Mathematical modelling and optimization of surface quality and productivity in turning process of AISI 12L14 free-cutting Steel

In this study, several series of experiments on turning process of AISI 12L14 free cutting steel characterized by its self-lubrication and the high percentage of lead in its composition were performed to rate the influence of cutting conditions (Vc, f and ap) on the machining performance such as surface roughness, cutting force, cutting power and material removal rate. A computer generated optimal design of experiment based on the I-optimality criteria along with analysis of variance was created to study the characterizations in turning of this steel, and desirability function was utilized for the optimization. The global optimization, combined high surface quality and productivity with low cutting power consumption, gave 12 optimal setting points provided high desirability values. The obtained correlation for surface roughness, cutting force, material removal rate and cutting power were 99.4%, 95.5%, 99.7% and 94.3%, respectively

International Business in an Accelerated VUCA World: Trends, Disruptions, and Coping Strategies

It is clear that the current business environment has changed fundamentally over the past several years. Major transformations were well underway prior to the global pandemic, but the latter and the ensuing global recession made the business landscape even more extraordinary. This paper discusses the new realities which define the contemporary global economy and provides insights into the changing nature of cross-border business. Specifically, we examine some of the short and long-term trends and disruptions that impact business. We also explore potential coping mechanisms and strategies that can help business thrive in this new environment

Anticancer chemotherapy and radiotherapy trigger both non-cell-autonomous and cell-autonomous death.

Even though cell death modalities elicited by anticancer chemotherapy and radiotherapy have been extensively studied, the ability of anticancer treatments to induce non-cell-autonomous death has never been investigated. By means of multispectral imaging flow-cytometry-based technology, we analyzed the lethal fate of cancer cells that were treated with conventional anticancer agents and co-cultured with untreated cells, observing that anticancer agents can simultaneously trigger cell-autonomous and non-cell-autonomous death in treated and untreated cells. After ionizing radiation, oxaliplatin, or cisplatin treatment, fractions of treated cancer cell populations were eliminated through cell-autonomous death mechanisms, while other fractions of the treated cancer cells engulfed and killed neighboring cells through non-cell-autonomous processes, including cellular cannibalism. Under conditions of treatment with paclitaxel, non-cell-autonomous and cell-autonomous death were both detected in the treated cell population, while untreated neighboring cells exhibited features of apoptotic demise. The transcriptional activity of p53 tumor-suppressor protein contributed to the execution of cell-autonomous death, yet failed to affect the non-cell-autonomous death by cannibalism for the majority of tested anticancer agents, indicating that the induction of non-cell-autonomous death can occur under conditions in which cell-autonomous death was impaired. Altogether, these results reveal that chemotherapy and radiotherapy can induce both non-cell-autonomous and cell-autonomous death of cancer cells, highlighting the heterogeneity of cell death responses to anticancer treatments and the unsuspected potential contribution of non-cell-autonomous death to the global effects of anticancer treatment

Everyday-Life Business Deviance Among Chinese SME Owners

Despite its prevalence in emerging economies, everyday-life business deviance (EBD) and its antecedents have received surprisingly little research attention. Drawing on strain theory and the business-ethics literature, we develop a socio-psychological explanation for this deviance. Our analysis of 741 owners of Chinese small- and medium-sized enterprises (SMEs) suggests that materialism and trust in institutional justice affect EBD both directly and indirectly in a relationship mediated by the ethical standards of SME owners. These findings have important implications for researching deviant business behavior within SMEs

Human Capital, Social Capital and Innovation: A Multi-Country Study

We examine the effects of two forms of capital, i.e. human capital and social capital, on innovation at the country level. We use secondary data from the World Development Report on a country’s overall human development to test for a relationship between human capital and innovation. We also use previous conceptualisations of social capital as comprising trust, associational activity, and norms of civic behaviour to test for relationships between these indicators of social capital and innovation using data from the World Values Survey. Unlike most previous studies that examined human and social capital within a given country, we develop and empirically test a theoretically grounded model that relates human and social capital to innovation at the societal level across 59 different countries, thus providing a more global view of the role of these two forms of capital in generating value. We find strong support for the positive relationship between human capital and innovation and partial support for the positive effect of trust and associational activity on innovation. However, contrary to our prediction, we find a negative relationship between norms of civic behaviour and one of our innovation measures.social capital; human capital; innovation; cross-country comparison

Key considerations before integrating modular construction: adaptation to the traditional French construction processes

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