Y\u27all Go Out and Make Us Proud: The Commencement Address and the Southern Writer

The college commencement address is traditionally regarded as the low point of an otherwise auspicious occasion. An ephemeral form of ceremonial oratory, the commencement speech is reviled for its conventional platitudes, its easy piety, and its abstractions on the well-lived life, the sunny future, and the ethics of adulthood. The South may differ, however, in its approach to the commencement speech genre, especially in the years between World War II and the millennium, when one of the South’s most significant assets became the southern writer. Throughout this dissertation, I have tried to situate eight commencement addresses given by such prominent and dissimilar writers as W.J. Cash, William Faulkner, Wendell Berry, Will D. Campbell, Lee Smith, Clyde Edgerton, Maya Angelou, and Fred Chappell, within the context of the times in which they were delivered and within the speakers\u27 written works. Through my analysis of these graduation talks, I discovered that southern writers typically abandon those repetitious conventions that render the commencement address forgettable in favor of the innovative techniques that were already at work in their written works

A tool for metadata analysis

We describe a Web-based metadata quality tool that provides statistical descriptions and visualisations of Dublin Core metadata harvested via the OAI protocol. The lightweight nature of development allows it to be used to gather contextualized requirements and some initial user feedback is discussed

PARKS, PEOPLE, & PLANNING: Open Spaces in Small Places

52 pagesAs a small, rural city of only 1000 residents, Coburg faces many challenges in updating their Parks and Open Space Master Plan. There are issues of size, density, quality, capacity, and use that are not accounted for in traditional park planning guidelines, which often favor large, urban settings. Current guidelines for parks planning are standardized and methodical, but often fail to provide clear guidance about the more qualitative measures such as public input. When starting the process of preparing the Parks and Open Space Master Plan Update for the City of Coburg, it seemed that addressing the issue of outdated and misrepresented level-of-service guidelines would be the biggest barrier to a successful plan. However, challenges with organization, community stakeholders, funding mechanisms, and the political issue of expanding the Urban Growth Boundary made the process much more interesting than the content of the plan itself and provided valuable lessons for myself as a student. This project first began in the summer of 2015, when the City of Coburg approached me with the opportunity to update their parks master plan. While the project has taken longer than initially expected, this left time to learn, grow, and analyze the results of my continued efforts. Since the plan is only half complete at this time, it made more sense to look closely at the tasks that have been accomplished and distill the process into a set of lessons learned. There is much to be gleaned from the community, the process, and the implementation that may be useful to other planners in pursuit of creating the perfect small town parks plan. Small town open space planners are often limited in staff and funding capacity, face opposition from long-time residents, and juggle multiple responsibilities at once. With the inventory and community outreach portions of the plan complete, there is now time to reflect on the successes and challenges of this process and look for opportunities moving forward. Eight key lessons were assembled from the process that can be applied to future parks planning in Coburg, or adapted to other planning processes moving forward. These lessons include: 1. Set appropriate Level-of-Service standards 2. Make public participation as easy as possible3. Embrace existing culture and values 4. Choose low-cost, high yield projects 5. Understand maintenance costs 6. Emphasize project prioritization 7. Be prepared to deal with resistance to change 8. Expect your timeline to be pushed back These are issues that are relevant to likely all facets of planning, however they are even more evident when dealing with limited resources and funding capacity. While this is not an exhaustive list, it seeks to highlight the highest and lowest points of the update process and suggest recommendations for other planners looking to develop or update a parks and open space master plan

Experiences in deploying metadata analysis tools for institutional repositories

Current institutional repository software provides few tools to help metadata librarians understand and analyze their collections. In this article, we compare and contrast metadata analysis tools that were developed simultaneously, but independently, at two New Zealand institutions during a period of national investment in research repositories: the Metadata Analysis Tool (MAT) at The University of Waikato, and the Kiwi Research Information Service (KRIS) at the National Library of New Zealand. The tools have many similarities: they are convenient, online, on-demand services that harvest metadata using OAI-PMH; they were developed in response to feedback from repository administrators; and they both help pinpoint specific metadata errors as well as generating summary statistics. They also have significant differences: one is a dedicated tool wheres the other is part of a wider access tool; one gives a holistic view of the metadata whereas the other looks for specific problems; one seeks patterns in the data values whereas the other checks that those values conform to metadata standards. Both tools work in a complementary manner to existing Web-based administration tools. We have observed that discovery and correction of metadata errors can be quickly achieved by switching Web browser views from the analysis tool to the repository interface, and back. We summarize the findings from both tools' deployment into a checklist of requirements for metadata analysis tools

Heme Oxygenase Induction Suppresses Hepatic Hepcidin and Rescues Ferroportin and Ferritin Expression in Obese Mice

Hepcidin, a phase II reactant secreted by hepatocytes, regulates cellular iron levels by increasing internalization of ferroportin-a transmembrane protein facilitating egress of cellular iron. Chronic low-grade inflammatory states, such as obesity, have been shown to increase oxidative stress and enhance hepcidin secretion from hepatocytes and macrophages. Heme-heme oxygenase (HO) is a stress response system which reduces oxidative stress. We investigated the effects of HO-1 induction on hepatic hepcidin levels and on iron homeostasis in hepatic tissues from lean and obese mice. Obese mice exhibited hyperglycemia (p < 0.05); increased levels of proinflammatory cytokines (MCP-1, IL-6, p < 0.05); oxidative stress (p < 0.05); and increased hepatic hepcidin levels (p < 0.05). Enhancement of hepcidin was reflected in the reduced expression of ferroportin in obese mice (p < 0.05). However, this effect is accompanied by a significant decline in ferritin expression. Additionally, there are reduced insulin receptor phosphorylation and attenuation of metabolic regulators pAMPK, pAKT, and pLKB1. Cobalt protoporphyrin- (CoPP-) induced HO-1 upregulation in obese mice reversed these alterations (p < 0.05), while attenuating hepatic hepcidin levels. These effects of CoPP were prevented in obese mice concurrently exposed to an inhibitor of HO (SnMP) (p < 0.05). Our results highlight a modulatory effect of HO on iron homeostasis mediated through the suppression of hepatic hepcidin

Dietary magnesium and copper affect survival time and neuroinflammation in chronic wasting disease

Chronic wasting disease (CWD), the only known wildlife prion disease, affects deer, elk and moose. The disease is an ongoing and expanding problem in both wild and captive North American cervid populations and is difficult to control in part due to the extreme environmental persistence of prions, which can transmit disease years after initial contamination. The role of exogenous factors in CWD transmission and progression is largely unexplored. In an effort to understand the influence of environmental and dietary constituents on CWD, we collected and analyzed water and soil samples from CWD-negative and positive captive cervid facilities, as well as from wild CWD-endozootic areas. Our analysis revealed that, when compared with CWD-positive sites, CWD-negative sites had a significantly higher concentration of magnesium, and a higher magnesium/copper (Mg/Cu) ratio in the water than that from CWD-positive sites. When cevidized transgenic mice were fed a custom diet devoid of Mg and Cu and drinking water with varied Mg/Cu ratios, we found that higher Mg/Cu ratio resulted in significantly longer survival times after intracerebral CWD inoculation. We also detected reduced levels of inflammatory cytokine gene expression in mice fed a modified diet with a higher Mg/Cu ratio compared to those on a standard rodent diet. These findings indicate a role for dietary Mg and Cu in CWD pathogenesis through modulating inflammation in the brain

Dietary magnesium and copper affect survival time and neuroinflammation in chronic wasting disease

Chronic wasting disease (CWD), the only known wildlife prion disease, affects deer, elk and moose. The disease is an ongoing and expanding problem in both wild and captive North American cervid populations and is difficult to control in part due to the extreme environmental persistence of prions, which can transmit disease years after initial contamination. The role of exogenous factors in CWD transmission and progression is largely unexplored. In an effort to understand the influence of environmental and dietary constituents on CWD, we collected and analyzed water and soil samples from CWD-negative and positive captive cervid facilities, as well as from wild CWD-endozootic areas. Our analysis revealed that, when compared with CWD-positive sites, CWD-negative sites had a significantly higher concentration of magnesium, and a higher magnesium/copper (Mg/Cu) ratio in the water than that from CWD-positive sites. When cevidized transgenic mice were fed a custom diet devoid of Mg and Cu and drinking water with varied Mg/Cu ratios, we found that higher Mg/Cu ratio resulted in significantly longer survival times after intracerebral CWD inoculation. We also detected reduced levels of inflammatory cytokine gene expression in mice fed a modified diet with a higher Mg/Cu ratio compared to those on a standard rodent diet. These findings indicate a role for dietary Mg and Cu in CWD pathogenesis through modulating inflammation in the brain