455 research outputs found
Novel Scintillating Materials Based on Phenyl-Polysiloxane for Neutron Detection and Monitoring
Neutron detectors are extensively used at many nuclear research facilities
across Europe. Their application range covers many topics in basic and applied
nuclear research: in nuclear structure and reaction dynamics (reaction
reconstruction and decay studies); in nuclear astrophysics (neutron emission
probabilities); in nuclear technology (nuclear data measurements and
in-core/off-core monitors); in nuclear medicine (radiation monitors,
dosimeters); in materials science (neutron imaging techniques); in homeland
security applications (fissile materials investigation and cargo inspection).
Liquid scintillators, widely used at present, have however some drawbacks given
by toxicity, flammability, volatility and sensitivity to oxygen that limit
their duration and quality. Even plastic scintillators are not satisfactory
because they have low radiation hardness and low thermal stability. Moreover
organic solvents may affect their optical properties due to crazing. In order
to overcome these problems, phenyl-polysiloxane based scintillators have been
recently developed at Legnaro National Laboratory. This new solution showed
very good chemical and thermal stability and high radiation hardness. The
results on the different samples performance will be presented, paying special
attention to a characterization comparison between synthesized phenyl
containing polysiloxane resins where a Pt catalyst has been used and a
scintillating material obtained by condensation reaction, where tin based
compounds are used as catalysts. Different structural arrangements as a result
of different substituents on the main chain have been investigated by High
Resolution X-Ray Diffraction, while the effect of improved optical
transmittance on the scintillation yield has been elucidated by a combination
of excitation/fluorescence measurements and scintillation yield under exposure
to alpha and {\gamma}-rays.Comment: InterM 2013 - International Multidisciplinary Microscopy Congres
Investigation of corrosion-erosion phenomena in the primary cooling system of SPIDER
SPIDER dedicated cooling plant has to remove up to 10 MW thermal power from in-vessel components and auxiliary systems. The circuit is characterized by three main heat transfer systems: primary, secondary and tertiary systems. The primary system is made of four circuits, with only three operating so far, these are called PC01, PC02 and PC03. These three circuits respectively cool SPIDER power supplies and the beam source components using ultrapure water. During 2019 SPIDER experimental campaigns, it was observed that electrical resistivity of water degraded considerably and more quickly (âŒ25 MΩ cm hâ1 in PC01) than estimated by design. To overcome this issue, water had to be restored very frequently to maintain the desired characteristics and avoid possible detrimental leakage currents throughout the circuit. The reason for this severe water degradation has to be better understood before issues such as abrupt failures may arise. This work presents a preliminary analysis of the two main circuits (PC01 and PC02) where an estimation of water degradation induced by general corrosion of stainless steels and copper components was made. This preliminary estimation showed that PC01 could be more prone to general corrosion than PC02; however, the rate of water conductivity increase was 5.3 times smaller than that observed during experiments in 2019 and 2020
Overview of the design of the ITER heating neutral beam injectors
The heating neutral beam injectors (HNBs) of ITER are designed to deliver 16.7MWof 1 MeVD0 or
0.87 MeVH0 to the ITER plasma for up to 3600 s. They will be the most powerful neutral beam\uf0a0(NB)
injectors ever, delivering higher energy NBs to the plasma in a tokamak for longer than any previous
systems have done. The design of the HNBs is based on the acceleration and neutralisation of negative
ions as the efficiency of conversion of accelerated positive ions is so low at the required energy that a
realistic design is not possible, whereas the neutralisation ofH 12 andD 12 remains acceptable ( 4856%).
The design of a long pulse negative ion based injector is inherently more complicated than that of
short pulse positive ion based injectors because:
\u2022 negative ions are harder to create so that they can be extracted and accelerated from the ion source;
\u2022 electrons can be co-extracted from the ion source along with the negative ions, and their
acceleration must be minimised to maintain an acceptable overall accelerator efficiency;
\u2022 negative ions are easily lost by collisions with the background gas in the accelerator;
\u2022 electrons created in the extractor and accelerator can impinge on the extraction and acceleration
grids, leading to high power loads on the grids;
\u2022 positive ions are created in the accelerator by ionisation of the background gas by the accelerated
negative ions and the positive ions are back-accelerated into the ion source creating a massive power
load to the ion source;
\u2022 electrons that are co-accelerated with the negative ions can exit the accelerator and deposit power on
various downstream beamline components.
The design of the ITER HNBs is further complicated because ITER is a nuclear installation which
will generate very large fluxes of neutrons and gamma rays. Consequently all the injector components
have to survive in that harsh environment. Additionally the beamline components and theNBcell,
where the beams are housed, will be activated and all maintenance will have to be performed remotely.
This paper describes the design of theHNBinjectors, but not the associated power supplies, cooling
system, cryogenic system etc, or the high voltage bushingwhich separates the vacuum of the beamline
fromthehighpressureSF6 of the high voltage (1MV) transmission line, through which the power, gas and
coolingwater are supplied to the beam source. Also themagnetic field reduction system is not described
Tissue carcinoembryonic antigen and oestrogen receptor status in breast carcinoma: an immunohistochemical study of clinical outcome in a series of 252 patients with long-term follow-up.
Carcinoembryonic antigen (CEA) is a well-known tumour marker whose immunohistochemical expression could be prognostically relevant in breast carcinomas. We evaluated CEA immunohistochemical expression, using the specific T84.66 monoclonal antibody, in a series of 252 consecutive cases of infiltrating breast carcinomas (104 N0, 148 N1/2) with median follow-up of 84 months. Oestrogen receptor (ER) status has been evaluated with the immunohistochemical method (ER1D5 antibody, 10% cut-off value): 121 cases were ER negative, 128 cases were ER positive and in three cases ER status was unknown. CEA staining was cytoplasmic; staining intensity and percentage of reacting cells were combined to obtain a final score (CEA score). The difference between the distribution of CEA score within the modalities of the other variables was not statistically significant. Univariate survival analysis has been performed on the series of node-negative and node-positive patients. In the latter subgroup, this has been performed separately for patients treated with systemic adjuvant hormonal therapy or chemotherapy. A multivariate analysis was only performed for node-positive patients treated with adjuvant therapy. CEA immunoreactivity was not prognostically relevant in any subset of analysed patients. The most important prognostic markers were nodal status and tumour size
PD-L1/PD-1 Pattern of Expression Within the Bone Marrow Immune Microenvironment in Smoldering Myeloma and Active Multiple Myeloma Patients
Background: The PD-1/PD-L1 axis has recently emerged as an immune checkpoint that controls antitumor immune responses also in hematological malignancies. However, the use of anti-PD-L1/PD-1 antibodies in multiple myeloma (MM) patients still remains debated, at least in part because of discordant literature data on PD-L1/PD-1 expression by MM cells and bone marrow (BM) microenvironment cells. The unmet need to identify patients which could benefit from this therapeutic approach prompts us to evaluate the BM expression profile of PD-L1/PD-1 axis across the different stages of the monoclonal gammopathies. Methods: The PD-L1/PD-1 axis was evaluated by flow cytometry in the BM samples of a total cohort of 141 patients with monoclonal gammopathies including 24 patients with Monoclonal Gammopathy of Undetermined Significance (MGUS), 38 patients with smoldering MM (SMM), and 79 patients with active MM, including either newly diagnosed or relapsed-refractory patients. Then, data were correlated with the main immunological and clinical features of the patients. Results: First, we did not find any significant difference between MM and SMM patients in terms of PD-L1/PD-1 expression, on both BM myeloid (CD14+) and lymphoid subsets. On the other hand, PD-L1 expression by CD138+ MM cells was higher in both SMM and MM as compared to MGUS patients. Second, the analysis on the total cohort of MM and SMM patients revealed that PD-L1 is expressed at higher level in CD14+CD16+ non-classical monocytes compared with classical CD14+CD16â cells, independently from the stage of disease. Moreover, PD-L1 expression on CD14+ cells was inversely correlated with BM serum levels of the anti-tumoral cytokine, IL-27. Interestingly, relapsed MM patients showed an inverted CD4+/CD8+ ratio along with high levels of pro-tumoral IL-6 and a positive correlation between Ă14+PD-L1+ and Ă8+PD-1+ cells as compared to both SMM and newly diagnosed MM patients suggesting a highly compromised immune-compartment with low amount of CD4+ effector cells. Conclusions: Our data indicate that SMM and active MM patients share a similar PD-L1/PD-1 BM immune profile, suggesting that SMM patients could be an interesting target for PD-L1/PD-1 inhibition therapy, in light of their less compromised and more responsive immune-compartment
DEDALO: PHASE II STUDY OF DARATUMUMAB PLUS POMALIDOMIDE AND DEXAMETHASONE (DPD) IN PATIENTS WITH RELAPSED/REFRACTORY MULTIPLE MYELOMA AND 17P DELETION
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