2,810 research outputs found
Graphical Nonbinary Quantum Error-Correcting Codes
In this paper, based on the nonbinary graph state, we present a systematic
way of constructing good non-binary quantum codes, both additive and
nonadditive, for systems with integer dimensions. With the help of computer
search, which results in many interesting codes including some nonadditive
codes meeting the Singleton bounds, we are able to construct explicitly four
families of optimal codes, namely, , ,
and for any odd dimension and a family of nonadditive code
for arbitrary . In the case of composite numbers as
dimensions, we also construct a family of stabilizer codes for odd , whose coding subspace is {\em not} of a dimension
that is a power of the dimension of the physical subsystem.Comment: 12 pages, 5 figures (pdf
Voltage-independent SK-channel dysfunction causes neuronal hyperexcitability in the hippocampus of Fmr1 knock-out mice
Neuronal hyperexcitability is one of the major characteristics of fragile X syndrome (FXS), yet the molecular mechanisms of this critical dysfunction remain poorly understood. Here we report a major role of voltage-independent potassium (
Chandra Observations of Galaxy Zoo Mergers: Frequency of Binary Active Nuclei in Massive Mergers
We present the results from a Chandra pilot study of 12 massive galaxy
mergers selected from Galaxy Zoo. The sample includes major mergers down to a
host galaxy mass of 10 that already have optical AGN
signatures in at least one of the progenitors. We find that the coincidences of
optically selected active nuclei with mildly obscured ( cm) X-ray nuclei are relatively common (8/12), but the
detections are too faint ( counts per nucleus; erg s cm) to reliably separate starburst and
nuclear activity as the origin of the X-ray emission. Only one merger is found
to have confirmed binary X-ray nuclei, though the X-ray emission from its
southern nucleus could be due solely to star formation. Thus, the occurrences
of binary AGN in these mergers are rare (0-8%), unless most merger-induced
active nuclei are very heavily obscured or Compton thick.Comment: 8 pages, including 5 figures and 1 table. Accepted by Ap
Mechanism and treatment for learning and memory deficits in mouse models of Noonan syndrome.
In Noonan syndrome (NS) 30-50% of subjects show cognitive deficits of unknown etiology and with no known treatment. Here, we report that knock-in mice expressing either of two NS-associated mutations in Ptpn11, which encodes the nonreceptor protein tyrosine phosphatase Shp2, show hippocampal-dependent impairments in spatial learning and deficits in hippocampal long-term potentiation (LTP). In addition, viral overexpression of an NS-associated allele PTPN11(D61G) in adult mouse hippocampus results in increased baseline excitatory synaptic function and deficits in LTP and spatial learning, which can be reversed by a mitogen-activated protein kinase kinase (MEK) inhibitor. Furthermore, brief treatment with lovastatin reduces activation of the GTPase Ras-extracellular signal-related kinase (Erk) pathway in the brain and normalizes deficits in LTP and learning in adult Ptpn11(D61G/+) mice. Our results demonstrate that increased basal Erk activity and corresponding baseline increases in excitatory synaptic function are responsible for the LTP impairments and, consequently, the learning deficits in mouse models of NS. These data also suggest that lovastatin or MEK inhibitors may be useful for treating the cognitive deficits in NS
Recommended from our members
Functional Brain and Age-Related Changes Associated with Congruency in Task Switching
Alternating between completing two simple tasks, as opposed to completing only one task, has been shown to produce costs to performance and changes to neural patterns of activity, effects which are augmented in old age. Cognitive conflict may arise from factors other than switching tasks, however. Sensorimotor congruency (whether stimulus-response mappings are the same or different for the two tasks) has been shown to behaviorally moderate switch costs in older, but not younger adults. In the current study, we used fMRI to investigate the neurobiological mechanisms of response-conflict congruency effects within a task switching paradigm in older (N=75) and younger (N=62) adults. Behaviorally, incongruency moderated age-related differences in switch costs. Neurally, switch costs were associated with greater activation in the dorsal attention network for older relative to younger adults. We also found that older adults recruited an additional set of brain areas in the ventral attention network to a greater extent than did younger adults to resolve congruency-related response-conflict. These results suggest both a network and an age-based dissociation between congruency and switch costs in task switching
Organ aging signatures in the plasma proteome track health and disease
Animal studies show aging varies between individuals as well as between organs within an individua
Power Integrity Characterization and Correlation of 3D Package Systems Using On-Chip Measurements
Abstract-System power integrity characterization for low-power high-speed memory interface in a 3D package system is a challenging task due to probing difficulties imposed by small form factor. In this paper, power integrity measurements including supply noise, PSIJ sensitivity and PDN impedance curve using on-chip noise generator and monitors are presented. On-chip measurement data are validated by off-chip sense line measurements. Good correlations between simulation and measurements close the loop between analysis and verification for the system power supply delivery design
- โฆ