Anthropometric discriminators of type 2 diabetes among White and Black American adults

BACKGROUND: The aim of the present study was to determine the best anthropometric discriminators of type 2 diabetes mellitus (T2DM) among White and Black males and females in a large US sample. METHODS: We used Atherosclerosis Risk in Communities study baseline data (1987–89) from 15 242 participants (1827 with T2DM) aged 45–65 years. Anthropometric measures included a body shape index (ABSI), body adiposity index (BAI), body mass index, waist circumference (WC), waist:height ratio (WHtR), and waist:hip ratio (WHR). All anthropometric measures were standardized to Z-scores. Using logistic regression, odds ratios for T2DM were adjusted for age, physical activity, and family history of T2DM. The Akaike information criterion and receiver operating characteristic C-statistic were used to select the best-fit models. RESULTS: Body mass index, WC, WHtR, and WHR were comparable discriminators of T2DM among White and Black males, and were superior to ABSI and BAI in predicting T2DM (P < 0.0001). Waist circumference, WHtR, and WHR were the best discriminators among White females, whereas WHR was the best discriminator among Black females. The ABSI was the poorest discriminator of T2DM for all race–gender groups except Black females. Anthropometric values distinguishing T2DM cases from non-cases were lower for Black than White adults. CONCLUSIONS: Anthropometric measures that included WC, either alone or relative to height (WHtR) or hip circumference (WHR), were the strongest discriminators of T2DM across race–gender groups. Body mass index was a comparable discriminator to WC, WHtR, and WHR among males, but not females

Disc Clearing of Young Stellar Objects: Evidence for Fast Inside-out Dispersal

The time-scale over which and the modality by which young stellar objects (YSOs) disperse their circumstellar discs dramatically influences the eventual formation and evolution of planetary systems. By means of extensive radiative transfer (RT) modelling, we have developed a new set of diagnostic diagrams in the infrared colour-colour plane (K-[24] vs. K-[8]), to aid with the classification of the evolutionary stage of YSOs from photometric observations. Our diagrams allow the differentiation of sources with unevolved (primordial) discs from those evolving according to different clearing scenarios (e.g. homologous depletion vs. inside-out dispersal), as well as from sources that have already lost their disc. Classification of over 1500 sources in 15 nearby star-forming regions reveals that approximately 39 % of the sources lie in the primordial disc region, whereas between 31 % and 32 % disperse from the inside-out and up to 22 % of the sources have already lost their disc. Less than 2 % of the objects in our sample lie in the homogeneous draining regime. Time-scales for the transition phase are estimated to be typically a few 10^5 years independent of stellar mass. Therefore, regardless of spectral type, we conclude that currently available infrared photometric surveys point to fast (of order 10 % of the global disc lifetime) inside-out clearing as the preferred mode of disc dispersal.Comment: 31 pages, 21 figures, 6 tables, accepted for publication in MNRA

Exploring the movement dynamics of deception

Both the science and the everyday practice of detecting a lie rest on the same assumption: hidden cognitive states that the liar would like to remain hidden nevertheless influence observable behavior. This assumption has good evidence. The insights of professional interrogators, anecdotal evidence, and body language textbooks have all built up a sizeable catalog of non-verbal cues that have been claimed to distinguish deceptive and truthful behavior. Typically, these cues are discrete, individual behaviors—a hand touching a mouth, the rise of a brow—that distinguish lies from truths solely in terms of their frequency or duration. Research to date has failed to establish any of these non-verbal cues as a reliable marker of deception. Here we argue that perhaps this is because simple tallies of behavior can miss out on the rich but subtle organization of behavior as it unfolds over time. Research in cognitive science from a dynamical systems perspective has shown that behavior is structured across multiple timescales, with more or less regularity and structure. Using tools that are sensitive to these dynamics, we analyzed body motion data from an experiment that put participants in a realistic situation of choosing, or not, to lie to an experimenter. Our analyses indicate that when being deceptive, continuous fluctuations of movement in the upper face, and somewhat in the arms, are characterized by dynamical properties of less stability, but greater complexity. For the upper face, these distinctions are present despite no apparent differences in the overall amount of movement between deception and truth. We suggest that these unique dynamical signatures of motion are indicative of both the cognitive demands inherent to deception and the need to respond adaptively in a social context

KCa 3.1-a microglial target ready for drug repurposing?

Over the past decade, glial cells have attracted attention for harboring unexploited targets for drug discovery. Several glial targets have attracted de novo drug discovery programs, as highlighted in this GLIA Special Issue. Drug repurposing, which has the objective of utilizing existing drugs as well as abandoned, failed, or not yet pursued clinical development candidates for new indications, might provide a faster opportunity to bring drugs for glial targets to patients with unmet needs. Here, we review the potential of the intermediate-conductance calcium-activated potassium channels KCa 3.1 as the target for such a repurposing effort. We discuss the data on KCa 3.1 expression on microglia in vitro and in vivo and review the relevant literature on the two KCa 3.1 inhibitors TRAM-34 and Senicapoc. Finally, we provide an outlook of what it might take to harness the potential of KCa 3.1 as a bona fide microglial drug target. GLIA 2016;64:1733-1741

Optical Spectroscopy and Nebular Oxygen Abundances of the Spitzer/SINGS Galaxies

We present intermediate-resolution optical spectrophotometry of 65 galaxies obtained in support of the Spitzer Infrared Nearby Galaxies Survey (SINGS). For each galaxy we obtain a nuclear, circumnuclear, and semi-integrated optical spectrum designed to coincide spatially with mid- and far-infrared spectroscopy from the Spitzer Space Telescope. We make the reduced, spectrophotometrically calibrated one-dimensional spectra, as well as measurements of the fluxes and equivalent widths of the strong nebular emission lines, publically available. We use optical emission-line ratios measured on all three spatial scales to classify the sample into star-forming, active galactic nuclei (AGN), and galaxies with a mixture of star formation and nuclear activity. We find that the relative fraction of the sample classified as star-forming versus AGN is a strong function of the integrated light enclosed by the spectroscopic aperture. We supplement our observations with a large database of nebular emission-line measurements of individual HII regions in the SINGS galaxies culled from the literature. We use these ancillary data to conduct a detailed analysis of the radial abundance gradients and average HII-region abundances of a large fraction of the sample. We combine these results with our new integrated spectra to estimate the central and characteristic (globally-averaged) gas-phase oxygen abundances of all 75 SINGS galaxies. We conclude with an in-depth discussion of the absolute uncertainty in the nebular oxygen abundance scale.Comment: ApJS, in press; 52 emulateapj pages, 12 figures, and two appendices; v2: final abundances revised due to minor error; conclusions unchange

Is Agricultural Policy Decoupling against Human Nature? Experimental Evidence of Fairness Expectations’ Contributions to Payment Incidence

The objective of this research is to measure individuals’ fairness expectations and relate them to their market behavior in a private-negotiation institution. By doing this, we may inform model parameterization of field data and increase understanding of payment incidence causation. We hypothesize agents will change both their market and UG behavior when the tenant/proposer receives a subsidy following a successful negotiation. We also hypothesize that agents’ market behavior does relate to their fairness expectations in the UG. Two economic experiments were developed to test our hypotheses, a market and an ultimatum bargaining game experiment. We recruited 106 undergraduate students and conducted the experiments in an experimental laboratory using a computer based market mechanism. Our findings suggest fairness expectations need to be considered as a possible constraint on agents’ profit maximization behavior in land markets. The experimental evidence indicates market sellers or landlords demand higher land rental prices when tenants receive per-unit subsidies. Their ability to obtain a higher price appears to be more formidable in markets with limited matching opportunities. We conclude fairness expectations may constrain individuals’ profit-maximization behavior in the land market and, in turn, affect payment incidence in this market.Agricultural and Food Policy,

Aviation Fueling: A Cleaner, Greener Approach

Projected growth of aviation depends on fueling where specific needs must be met. Safety is paramount, and along with political, social, environmental and legacy transport systems requirements, alternate aviation fueling becomes an opportunity of enormous proportions. Biofuels sourced from halophytes, algae, cyanobacteria, and weeds using wastelands, waste water, and seawater have the capacity to be drop-in fuel replacements for petroleum fuels. Biojet fuels from such sources solves the aviation CO2 emissions issue and do not compete with food or freshwater needs. They are not detrimental to the social or environmental fabric and use the existing fuels infrastructure. Cost and sustainable supply remains the major impediments to alternate fuels. Halophytes are the near-term solution to biomass/biofuels capacity at reasonable costs; they simply involve more farming, at usual farming costs. Biofuels represent a win-win approach, proffering as they do at least the ones we are studying massive capacity, climate neutral-to-some sequestration, and ultimately, reasonable costs