N-Heterocyclic Carbene-Platinum Complexes Featuring an Anthracenyl Moiety: Anti-Cancer Activity and DNA Interaction

International audienceA platinum (II) complex stabilized by a pyridine and an N-heterocyclic carbene ligand featuring an anthracenyl moiety was prepared. The compound was fully characterized and its molecular structure was determined by single-crystal X-ray diffraction. The compound demonstrated high in vitro antiproliferative activities against cancer cell lines with IC50 ranging from 10 to 80 nM. The presence of the anthracenyl moiety on the N-heterocyclic carbene (NHC) Pt complex was used as a luminescent tag to probe the metal interaction with the nucleobases of the DNA through a pyridine-nucleobase ligand exchange. Such interaction of the platinum complex with DNA was corroborated by optical tweezers techniques and liquid phase atomic force microscopy (AFM). The results revealed a two-state interaction between the platinum complex and the DNA strands. This two-state behavior was quantified from the different experiments due to contour length variations. At 24 h incubation, the stretching curves revealed multiple structural breakages, and AFM imaging revealed a highly compact and dense structure of platinum complexes bridging the DNA strands

IRISS (Increasing Resilience in Surveillance Societies) FP7 European Research Project, Deliverable 3.2: Surveillance Impact Report

External research report produced for the European Commission as part of the FP7 IRISS project: Increasing Resilience in Surveillance Socieities, containing European case studies on the varying formats of neighbourhood watch, including the cultural and historical factors which may influence the creation of neighbourhood watch groups in the first instance. Overview of neighbourhood watch in the United Kingdom and analysis of the changing role of the police in relation to community policing and the impact which this has had on the primary purpose of neighbourhood watch organisations.This deliverable was written as part of the IRISS project which received funding from the European Union’s Seventh Framework Programme for research, technological development and demonstration under Grant Agreement No. 285593. Additional co-authors: Alessia Ceresa, Chiara Fonio, Walter Peissl, Robert Rothman, Jaro Sterbik Lamina, Ivan Szekely, Beatrix Vissy, Wolfgang Bonß, Daniel Fischer, Gemma Galdon Clavell, Reinhard Kreissl, Alexander Neumann, Nils Zurawsk

Search and indignify: Automatic number plate recognition in Europe

Chapter 4 examines the harms and controversies associated with the deployment of Automatic Number Plate Recognition in Belgium, Germany, Slovakia and the UK. The chapter explains the surveillance practice, how it is formally governed and any evidence of surveillance harm. In the case of ANPR, it is evident that it was initially deployed in a closed institutional setting and its use was only questioned after implementation, following controversy and as a result of adversarial power relations, such as legal challenges and public enquiries. Using the participatory lens, the case of ANPR demonstrates how institutions can become open to scrutiny in a variety of ways and how surveillance practices can sometimes be renegotiated. However, in practice the power to renegotiate ANPR is reserved for political and regulatory elites, rather than ordinary citizens

Complex hazard cascade culminating in the Anak Krakatau sector collapse

Flank instability and sector collapses, which pose major threats, are common on volcanic islands. On 22 Dec 2018, a sector collapse event occurred at Anak Krakatau volcano in the Sunda Strait, triggering a deadly tsunami. Here we use multiparametric ground-based and space-borne data to show that prior to its collapse, the volcano exhibited an elevated state of activity, including precursory thermal anomalies, an increase in the island's surface area, and a gradual seaward motion of its southwestern flank on a dipping decollement. Two minutes after a small earthquake, seismic signals characterize the collapse of the volcano's flank at 13:55 UTC. This sector collapse decapitated the cone-shaped edifice and triggered a tsunami that caused 430 fatalities. We discuss the nature of the precursor processes underpinning the collapse that culminated in a complex hazard cascade with important implications for the early detection of potential flank instability at other volcanoes