We resolved all final molecular channels in a tomographic manner using ion-electron coincidence detection. We demonstrate the nonstatistical nature of the final-state distribution. By performing quantum scattering calculations on ab initio potential energy surfaces, we show that the isolation of the Feshbach resonance pathways reveals their distinctive fingerprints in the collision outcome
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