In search of disorders: internalizing symptom networks in a large clinical sample.

Background The co‐occurrence of internalizing disorders is a common form of psychiatric comorbidity, raising questions about the boundaries between these diagnostic categories. We employ network psychometrics in order to: (a) determine whether internalizing symptoms cluster in a manner reflecting DSM diagnostic criteria, (b) gauge how distinct these diagnostic clusters are and (c) examine whether this network structure changes from childhood to early and then late adolescence. Method Symptom‐level data were obtained for service users in publicly funded mental health services in England between 2011 and 2015 (N = 37,162). A symptom network (i.e. Gaussian graphical model) was estimated, and a community detection algorithm was used to explore the clustering of symptoms. Results The estimated network was densely connected and characterized by a multitude of weak associations between symptoms. Six communities of symptoms were identified; however, they were weakly demarcated. Two of these communities corresponded to social phobia and panic disorder, and four did not clearly correspond with DSM diagnostic categories. The network structure was largely consistent by sex and across three age groups (8–11, 12–14 and 15–18 years). Symptom connectivity in the two older age groups was significantly greater compared to the youngest group and there were differences in centrality across the age groups, highlighting the age‐specific relevance of certain symptoms. Conclusions These findings clearly demonstrate the interconnected nature of internalizing symptoms, challenging the view that such pathology takes the form of distinct disorders

Mindfulness meditators do not show differences in electrophysiological measures of error processing

Mindfulness meditation may improve attention and self-regulation. One component of attention and self-regulation that may allow these improvements is performance monitoring. Neural correlates of performance monitoring can be objectively measured with electroencephalogram (EEG) via the error-related negativity (ERN) and error positivity (Pe). Previous research assessing the ERN and Pe in meditators has resulted in inconsistent findings; some have reported alteration in peak amplitudes from both very brief meditation practice and long-term meditation practice, while others have failed to provide evidence for differences in the ERN or Pe. However, recently developed EEG analysis techniques allow for more rigorous analyses than have been used in past investigations.Neil W. Bailey, Kavya Raj, Gabrielle Freedman, Bernadette M. Fitzgibbon, Nigel C. Rogasch, Nicholas T. Van Dam, Paul B. Fitzgeral

Factors associated with substance use and sexual behavior among drug users in three mountainous provinces of Vietnam

10.3390/ijerph15091885International Journal of Environmental Research and Public Health159188

A genome-wide association study identifies a functional ERAP2 haplotype associated with birdshot chorioretinopathy

Birdshot chorioretinopathy (BSCR) is a rare form of autoimmune uveitis that can lead to severe visual impairment. Intriguingly, >95% of cases carry the HLA-A29 allele, which defines the strongest documented HLA association for a human disease. We have conducted a genome-wide association study in 96 Dutch and 27 Spanish cases, and 398 unrelated Dutch and 380 Spanish controls. Fine-mapping the primary MHC association through high-resolution imputation at classicalHLA loci, identified HLA-A*29:02 as the principalMHCassociation (odds ratio (OR) 5 157.5, 95% CI 91.6-272.6, P = 6.6 × 10-74). We also identified two novel susceptibility loci at 5q15 nearERAP2 (rs7705093;OR 5 2.3,95%CI 1.7-3.1, for the T allele,P = 8.6 × 10-8) and at 14q32.31 in theTECPR2 gene (rs150571175;OR 5 6.1,95%CI 3.2-11.7, for theAallele,P = 3.2 × 10-8). The association nearERAP2was confirmed in an independent British case-control samples (combined meta-analysis P = 1.7 × 10-9). Functional analyses revealed that the risk allele of the polymorphism near ERAP2 is strongly associated with high mRNA and protein expression of ERAP2 in B cells. This study further defined an extremely strong MHC risk component in BSCR, and detected evidence for a novel disease mechanism that affects peptide processing in the endoplasmic r

Desenvolvimento de um modelo fractal para a estimativa da condutividade hidráulica de solos não saturados A fractal model to estimate the unsaturated hydraulic conductivity of soils

Baseado nos conceitos da geometria fractal e nas leis de Laplace e de Poiseuille, foi criado um modelo geral para estimar a condutividade hidráulica de solos não saturados, utilizando a curva de retenção da água no solo, conforme representada por um modelo em potência. Considerando o fato de que este novo modelo da condutividade hidráulica introduz um parâmetro de interpolação ainda desconhecido, e que, por sua vez, depende das propriedades dos solos, a validação do modelo foi realizada, utilizando dois valores-limite fisicamente representativos. Para a aplicação do modelo, os parâmetros de forma da curva de retenção da água no solo foram escolhidos de maneira a se obter o modelo de van Genuchten. Com a finalidade de obter fórmulas algébricas da condutividade hidráulica, foram impostas relações entre seus parâmetros de forma. A comparação dos resultados obtidos com o modelo da condutividade e a curva experimental da condutividade dos dois solos, Latossolo Vermelho-Amarelo e Argissolo Amarelo, permitiu concluir que o modelo proposto é simples em sua utilização e é capaz de predizer satisfatoriamente a condutividade hidráulica dos solos não saturados.<br>From a conceptual model based on fractal geometry and Laplace's and Poiseuille's laws, a versatile and general fractal model for the hydraulic conductivity to be used in the soils was developed. The soil-moisture retention curve is derived from a power model. Due to the fact that the proposed model of hydraulic conductivity introduces a still unknown interpolation parameter, which in turn is a function of soil properties, its limiting values were considered for the analysis. To apply the model in the soil, the form parameters of the soil-moisture retention curve were chosen so as to reproduce van Genuchten's equation. In order to obtain a closed-form equation for the hydraulic conductivity, relationships between the form parameters were imposed. The comparison between the predicted and experimental hydraulic conductivity from two soils, Oxisol and Yellow Utilsol, demonstrated that the proposed model is flexible and that it can be used to predict the unsaturated hydraulic conductivity of soils with good accuracy

Socio-inspired ICT: Towards a socially grounded society-ICT symbiosis

Modern ICT (Information and Communication Technology) has developed a vision where the “computer” is no longer associated with the concept of a single device or a network of devices, but rather the entirety of situated services originating in a digital world, which are perceived through the physical world. It is observed that services with explicit user input and output are becoming to be replaced by a computing landscape sensing the physical world via a huge variety of sensors, and controlling it via a plethora of actuators. The nature and appearance of computing devices is changing to be hidden in the fabric of everyday life, invisibly networked, and omnipresent, with applications greatly being based on the notions of context and knowledge. Interaction with such globe spanning, modern ICT systems will presumably be more implicit, at the periphery of human attention, rather than explicit, i.e. at the focus of human attention.Socio-inspired ICT assumes that future, globe scale ICT systems should be viewed as social systems. Such a view challenges research to identify and formalize the principles of interaction and adaptation in social systems, so as to be able to ground future ICT systems on those principles. This position paper therefore is concerned with the intersection of social behaviour and modern ICT, creating or recreating social conventions and social contexts through the use of pervasive, globe-spanning, omnipresent and participative ICTValues and TechnologyTechnology, Policy and Managemen