85 research outputs found
When central populations exhibit more genetic diversity than peripheral populations: A simulation study
PAK5 mediates cell: cell adhesion integrity via interaction with E-cadherin in bladder cancer cells
mlegp: statistical analysis for computer models of biological systems using R
Summary: Gaussian processes (GPs) are flexible statistical models commonly used for predicting output from complex computer codes. As such, GPs are well suited for the analysis of computer models of biological systems, which have been traditionally difficult to analyze due to their high-dimensional, non-linear and resource-intensive nature. We describe an R package, mlegp, that fits GPs to computer model outputs and performs sensitivity analysis to identify and characterize the effects of important model inputs
Stochastic Intrinsic Kriging for Simulation Metamodelling
We derive intrinsic Kriging, using Matherons intrinsic random functions which eliminate the trend in classic Kriging. We formulate this intrinsic Kriging as a metamodel in deterministic and random simulation models. For random simulation we derive an experimental design that also specifies the number of replications that varies with the input combinations. We compare intrinsic Kriging and classic Kriging in several numerical experiments with deterministic and random simulations. These experiments suggest that intrinsic Kriging gives more accurate metamodel, in most experiments
Population structure, gene diversity, and differentiation in natural populations of Cedar pines (Pinus subsect.Cembrae, Pinaceae) in the USSR
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