302 research outputs found
Model-based Aeroservoelastic Design and Load Alleviation of Large Wind Turbine Blades
This paper presents an aeroservoelastic modeling approach for dynamic load alleviation
in large wind turbines with trailing-edge aerodynamic surfaces. The tower, potentially on a
moving base, and the rotating blades are modeled using geometrically non-linear composite
beams, which are linearized around reference conditions with arbitrarily-large structural
displacements. Time-domain aerodynamics are given by a linearized 3-D unsteady vortexlattice
method and the resulting dynamic aeroelastic model is written in a state-space
formulation suitable for model reductions and control synthesis. A linear model of a single
blade is used to design a Linear-Quadratic-Gaussian regulator on its root-bending moments,
which is finally shown to provide load reductions of about 20% in closed-loop on the full
wind turbine non-linear aeroelastic model
Cohort Profile:The Danish National Cohort Study of Effectiveness and Safety of SARS-CoV-2 vaccines (ENFORCE)
Data-driven analysis of <i>JAK2</i> V617F kinetics during interferon-alpha2 treatment of patients with polycythemia vera and related neoplasms
The communication of a secondary care diagnosis of autoimmune hepatitis to primary care practitioners: a population-based study
Background
Autoimmune Hepatitis is a chronic liver disease which affects young people and can result in liver failure leading to death or transplantation yet there is a lack of information on the incidence and prevalence of this disease and its natural history in the UK. A means of obtaining this information is via the use of clinical databases formed of electronic primary care records. How reliably the diagnosis is coded in such records is however unknown. The aim of this study therefore was to assess the proportion of consultant hepatologist diagnoses of Autoimmune Hepatitis which were accurately recorded in General Practice computerised records.
Methods
Our study population were patients with Autoimmune Hepatitis diagnosed by consultant hepatologists in the Queens Medical Centre, Nottingham University Hospitals (UK) between 2004 and 2009. We wrote to the general practitioners of these patients to obtain the percentage of patients who had a valid READ code specific for Autoimmune Hepatitis.
Results
We examined the electronic records of 51 patients who had biopsy evidence and a possible diagnosis of Autoimmune Hepatitis. Forty two of these patients had a confirmed clinical diagnosis of Autoimmune Hepatitis by a consultant hepatologist: we contacted the General Practitioners of these patients obtaining a response rate of 90.5% (39/42 GPs). 37/39 of these GPs responded with coding information and 89% of these patients (33/37) used Read code J638.00 (Autoimmune Hepatitis) to record a diagnosis.
Conclusions
The diagnosis of Autoimmune Hepatitis made by a Consultant Hepatologist is accurately communicated to and electronically recorded by primary care in the UK. As a large proportion of cases of Autoimmune Hepatitis are recorded in primary care, this minimises the risk of introducing selection bias and therefore selecting cases using these data will be a valid method of conducting population based studies on Autoimmune Hepatitis
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Genetic analysis of a major international collection of cultivated apple varieties reveals previously unknown historic heteroploid and inbred relationships
Domesticated apple (Malus x domestica Borkh.) is a major global crop and the genetic diversity held within the pool of cultivated varieties is important for the development of future cultivars. The aim of this study was to investigate the diversity held within the domesticated form, through the analysis of a major international germplasm collection of cultivated varieties, the UK National Fruit Collection, consisting of over 2,000 selections of named cultivars and seedling varieties. We utilised Diversity Array Technology (DArT) markers to assess the genetic diversity within the collection. Clustering attempts, using the software STRUCTURE revealed that the accessions formed a complex and historically admixed group for which clear clustering was challenging. Comparison of accessions using the Jaccard similarity coefficient allowed us to identify clonal and duplicate material as well as revealing pairs and groups that appeared more closely related than a standard parent-offspring or full-sibling relations. From further investigation, we were able to propose a number of new pedigrees, which revealed that some historically important cultivars were more closely related than previously documented and that some of them were partially inbred. We were also able to elucidate a number of parent-offspring relationships that had resulted in a number of important polyploid cultivars. This included reuniting polyploid cultivars that in some cases dated as far back as the 18th century, with diploid parents that potentially date back as far as the 13th century
Unitarity bounds on low scale quantum gravity
We study the unitarity of models with low scale quantum gravity both in four
dimensions and in models with a large extra-dimensional volume. We find that
models with low scale quantum gravity have problems with unitarity below the
scale at which gravity becomes strong. An important consequence of our work is
that their first signal at the Large Hadron Collider would not be of a
gravitational nature such as graviton emission or small black holes, but rather
linked to the mechanism which fixes the unitarity problem. We also study models
with scalar fields with non minimal couplings to the Ricci scalar. We consider
the strength of gravity in these models and study the consequences for
inflation models with non-minimally coupled scalar fields. We show that a
single scalar field with a large non-minimal coupling can lower the Planck mass
in the TeV region. In that model, it is possible to lower the scale at which
gravity becomes strong down to 14 TeV without violating unitarity below that
scale.Comment: 15 page
Autoimmune hepatitis triggered by nitrofurantoin: a case series
<p>Abstract</p> <p>Introduction</p> <p>Drugs can occasionally trigger the onset of autoimmune liver disease.</p> <p>Case presentation</p> <p>Three Caucasian women (aged 65, 42 and 74 years old) who were receiving long-term nitrofurantoin as prophylaxis against recurrent urinary tract infections developed hepatitic liver disease. Serological auto-antibody profiles and liver histology appearances were consistent with autoimmune hepatitis. Two of the patients presented with jaundice, and one required a prolonged hospital admission for liver failure. In all three patients nitrofurantoin was withdrawn, and long-term immunosuppressive therapy with prednisolone and azathioprine or mycophenolate was given. The patients responded well, with liver biochemistry returning to normal within a few months.</p> <p>Conclusions</p> <p>Although nitrofurantoin rarely causes autoimmune hepatitis, this antimicrobial is increasingly used as long-term prophylaxis against recurrent urinary tract infection. General practitioners and urologists who prescribe long-term nitrofurantoin therapy should be aware of this adverse effect.</p
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